Time to appropriate antibiotic therapy is an independent determinant of postinfection ICU and hospital lengths of stay in patients with sepsis

Critical Care Medicine

Volumn 43, Issue 10, 2015, Pages 2133-2140

  Zhang, David ^a   Micek, Scott T ^b   Kollef, Marin H ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST LOUIS COLLEGE OF PHARMACY   (United States)

Author keywords

Antibiotics; Length of stay; Septic shock; Severe sepsis

Indexed keywords

CEFEPIME; CIPROFLOXACIN; DAPTOMYCIN; FLUCONAZOLE; GENTAMICIN; IMIPENEM; LINEZOLID; MEROPENEM; MICAFUNGIN; PIPERACILLIN PLUS TAZOBACTAM; VANCOMYCIN; ANTIINFECTIVE AGENT;

ACINETOBACTER; ADULT; ANTIBIOTIC THERAPY; APACHE; ARTICLE; ARTIFICIAL VENTILATION; BACTEROIDES; BURKHOLDERIA CEPACIA; CANDIDA ALBICANS; CHARLSON COMORBIDITY INDEX; COMORBIDITY; DISEASE SEVERITY; ENTEROBACTER; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; ESCHERICHIA COLI; FEMALE; HOSPITALIZATION; HUMAN; INTENSIVE CARE UNIT; KLEBSIELLA; LENGTH OF STAY; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEUS; PSEUDOMONAS AERUGINOSA; RETROSPECTIVE STUDY; SEPSIS; SERRATIA MARCESCENS; STAPHYLOCOCCUS AUREUS; STENOTROPHOMONAS MALTOPHILIA; STREPTOCOCCUS PNEUMONIAE; COHORT ANALYSIS; MIDDLE AGED; STATISTICS AND NUMERICAL DATA; TIME;

ANTI-BACTERIAL AGENTS; COHORT STUDIES; FEMALE; HUMANS; INTENSIVE CARE UNITS; LENGTH OF STAY; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SEPSIS; TIME FACTORS;

EID: 84937225830     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000001140     Document Type: Article

References (30)

1. Kahn JM, Le T, Angus DC, et al; ProVent Study Group Investigators: The epidemiology of chronic critical illness in the United States. Crit Care Med 2015;43:282-287
2. Mitka M: Hospitalizations for extreme conditions mean extreme expenses, study verifies. JAMA 2010;304:2579-2580
3. Dellinger RP, Levy MM, Rhodes A, et al; Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup: Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013;41:580-637
4. Kollef MH, Sherman G, Ward S, et al: Inadequate antimicrobial treatment of infections: A risk factor for hospital mortality among critically ill patients. Chest 1999;115:462-474
5. Kumar A, Roberts D, Wood KE, et al: Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006;34:1589-1596
6. Weiss SL, Fitzgerald JC, Balamuth F, et al: Delayed antimicrobial therapy increases mortality and organ dysfunction duration in pediatric sepsis. Crit Care Med 2014;42:2409-2417
7. Chung DR, Song JH, Kim SH, et al; Asian Network for Surveillance of Resistant Pathogens Study Group: High prevalence of multidrugresistant nonfermenters in hospital-acquired pneumonia in Asia. Am J Respir Crit Care Med 2011;184:1409-1417
8. Cantón R, Akóva M, Carmeli Y, et al; European Network on Carbapenemases: Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. Clin Microbiol Infect 2012;18:413-431
9. Brennan BM, Coyle JR, Marchaim D, et al: Statewide surveillance of carbapenem-resistant enterobacteriaceae in Michigan. Infect Control Hosp Epidemiol 2014;35:342-349
10. Kollef MH, Micek ST: Rational use of antibiotics in the ICU: Balancing stewardship and clinical outcomes. JAMA 2014;312:1403-1404
11. Darbà J, Kaskens L, Hark M, et al: Costs of surviving meningococcal disease in Spain: Evaluation for two cases of severe meningitis and septicaemia. Vaccine 2014;32:5006-5012
12. De Smet AM, Kluytmans JA, Cooper BS, et al: Decontamination of the digestive tract and oropharynx in ICU patients. N Engl J Med 2009;360:20-31
13. Knaus WA, Draper EA, Wagner DP, et al: APACHE II: A severity of disease classification system. Crit Care Med 1985;13:818-829
14. Angus DC, Linde-Zwirble WT, Lidicker J, et al: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001;29:1303-1310
15. Magiorakos AP, Srinivasan A, Carey RB, et al: Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: An international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect 2012;18:268-281
16. Micek ST, Roubinian N, Heuring T, et al: Before-after study of a standardized hospital order set for the management of septic shock. Crit Care Med 2006;34:2707-2713
17. Thiel SW, Asghar MF, Micek ST, et al: Hospital-wide impact of a standardized order set for the management of bacteremic severe sepsis. Crit Care Med 2009;37:819-824
18. Clinical Laboratory Standards Institute: Performance Standards for Antimicrobial Susceptibility Testing: Seventeenth Informational Supplement. M100-S17. Wayne, PA, Clinical Laboratory Standards Institute, 2007
19. Clinical Laboratory Standards Institute: Performance Standards for Antimicrobial Susceptibility Testing: Seventeenth Informational Supplement. M100-S22. Wayne, PA, Clinical Laboratory Standards Institute, 2012
20. Akaike H: A new look at the statistical model identification. IEEE Trans Automat Contr 1974;19:716-723
21. Ferrer R, Martin-Loeches I, Phillips G, et al: Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: Results from a guideline-based performance improvement program. Crit Care Med 2014;42:1749-1755
22. Ferrer R, Artigas A, Suarez D, et al; Edusepsis Study Group: Effectiveness of treatments for severe sepsis: A prospective, multicenter, observational study. Am J Respir Crit Care Med 2009;180:861-866
23. Kerremans JJ, Verbrugh HA, Vos MC: Frequency of microbiologically correct antibiotic therapy increased by infectious disease consultations and microbiological results. J Clin Microbiol 2012;50:2066-2068
24. De Bus L, Saerens L, Gadeyne B, et al: Development of antibiotic treatment algorithms based on local ecology and respiratory surveillance cultures to restrict the use of broad-spectrum antimicrobial drugs in the treatment of hospital-acquired pneumonia in the intensive care unit: A retrospective analysis. Crit Care 2014;18:R152
25. Kumar A, Zarychanski R, Light B, et al; Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group: Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: A propensity-matched analysis. Crit Care Med 2010;38:1773-1785
26. Micek ST, Welch EC, Khan J, et al: Empiric combination antibiotic therapy is associated with improved outcome against sepsis due to Gram-negative bacteria: A retrospective analysis. Antimicrob Agents Chemother 2010;54:1742-1748
27. Johnson MT, Reichley R, Hoppe-Bauer J, et al: Impact of previous antibiotic therapy on outcome of Gram-negative severe sepsis. Crit Care Med 2011;39:1859-1865
28. Muszynski JA, Knatz NL, Sargel CL, et al: Timing of correct parenteral antibiotic initiation and outcomes from severe bacterial communityacquired pneumonia in children. Pediatr Infect Dis J 2011;30:295-301
29. Geerlings SE, Hulscher M, Prins JM: [Appropriate use of antibiotics shortens length of hospital stay]. Ned Tijdschr Geneeskd 2014;158:A7288
30. Douglas IS, Price CS, Overdier KH, et al: Rapid automated microscopy for microbiological surveillance of ventilator-associated pneumonia. Am J Respir Crit Care Med 2015;191:566-573