Clonal transmission of gram-negative bacteria with carbapenemases NDM-1, VIM-1, and OXA-23/72 in a Bulgarian Hospital

Microbial Drug Resistance

Volumn 23, Issue 3, 2017, Pages 301-307

  Pfeifer, Yvonne ^a   Trifonova, Angelina ^b   Pietsch, Michael ^a   Brunner, Magdalena ^a   Todorova, Iva ^b   Gergova, Ivanka ^b   Wilharm, Gottfried ^a   Werner, Guido ^a   Savov, Encho ^b  

^a ROBERT KOCH INSTITUTE   (Germany)

^b MILITARY MEDICAL ACADEMY   (Bulgaria)

Author keywords

Acinetobacter baumannii; E. coli; Enterobacteriaceae; ESBL; MLST; multidrug resistance

Indexed keywords

AMIKACIN; AZTREONAM; CARBAPENEMASE; CARBAPENEMASE NDM 1; CARBAPENEMASE OXA 23/72; CARBAPENEMASE VIM 1; CEFEPIME; CEFTAZIDIME; CIPROFLOXACIN; COLISTIN; COTRIMOXAZOLE; FOSFOMYCIN; GENTAMICIN; IMIPENEM; LEVOFLOXACIN; MEROPENEM; MINOCYCLINE; NITROFURANTOIN; PIPERACILLIN PLUS TAZOBACTAM; TOBRAMYCIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAMASE; BETA-LACTAMASE NDM-1; BETA-LACTAMASE OXA-23; CARBAPENEM DERIVATIVE; OXA-72 CARBAPENEMASE, ACINETOBACTER BAUMANNII; VIM-1 METALLO-BETA-LACTAMASE;

ACINETOBACTER; ACINETOBACTER BAUMANNII; ACINETOBACTER PITTII; ACINETOBACTER RADIORESISTENS; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL TRANSMISSION; BACTERIUM ISOLATE; BULGARIA; CLONE; ENTEROBACTER CLOACAE; ESCHERICHIA COLI; GENE SEQUENCE; GRAM NEGATIVE BACTERIUM; HOSPITAL; HUMAN; MOLECULAR PHYLOGENY; MORGANELLA MORGANII; MULTILOCUS SEQUENCE TYPING; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEUS MIRABILIS; PROVIDENCIA RETTGERI; PSEUDOMONAS AERUGINOSA; PULSED FIELD GEL ELECTROPHORESIS; ACINETOBACTER INFECTION; DRUG EFFECTS; GENETICS; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PROCEDURES;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; BULGARIA; CARBAPENEMS; ESCHERICHIA COLI; GRAM-NEGATIVE BACTERIA; HOSPITALS; HUMANS; MICROBIAL SENSITIVITY TESTS; MULTILOCUS SEQUENCE TYPING; PSEUDOMONAS AERUGINOSA;

EID: 85017113437     PISSN: 10766294     EISSN: 19318448     Source Type: Journal    
DOI: 10.1089/mdr.2016.0059     Document Type: Article

References (39)

