메뉴 건너뛰기




Volumn 7, Issue , 2017, Pages

BMP6 Regulates Proliferation and Apoptosis of Human Sertoli Cells Via Smad2/3 and Cyclin D1 Pathway and DACH1 and TFAP2A Activation

Author keywords

[No Author keywords available]

Indexed keywords

BMP6 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN 6; CCND1 PROTEIN, HUMAN; CYCLIN D1; DACH1 PROTEIN, HUMAN; EYE PROTEIN; SMAD PROTEIN; SMAD2 PROTEIN; SMAD2 PROTEIN, HUMAN; SMAD3 PROTEIN; SMAD3 PROTEIN, HUMAN; TFAP2A PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 2;

EID: 85017097464     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep45298     Document Type: Article
Times cited : (34)

References (54)
  • 1
    • 0033304938 scopus 로고    scopus 로고
    • Infertility in men: Recent advances and continuing controversies
    • De Kretser, D. M. & Baker, H. W. Infertility in men: recent advances and continuing controversies. J Clin Endocrinol Metab 84, 3443-3450 (1999).
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 3443-3450
    • De Kretser, D.M.1    Baker, H.W.2
  • 3
    • 44649104429 scopus 로고    scopus 로고
    • Gdnf signaling pathways within the mammalian spermatogonial stem cell niche
    • Hofmann, M. C. Gdnf signaling pathways within the mammalian spermatogonial stem cell niche. Mol Cell Endocrinol 288, 95-103 (2008).
    • (2008) Mol Cell Endocrinol , vol.288 , pp. 95-103
    • Hofmann, M.C.1
  • 4
    • 0023901568 scopus 로고
    • Evidence from Sertoli cell-depleted rats indicates that spermatid number in adults depends on numbers of Sertoli cells produced during perinatal development
    • Orth, J. M., Gunsalus, G. L. & Lamperti, A. A. Evidence from Sertoli cell-depleted rats indicates that spermatid number in adults depends on numbers of Sertoli cells produced during perinatal development. Endocrinology 122, 787-794 (1988).
    • (1988) Endocrinology , vol.122 , pp. 787-794
    • Orth, J.M.1    Gunsalus, G.L.2    Lamperti, A.A.3
  • 5
    • 51049098368 scopus 로고    scopus 로고
    • BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells
    • Lavery, K., Swain, P., Falb, D. & Alaoui-Ismaili, M. H. BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. J Biol Chem 283, 20948-20958 (2008).
    • (2008) J Biol Chem , vol.283 , pp. 20948-20958
    • Lavery, K.1    Swain, P.2    Falb, D.3    Alaoui-Ismaili, M.H.4
  • 6
    • 33745272290 scopus 로고    scopus 로고
    • Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ligands
    • Mazerbourg, S. & Hsueh, A. J. Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ligands. Hum Reprod Update 12, 373-383 (2006).
    • (2006) Hum Reprod Update , vol.12 , pp. 373-383
    • Mazerbourg, S.1    Hsueh, A.J.2
  • 7
    • 0035504887 scopus 로고    scopus 로고
    • Intracellular BMP signaling regulation in vertebrates: Pathway or network?
    • von Bubnoff, A. & Cho, K. W. Intracellular BMP signaling regulation in vertebrates: pathway or network? Dev Biol 239, 1-14 (2001).
    • (2001) Dev Biol , vol.239 , pp. 1-14
    • Von Bubnoff, A.1    Cho, K.W.2
  • 8
    • 84940477946 scopus 로고    scopus 로고
    • BMP4 promotes human Sertoli cell proliferation via Smad1/5 and ID2/3 pathway and its abnormality is associated with azoospermia
    • Hai, Y. et al. BMP4 promotes human Sertoli cell proliferation via Smad1/5 and ID2/3 pathway and its abnormality is associated with azoospermia. Discovery medicine 19, 311-325 (2015).
