메뉴 건너뛰기




Volumn 65, Issue 6, 2017, Pages 1963-1978

The Linear ubiquitin chain assembly complex acts as a liver tumor suppressor and inhibits hepatocyte apoptosis and hepatitis

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; CASPASE; CASPASE 8; CRE RECOMBINASE; DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEIN; DNA; HEME OXIDIZED IRON REGULATORY PROTEIN 2 UBIQUITIN LIGASE 1 INTERACTING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IRON REGULATORY PROTEIN 2; LINEAR UBIQUITIN CHAIN ASSEMBLY COMPLEX; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; RNF31 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR;

EID: 85017423336     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.29074     Document Type: Article
Times cited : (33)

References (43)
  • 2
    • 79958222619 scopus 로고    scopus 로고
    • Chronic liver inflammation and hepatocellular carcinoma: persistence matters
    • Weber A, Boege Y, Reisinger F, Heikenwalder M. Chronic liver inflammation and hepatocellular carcinoma: persistence matters. Swiss Med Wkly 2011;141:w13197.
    • (2011) Swiss Med Wkly , vol.141 , pp. w13197
    • Weber, A.1    Boege, Y.2    Reisinger, F.3    Heikenwalder, M.4
  • 3
    • 33645799492 scopus 로고    scopus 로고
    • Mechanisms of liver injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways
    • Schwabe RF, Brenner DA. Mechanisms of liver injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol 2006;290:G583-G589.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290 , pp. G583-G589
    • Schwabe, R.F.1    Brenner, D.A.2
  • 4
    • 58149464887 scopus 로고    scopus 로고
    • Adalimumab could suppress the activity of non alcoholic steatohepatitis (NASH)
    • Schramm C, Schneider A, Marx A, Lohse AW. Adalimumab could suppress the activity of non alcoholic steatohepatitis (NASH). Z Gastroenterol 2008;46:1369-1371.
    • (2008) Z Gastroenterol , vol.46 , pp. 1369-1371
    • Schramm, C.1    Schneider, A.2    Marx, A.3    Lohse, A.W.4
  • 5
    • 80055028155 scopus 로고    scopus 로고
    • Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trial
    • Zein CO, Yerian LM, Gogate P, Lopez R, Kirwan JP, Feldstein AE, et al. Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trial. Hepatology 2011;54:1610-1619.
    • (2011) Hepatology , vol.54 , pp. 1610-1619
    • Zein, C.O.1    Yerian, L.M.2    Gogate, P.3    Lopez, R.4    Kirwan, J.P.5    Feldstein, A.E.6
  • 8
    • 21244472975 scopus 로고    scopus 로고
    • IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • Maeda S, Kamata H, Luo JL, Leffert H, Karin M. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 2005;121:977-990.
    • (2005) Cell , vol.121 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.L.3    Leffert, H.4    Karin, M.5
  • 9
    • 77952107213 scopus 로고    scopus 로고
    • TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer
    • Bettermann K, Vucur M, Haybaeck J, Koppe C, Janssen J, Heymann F, et al. TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer. Cancer Cell 2010;17:481-496.
    • (2010) Cancer Cell , vol.17 , pp. 481-496
    • Bettermann, K.1    Vucur, M.2    Haybaeck, J.3    Koppe, C.4    Janssen, J.5    Heymann, F.6
  • 10
    • 33846839443 scopus 로고    scopus 로고
    • Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma
    • Luedde T, Beraza N, Kotsikoris V, van Loo G, Nenci A, De Vos R, et al. Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell 2007;11:119-132.
    • (2007) Cancer Cell , vol.11 , pp. 119-132
    • Luedde, T.1    Beraza, N.2    Kotsikoris, V.3    van Loo, G.4    Nenci, A.5    De Vos, R.6
  • 11
    • 84883296695 scopus 로고    scopus 로고
    • RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling caspase-8- and JNK-dependent compensatory cell proliferation
    • Vucur M, Reisinger F, Gautheron J, Janssen J, Roderburg C, Cardenas DV, et al. RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling caspase-8- and JNK-dependent compensatory cell proliferation. Cell Rep 2013;4:776-790.