1. Llaca-Diaz, J.M., S. Mendoza-Olazaran, A. Camacho-Ortiz, S. Flores, and E. Garza-Gonzalez. 2012. One-year surveillance of ESKAPE pathogens in an intensive care unit of Monterrey, Mexico. Chemotherapy. 58:475-481.
2. Garnacho-Montero, J., R. Amaya-Villar, C. Ferrandiz-Millon, A. Diaz-Martin, J.M. Lopez-Sanchez, and A. Gutierrez-Pizarraya. 2015.Optimum treatment strategies for carbapenemresistant Acinetobacter baumannii bacteremia. Expert Rev. Anti. Infect. Ther. 13:769-777.
3. Livermore, D.M., and N. Woodford. 2006. The betalactamase threat in Enterobacteriaceae, Pseudomonas and Acinetobacter. Trends Microbiol. 14:413-420.
4. Higgins, P.G., C. Dammhayn, M. Hackel, and H. Seifert. 2010. Global spread of carbapenem-resistant Acinetobacter baumannii. J. Antimicrob. Chemother. 65:233-238.
5. Turton, J.F., S.N. Gabriel, S. Valderrey, M.E. Kaufmann, and T.L. Pitt. 2007. Use of sequence-based typing and multiplex PCR to identify clonal lineages of outbreak strains of Acinetobacter baumannii. Clin. Microbiol. Infect. 13:807-815.
6. Viau, R., K.M. Frank, M.R. Jacobs, B. Wilson, K. Kaye, C.J. Donskey, F. Perez, A. Endimiani, and R.A. Bonomo. 2016. Intestinal carriage of carbapenemase-producing organisms: current status of surveillance methods. Clin. Microbiol. Rev. 29:1-27.
7. Nemec, A., M. Musilek, M. Maixnerova, T. De Baere, T.J. van der Reijden, M. Vaneechoutte, and L. Dijkshoorn. 2009. Acinetobacter beijerinckii sp. nov., and Acinetobacter gyllenbergii sp. nov., haemolytic organisms isolated from humans. Int. J. Syst. Evol. Microbiol. 59:118-124.
8. Weisburg, W.G., S.M. Barns, D.A. Pelletier, and D.J. Lane. 1991. 16S ribosomal DNA amplification for phylogenetic study. J. Bacteriol. 173:697-703.
9. Gröbner, S., D. Linke, W. Schütz, C. Fladerer, J. Madlung, I.B. Autenrieth, W. Witte, and Y. Pfeifer. 2009. Emergence of carbapenem-non-susceptible extended-spectrum-betalactamase (ESBL)-producing Klebsiella pneumoniae isolates at the university hospital of Tübingen, Germany. J. Med. Microbiol. 58:912-922.
10. Pfeifer, Y., G. Wilharm, E. Zander, T.A. Wichelhaus, S. Göttig, K.P. Hunfeld, H. Seifert, W. Witte, and P.G. Higgins. 2011. Molecular characterization of blaNDM-1 in an Acinetobacter baumannii strain isolated in Germany in 2007. J. Antimicrob. Chemother. 66:1998-2001.
11. Turton, J.F., M.E. Ward, N. Woodford, M.E. Kaufmann, R. Pike, D.M. Livermore, and T.L. Pitt. 2006. The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii. FEMS Microbiol. Lett. 258: 72-77.
12. Pfeifer, Y., J. Matten, and W. Rabsch. 2009. Salmonella enterica serovar Typhi with CTX-M beta-lactamase, Germany. Emerg. Infect. Dis. 15:1533-1535.
13. Park, C.H., A. Robicsek, G.A. Jacoby, D. Sahm, and D.C. Hooper. 2006. Prevalence in the United States of aac(6¢)-Ib-cr Encoding a Ciprofloxacin-Modifying Enzyme. Antimicrob. Agents Chemother. 50:3953-3955.
14. Doi, Y., and Y. Arakawa. 2007. 16S ribosomal RNA methylation: emerging resistance mechanism against aminoglycosides. Clin. Infect. Dis. 45:88-94.
15. Zander, E., A. Nemec, H. Seifert, and P.G. Higgins. 2012. Association between b-lactamase-encoding bla(OXA-51) variants and DiversiLab rep-PCR-based typing of Acinetobacter baumannii isolates. J. Clin. Microbiol. 50:1900-1904.
16. Clermont, O., S. Bonacorsi, and E. Bingen. 2000. Rapid and simple determination of the Escherichia coli Phylogenetic Group. Appl. Environ. Microbiol. 66:4555-4558.
17. Schultz, E., M. Haenni, L. Mereghetti, E. Siebor, C. Neuwirth, J.Y. Madec, A. Cloeckaert, and B. Doublet. 2015. Survey of multidrug resistance integrative mobilizable elements SGI1 and PGI1 in Proteus mirabilis in humans and dogs in France, 2010-13. J. Antimicrob. Chemother. 70: 2543-2546.
18. Tenover, F.C., R.D. Arbeit, R.V. Goering, P.A. Mickelsen, B.E. Murray, D.H. Persing, and B. Swaminathan. 1995. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J. Clin. Microbiol. 33:2233-2239.
19. Savov, E., Y. Pfeifer, G. Wilharm, A. Trifonova, I. Todorova, I. Gergova, M. Borisova, and E. Kjoseva. 2015. Isolation of Acinetobacter radioresistens from a clinical sample in Bulgaria. J. Global Antimicrob. Res. DOI: 10.1016/j.jgar.2015.10.008.
20. Gogou, V., S. Pournaras, M. Giannouli, E. Voulgari, E.T. Piperaki, R. Zarrilli, and A. Tsakris. 2011. Evolution of multidrug-resistant Acinetobacter baumannii clonal lineages: a 10 year study in Greece (2000-2009). J. Antimicrob. Chemother. 66:2767-2772.
21. Stoeva, T., P.G. Higgins, E. Savov, R. Markovska, I. Mitov, and H. Seifert. 2009. Nosocomial spread of OXA-23 and OXA-58 beta-lactamase-producing Acinetobacter baumannii in a Bulgarian hospital. J. Antimicrob. Chemother. 63:618-620.