    • (2015) Discovery Medicine , vol.19 , pp. 311-325
    • Hai, Y.1
  • 9
    • 66449121462 scopus 로고    scopus 로고
    • Growth differentiation factor 9 is a germ cell regulator of Sertoli cell function
    • Nicholls, P. K., Harrison, C. A., Gilchrist, R. B., Farnworth, P. G. & Stanton, P. G. Growth differentiation factor 9 is a germ cell regulator of Sertoli cell function. Endocrinology 150, 2481-2490 (2009).
    • (2009) Endocrinology , vol.150 , pp. 2481-2490
    • Nicholls, P.K.1    Harrison, C.A.2    Gilchrist, R.B.3    Farnworth, P.G.4    Stanton, P.G.5
  • 10
    • 0034804599 scopus 로고    scopus 로고
    • BMP-6 enhances chondrogenesis in a subpopulation of human marrow stromal cells
    • Sekiya, I., Colter, D. C. & Prockop, D. J. BMP-6 enhances chondrogenesis in a subpopulation of human marrow stromal cells. Biochem Biophys Res Commun 284, 411-418 (2001).
    • (2001) Biochem Biophys Res Commun , vol.284 , pp. 411-418
    • Sekiya, I.1    Colter, D.C.2    Prockop, D.J.3
  • 11
    • 1842559510 scopus 로고    scopus 로고
    • Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary
    • Song, X. et al. Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary. Development 131, 1353-1364 (2004).
    • (2004) Development , vol.131 , pp. 1353-1364
    • Song, X.1
  • 12
    • 0032563165 scopus 로고    scopus 로고
    • Decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary
    • Xie, T. & Spradling, A. C. decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. Cell 94, 251-260 (1998).
    • (1998) Cell , vol.94 , pp. 251-260
    • Xie, T.1    Spradling, A.C.2
  • 13
    • 0142136097 scopus 로고    scopus 로고
    • Dpp signaling silences bam transcription directly to establish asymmetric divisions of germline stem cells
    • Chen, D. & McKearin, D. Dpp signaling silences bam transcription directly to establish asymmetric divisions of germline stem cells. Curr Biol 13, 1786-1791 (2003).
    • (2003) Curr Biol , vol.13 , pp. 1786-1791
    • Chen, D.1    McKearin, D.2
  • 14
    • 0242363225 scopus 로고    scopus 로고
    • Identification of the haematopoietic stem cell niche and control of the niche size
    • Zhang, J. et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425, 836-841 (2003).
    • (2003) Nature , vol.425 , pp. 836-841
    • Zhang, J.1
  • 15
    • 77956509034 scopus 로고    scopus 로고
    • Erythropoietin couples hematopoiesis with bone formation
    • Shiozawa, Y. et al. Erythropoietin couples hematopoiesis with bone formation. PLoS One 5, e10853 (2010).
    • (2010) PLoS One , vol.5 , pp. e10853
    • Shiozawa, Y.1
  • 16
    • 0037163430 scopus 로고    scopus 로고
    • BMP mRNA and protein expression in the developing mouse olfactory system
    • Peretto, P. et al. BMP mRNA and protein expression in the developing mouse olfactory system. J Comp Neurol 451, 267-278 (2002).
    • (2002) J Comp Neurol , vol.451 , pp. 267-278
    • Peretto, P.1
  • 17
    • 77956843852 scopus 로고    scopus 로고
    • Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis
    • Crews, L. et al. Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis. J Neurosci 30, 12252-12262 (2010).
    • (2010) J Neurosci , vol.30 , pp. 12252-12262
    • Crews, L.1
  • 18
    • 0034644472 scopus 로고    scopus 로고
    • TGFbeta signaling in growth control, cancer, and heritable disorders
    • Massague, J., Blain, S. W. & Lo, R. S. TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 103, 295-309 (2000).