    • (2013) Cell Rep , vol.4 , pp. 776-790
    • Vucur, M.1    Reisinger, F.2    Gautheron, J.3    Janssen, J.4    Roderburg, C.5    Cardenas, D.V.6
  • 12
    • 84946544180 scopus 로고    scopus 로고
    • NEMO prevents steatohepatitis and hepatocellular carcinoma by inhibiting RIPK1 kinase activity–mediated hepatocyte apoptosis
    • Kondylis V, Polykratis A, Ehlken H, Ochoa-Callejero L, Straub BK, Krishna-Subramanian S, et al. NEMO prevents steatohepatitis and hepatocellular carcinoma by inhibiting RIPK1 kinase activity–mediated hepatocyte apoptosis. Cancer Cell 2015;28:582-598.
    • (2015) Cancer Cell , vol.28 , pp. 582-598
    • Kondylis, V.1    Polykratis, A.2    Ehlken, H.3    Ochoa-Callejero, L.4    Straub, B.K.5    Krishna-Subramanian, S.6
  • 13
    • 84947923888 scopus 로고    scopus 로고
    • NF-kappaB-independent role of IKKalpha/IKKbeta in preventing RIPK1 kinase-dependent apoptotic and necroptotic cell death during TNF signaling
    • Dondelinger Y, Jouan-Lanhouet S, Divert T, Theatre E, Bertin J, Gough PJ, et al. NF-kappaB-independent role of IKKalpha/IKKbeta in preventing RIPK1 kinase-dependent apoptotic and necroptotic cell death during TNF signaling. Mol Cell 2015;60:63-76.
    • (2015) Mol Cell , vol.60 , pp. 63-76
    • Dondelinger, Y.1    Jouan-Lanhouet, S.2    Divert, T.3    Theatre, E.4    Bertin, J.5    Gough, P.J.6
  • 15
    • 33750219981 scopus 로고    scopus 로고
    • A ubiquitin ligase complex assembles linear polyubiquitin chains
    • Kirisako T, Kamei K, Murata S, Kato M, Fukumoto H, Kanie M, et al. A ubiquitin ligase complex assembles linear polyubiquitin chains. EMBO J 2006;25:4877-4887.
    • (2006) EMBO J , vol.25 , pp. 4877-4887
    • Kirisako, T.1    Kamei, K.2    Murata, S.3    Kato, M.4    Fukumoto, H.5    Kanie, M.6
  • 16
    • 84931055813 scopus 로고    scopus 로고
    • Linear ubiquitination signals in adaptive immune responses
    • Ikeda F. Linear ubiquitination signals in adaptive immune responses. Immunol Rev 2015;266:222-236.
    • (2015) Immunol Rev , vol.266 , pp. 222-236
    • Ikeda, F.1
  • 18
    • 84864222562 scopus 로고    scopus 로고
    • Atypical ubiquitylation—the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages
    • Kulathu Y, Komander D. Atypical ubiquitylation—the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages. Nat Rev Mol Cell Biol 2012;13:508-523.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 508-523
    • Kulathu, Y.1    Komander, D.2
  • 20
    • 84907995994 scopus 로고    scopus 로고
    • HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death
    • Peltzer N, Rieser E, Taraborrelli L, Draber P, Darding M, Pernaute B, et al. HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death. Cell Rep 2014;9:153-165.
    • (2014) Cell Rep , vol.9 , pp. 153-165
    • Peltzer, N.1    Rieser, E.2    Taraborrelli, L.3    Draber, P.4    Darding, M.5    Pernaute, B.6
  • 24
    • 0032898369 scopus 로고    scopus 로고
    • Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell–specific gene knock-outs using Cre recombinase
    • Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, et al. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell–specific gene knock-outs using Cre recombinase. J Biol Chem 1999;274:305-315.
