Effect of 50 000 IU vitamin A given with BCG vaccine on mortality in infants in Guinea-Bissau: Randomised placebo controlled trial

BMJ

Volumn 336, Issue 7658, 2008, Pages 1416-1420

  Benn, Christine Stabell ^a   Diness, Birgitte Rode ^a   Roth, Adam ^a,b   Nante, Ernesto ^c   Fisker, Ane Bærent ^c   Lisse, Ida Maria ^d   Yazdanbakhsh, Maria ^e   Whittle, Hilton ^f   Rodrigues, Amabelia ^c   Aaby, Peter ^c  

^a STATENS SERUM INSTITUT   (Denmark)

^b LUND UNIVERSITY   (Sweden)

^c Studies of the Epidemiology of Epilepsy in Demographic Surveillance Systems   (Denmark)

^d GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^f MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; PLACEBO; RETINOL;

AFRICA; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMOGRAPHY; DOSE RESPONSE; DRUG EFFECT; DRUG MEGADOSE; FEMALE; FOLLOW UP; GUINEA-BISSAU; HEALTH SURVEY; HUMAN; INFANT; INFANT MORTALITY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; UNSPECIFIED SIDE EFFECT; VITAMIN SUPPLEMENTATION;

BCG VACCINE; CAUSE OF DEATH; FEMALE; GUINEA-BISSAU; HUMANS; INFANT MORTALITY; INFANT, NEWBORN; MALE; SEASONS; SEX DISTRIBUTION; SURVIVAL RATE; VITAMIN A; VITAMINS;

EID: 46749121528     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.39542.509444.AE     Document Type: Article

References (20)

1. Fawzi WW, Chalmers TC, Herrera MG, Mosteller F. Vitamin A supplementation and child mortality: a meta-analysis. JAMA 1993;269:898-903.
2. Benn CS, Balé C, Sommerfelt H, Friis H, Aaby P. Vitamin A supplementation and childhood mortality: amplification of the non-specific effects of vaccines? Int J Epidemiol 2003;32:822-8.
3. Humphrey JH, Agoestina T, Wu L, Usman A, Nurachim M, Subardja D, et al. Impact of neonatal vitamin A supplementation on infant morbidity and mortality. J Pediatr 1996;128:489-96.
4. Rahmathullah L, Tielsch JM, Thulasiraj RD, Katz J, Coles C, Devi S, et al. Impact of supplementing newborn infants with vitamin A on early infant mortality: community based randomised trial in southern India. BMJ 2003;327:254.
5. Unicef. Vitamin and mineral deficiency. New York: Unicef, 2004 (www.unicef.org/videoaudio/PDFs/africa_dar.pdf).
6. Nante JE, Diness BR, Ravn H, Roth A, Aaby P, Benn CS. No adverse events after simultaneous administration of 50,000 IU vitamin A and Bacille Calmette-Guerin vaccination to normal-birth-weight newborns in Guinea-Bissau. Eur J Clin Nutr 2007, doi: 10.1038/sj.ejcn.1602796.
7. Diness BR, Fisker AB, Roth A, Yazdanbakhsh M, Sartono E, Whittle H, et al. The effect of high-dose vitamin A supplementation on the immune response to Bacille Calmette-Guerin vaccination. Am J Clin Nutr 2007;86:1152-9.
8. Benn CS, Martins C, Rodrigues A, Jensen H, Lisse IM, Aaby P. Randomised study of the impact of different doses of vitamin A on childhood morbidity and mortality. BMJ 2005;331:1428-32.
9. Benn CS, Fisker AB, Diness BR, Aaby P. Sex-differential effect of neonatal vitamin A supplementation on mortality? J Infect Dis 2006;194:721.
10. Benn CS, Fisker AB, Jørgensen MJ, Aaby P. Why worry: vitamin A with DTP vaccine? Vaccine 2007;25:777-9.
11. Kjolhede CL, Stallings RY, Dibley MJ, Sadjimin T, Dawiesah S, Padmawati S. Serum retinol levels among preschool children in Central Java: demographic and socioeconomic determinants. Int J Epidemiol 1995;24:399-403.
12. Fisker AB, Lisse IM, Aaby P, Erhardt J, Rodrigues A, Bibby BM, et al. Impact of neonatal vitamin A supplementation with BCG vaccine on vitamin A status at 6 weeks and 4 months of age. Am J Clin Nutr 2007;86:1032-9.
13. Rondo PH, Abbott R, Tomkins AM. Vitamin A and neonatal anthropometry. J Trop Pediatr 2001;47:307-10.
14. Benn CS, Aaby P, Balé C, Olsen J, Michaelsen KF, George E, et al. Randomised trial of effect of vitamin A supplementation on antibody response to measles vaccine in Guinea-Bissau, West Africa. Lancet 1997;350:101-5.
15. Hadi H, Dibley MJ, West KP Jr. Complex interactions with infection and diet may explain seasonal growth responses to vitamin A in preschool aged Indonesian children. Eur J Clin Nutr 2004;58:990-9.
16. Bahl R, Bhandari N, Taneja S, Bhan MK. The impact of vitamin A supplementation on physical growth of children is dependent on season. Eur J Clin Nutr 1997;51:26-9.
17. West KP, LeClerq SC, Shrestha SR, Wu LS, Pradhan EK, Kathry SK, et al. Effects of vitamin A on growth of vitamin A-deficient children: field studies in Nepal. J Nutr 1997;127:1957-65.
18. Villamor E, Fawzi WW. Effects of vitamin A supplementation on immune responses and correlation with clinical outcomes. Clin Microbiol Rev 2005;18:446-64.
19. West Jr K, Sommer A. Newborn vitamin A dosing: policy implications for Southern Asia and Africa. Abstract presented at the 1st Micronutrient Forum Meeting in Istanbul, Turkey, April 2007. www. micronutrientforum.org/ Meeting2007/MN%20Forum%20Program %20Part%20II_Abstracts.pdf (abstract T116).
20. Bhutta ZA, Ahmed T, Black RE, Cousens S, Dewey K, Giugliani E, et al. What works? Interventions for maternal and child undernutrition and survival. Lancet 2008;371:417-40.