Lipid mobilization in subcutaneous adipose tissue during exercise in lean and obese humans. Roles of insulin and natriuretic peptides

American Journal of Physiology - Endocrinology and Metabolism

Volumn 299, Issue 2, 2010, Pages

  Koppo, Katrien ^a,b   Larrouy, Dominique ^a,c   Marques, Marie A ^a,c   Berlan, Michel ^a,c   Bajzova, Magda ^a   Polak, Jan ^a   Van De Voorde, Johan ^b   Bülow, Jens ^d   Lafontan, Max ^c   Crampes, François ^a,c   Langin, Dominique ^a,c,e   Stich, Vladimir ^a   De Glisezinski, Isabelle ^a,c,e  

^a CHARLES UNIVERSITY   (Czech Republic)

^b GHENT UNIVERSITY   (Belgium)

^c INSERM   (France)

^d BISPEBJERG HOSPITAL   (Denmark)

^e TOULOUSE UNIVERSITY HOSPITAL   (France)

Author keywords

Adenosine; Catecholamines; Exercise induced lipolysis; Microdialysis; Octreotide

Indexed keywords

ADENOSINE; ADENOSINE RECEPTOR BLOCKING AGENT; ADRENALIN; AMINOPHYLLINE; ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; C PEPTIDE; FATTY ACID; GLUCOSE; GLYCEROL; GROWTH HORMONE; INSULIN; LACTIC ACID; LIPID; NORADRENALIN; OCTREOTIDE; OXYGEN; PHENTOLAMINE MESYLATE; PHOSPHODIESTERASE; PROPRANOLOL; SODIUM CHLORIDE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CATECHOLAMINE; NATRIURETIC FACTOR; PHOSPHODIESTERASE III; PHOSPHODIESTERASE INHIBITOR;

ADRENALIN BLOOD LEVEL; ADRENALIN RELEASE; ADRENERGIC RECEPTOR BLOCKING; ADULT; ARTICLE; BICYCLE ERGOMETRY; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIALYSATE; DRUG EFFECT; EXERCISE; EXERCISE RECOVERY; FATTY ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLYCEROL BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; HORMONE ACTION; HORMONE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LACTATE BLOOD LEVEL; LEAN BODY WEIGHT; LIPID METABOLISM; LIPOLYSIS; MALE; METABOLIC REGULATION; MICRODIALYSIS; MOLECULAR PROBE; MORNING DOSAGE; NORADRENALIN BLOOD LEVEL; NORMAL HUMAN; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; REGULATORY MECHANISM; REST; SUBCUTANEOUS FAT; ADIPOSE TISSUE; ANAEROBIC THRESHOLD; BIOSYNTHESIS; CONTROLLED CLINICAL TRIAL; DRUG POTENTIATION; EXERCISE TEST; METABOLISM; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADIPOSE TISSUE; ADRENERGIC ALPHA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ADULT; AMINOPHYLLINE; ANAEROBIC THRESHOLD; CATECHOLAMINES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; EXERCISE; EXERCISE TEST; GLYCEROL; HUMANS; INSULIN; LIPID METABOLISM; MALE; NATRIURETIC PEPTIDES; OBESITY; OCTREOTIDE; PHOSPHODIESTERASE INHIBITORS; RECEPTORS, ADRENERGIC, ALPHA-2; REST; YOUNG ADULT;

EID: 77954941825     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00767.2009     Document Type: Article

References (37)