    • (1999) J Biol Chem , vol.274 , pp. 305-315
    • Postic, C.1    Shiota, M.2    Niswender, K.D.3    Jetton, T.L.4    Chen, Y.5    Moates, J.M.6
  • 25
    • 71149105333 scopus 로고    scopus 로고
    • Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
    • Haas TL, Emmerich CH, Gerlach B, Schmukle AC, Cordier SM, Rieser E, et al. Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol Cell 2009;36:831-844.
    • (2009) Mol Cell , vol.36 , pp. 831-844
    • Haas, T.L.1    Emmerich, C.H.2    Gerlach, B.3    Schmukle, A.C.4    Cordier, S.M.5    Rieser, E.6
  • 26
    • 84926373774 scopus 로고    scopus 로고
    • A triple stain of reticulin, glypican-3, and glutamine synthetase: a useful aid in the diagnosis of liver lesions
    • Swanson BJ, Yearsley MM, Marsh W, Frankel WL. A triple stain of reticulin, glypican-3, and glutamine synthetase: a useful aid in the diagnosis of liver lesions. Arch Pathol Lab Med 2015;139:537-542.
    • (2015) Arch Pathol Lab Med , vol.139 , pp. 537-542
    • Swanson, B.J.1    Yearsley, M.M.2    Marsh, W.3    Frankel, W.L.4
  • 27
    • 33846463379 scopus 로고    scopus 로고
    • Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets
    • Boyault S, Rickman DS, de Reynies A, Balabaud C, Rebouissou S, Jeannot E, et al. Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets. Hepatology 2007;45:42-52.
    • (2007) Hepatology , vol.45 , pp. 42-52
    • Boyault, S.1    Rickman, D.S.2    de Reynies, A.3    Balabaud, C.4    Rebouissou, S.5    Jeannot, E.6
  • 28
    • 4544273428 scopus 로고    scopus 로고
    • Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling
    • Lee JS, Chu IS, Heo J, Calvisi DF, Sun Z, Roskams T, et al. Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling. Hepatology 2004;40:667-676.
    • (2004) Hepatology , vol.40 , pp. 667-676
    • Lee, J.S.1    Chu, I.S.2    Heo, J.3    Calvisi, D.F.4    Sun, Z.5    Roskams, T.6
  • 29
    • 84899729602 scopus 로고    scopus 로고
    • Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming
    • Miyajima A, Tanaka M, Itoh T. Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming. Cell Stem Cell 2014;14:561-574.
    • (2014) Cell Stem Cell , vol.14 , pp. 561-574
    • Miyajima, A.1    Tanaka, M.2    Itoh, T.3
  • 30
    • 33646160623 scopus 로고    scopus 로고
    • Inflammation, a key event in cancer development
    • Lu H, Ouyang W, Huang C. Inflammation, a key event in cancer development. Mol Cancer Res 2006;4:221-233.
    • (2006) Mol Cancer Res , vol.4 , pp. 221-233
    • Lu, H.1    Ouyang, W.2    Huang, C.3
  • 32
    • 84919465499 scopus 로고    scopus 로고
    • Cell death and cell death responses in liver disease: mechanisms and clinical relevance
    • Luedde T, Kaplowitz N, Schwabe RF. Cell death and cell death responses in liver disease: mechanisms and clinical relevance. Gastroenterology 2014;147:765-783.
    • (2014) Gastroenterology , vol.147 , pp. 765-783
    • Luedde, T.1    Kaplowitz, N.2    Schwabe, R.F.3
  • 33
    • 21044445452 scopus 로고    scopus 로고
    • Apoptosis: a mechanism of acute and chronic liver injury
    • Guicciardi ME, Gores GJ. Apoptosis: a mechanism of acute and chronic liver injury. Gut 2005;54:1024-1033.