    • (2000) Cell , vol.103 , pp. 295-309
    • Massague, J.1    Blain, S.W.2    Lo, R.S.3
  • 19
    • 47849106714 scopus 로고    scopus 로고
    • Regulation of immature cartilage growth by IGF-I, TGF-beta1, BMP-7, and PDGF-AB: Role of metabolic balance between fixed charge and collagen network
    • Asanbaeva, A., Masuda, K., Thonar, E. J., Klisch, S. M. & Sah, R. L. Regulation of immature cartilage growth by IGF-I, TGF-beta1, BMP-7, and PDGF-AB: role of metabolic balance between fixed charge and collagen network. Biomech Model Mechanobiol 7, 263-276 (2008).
    • (2008) Biomech Model Mechanobiol , vol.7 , pp. 263-276
    • Asanbaeva, A.1    Masuda, K.2    Thonar, E.J.3    Klisch, S.M.4    Sah, R.L.5
  • 20
    • 33646111694 scopus 로고    scopus 로고
    • Bone morphogenetic proteins and growth differentiation factors as drug targets in cardiovascular and metabolic disease
    • Tobin, J. F. & Celeste, A. J. Bone morphogenetic proteins and growth differentiation factors as drug targets in cardiovascular and metabolic disease. Drug Discov Today 11, 405-411 (2006).
    • (2006) Drug Discov Today , vol.11 , pp. 405-411
    • Tobin, J.F.1    Celeste, A.J.2
  • 21
    • 84874710761 scopus 로고    scopus 로고
    • Analysis and characterization of the functional TGFbeta receptors required for BMP6-induced osteogenic differentiation of mesenchymal progenitor cells
    • Zhang, Y. et al. Analysis and characterization of the functional TGFbeta receptors required for BMP6-induced osteogenic differentiation of mesenchymal progenitor cells. BMB Rep 46, 107-112 (2013).
    • (2013) BMB Rep , vol.46 , pp. 107-112
    • Zhang, Y.1
  • 22
    • 85011408043 scopus 로고    scopus 로고
    • Normal levels of sox9 expression in the developing mouse testis depend on the TES/TESCO enhancer, but this does not act alone
    • Gonen, N., Quinn, A., O'Neill, H. C., Koopman, P. & Lovell-Badge, R. Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone. PLoS Genet 13, e1006520 (2017).
    • (2017) PLoS Genet , vol.13 , pp. e1006520
    • Gonen, N.1    Quinn, A.2    O'Neill, H.C.3    Koopman, P.4    Lovell-Badge, R.5
  • 23
    • 0037378623 scopus 로고    scopus 로고
    • Sertoli cell tight junction dynamics: Their regulation during spermatogenesis
    • Lui, W. Y., Mruk, D., Lee, W. M. & Cheng, C. Y. Sertoli cell tight junction dynamics: their regulation during spermatogenesis. Biology of reproduction 68, 1087-1097 (2003).
    • (2003) Biology of Reproduction , vol.68 , pp. 1087-1097
    • Lui, W.Y.1    Mruk, D.2    Lee, W.M.3    Cheng, C.Y.4
  • 24
    • 9144235935 scopus 로고    scopus 로고
    • DACH1 inhibits transforming growth factor-beta signaling through binding Smad4
    • Wu, K. et al. DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. J Biol Chem 278, 51673-51684 (2003).
    • (2003) J Biol Chem , vol.278 , pp. 51673-51684
    • Wu, K.1
  • 25
    • 58149468095 scopus 로고    scopus 로고
    • Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling
    • Koinuma, D. et al. Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling. Molecular and cellular biology 29, 172-186 (2009).
    • (2009) Molecular and Cellular Biology , vol.29 , pp. 172-186
    • Koinuma, D.1
  • 26
    • 84979536797 scopus 로고    scopus 로고
    • Establishment and applications of male germ cell and Sertoli cell lines
    • Wang, H. et al. Establishment and applications of male germ cell and Sertoli cell lines. Reproduction 152, R31-40 (2016).
    • (2016) Reproduction , vol.152 , pp. R31-R40
    • Wang, H.1
  • 27
    • 0038346008 scopus 로고    scopus 로고
    • Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood
    • Sharpe, R. M., McKinnell, C., Kivlin, C. & Fisher, J. S. Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood. Reproduction 125, 769-784 (2003).
