The effect of neonatal vitamin A supplementation on morbidity and mortality at 12 months: A randomized trial

International Journal of Epidemiology

Volumn 45, Issue 6, 2016, Pages 2112-2121

  Smith, Emily R ^a   Muhihi, Alfa ^b   Mshamu, Salum ^b   Sudfeld, Christopher R ^a   Noor, Ramadhani Abdallah ^a,b   Spiegelman, Donna ^a,b   Shapiro, Roger L ^a   Masanja, Honorati ^c   Fawzi, Wafaie ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b Africa Academy for Public Health (AAPH)   (Tanzania)

^c IFAKARA HEALTH INSTITUTE   (Tanzania)

Author keywords

Hospitalization; Infant mortality; Morbidity; Neonatal vitamin A supplementation; Tanzania

Indexed keywords

PLACEBO; RETINOL; VITAMIN;

DISEASE INCIDENCE; FOOD SUPPLEMENTATION; HEALTH RISK; HETEROGENEITY; HOSPITAL SECTOR; HUMAN IMMUNODEFICIENCY VIRUS; INFANT MORTALITY; MORBIDITY; MORTALITY; VITAMIN; WOMENS HEALTH;

ARTICLE; CHILD HOSPITALIZATION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; HUMAN; INFANT MORTALITY; INFANT NUTRITION; LIVE BIRTH; MAJOR CLINICAL STUDY; MALE; MATERNAL CARE; MATERNAL NUTRITION; MORTALITY RISK; NEWBORN; NEWBORN CARE; NEWBORN MORBIDITY; NEWBORN MORTALITY; OBSTETRIC DELIVERY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RETINOL DEFICIENCY; SINGLE DRUG DOSE; TANZANIA; VITAMIN SUPPLEMENTATION; DIETARY SUPPLEMENT; HOSPITALIZATION; INFANT; MORBIDITY; REGRESSION ANALYSIS; STATISTICS AND NUMERICAL DATA;

TANZANIA;

DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HOSPITALIZATION; HUMANS; INFANT; INFANT MORTALITY; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; INFANT, NEWBORN; MALE; MORBIDITY; REGRESSION ANALYSIS; TANZANIA; VITAMIN A; VITAMIN A DEFICIENCY; VITAMINS;

EID: 85017122746     PISSN: 03005771     EISSN: 14643685     Source Type: Journal    
DOI: 10.1093/ije/dyw238     Document Type: Article

References (49)