    • (2005) Gut , vol.54 , pp. 1024-1033
    • Guicciardi, M.E.1    Gores, G.J.2
  • 34
    • 74549217325 scopus 로고    scopus 로고
    • Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation
    • He G, Yu GY, Temkin V, Ogata H, Kuntzen C, Sakurai T, et al. Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cell 2010;17:286-297.
    • (2010) Cancer Cell , vol.17 , pp. 286-297
    • He, G.1    Yu, G.Y.2    Temkin, V.3    Ogata, H.4    Kuntzen, C.5    Sakurai, T.6
  • 35
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 2010;140:197-208.
    • (2010) Cell , vol.140 , pp. 197-208
    • Park, E.J.1    Lee, J.H.2    Yu, G.Y.3    He, G.4    Ali, S.R.5    Holzer, R.G.6
  • 36
    • 84932174753 scopus 로고    scopus 로고
    • Death receptor–independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout
    • Ehlken H, Krishna-Subramanian S, Ochoa-Callejero L, Kondylis V, Nadi NE, Straub BK, et al. Death receptor–independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout. Cell Death Differ 2014;21:1721-1732.
    • (2014) Cell Death Differ , vol.21 , pp. 1721-1732
    • Ehlken, H.1    Krishna-Subramanian, S.2    Ochoa-Callejero, L.3    Kondylis, V.4    Nadi, N.E.5    Straub, B.K.6
  • 37
    • 79960922705 scopus 로고    scopus 로고
    • cIAPs block ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms
    • Feoktistova M, Geserick P, Kellert B, Dimitrova DP, Langlais C, Hupe M, et al. cIAPs block ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell 2011;43:449-463.
    • (2011) Mol Cell , vol.43 , pp. 449-463
    • Feoktistova, M.1    Geserick, P.2    Kellert, B.3    Dimitrova, D.P.4    Langlais, C.5    Hupe, M.6
  • 38
    • 79960921946 scopus 로고    scopus 로고
    • The ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs
    • Tenev T, Bianchi K, Darding M, Broemer M, Langlais C, Wallberg F, et al. The ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol Cell 2011;43:432-448.
    • (2011) Mol Cell , vol.43 , pp. 432-448
    • Tenev, T.1    Bianchi, K.2    Darding, M.3    Broemer, M.4    Langlais, C.5    Wallberg, F.6
  • 40
    • 43049152912 scopus 로고    scopus 로고
    • TNF-alpha induces two distinct caspase-8 activation pathways
    • Wang L, Du F, Wang X. TNF-alpha induces two distinct caspase-8 activation pathways. Cell 2008;133:693-703.
    • (2008) Cell , vol.133 , pp. 693-703
    • Wang, L.1    Du, F.2    Wang, X.3
  • 41
    • 84901678314 scopus 로고    scopus 로고
    • Cutting edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice
    • Berger SB, Kasparcova V, Hoffman S, Swift B, Dare L, Schaeffer M, et al. Cutting edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice. J Immunol 2014;192:5476-5480.
    • (2014) J Immunol , vol.192 , pp. 5476-5480
    • Berger, S.B.1    Kasparcova, V.2    Hoffman, S.3    Swift, B.4    Dare, L.5    Schaeffer, M.6
  • 42
    • 84861197159 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace
    • Baffy G, Brunt EM, Caldwell SH. Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace. J Hepatol 2012;56:1384-1391.
    • (2012) J Hepatol , vol.56 , pp. 1384-1391
    • Baffy, G.1    Brunt, E.M.2    Caldwell, S.H.3
  • 43
    • 34548336791 scopus 로고    scopus 로고
    • Oral IDN-6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C
    • Pockros PJ, Schiff ER, Shiffman ML, McHutchison JG, Gish RG, Afdhal NH, et al. Oral IDN-6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C. Hepatology 2007;46:324-329.
    • (2007) Hepatology , vol.46 , pp. 324-329
    • Pockros, P.J.1    Schiff, E.R.2    Shiffman, M.L.3    McHutchison, J.G.4    Gish, R.G.5    Afdhal, N.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.