    • (2003) Reproduction , vol.125 , pp. 769-784
    • Sharpe, R.M.1    McKinnell, C.2    Kivlin, C.3    Fisher, J.S.4
  • 28
    • 84869222564 scopus 로고    scopus 로고
    • Is the adult Sertoli cell terminally differentiated?
    • Tarulli, G. A., Stanton, P. G. & Meachem, S. J. Is the adult Sertoli cell terminally differentiated? Biol Reprod 87, 13, 11-11 (2012).
    • (2012) Biol Reprod , vol.87 , Issue.13 , pp. 11
    • Tarulli, G.A.1    Stanton, P.G.2    Meachem, S.J.3
  • 29
    • 33645967800 scopus 로고    scopus 로고
    • Adult sertoli cells are not terminally differentiated in the Djungarian hamster: Effect of FSH on proliferation and junction protein organization
    • Tarulli, G. A., Stanton, P. G., Lerchl, A. & Meachem, S. J. Adult sertoli cells are not terminally differentiated in the Djungarian hamster: effect of FSH on proliferation and junction protein organization. Biol Reprod 74, 798-806 (2006).
    • (2006) Biol Reprod , vol.74 , pp. 798-806
    • Tarulli, G.A.1    Stanton, P.G.2    Lerchl, A.3    Meachem, S.J.4
  • 30
    • 84928155597 scopus 로고    scopus 로고
    • Long-term culture and significant expansion of human Sertoli cells whilst maintaining stable global phenotype and AKT and SMAD1/5 activation
    • Guo, Y. et al. Long-term culture and significant expansion of human Sertoli cells whilst maintaining stable global phenotype and AKT and SMAD1/5 activation. Cell communication and signaling: CCS 13, 20 (2015).
    • (2015) Cell Communication and Signaling: CCS , vol.13 , pp. 20
    • Guo, Y.1
  • 31
    • 67649667299 scopus 로고    scopus 로고
    • Identification of glial cell line-derived neurotrophic factor-regulated genes important for spermatogonial stem cell self-renewal in the rat
    • Schmidt, J. A., Avarbock, M. R., Tobias, J. W., & Brinster, R. L. Identification of glial cell line-derived neurotrophic factor-regulated genes important for spermatogonial stem cell self-renewal in the rat. Biol Reprod 81, 56-66 (2009).
    • (2009) Biol Reprod , vol.81 , pp. 56-66
    • Schmidt, J.A.1    Avarbock, M.R.2    Tobias, J.W.3    Brinster, R.L.4
  • 32
    • 34548482497 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor regulation of genes essential for selfrenewal of mouse spermatogonial stem cells is dependent on Src family kinase signaling
    • Oatley, J. M., Avarbock, M. R. & Brinster, R. L. Glial cell line-derived neurotrophic factor regulation of genes essential for selfrenewal of mouse spermatogonial stem cells is dependent on Src family kinase signaling. J Biol Chem 282, 25842-25851 (2007).
    • (2007) J Biol Chem , vol.282 , pp. 25842-25851
    • Oatley, J.M.1    Avarbock, M.R.2    Brinster, R.L.3
  • 33
    • 38349052363 scopus 로고    scopus 로고
    • Gdnf upregulates c-Fos transcription via the Ras/Erk1/2 pathway to promote mouse spermatogonial stem cell proliferation
    • He, Z. et al. Gdnf upregulates c-Fos transcription via the Ras/Erk1/2 pathway to promote mouse spermatogonial stem cell proliferation. Stem Cells 26, 266-278 (2008).
    • (2008) Stem Cells , vol.26 , pp. 266-278
    • He, Z.1
  • 34
    • 84885629762 scopus 로고    scopus 로고
    • Effects of glial cell line-derived neurotrophic factor, fibroblast growth factor 2 and epidermal growth factor on proliferation and the expression of some genes in buffalo (Bubalus bubalis) spermatogonial cells
    • Kadam, P. H. et al. Effects of glial cell line-derived neurotrophic factor, fibroblast growth factor 2 and epidermal growth factor on proliferation and the expression of some genes in buffalo (Bubalus bubalis) spermatogonial cells. Reproduction, fertility, and development 25, 1149-1157 (2013).
