Patient and Organizational Factors Associated with Delays in Antimicrobial Therapy for Septic Shock∗

Critical Care Medicine

Volumn 44, Issue 12, 2016, Pages 2145-2153

  Amaral, Andre C K B ^a   Fowler, Robert A ^a   Pinto, Ruxandra ^a   Rubenfeld, Gordon D ^a   Ellis, Paul ^b   Bookatz, Brian ^c   Marshall, John C ^d   Martinka, Greg ^e   Keenan, Sean ^f   Laporta, Denny ^g   Roberts, Daniel ^h   Kumar, Anand ^h  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c Critical Care Medicine   (Canada)

^d ST MICHAEL'S HOSPITAL   (Canada)

^e Division of Infectious Diseases   (Canada)

^f ROYAL COLUMBIAN HOSPITAL   (Canada)

^g MCGILL UNIVERSITY   (Canada)

^h WINNIPEG REGIONAL HEALTH AUTHORITY   (Canada)

Author keywords

antimicrobials; health services research; quality improvement; sepsis; shock

Indexed keywords

ANTIINFECTIVE AGENT;

ADULT; ANTIMICROBIAL THERAPY; ARTICLE; CLINICAL ASSESSMENT TOOL; COMMUNITY ACQUIRED INFECTION; COMORBIDITY; CRITICALLY ILL PATIENT; EMERGENCY WARD; FEMALE; HIGHER ACUTE PHYSIOLOGY SCORE; HOSPITAL ADMISSION; HUMAN; HYPOTENSION; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; ORGANIZATION; PATIENT; PNEUMONIA; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEPTIC SHOCK; SURGICAL WARD; THERAPY DELAY; INTENSIVE CARE UNIT; MIDDLE AGED; ORGANIZATION AND MANAGEMENT; RISK FACTOR; SHOCK, SEPTIC; STATISTICS AND NUMERICAL DATA; TIME FACTOR; TOTAL QUALITY MANAGEMENT;

ANTI-INFECTIVE AGENTS; FEMALE; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; QUALITY IMPROVEMENT; RETROSPECTIVE STUDIES; RISK FACTORS; SHOCK, SEPTIC; TIME FACTORS;

EID: 84979085394     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000001868     Document Type: Article

References (38)