1. Alberti KG, Christensen NJ, Christensen SE, Hansen AP, Iversen J, Lundbaek K, Seyer-Hansen K, Orskov H. Inhibition of insulin secretion by somatostatin. Lancet 2: 1299-1301, 1973.
2. Arner P, Kriegholm E, Engfeldt P, Bolinder J. Adrenergic regulation of lipolysis in situ at rest and during exercise. J Clin Invest 85: 893-898, 1990. (Pubitemid 20087493)
3. Barbe P, Stich V, Galitzky J, Kunesova M, Hainer V, Lafontan M, Berlan M. In vivo increase in β-adrenergic lipolytic response in subcutaneous adipose tissue of obese subjects submitted to a hypocaloric diet. J Clin Endocrinol Metab 82: 63-69, 1997.
4. Bernst E, Gutman I. Determination of ethanol with alcohol deshydrogenase and NAD. In: Methods of Enzymatic Analysis 3, edited by H. U. Bergmeyer. New York: Verlag Chemie, Academic, 1974, p. 1499-1505.
5. Coppack SW, Frayn KN, Humphreys SM, Dhar H, Hockaday TD. Effects of insulin on human adipose tissue metabolism in vivo. Clin Sci (Lond) 77: 663-670, 1989.
6. de Glisezinski I, Larrouy D, Bajzova M, Koppo K, Polak J, Berlan M, Bülow J, Langin D, Marques MA, Crampes F, Lafontan M, Stich V. Epinephrine but not norepinephrine is a determinant of exercise-induced lipid mobilization in human subcutaneous adipose tissue. J Physiol 587: 3393-3404, 2009.
7. Dhalla AK, Santikul M, Chisholm JW, Belardinelli L, Reaven GM. Comparison of the antilipolytic effects of an A1 adenosine receptor partial agonist in normal and diabetic rats. Diabetes Obes Metab 11: 95-101, 2009.
8. Di Luigi L, Conti FG, Casini A, Guidetti L, Zezze G, Pigozzi F, Spera G, Fortunio G, Romanelli F. Growth hormone and insulin-like growth factor I responses to moderate submaximal acute physical exercise in man: effects of octreotide, a somatostatin analogue, administration. Int J Sports Med 18: 257-263, 1997.
9. Divertie GD, Jensen MD, Miles JM. Stimulation of lipolysis in humans by physiological hypercortisolemia. Diabetes 40: 1228-1232, 1991.
10. Djurhuus CB, Gravholt CH, Nielsen S, Mengel A, Christiansen JS, Schmitz OE, Møller N. Effects of cortisol on lipolysis and regional interstitial glycerol levels in humans. Am J Physiol Endocrinol Metab 283: E172-E177, 2002. (Pubitemid 34686683)
11. Djurhuus CB, Gravholt CH, Nielsen S, Pedersen SB, Møller N, Schmitz O. Additive effects of cortisol and growth hormone on regional and systemic lipolysis in humans. Am J Physiol Endocrinol Metab 286: E488-E494, 2004.
12. Enevoldsen LH, Simonsen L, Macdonald IA, Bülow J. The combined effects of exercise and food intake on adipose tissue and splanchnic metabolism. J Physiol 561: 871-882, 2004.
13. Enevoldsen LH, Polak J, Simonsen L, Hammer T, Macdonald I, Crampes F, de Glisezinski I, Stich V, Bülow J. Post-exercise abdominal, subcutaneous adipose tissue lipolysis in fasting subjects is inhibited by infusion of the somatostatin analogue octreotide. Clin Physiol Funct Imaging 27: 320-326, 2007.
14. Galitzky J, Lafontan M, Nordenström J, Arner P. Role of vascular alpha-2 adrenoceptors in regulating lipid mobilization from human adipose tissue. J Clin Invest 91: 1997-2003, 1993.
15. Gibney J, Healy ML, Sonksen PH. The growth hormone/insulin-like growth factor-I axis in exercise and sport. Endocr Rev 28: 603-624, 2007. (Pubitemid 47610444)
16. Goodman HM, Grichting G. Growth hormone and lipolysis: a reevaluation. Endocrinology 113: 1697-1702, 1983.
17. Hansen TK, Gravholt CH, Orskov H, Rasmunsen MH, Christiansen JS, Jorgensen JOL. Dose dependency of the pharmacokinetics and acute lipolytic actions of growth hormone. J Clin Endocrinol Metab 87: 4691-4698, 2002.
18. Harant I, Beauville M, Crampes F, Riviere D, Tauber MT, Tauber JP, Garrigues M. Response of fat cells to growth hormone (GH): effect of long term treatment with recombinant human GH in GH-deficient adults. J Clin Endocrinol Metab 78: 1392-1395, 1994.
