Epigenetic silencing of DACH1 induces the invasion and metastasis of gastric cancer by activating TGF-β signalling

Journal of Cellular and Molecular Medicine

Volumn 18, Issue 12, 2014, Pages 2499-2511

  Yan, Wenji ^a   Wu, Kongming ^b   Herman, James G ^c   Brock, Malcolm V ^c   Zhou, Yusen ^d   Lu, Youyong ^e   Zhang, Zhiqian ^e   Yang, Yunsheng ^a   Guo, Mingzhou ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^e PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

Chemosensitive marker; DACH1; DNA methylation; Docetaxel; Gastric cancer; Invasion; Metastasis

Indexed keywords

DACH1 PROTEIN, HUMAN; DOCETAXEL; EYE PROTEIN; TAXOID; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; BAGG ALBINO MOUSE; CELL LINE; CELL MOTION; CELL SURVIVAL; DNA METHYLATION; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; FEMALE; GENETIC EPIGENESIS; GENETICS; HUMAN; MALE; METABOLISM; METASTASIS; MIDDLE AGED; NUDE MOUSE; PATHOLOGY; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TUMOR CELL LINE; TUMOR INVASION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; DNA METHYLATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIGENESIS, GENETIC; EYE PROTEINS; FEMALE; HUMANS; MALE; MICE, INBRED BALB C; MICE, NUDE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TAXOIDS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84911985430     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12325     Document Type: Article

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