Structural analysis and insight into Zika virus NS5 mediated interferon inhibition

Infection, Genetics and Evolution

Volumn 51, Issue , 2017, Pages 143-152

  Dar, Hamza Arshad ^a   Zaheer, Tahreem ^a   Paracha, Rehan Zafar ^a   Ali, Amjad ^a  

^a NATIONAL UNIVERSITY OF SCIENCES AND TECHNOLOGY   (Pakistan)

Author keywords

Interferon antagonism; NS5 docking; Phylogenetic analysis; STAT2 degradation; Zika virus

Indexed keywords

ARGININE; ASPARTIC ACID; CYSTEINE; GLYCINE; INTERFERON; LYSINE; NONSTRUCTURAL PROTEIN 5; PHENYLALANINE; PROTEASOME; SEVEN IN ABSENTIA HOMOLOG 2 PROTEIN; STAT2 PROTEIN; THREONINE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; NS5 PROTEIN, FLAVIVIRUS; NUCLEAR PROTEIN; PROTEIN BINDING; SEVEN IN ABSENTIA PROTEINS; STAT2 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE; VIRAL PROTEIN;

ARTICLE; COMPUTER MODEL; CRYSTAL STRUCTURE; HYDROGEN BOND; MOLECULAR MODEL; MOLECULAR PHYLOGENY; PREDICTION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS INHIBITION; SEQUENCE ALIGNMENT; STRUCTURE ANALYSIS; UBIQUITINATION; ZIKA VIRUS; ALPHA HELIX; AMINO ACID SEQUENCE; BETA SHEET; BINDING SITE; CHEMISTRY; ENZYMOLOGY; GENE EXPRESSION; GENETICS; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOLOGY; METABOLISM; MOLECULAR DOCKING; PROTEIN DOMAIN; SEQUENCE HOMOLOGY; VIROLOGY; X RAY CRYSTALLOGRAPHY; ZIKA FEVER;

AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; GENE EXPRESSION; HOST-PATHOGEN INTERACTIONS; HUMANS; INTERFERONS; MOLECULAR DOCKING SIMULATION; NUCLEAR PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN CONFORMATION, ALPHA-HELICAL; PROTEIN CONFORMATION, BETA-STRAND; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEOLYSIS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STAT2 TRANSCRIPTION FACTOR; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION; VIRAL NONSTRUCTURAL PROTEINS; ZIKA VIRUS; ZIKA VIRUS INFECTION;

EID: 85017117725     PISSN: 15671348     EISSN: 15677257     Source Type: Journal    
DOI: 10.1016/j.meegid.2017.03.027     Document Type: Article

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