Regulation of bone remodeling by vitamin K2

Oral Diseases

Volumn 23, Issue 8, 2017, Pages 1021-1028

  Myneni, V D ^a   Mezey, E ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

bone remodeling; osteocalcin; osteoporosis; vitamin K2

Indexed keywords

FARNOQUINONE; MARGARINE; OSTEOCALCIN; PROTEIN S; VEGETABLE OIL; CALCIUM BINDING PROTEIN; MATRIX GLA PROTEIN; SCLEROPROTEIN;

BONE CELL; BONE LINING CELL; BONE REMODELING; CATALYSIS; CELL ACTIVATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CHEESE; DRUG ABSORPTION; DRUG EXCRETION; HEMATOPOIETIC STEM CELL; HUMAN; LEAFY VEGETABLE; META ANALYSIS (TOPIC); NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOCYTE; OSTEOLYSIS; OSTEOPOROSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RODENT MODEL; ANIMAL; BONE; BONE DEVELOPMENT; METABOLISM; PHYSIOLOGY;

ANIMALS; BONE AND BONES; BONE DEVELOPMENT; BONE REMODELING; CALCIUM-BINDING PROTEINS; EXTRACELLULAR MATRIX PROTEINS; HUMANS; OSTEOBLASTS; OSTEOCALCIN; OSTEOCLASTS; OSTEOCYTES; PROTEIN S; VITAMIN K 2;

EID: 85017380184     PISSN: 1354523X     EISSN: 16010825     Source Type: Journal    
DOI: 10.1111/odi.12624     Document Type: Review

References (68)