22. Stoeva, T., P.G. Higgins, K. Bojkova, and H. Seifert. 2008. Clonal spread of carbapenem-resistant OXA-23-positive Acinetobacter baumannii in a Bulgarian university hospital. Clin. Microbiol. Infect. 14:723-727.
23. Todorova, B., T. Velinov, I. Ivanov, E. Dobreva, and T. Kantardjiev T. 2014. First detection of OXA-24 carbapenemaseproducing Acinetobacter baumannii isolates in Bulgaria.World J. Microbiol. Biotechnol. 30:1427-1430.
24. Zarrilli, R., S. Pournaras, M. Giannouli, and A. Tsakris. 2013. Global evolution of multidrug-resistant Acinetobacter baumannii clonal lineages. Int. J. Antimicrob. Agents. 41:11-19.
25. Strateva, T., A. Todorova, V. Ouzounova-Raykova, and I. Mitov. 2008. Emergence of a PER-1 extended-spectrum beta-lactamase-producing Acinetobacter baumannii clinical isolate in Bulgaria. J. Chemother. 20:391-392.
26. Bonnin, R.A., L. Poirel, M. Licker, and P. Nordmann. 2011. Genetic diversity of carbapenem-hydrolysing blactamases in Acinetobacter baumannii from Romanian hospitals. Clin. Microbiol. Infect. 17:1524-1528.
27. Bae, I.K., S.J. Jang, J. Kim, S.H. Jeong, B. Cho, and K. Lee. 2011. Interspecies dissemination of the bla gene encoding PER-1 extended-spectrum b-lactamase. Antimicrob. Agents Chemother. 55:1305-1307.
28. Gheorghe, I., A. Novais, F. Grosso, C. Rodrigues, M.C. Chifiriuc, V. Lazar, and L. Peixe. 2015. Snapshot on carbapenemaseproducing Pseudomonas aeruginosa and Acinetobacter baumannii in Bucharest hospitals reveals unusual clones and novel genetic surroundings for blaOXA-23. J. Antimicrob. Chemother. 70:1016-1020.
29. Asai, S., K. Umezawa, H. Iwashita, T. Ohshima, M. Ohashi, M. Sasaki, H. Hayashi, M. Matsui, K. Shibayama, S. Inokuchi, and H. Miyachi. 2014. An outbreak of blaOXA-51-likeand blaOXA-66-positive Acinetobacter baumannii ST208 in the emergency intensive care unit. J. Med. Microbiol. 63: 1517-1523.
30. Zowawi, H.M., A.L. Sartor, H.E. Sidjabat, H.H. Balkhy, T.R. Walsh, S.M. Al Johani, R.Y. AlJindan, M. Alfaresi, E. Ibrahim, A. Al-Jardani, J. Al Salman, A.A. Dashti, K. Johani, and D.L. Paterson. 2015. Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii isolates in the Gulf Cooperation Council States: dominance of OXA-23-Type producers. J. Clin. Microbiol. 53:896-903.
31. Lopes, B.S., M.H. Al-Agamy, M.A. Ismail, A.M. Shibl, A.A. Al-Qahtani, M.N. Al-Ahdal, and K.J. Forbes. 2015. The transferability of blaOXA-23 gene in multidrugresistant Acinetobacter baumannii isolates from Saudi Arabia and Egypt. Int. J. Med. Microbiol. 305:581-588.
32. Solomennyi, A., A. Goncharov, and L. Zueva. 2015. Extensively drug-resistant Acinetobacter baumannii belonging to the international clonal lineage I in a Russian burn intensive care unit. Int. J. Antimicrob. Agents. 45:525-528.
33. Martins, N., I.S. Martins, W.V. de Freitas, J.A. de Matos, A.C. Magalhães, V.b. Girão, R.C. Dias, T.C. de Souza, F.L. Pellegrino, L.D. Costa, C.H. Boasquevisque, S.A. Nouer, L.W. Riley, G. Santoro-Lopes, and B.M. Moreira. 2012. Severe infection in a lung transplant recipient caused by donor-Transmitted carbapenem-resistant Acinetobacter baumannii. Transpl. Infect. Dis. 14:316-320.
34. Tada, T., T. Miyoshi-Akiyama, R.K. Dahal, M.K. Sah, H. Ohara, K. Shimada, T. Kirikae, and B.M. Pokhrel. 2014. NDM-1 Metallo-b-Lactamase and ArmA 16S rRNA methylase producing Providencia rettgeri clinical isolates in Nepal. BMC Infect. Dis. 14:56. Doi: 10.1186/1471-2334-14-56.
35. Aibinu, I.E., Y. Pfeifer, F. Ogunsola, T. Odugbemi, W. Koenig, and B. Ghebremedhin. 2011. Emergence of blactamases OXA-10, VEB-1 and CMY in Providencia spp. from Nigeria. J. Antimicrob. Chemother. 66:1931-1932.
36. Tijet, N., D. Richardson, G. MacMullin, S.N. Patel, and R.G. Melano. 2015. Characterization of multiple NDM-1-producing Enterobacteriaceae isolates from the same patient. Antimicrob. Agents Chemother. 59:3648-3651.
37. Poirel, L., E. Savov E, A. Nazli, A. Trifonova, I. Todorova, I. Gergova, and P. Nordmann. 2014. Outbreak caused by NDM-1-And RmtB-producing Escherichia coli in Bulgaria. Antimicrob. Agents Chemother. 58:2472-2474.
38. Mushtaq, S., S. Irfan, J.B. Sarma, M. Doumith, R. Pike, J. Pitout, D.M. Livermore, and N. Woodford. 2011. Phylogenetic diversity of Escherichia coli strains producing NDM-Type carbapenemases. J. Antimicrob. Chemother. 66: 2002-2005.
39. Schneider, I., R. Markovska, Y. Marteva-Proevska, I. Mitov, B. Markova, and A. Bauernfeind. 2014. Detection of CMY-99, a novel acquired AmpC-Type b-lactamase, and VIM-1 in Proteus mirabilis isolates in Bulgaria. Antimicrob. Agents Chemother. 58:620-621.