1. Wang H, Liddell CA, CoatesMMet al. Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014;384:957-79.
2. Imdad A, Herzer K, Mayo-Wilson E, Yakoob MY, Bhutta ZA. Vitamin A supplementation for preventing morbidity and mortality in children from 6 months to 5 years of age. Cochrane Database Syst Rev 2010;12:CD008524.
3. Mazumder S, Taneja S, Bhatia K et al. Efficacy of early neonatal supplementation with vitamin A to reduce mortality in infancy in Haryana, India (Neovita): a randomised, double-blind, placebo- controlled trial. Lancet 2015;385:1333-42.
4. Rahmathullah L, Tielsch JM, Thulasiraj RD et al. Impact of supplementing newborn infants with vitamin A on early infant mortality: community based randomised trial in southern India. BMJ 2003;327:254.
5. Masanja H, Smith ER, Muhihi A et al. Effect of neonatal vitamin A supplementation on mortality in infants in Tanzania (Neovita): a randomised, double-blind, placebo-controlled trial. Lancet 2015;385:1324-32.
6. Edmond KM, Newton S, Shannon C et al. Effect of early neonatal vitamin A supplementation on mortality during infancy in Ghana (Neovita): a randomised, double-blind, placebocontrolled trial. Lancet 2015;385:1315-23.
7. Haider BA, Bhutta ZA. Neonatal vitamin A supplementation: time to move on. Lancet 2015;385:1268-71.
8. Klemm RD, Labrique AB, Christian P et al. Newborn vitamin A supplementation reduced infant mortality in rural Bangladesh. Pediatrics 2008;122:e242-50.
9. Humphrey JH, Agoestina T, Wu L et al. Impact of neonatal vitamin A supplementation on infant morbidity and mortality. J Pediatr 1996;128:489-96.
10. West KP J., Katz J, Shrestha SR et al. Mortality of infants < 6mo of age supplemented with vitamin A: a randomized, doublemasked trial in Nepal. Am J Clin Nutr 1995;62:143-48.
11. Benn CS, Diness BR, Roth A et al. Effect of 50,000 IU vitamin A given with BCG vaccine on mortality in infants in Guinea-Bissau: randomised placebo controlled trial. BMJ 2008;336:1416-20.
12. Benn CS, Fisker AB, Napirna BM, Roth A et al. Vitamin A supplementation and BCG vaccination at birth in low birthweight neonates: two by two factorial randomised controlled trial. BMJ 2010;340:c1101.
13. Malaba LC, Iliff PJ, Nathoo KJ et al. Effect of postpartum maternal or neonatal vitamin A supplementation on infant mortality among infants born to HIV-negative mothers in Zimbabwe. Am J Clin Nutr 2005;81:454-60.
14. Benn CS, Diness BR, Balde I et al. Two different doses of supplemental vitamin A did not affect mortality of normal-birthweight neonates in Guinea-Bissau in a randomized controlled trial. J Nutr 2014;144:1474-79.
15. Humphrey JH, Iliff PJ, Marinda ET et al. Effects of a single large dose of vitamin A, given during the postpartum period to HIV-positive women and their infants, on child HIV infection, HIV-free survival, and mortality. J Infect Dis 2006;193:860-71.
16. Fawzi WW, Msamanga GI, Hunter D et al. Randomized trial of vitamin supplements in relation to transmission of HIV-1 through breastfeeding and early child mortality. AIDS 2002;16: 1935-44.
17. Darlow BA, Graham PJ. Vitamin A supplementation to prevent mortality and short- and long-term morbidity in very low birthweight infants. Cochrane Database Syst Rev. 2011;10: CD000501.
18. Benn CS, Aaby P, Arts RJ, Jensen KJ, Netea MG, Fisker AB. An enigma: why vitamin A supplementation does not always reduce mortality even though vitamin A deficiency is associated with increased mortality Int J Epidemiol 2015;44: 906-18.
19. NEOVITA Study Author Group; Bahl R, Bhandari N, Dube B et al. Efficacy of early neonatal vitamin A supplementation in reducing mortality during infancy in Ghana, India and Tanzania: study protocol for a randomized controlled trial. Trials 2012; 13:22.
20. Food and Nutrition Board, Institute of Medicine and Subcommittees. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington DC: National Academies Press, 2001.
21. Abioye AI, Isanaka S, Liu E et al. Gender differences in diet and nutrition among adults initiating antiretroviral therapy in Dar es Salaam, Tanzania. AIDS Care 2015;27:706-15.
22. Villamor E, Mugusi F, Urassa W et al. A trial of the effect of micronutrient supplementation on treatment outcome, T cell counts, morbidity, and mortality in adults with pulmonary tuberculosis. J Infect Dis 2008;197:1499-505.
23. Lukmanji Z, Hertzmark E, Spiegelman D, Fawzi WW. Dietary patterns, nutrient intake, and sociodemographic characteristics in HIV-infected Tanzanian pregnant women. Ecol Food Nutr 2013;52:34-62.
24. Kupka R, Mugusi F, Aboud S et al. Randomized, double-blind, placebo-controlled trial of selenium supplements among HIVinfected pregnant women in Tanzania: effects on maternal and child outcomes. Am J Clin Nutr 2008;87:1802-08.