1. Allen MR, Burr DB (2014). Bone modeling and remodeling. Basic and Applied Bone Biology, Chapter 4. Elsevier: Oxford, UK, pp. 75–90.
2. Barkhan P, Shearer MJ (1977). Metabolism of vitamin K1 (phylloquinone) in man. Proc R Soc Med 70: 93–96.
3. Bentley R, Meganathan R (1982). Biosynthesis of vitamin K (menaquinone) in bacteria. Microbiol Rev 46: 241–280.
4. Beulens JW, Booth SL, van den Heuvel EG, Stoecklin E, Baka A, Vermeer C (2013). The role of menaquinones (vitamin K(2)) in human health. Br J Nutr 110: 1357–1368.
5. Binkley N, Harke J, Krueger D et al (2009). Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American women. J Bone Miner Res 24: 983–991.
6. Booth SL (1997). Skeletal functions of vitamin K-dependent proteins: not just for clotting anymore. Nutr Rev 55: 282–284.
7. Booth SL (2012). Vitamin K: food composition and dietary intakes. Food Nutr Res 56: doi: 10.3402/fnr.v56i0.5505.
8. Booth SL, Suttie JW (1998). Dietary intake and adequacy of vitamin K. J Nutr 128: 785–788.
9. Booth SL, Pennington JA, Sadowski JA (1996). Food sources and dietary intakes of vitamin K-1 (phylloquinone) in the American diet: data from the FDA Total Diet Study. J Am Diet Assoc 96: 149–154.
10. Booth SL, Tucker KL, Chen H et al (2000). Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. Am J Clin Nutr 71: 1201–1208.
11. Bugel S (2008). Vitamin K and bone health in adult humans. Vitam Horm 78: 393–416.
12. Cairns JR, Price PA (1994). Direct demonstration that the vitamin K-dependent bone Gla protein is incompletely gamma-carboxylated in humans. J Bone Miner Res 9: 1989–1997.
13. Clarke B (2008). Normal bone anatomy and physiology. Clin J Am Soc Nephrol 3(Suppl 3): S131–S139.
14. Cockayne S, Adamson J, Lanham-New S, Shearer MJ, Gilbody S, Torgerson DJ (2006). Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials. Arch Intern Med 166: 1256–1261.
15. Eisman JA, Bouillon R (2014). Vitamin D: direct effects of vitamin D metabolites on bone: lessons from genetically modified mice. Bonekey Rep 3: 499.
16. Emaus N, Gjesdal CG, Almas B et al (2010). Vitamin K2 supplementation does not influence bone loss in early menopausal women: a randomised double-blind placebo-controlled trial. Osteoporos Int 21: 1731–1740.
17. Feng X, McDonald JM (2011). Disorders of bone remodeling. Ann Rev Pathol 6: 121–145.
18. Ferland G (1998). The vitamin K-dependent proteins: an update. Nutr Rev 56: 223–230.
19. Feskanich D, Weber P, Willett WC, Rockett H, Booth SL, Colditz GA (1999). Vitamin K intake and hip fractures in women: a prospective study. Am J Clin Nutr 69: 74–79.
20. Ficarra G, Beninati F, Rubino I et al (2005). Osteonecrosis of the jaws in periodontal patients with a history of bisphosphonates treatment. J Clin Periodontol 32: 1123–1128.
21. Gigante A, Torcianti M, Boldrini E et al (2008). Vitamin K and D association stimulates in vitro osteoblast differentiation of fracture site derived human mesenchymal stem cells. J Biol Regul Homeost Agents 22: 35–44.
22. Greenspan SL, Harris ST, Bone H et al (2000). Bisphosphonates: safety and efficacy in the treatment and prevention of osteoporosis. Am Fam Physician 61: 2731–2736.
23. Gundberg CM, Nieman SD, Abrams S, Rosen H (1998). Vitamin K status and bone health: an analysis of methods for determination of undercarboxylated osteocalcin. J Clin Endocrinol Metab 83: 3258–3266.
24. Holick MF, Nieves JW (2015). Preface. Nutrition and bone health. Springer: New York.
25. Horiuchi T, Kazama H, Araki A et al (2004). Impaired gamma carboxylation of osteocalcin in elderly women with type II diabetes mellitus: relationship between increase in undercarboxylated osteocalcin levels and low bone mineral density. J Bone Miner Metab 22: 236–240.
26. Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW (2015). Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int 26: 1175–1186.
27. Inoue T, Fujita T, Kishimoto H et al (2009). Randomized controlled study on the prevention of osteoporotic fractures (OF study): a phase IV clinical study of 15-mg menatetrenone capsules. J Bone Miner Metab 27: 66–75.
28. Iwamoto J (2014). Vitamin K(2) therapy for postmenopausal osteoporosis. Nutrients 6: 1971–1980.
29. Iwamoto J, Takeda T, Ichimura S (2003a). Treatment with vitamin D3 and/or vitamin K2 for postmenopausal osteoporosis. Keio J Med 52: 147–150.
30. Iwamoto J, Yeh JK, Takeda T (2003b). Effect of vitamin K2 on cortical and cancellous bones in orchidectomized and/or sciatic neurectomized rats. J Bone Miner Res 18: 776–783.
31. Iwamoto J, Matsumoto H, Takeda T, Sato Y, Liu X, Yeh JK (2008). Effects of vitamin K(2) and risedronate on bone formation and resorption, osteocyte lacunar system, and porosity in the cortical bone of glucocorticoid-treated rats. Calcif Tissue Int 83: 121–128.
32. Iwamoto J, Matsumoto H, Tadeda T, Sato Y, Yeh JK (2009). Comparison of the effect of vitamin K(2) and risedronate on trabecular bone in glucocorticoid-treated rats: a bone histomorphometry study. Yonsei Med J 50: 189–194.
33. Iwamoto J, Matsumoto H, Takeda T, Sato Y, Yeh JK (2010). Effects of vitamin K2 on cortical and cancellous bone mass, cortical osteocyte and lacunar system, and porosity in sciatic neurectomized rats. Calcif Tissue Int 87: 254–262.
34. Kameda T, Miyazawa K, Mori Y et al (1996). Vitamin K2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosis. Biochem Biophys Res Commun 220: 515–519.