19. Hellström L, Blaak E, Hagström-Toft E. Gender differences in adrenergic regulation of lipid mobilization during exercise. Int J Sports Med 17: 439-447, 1996.
20. Hickner RC, Racette SB, Binder EF, Fisher JS, Kohrt WM. Suppression of whole body and regional lipolysis by insulin: effects of obesity and exercise. J Clin Endocrinol Metab 84: 3886-3895, 1999.
21. Jensen MD, Caruso M, Heiling V, Miles JM. Insulin regulation of lipolysis in nondiabetic and IDDM subjects. Diabetes 38: 1595-1601, 1989.
22. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sukkivan G, Quon MJ. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85: 2402-2410, 2000.
23. Lafontan M, Langin D. Lipolysis and lipid mobilization in human adipose tissue. Prog Lipid Res 48: 275-297, 2009.
24. Lönnroth P, Jansson PA, Fredholm BB, Smith U. Microdialysis of intercellular adenosine concentration in subcutaneous tissue in humans. Am J Physiol Endocrinol Metab 256: E250-E255, 1989.
25. Moro C, Crampes F, Sengenès C, De Glisezinski I, Galitzky J, Thalamas C, Lafontan M, Berlan M. Atrial natriuretic peptide contributes to physiological control of lipid mobilization in humans. FASEB J 18: 908-910, 2004.
26. Moro C, Pillard F, de Glisezinski I, Crampes F, Thalamas C, Harant I, Marques MA, Lafontan M, Berlan M. Atrial natriuretic peptide contribution to lipid mobilization and utilization during head-down bed rest in man. Am J Physiol Regul Integr Comp Physiol 293: R612-R617, 2007.
27. Nielsen S, Guo Z, Albu JB, Klein S, O'Brien PC, Jensen MD. Energy expenditure, sex, and endogenous fuel availability in humans. J Clin Invest 111: 981-988, 2003. (Pubitemid 36397474)
28. Ormsbee MJ, Choi MD, Medlin JK, Geyer GH, Trantham LH, Dubis GS, Hickner RC. Regulation of fat metabolism during resistance exercise in sedentary lean and obese men. J Appl Physiol 106: 1529-1537, 2009.
29. Perseghin G, Caumo A, Caloni M, Testolin G, Luzi L. Incorporation of the fasting plasma FFA concentration into QUICKI improves its association with insulin sensitivity in nonobese individuals. J Clin Endocrinol Metab 86: 4776-4781, 2001.
30. Sarzani R, Strazzullo P, Salvi F, Iacone R, Pietrucci F, Siani A, Barba G, Gerardi MC, Dessμ-Fulgheri P, Rappelli A. Natriuretic peptide clearance receptor alleles and susceptibility to abdominal adiposity. Obes Res 12: 351-356, 2004.
31. Sengenès C, Berlan M, De Glisezinski I, Lafontan M, Galitzky J. Natriuretic peptides: a new lipolytic pathway in human adipocytes. FASEB J 14: 1345-1351, 2000. (Pubitemid 30439743)
32. Sengenes C, Stich V, Berlan M, Hejnova J, Lafontan M, Pariskova Z, Galitzky J. Increased lipolysis in adipose tissue and lipid mobilization to natriuretic peptides during low-calorie diet in obese women. Int J Obes Relat Metab Disord 26: 24-32, 2002.
33. Sengenès C, Bouloumié A, Hauner H, Berlan M, Busse R, Lafontan M, Galitzky J. Involvement of a cGMP-dependent pathway in the natriuretic peptide-mediated hormone-sensitive lipase phosphorylation in human adipocytes. J Biol Chem 278: 48617-48626, 2003.
34. Stallknecht B, Lorentsen J, Enevoldsen LH, Bülow J, Biering- Sørensen F, Galbo H, Kjaer M. Role of the sympathoadrenergic system in adipose tissue metabolism during exercise in humans. J Physiol 536: 283-294, 2001. (Pubitemid 32952237)
35. Stich V, de Glisezinski I, Berlan M, Bülow J, Galitzky J, Harant I, Suljkovicova H, Lafontan M, Rivière D, Crampes F. Adipose tissue lipolysis is increased during a repeated bout of aerobic exercise. J Appl Physiol 88: 1277-1283, 2000.
36. 2- adrenergic receptors impairs exercise-induced lipolysis in SCAT of obese subjects. Am J Physiol Regul Integr Comp Physiol 279: R499-R504, 2000.
37. Wang TJ, Larson MG, Levy D, Benjamin EJ, Leip EP, Wilson PW, Vasan RS. Impact of obesity on plasma natriuretic peptide levels. Circulation 109: 594-600, 2004.