25. Fawzi WW, Msamanga GI, Spiegelman D et al. Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania. Lancet 1998;351:1477-82.
26. Zohra Lukmanji EH, Nicolas Mlingi, Vincent Assey, Godwin Ndossi, Wafaie Fawzi. Tanzania Food Composition Tables. 1st edn. Dar es Salaam: Muhimbili University of Health and Allied Sciences and Tanzania and Tanzania Food and Nutrition Centre; and Boston, MA, USA: Tanzania and Harvard School of Public Health, 2008.
27. Papageorghiou AT, Ohuma EO, Altman DG et al. International standards for fetal growth based on serial ultrasound measurements: the Fetal Growth Longitudinal Study of the INTERGROWTH-21st Project. Lancet 2014;384:869-79.
28. Gogia S, Sachdev HS. Neonatal vitamin A supplementation for prevention of mortality and morbidity in infancy: systematic review of randomised controlled trials. BMJ 2009; 338:b919.
29. Dibley MJ, Sadjimin T, Kjolhede CL, Moulton LH. Vitamin A supplementation fails to reduce incidence of acute respiratory illness and diarrhea in preschool-age Indonesian children. J Nutr 1996;126:434-42.
30. Tielsch JM, Rahmathullah L, Thulasiraj RD et al. Newborn vitamin A dosing reduces the case fatality but not incidence of common childhood morbidities in South India. J Nutr 2007;137: 2470-74.
31. Stephensen CB, Franchi LM, Hernandez H, Campos M, Gilman RH, Alvarez JO. Adverse effects of high-dose vitamin A supplements in children hospitalized with pneumonia. Pediatrics 1998;101: E3.
32. Mahalanabis D, Lahiri M, Paul D et al. Randomized, doubleblind, placebo-controlled clinical trial of the efficacy of treatment with zinc or vitamin A in infants and young children with severe acute lower respiratory infection. Am J Clin Nutr 2004;79: 430-3-6.
33. Fawzi WW, Mbise RL, FatakiMR et al. Vitamin A supplementation and severity of pneumonia in children admitted to the hospital in Dar es Salaam, Tanzania. Am J Clin Nutr 1998;68: 187-92.
34. Villamor E, Fawzi WW. Effects of vitamin A supplementation on immune responses and correlation with clinical outcomes. Clin Microbiol Rev 2005;18:446-64.
35. Kirkwood B, Humphrey J, Moulton L, Martines J. Neonatal vitamin A supplementation and infant survival. Lancet 2010; 376:1643-44.
36. Arthur P, Kirkwood B, Ross D et al. Impact of vitamin A supplementation on childhood morbidity in northern Ghana. Lancet 1992;339:361-62.
37. Bhutta ZA, Baker SK. Premature abandonment of global vitamin A supplementation programmes is not prudent! Int J Epidemiol 2015;44:297-99.
38. Tielsch JM, Rahmathullah L, Katz J et al. Maternal night blindness during pregnancy is associated with low birthweight, morbidity, and poor growth in South India. J Nutr 2008;138: 787-92.
39. Jain A, Kumar P, Awasthi S. High nasopharyngeal carriage of drug resistant Streptococcus pneumoniae and Haemophilus influenzae in North Indian schoolchildren. Trop Med Int Health 2005;10:234-39.
40. Coles CL, Kanungo R, Rahmathullah L et al. Pneumococcal nasopharyngeal colonization in young South Indian infants. Pediatr Infect Dis J 2001;20:289-95.
41. Huebner RE, Wasas A, Mushi A, Mazhani L, Klugman K. Nasopharyngeal carriage and antimicrobial resistance in isolates of Streptococcus pneumoniae and Haemophilus influenzae type b in children under 5 years of age in Botswana. Int J Infect Dis 1998;3:18-25.
42. Milton RC, Reddy V, Naidu AN. Mild vitamin A deficiency and childhood morbidity - an Indian experience. Am J Clin Nutr 1987;46:827-29.
43. Bloem MW, Wedel M, Egger RJ et al. Mild vitamin A deficiency and risk of respiratory tract diseases and diarrhea in preschool and school children in northeastern Thailand. Am J Epidemiol 1990;131:332-29.
44. Coles CL, Rahmathullah L, Kanungo R et al. Vitamin A supplementation at birth delays pneumococcal colonization in South Indian infants. J Nutr2001;131:255-61.
45. Coles CL, Labrique A, Saha SK et al. Newborn vitamin A supplementation does not affect nasopharyngeal carriage of Streptococcus pneumoniae in Bangladeshi infants at age 3 months. J Nutr 2011;141:1907-11.
46. Gogia S, Sachdev HS. Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less. Cochrane Database Syst Rev 2011;10:CD007480.
47. Abdeljaber MH, Monto AS, Tilden RL, Schork MA, Tarwotjo I. The impact of vitamin A supplementation on morbidity: a randomized community intervention trial. Am J Public Health 1991;81:1654-56.
48. Rahmathullah L, Underwood BA, Thulasiraj RD, Milton RC. Diarrhea, respiratory infections, and growth are not affected by a weekly low-dose vitamin A supplement: a masked, controlled field trial in children in southern India. Am J Clin Nutr 1991;54:568-77.
49. WHO. Guideline: Vitamin A Supplementation in Postpartum Women. Geneva: World Health Organization, 2011.