35. Kaneki M, Hodges SJ, Hosoi T et al (2001). Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk. Nutrition 17: 315–321.
36. Knapen MH, Schurgers LJ, Vermeer C (2007). Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporos Int 18: 963–972.
37. Knapen MH, Drummen NE, Smit E, Vermeer C, Theuwissen E (2013). Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int 24: 2499–2507.
38. Kobayashi M, Hara K, Akiyama Y (2002). Effect of menatetrenone (V.K2) on bone mineral density and bone strength in Ca/Mg deficient rats. Nihon Yakurigaku Zasshi 120: 195–204.
39. Koshihara Y, Hoshi K, Okawara R, Ishibashi H, Yamamoto S (2003). Vitamin K stimulates osteoblastogenesis and inhibits osteoclastogenesis in human bone marrow cell culture. J Endocrinol 176: 339–348.
40. Luo G, Ducy P, McKee MD et al (1997). Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386: 78–81.
41. Martin T, Gooi JH, Sims NA (2009). Molecular mechanisms in coupling of bone formation to resorption. Crit Rev Eukaryot Gene Expr 19: 73–88.
42. Marx RE (2003). Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 61: 1115–1117.
43. McGowen JA, Raisz LG, Noonan AS, Al E (2004). The frequency of bone diseases. Bone health and osteoporosis: a report of the Surgeon General. Office of the Surgeon General (US): Rockville, MD.
44. Megson E, Kapellas K, Bartold PM (2010). Relationship between periodontal disease and osteoporosis. Int J Evid Based Healthc 8: 129–139.
45. Murshed M, Schinke T, McKee MD, Karsenty G (2004). Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins. J Cell Biol 165: 625–630.
46. Nakamura YS, Hakeda Y, Takakura N et al (1998). Tyro 3 receptor tyrosine kinase and its ligand, Gas6, stimulate the function of osteoclasts. Stem cells 16: 229–238.
47. Nakao M, Nishiuchi Y, Nakata M, Kimura T, Sakakibara S (1994). Synthesis of human osteocalcins: gamma-carboxyglutamic acid at position 17 is essential for a calcium-dependent conformational transition. Pept Res 7: 171–174.
48. Oldenburg J, Marinova M, Müller-Reible C, Watzka M (2008). The vitamin K cycle. Vitamins & Hormones. Academic Press, Cambridge, MA, pp. 35–62.
49. Orimo H, Nakamura T, Hosoi T et al (2012). Japanese 2011 guidelines for prevention and treatment of osteoporosis—executive summary. Arch Osteoporos 7: 3–20.
50. Pan EY, Gomperts ED, Millen R, Gilsanz V (1990). Bone mineral density and its association with inherited protein S deficiency. Thromb Res 58: 221–231.
51. Parfitt AM (2008). Skeletal heterogeneity and the purposes of bone remodeling: implications for the understanding of osteoporosis. Fundamentals of osteoporosis, Chapter 3. Academic Press: Cambridge, MA, pp. 35–53.
52. Parra-Torres AY, Valdés-Flores M, Orozco L, Velázquez-Cruz R (2013). Molecular aspects of bone remodeling. InTech: Rijeka, Croatia.
53. Raisz LG (1988). Hormonal regulation of bone growth and remodelling. Ciba Found Symp 136: 226–238.
54. Raisz LG (1999). Physiology and pathophysiology of bone remodeling. Clin Chem 45: 1353–1358.
55. Robling AG, Castillo AB, Turner CH (2006). Biomechanical and molecular regulation of bone remodeling. Annu Rev Biomed Eng 8: 455–498.
56. Rodan GA, Martin TJ (2000). Therapeutic approaches to bone diseases. Science 289: 1508–1514.
57. Sasaki H, Miyakoshi N, Kasukawa Y et al (2010). Effects of combination treatment with alendronate and vitamin K(2) on bone mineral density and strength in ovariectomized mice. J Bone Miner Metab 28: 403–409.
58. Sato T, Ohtani Y, Yamada Y, Saitoh S, Harada H (2002). Difference in the metabolism of vitamin K between liver and bone in vitamin K-deficient rats. Br J Nutr 87: 307–314.
59. Schurgers LJ, Vermeer C (2002). Differential lipoprotein transport pathways of K-vitamins in healthy subjects. Biochim Biophys Acta 1570: 27–32.
60. Shearer MJ, Newman P (2008). Metabolism and cell biology of vitamin K. Thromb Haemost 100: 530–547.
61. Sims NA, Martin TJ (2014). Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit. Bonekey Rep 3: 481.
62. Tanaka I, Oshima H (2007). Vitamin K2 as a potential therapeutic agent for glucocorticoid-induced osteoporosis. Clin Calcium 17: 1738–1744.
63. Theuwissen E, Smit E, Vermeer C (2012). The role of vitamin K in soft-tissue calcification. Adv Nutr Int Rev J 3: 166–173.
64. Tsugawa N, Shiraki M, Suhara Y, Kamao M, Tanaka K, Okano T (2006). Vitamin K status of healthy Japanese women: age-related vitamin K requirement for gamma-carboxylation of osteocalcin. Am J Clin Nutr 83: 380–386.
65. Urayama S, Kawakami A, Nakashima T et al (2000). Effect of vitamin K2 on osteoblast apoptosis: vitamin K2 inhibits apoptotic cell death of human osteoblasts induced by Fas, proteasome inhibitor, etoposide, and staurosporine. J Lab Clin Med 136: 181–193.
66. Ushiroyama T, Ikeda A, Ueki M (2002). Effect of continuous combined therapy with vitamin K(2) and vitamin D(3) on bone mineral density and coagulofibrinolysis function in postmenopausal women. Maturitas 41: 211–221.
67. Weaver CM, Gallant KMH (2014). Nutrition. Basic and applied bone biology, Chapter 14. Academic Press: Cambridge, MA, pp. 283–297.
68. Yonemura K, Kimura M, Miyaji T, Hishida A (2000). Short-term effect of vitamin K administration on prednisolone-induced loss of bone mineral density in patients with chronic glomerulonephritis. Calcif Tissue Int 66: 123–128.