    • (2013) Reproduction, Fertility, and Development , vol.25 , pp. 1149-1157
    • Kadam, P.H.1
  • 35
    • 0032756373 scopus 로고    scopus 로고
    • Stem cell factor/c-kit system in spermatogenesis
    • Mauduit, C., Hamamah, S. & Benahmed, M. Stem cell factor/c-kit system in spermatogenesis. Hum Reprod Update 5, 535-545 (1999).
    • (1999) Hum Reprod Update , vol.5 , pp. 535-545
    • Mauduit, C.1    Hamamah, S.2    Benahmed, M.3
  • 36
    • 0034682805 scopus 로고    scopus 로고
    • Stem cell factor/c-kit up-regulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogonia
    • Feng, L. X., Ravindranath, N. & Dym, M. Stem cell factor/c-kit up-regulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogonia. J Biol Chem 275, 25572-25576 (2000).
    • (2000) J Biol Chem , vol.275 , pp. 25572-25576
    • Feng, L.X.1    Ravindranath, N.2    Dym, M.3
  • 37
    • 65249154823 scopus 로고    scopus 로고
    • Androgen receptor roles in spermatogenesis and fertility: Lessons from testicular cellspecific androgen receptor knockout mice
    • Wang, R. S., Yeh, S., Tzeng, C. R. & Chang, C. Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cellspecific androgen receptor knockout mice. Endocrine reviews 30, 119-132 (2009).
    • (2009) Endocrine Reviews , vol.30 , pp. 119-132
    • Wang, R.S.1    Yeh, S.2    Tzeng, C.R.3    Chang, C.4
  • 39
    • 2342595087 scopus 로고    scopus 로고
    • Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells
    • Chang, C. et al. Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells. Proceedings of the National Academy of Sciences of the United States of America 101, 6876-6881 (2004).
    • (2004) Proceedings of the National Academy of Sciences of the United States of America , vol.101 , pp. 6876-6881
    • Chang, C.1
  • 40
    • 18844407557 scopus 로고    scopus 로고
    • The role of androgens in sertoli cell proliferation and functional maturation: Studies in mice with total or Sertoli cell-selective ablation of the androgen receptor
    • Tan, K. A. et al. The role of androgens in sertoli cell proliferation and functional maturation: studies in mice with total or Sertoli cell-selective ablation of the androgen receptor. Endocrinology 146, 2674-2683 (2005).
    • (2005) Endocrinology , vol.146 , pp. 2674-2683
    • Tan, K.A.1
  • 41
    • 34948871606 scopus 로고    scopus 로고
    • Differential effects of spermatogenesis and fertility in mice lacking androgen receptor in individual testis cells
    • Tsai, M. Y. et al. Differential effects of spermatogenesis and fertility in mice lacking androgen receptor in individual testis cells. Proceedings of the National Academy of Sciences of the United States of America 103, 18975-18980 (2006).
    • (2006) Proceedings of the National Academy of Sciences of the United States of America , vol.103 , pp. 18975-18980
    • Tsai, M.Y.1
  • 42
    • 78649788550 scopus 로고    scopus 로고
    • Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development
    • Willems, A. et al. Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development. PLoS One 5, e14168 (2010).
    • (2010) PLoS One , vol.5 , pp. e14168
    • Willems, A.1
  • 43
    • 65549093602 scopus 로고    scopus 로고
    • Androgen receptor in Sertoli cells is not required for testosterone-induced suppression of spermatogenesis, but contributes to Sertoli cell organization in Utp14b jsd mice
    • Wang, G. et al. Androgen receptor in Sertoli cells is not required for testosterone-induced suppression of spermatogenesis, but contributes to Sertoli cell organization in Utp14b jsd mice. Journal of andrology 30, 338-348 (2009).
    • (2009) Journal of Andrology , vol.30 , pp. 338-348
    • Wang, G.1
  • 44
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck, R. & Zhang, Y. E. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425, 577-584 (2003).