1. Chassin MR, Galvin RW: The urgent need to improve health care quality. Institute of Medicine National Roundtable on Health Care Quality. JAMA 1998; 280:1000-1005
2. Schuster MA, McGlynn EA, Brook RH: How good is the quality of health care in the United States? 1998. Milbank Q 2005; 83:843-895
3. Hsu DJ, Stone RA, Obrosky DS, et al: Predictors of timely antibiotic administration for patients hospitalized with community-acquired pneumonia from the cluster-randomized EDCAP trial. Am J Med Sci 2010; 339:307-313
4. Ferrer R, Artigas A, Levy MM, et al; Edusepsis Study Group: Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain. JAMA 2008; 299:2294-2303
5. Grimshaw JM, Thomas RE, MacLennan G, et al: Effectiveness and efficiency of guideline dissemination and implementation strategies. Health Technol Assess 2004; 8:iii-iv, 1-72
6. Walsh JM, McDonald KM, Shojania KG, et al: Quality improvement strategies for hypertension management: A systematic review. Med Care 2006; 44:646-657
7. Sinuff T, Cook D, Giacomini M, et al: Facilitating clinician adherence to guidelines in the intensive care unit: A multicenter, qualitative study. Crit Care Med 2007; 35:2083-2089
8. Treggiari MM, Martin DP, Yanez ND, et al: Effect of intensive care unit organizational model and structure on outcomes in patients with acute lung injury. Am J Respir Crit Care Med 2007; 176:685-690
9. Ilan R, Fowler RA, Geerts R, et al: Knowledge translation in critical care: Factors associated with prescription of commonly recommended best practices for critically ill patients. Crit Care Med 2007; 35:1696-1702
10. Rubenfeld GD, Caldwell E, Peabody E, et al: Incidence and outcomes of acute lung injury. N Engl J Med 2005; 353:1685-1693
11. Dreiher J, Almog Y, Sprung CL, et al: Temporal trends in patient characteristics and survival of intensive care admissions with sepsis: A multicenter analysis. Crit Care Med 2012; 40:855-860
12. Ranieri VM, Thompson BT, Barie PS, et al; PROWESS-SHOCK Study Group: Drotrecogin alfa (activated) in adults with septic shock. New Eng J Med 2012; 366:2055-2064
13. Bernard GR, Vincent JL, Laterre PF, et al; Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344:699-709
14. Rivers E, Nguyen B, Havstad S, et al; Early Goal-Directed Therapy Collaborative Group: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345:1368-1377
15. Yealy DM, Kellum JA, Huang DT, et al; ProCESS Investigators: A randomized trial of protocol-based care for early septic shock. N Engl J Med 2014; 370:1683-1693
16. Kumar A, Roberts D, Wood KE, et al: Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34:1589-1596
17. Dellinger RP, Levy MM, Carlet JM, et al; International Surviving Sepsis Campaign Guidelines Committee; American Association of Critical-Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society of Clinical Microbiology and Infectious Diseases; European Society of Intensive Care Medicine; European Respiratory Society; International Sepsis Forum; Japanese Association for Acute Medicine; Japanese Society of Intensive Care Medicine; Society of Critical Care Medicine; Society of Hospital Medicine; Surgical Infection Society; World Federation of Societies of Intensive and Critical Care Medicine: Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008; 36:296-327
18. Dellinger RP, Levy MM, Rhodes A, et al; Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup: Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013; 41:580-637
19. Levy MM, Dellinger RP, Townsend SR, et al; Surviving Sepsis Campaign: The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med 2010; 38:367-374
20. Damiani E, Donati A, Serafini G, et al: Effect of performance improvement programs on compliance with sepsis bundles and mortality: A systematic review and meta-analysis of observational studies. PLoS One 2015; 10:e0125827
21. Kumar A, Zarychanski R, Light B, et al; Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group: Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: A propensity-matched analysis. Crit Care Med 2010; 38:1773-1785
22. Levy MM, Fink MP, Marshall JC, et al; SCCM/ESICM/ACCP/ATS/ SIS: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003; 31:1250-1256
23. McGeer A, Campbell B, Emori TG, et al: Definitions of infection for surveillance in long-term care facilities. Am J Infect Control 1991; 19:1-7
24. Hanley JA, McNeil BJ: A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology 1983; 148:839-843
25. Kumar A, Safdar N, Kethireddy S, et al: A survival benefit of combination antibiotic therapy for serious infections associated with sepsis and septic shock is contingent only on the risk of death: A meta-analytic/ meta-regression study. Crit Care Med 2010; 38:1651-1664
26. Lott JP, Iwashyna TJ, Christie JD, et al: Critical illness outcomes in specialty versus general intensive care units. Am J Respir Crit Care Med 2009; 179:676-683
27. Wallace DJ, Angus DC, Barnato AE, et al: Nighttime intensivist staffing and mortality among critically ill patients. N Engl J Med 2012; 366:2093-2101
28. Rubin HR, Pronovost P, Diette GB: The advantages and disadvantages of process-based measures of health care quality. Int J Qual Health Care 2001; 13:469-474
29. Reader TW, Flin R, Mearns K, et al: Team situation awareness and the anticipation of patient progress during ICU rounds. BMJ Qual Saf 2011; 20:1035-1042
30. Kanwar M, Brar N, Khatib R, et al: Misdiagnosis of community-acquired pneumonia and inappropriate utilization of antibiotics: Side effects of the 4-h antibiotic administration rule. Chest 2007; 131:1865-1869
31. Tunkel AR, Hartman BJ, Kaplan SL, et al: Practice guidelines for the management of bacterial meningitis. Clin Infect Dis 2004; 39:1267-1284
32. Begg N, Cartwright KA, Cohen J, et al: Consensus statement on diagnosis, investigation, treatment and prevention of acute bacterial meningitis in immunocompetent adults. British Infection Society Working Party. J Infect 1999; 39:1-15
33. Puskarich MA, Trzeciak S, Shapiro NI, et al; Emergency Medicine Shock Research Network (EMSHOCKNET): Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med 2011; 39:2066-2071
34. Pines JM, Isserman JA, Hinfey PB: The measurement of time to first antibiotic dose for pneumonia in the emergency department: A white paper and position statement prepared for the American Academy of Emergency Medicine. J Emerg Med 2009; 37:335-340
35. Meehan TP, Fine MJ, Krumholz HM, et al: Quality of care, process, and outcomes in elderly patients with pneumonia. JAMA 1997; 278:2080-2084
36. Aronin SI, Peduzzi P, Quagliarello VJ: Community-acquired bacterial meningitis: Risk stratification for adverse clinical outcome and effect of antibiotic timing. Ann Intern Med 1998; 129:862-869
37. Køster-Rasmussen R, Korshin A, Meyer CN: Antibiotic treatment delay and outcome in acute bacterial meningitis. J Infect 2008; 57:449-454
38. Kahn JM, Goss CH, Heagerty PJ, et al: Hospital volume and the outcomes of mechanical ventilation. N Engl J Med 2006; 355:41-50