Antibiotics in sepsis: The new frontier

Critical Care Medicine

Volumn 45, Issue 5, 2017, Pages 907-908

  Levy, Mitchell M ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Antibiotics; Quality improvement; Sepsis; Timely

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT;

ANTIBIOTIC THERAPY; EDITORIAL; EMERGENCY CARE; HUMAN; PRIORITY JOURNAL; SEPSIS; SEPTIC SHOCK; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE;

ANTI-BACTERIAL AGENTS; HUMANS; SEPSIS;

EID: 85017408604     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000002390     Document Type: Editorial

References (13)

1. Ferrer R, Artigas A, Suarez D, et al; Edusepsis Study Group: Effectiveness of treatments for severe sepsis: A prospective, multicenter, observational study. Am J Respir Crit Care Med 2009; 180:861-866.
2. Kumar A, Roberts D, Wood KE, et al: Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34:1589-1596.
3. Ferrer R, Martin-Loeches I, Phillips G, et al: Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: Results from a guideline-based performance improvement program. Crit Care Med 2014; 42:1749-1755.
4. Zhang D, Micek ST, Kollef MH: Time to appropriate antibiotic therapy is an independent determinant of postinfection ICU and hospital lengths of stay in patients with sepsis. Crit Care Med 2015; 43:2133-2140.
5. de Groot B, Ansems A, Gerling DH, et al: The association between time to antibiotics and relevant clinical outcomes in emergency department patients with various stages of sepsis: A prospective multi-center study. Crit Care 2015; 19:194.
6. Barie PS, Hydo LJ, Shou J, et al: Influence of antibiotic therapy on mortality of critical surgical illness caused or complicated by infection. Surg Infect (Larchmt) 2005; 6:41-54.
7. Gaieski DF, Mikkelsen ME, Band RA, et al: Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department. Crit Care Med 2010; 38:1045-1053.
8. Kumar A: Systematic bias in meta-Analyses of time to antimicrobial in sepsis studies. Crit Care Med 2016; 44:e234-e235.
9. Sterling SA, Miller WR, Pryor J, et al: The impact of timing of antibiotics on outcomes in severe sepsis and septic shock: A systematic review and meta-Analysis. Crit Care Med 2015; 43:1907-1915.
10. Centers for Medicare and Medicaid Services: CMS to Improve Quality of Care during Hospital Inpatient Stays. 2014. Available at: https://www.cms.gov/Newsroom/MediaReleaseDatabase/Fact-sheets/2014-Fact-sheets-items/2014-08-04-2.html. Accessed January 30, 2017.
11. Seymour CW, kahn JM, Martin-Gill C, et al: Delays From First Medical Contact to Antibiotic Administration for Sepsis. Crit Care Med 2017; 45:759-765.
12. Levy MM, Dellinger RP, Townsend SR, et al: The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med 2010; 36:222-231.
13. Amaral AC, Fowler RA, Pinto R, et al; Cooperative Antimicrobial Therapy of Septic Shock Database Research Group: Patient and organizational factors associated with delays in antimicrobial therapy for septic shock. Crit Care Med 2016; 44:2145-2153.