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COI: 1:CAS:528:DC%2BC3MXhvVaht70%3D, PID: 20682481
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Ren X, McHale CM, Skibola CF, et al. An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis. Environ Health Perspect. 2011;119(1):11–9.
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Effects of arsenic exposure on DNA methylation and epigenetic gene regulation
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Reichard JF, Puga A. Effects of arsenic exposure on DNA methylation and epigenetic gene regulation. Epigenomics. 2010;2(1):87–104.
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Effect of prenatal arsenic exposure on DNA methylation and leukocyte subpopulations in cord blood
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This study observed an association between prenatal arsenic exposure and cord blood DNA methylation, adjusting analyses for cell heterogeneity
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Kile ML, Houseman EA, Baccarelli A, et al. Effect of prenatal arsenic exposure on DNA methylation and leukocyte subpopulations in cord blood. Epigenetics. 2014;9(5). This study observed an association between prenatal arsenic exposure and cord blood DNA methylation, adjusting analyses for cell heterogeneity
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Epigenetics
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Kile, M.L.1
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Differential DNA methylation in umbilical cord blood of infants exposed to low levels of arsenic in utero
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PID: 23757598, This study evaluated prenatal arsenic exposure on methylomic changes and is particularly informative for the analyses evaluating the genomic location as well as effect of arsenic on cell heterogeneity
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Koestler DC, Avissar-Whiting M, Houseman EA, et al. Differential DNA methylation in umbilical cord blood of infants exposed to low levels of arsenic in utero. Environ Health Perspect. 2013;121(8):971–7. This study evaluated prenatal arsenic exposure on methylomic changes and is particularly informative for the analyses evaluating the genomic location as well as effect of arsenic on cell heterogeneity.
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Koestler, D.C.1
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50
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Prenatal arsenic exposure and the epigenome: identifying sites of 5-methyl cytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes
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This study observed associations between prenatal arsenic exposure and cord blood DNA methylation, as well as evaluated functional evidence using gene expression data, and validation through disease outcomes
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Rojas D, Rager JE, Smeester L, et al. Prenatal arsenic exposure and the epigenome: identifying sites of 5-methyl cytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2014. doi:10.1093/toxsci/kfu210. This study observed associations between prenatal arsenic exposure and cord blood DNA methylation, as well as evaluated functional evidence using gene expression data, and validation through disease outcomes.
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Toxicol Sci
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Rojas, D.1
Rager, J.E.2
Smeester, L.3
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51
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Arsenic exposure in early pregnancy alters genome-wide DNA methylation in cord blood, particularly in boys
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COI: 1:CAS:528:DC%2BC2cXhtVCjsrnN, PID: 24965135, This study observed associations between prenatal arsenic exposure and cord blood DNA methylation among boys, showing sex-specific effects of arsenic on the methylome
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Broberg K, Ahmed S, Engstrom K, et al. Arsenic exposure in early pregnancy alters genome-wide DNA methylation in cord blood, particularly in boys. J Dev Orig Health Dis. 2014;5(4):288–98. This study observed associations between prenatal arsenic exposure and cord blood DNA methylation among boys, showing sex-specific effects of arsenic on the methylome.
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J Dev Orig Health Dis
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Broberg, K.1
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Epigenetic changes in individuals with arsenicosis
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COI: 1:CAS:528:DC%2BC3MXhsFalsr0%3D, PID: 21291286
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Smeester L, Rager JE, Bailey KA, et al. Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011;24(2):165–7.
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53
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Epigenome-wide DNA methylation changes with development of arsenic-induced skin lesions in Bangladesh: a case–control follow-up study
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PID: 24677489, Although no significant associations were observed, this study employed a repeated assessment of DNA methylation to evaluate changes methylation relation to skin lesion incidence
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Seow WJ, Kile ML, Baccarelli AA, et al. Epigenome-wide DNA methylation changes with development of arsenic-induced skin lesions in Bangladesh: a case–control follow-up study. Environ Mol Mutagen. 2014;55(6):449–56. Although no significant associations were observed, this study employed a repeated assessment of DNA methylation to evaluate changes in methylation in relation to skin lesion incidence.
