Cutting edge: Targeting epithelial ORMDL3 increases, rather than reduces, airway responsiveness and is associated with increased sphingosine-1-phosphate

Journal of Immunology

Volumn 198, Issue 8, 2017, Pages 3017-3022

  Miller, Marina ^a   Tam, Arvin B ^b   Mueller, James L ^a,c   Rosenthal, Peter ^a   Beppu, Andrew ^a   Gordillo, Ruth ^d   McGeough, Matthew D ^a,c   Vuong, Christine ^a   Doherty, Taylor A ^a   Hoffman, Hal M ^a,c   Niwa, Maho ^b   Broide, David H ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; ORMDL3 PROTEIN; SMALL INTERFERING RNA; SPHINGOSINE 1 PHOSPHATE; UNCLASSIFIED DRUG; LYSOPHOSPHOLIPID; ORMDL3 PROTEIN, MOUSE; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

AIRWAY EPITHELIUM CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; HUMAN; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RESPIRATORY TRACT ALLERGY; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; ASTHMA; C57BL MOUSE; DISEASE MODEL; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; POLYMERASE CHAIN REACTION;

ANIMALS; ASTHMA; DISEASE MODELS, ANIMAL; LYSOPHOSPHOLIPIDS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; POLYMERASE CHAIN REACTION; RESPIRATORY HYPERSENSITIVITY; SPHINGOSINE;

EID: 85017398436     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1601848     Document Type: Article

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