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 45
    • 84911985430 scopus 로고    scopus 로고
    • Epigenetic silencing of DACH1 induces the invasion and metastasis of gastric cancer by activating TGF-beta signalling
    • Yan, W. et al. Epigenetic silencing of DACH1 induces the invasion and metastasis of gastric cancer by activating TGF-beta signalling. Journal of cellular and molecular medicine 18, 2499-2511 (2014).
    • (2014) Journal of Cellular and Molecular Medicine , vol.18 , pp. 2499-2511
    • Yan, W.1
  • 46
    • 0023651331 scopus 로고
    • And negative regulation of transcription in vitro: Enhancer-binding protein AP-2 is inhibited by SV40 T antigen
    • Mitchell, P. J., Wang, C. & Tjian, R. Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen. Cell 50, 847-861 (1987).
    • (1987) Cell , vol.50 , pp. 847-861
    • Mitchell, P.J.1    Wang, C.2    Positive, T.R.3
  • 47
    • 0023663116 scopus 로고
    • Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP
    • Imagawa, M., Chiu, R. & Karin, M. Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP. Cell 51, 251-260 (1987).
    • (1987) Cell , vol.51 , pp. 251-260
    • Imagawa, M.1    Chiu, R.2    Karin, M.3
  • 48
    • 0031012251 scopus 로고    scopus 로고
    • AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression
    • Zeng, Y. X., Somasundaram, K. & el-Deiry, W. S. AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression. Nature genetics 15, 78-82 (1997).
    • (1997) Nature Genetics , vol.15 , pp. 78-82
    • Zeng, Y.X.1    Somasundaram, K.2    El-Deiry, W.S.3
  • 49
    • 84936791194 scopus 로고    scopus 로고
    • Fractionation of human spermatogenic cells using STA-PUT gravity sedimentation and their miRNA profiling
    • Liu, Y. et al. Fractionation of human spermatogenic cells using STA-PUT gravity sedimentation and their miRNA profiling. Sci Rep 5, 8084 (2015).
    • (2015) Sci Rep , vol.5 , pp. 8084
    • Liu, Y.1
  • 50
    • 34848925743 scopus 로고    scopus 로고
    • Gfra1 silencing in mouse spermatogonial stem cells results in their differentiation via the inactivation of RET tyrosine kinase
    • He, Z., Jiang, J., Hofmann, M. C. & Dym, M. Gfra1 silencing in mouse spermatogonial stem cells results in their differentiation via the inactivation of RET tyrosine kinase. Biology of reproduction 77, 723-733 (2007).
    • (2007) Biology of Reproduction , vol.77 , pp. 723-733
    • He, Z.1    Jiang, J.2    Hofmann, M.C.3    Dym, M.4
  • 51
    • 84978745106 scopus 로고    scopus 로고
    • Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice
    • Hadad, N. et al. Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice. Epigenetics & chromatin 9, 30 (2016).
    • (2016) Epigenetics & Chromatin , vol.9 , pp. 30
    • Hadad, N.1
  • 53
    • 76749140452 scopus 로고    scopus 로고
    • Methylation of Dickkopf-3 as a prognostic factor in cirrhosis-related hepatocellular carcinoma
    • Yang, B. et al. Methylation of Dickkopf-3 as a prognostic factor in cirrhosis-related hepatocellular carcinoma. World journal of gastroenterology 16, 755-763 (2010).
    • (2010) World Journal of Gastroenterology , vol.16 , pp. 755-763
    • Yang, B.1
  • 54
    • 2142799562 scopus 로고    scopus 로고
    • Use of multiplex reverse transcription-PCR to study the expression of a laccase gene family in a basidiomycetous fungus
    • Gonzalez, T. et al. Use of multiplex reverse transcription-PCR to study the expression of a laccase gene family in a basidiomycetous fungus. Applied and environmental microbiology 69, 7083-7090 (2003).
    • (2003) Applied and Environmental Microbiology , vol.69 , pp. 7083-7090
    • Gonzalez, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.