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Environ Mol Mutagen
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Seow, W.J.1
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Arsenic and the epigenome: interindividual differences in arsenic metabolism related to distinct patterns of DNA methylation
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COI: 1:CAS:528:DC%2BC3sXnt1WrsA%3D%3D, PID: 23315758
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Bailey KA, Wu MC, Ward WO, et al. Arsenic and the epigenome: interindividual differences in arsenic metabolism related to distinct patterns of DNA methylation. J Biochem Mol Toxicol. 2013;27(2):106–15.
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Blood methylomics in response to arsenic exposure in a low-exposed US population
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COI: 1:CAS:528:DC%2BC3sXhvF2rtr7N, PID: 24368509, Although no significant associations were observed, this study conducted a prospective analysis of arsenic exposure on subsequent DNA methylation alterations
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Liu X, Zheng Y, Zhang W, et al. Blood methylomics in response to arsenic exposure in a low-exposed US population. J Expo Sci Environ Epidemiol. 2014;24(2):145–9. Although no significant associations were observed, this study conducted a prospective analysis of arsenic exposure on subsequent DNA methylation alterations.
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Liu, X.1
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Zhang, W.3
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Gene-specific differential DNA methylation and chronic arsenic exposure in an epigenome-wide association study of adults in Bangladesh
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PID: 25325195, This study observed associations between blood and urinary arsenic exposure and white blood cell DNA methylation, evaluated functional evidence using gene expression data, and replicated a subset of study findings an independent cohort
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Argos M, Chen L, Jasmine F, et al. Gene-specific differential DNA methylation and chronic arsenic exposure in an epigenome-wide association study of adults in Bangladesh. Environ Health Perspect. 2015;123(1):64–71. This study observed associations between blood and urinary arsenic exposure and white blood cell DNA methylation, evaluated functional evidence using gene expression data, and replicated a subset of study findings in an independent cohort.
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Environ Health Perspect
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Argos, M.1
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Comparison of genome-wide DNA methylation in urothelial carcinomas of patients with and without arsenic exposure
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COI: 1:CAS:528:DC%2BC3sXhvVKgs7vM, PID: 24268366
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Yang TY, Hsu LI, Chiu AW, et al. Comparison of genome-wide DNA methylation in urothelial carcinomas of patients with and without arsenic exposure. Environ Res. 2014;128:57–63.
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Prenatal arsenic exposure and the epigenome: altered microRNAs associated with innate and adaptive immune signaling in newborn cord blood
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COI: 1:CAS:528:DC%2BC3sXhvV2lur%2FO, PID: 24327377
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Rager JE, Bailey KA, Smeester L, et al. Prenatal arsenic exposure and the epigenome: altered microRNAs associated with innate and adaptive immune signaling in newborn cord blood. Environ Mol Mutagen. 2014;55(3):196–208.
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Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology
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Liang L, Cookson WO. Grasping nettles: cellular heterogeneity and other confounders in epigenome-wide association studies. Hum Mol Genet. 2014;23(R1):R83–8.
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Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility
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Reinius LE, Acevedo N, Joerink M, et al. Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility. PLoS ONE. 2012;7(7):e41361.
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Reference-free cell mixture adjustments in analysis of DNA methylation data
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COI: 1:CAS:528:DC%2BC2cXnslOitL4%3D, PID: 24451622, This paper presents a novel statistical method for inferring cell type proportions for tissues (e.g., placenta, saliva, adipose or tumor tissue) where the relevant underlying cell types may not be known
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Houseman EA, Molitor J, Marsit CJ. Reference-free cell mixture adjustments in analysis of DNA methylation data. Bioinformatics. 2014;30(10):1431–9. This paper presents a novel statistical method for inferring cell type proportions for tissues (e.g., placenta, saliva, adipose or tumor tissue) where the relevant underlying cell types may not be known.
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Genome-wide investigation of regional blood-based DNA methylation adjusted for complete blood counts implicates BNC2 in ovarian cancer
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Winham SJ, Armasu SM, Cicek MS, et al. Genome-wide investigation of regional blood-based DNA methylation adjusted for complete blood counts implicates BNC2 in ovarian cancer. Genet Epidemiol. 2014;38(5):457–66.
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