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Volumn 42, Issue 8, 2017, Pages 2326-2335

Liraglutide Improves Water Maze Learning and Memory Performance While Reduces Hyperphosphorylation of Tau and Neurofilaments in APP/PS1/Tau Triple Transgenic Mice

Author keywords

3 Tg mice; Alzheimer disease; ERK; JNK; Liraglutide; Tau

Indexed keywords

AMYLOID PRECURSOR PROTEIN; GLUCOSE; LIRAGLUTIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PRESENILIN 1; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; TAU PROTEIN; ANTIDIABETIC AGENT;

EID: 85017097082     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-017-2250-8     Document Type: Article
Times cited : (67)

References (39)
  • 1
    • 84920901668 scopus 로고    scopus 로고
    • Erythropoietin improves synaptic plasticity and memory deficits by decrease of the neurotransmitter release probability in the rat model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC2MXmtV2lsA%3D%3D
    • EsmaeiliTazangi P, Moosavi SM, Shabani M, Haghani M (2015) Erythropoietin improves synaptic plasticity and memory deficits by decrease of the neurotransmitter release probability in the rat model of Alzheimer’s disease. Pharmacol Biochem Behav 130:15–21
    • (2015) Pharmacol Biochem Behav , vol.130 , pp. 15-21
    • EsmaeiliTazangi, P.1    Moosavi, S.M.2    Shabani, M.3    Haghani, M.4
  • 4
    • 84964341265 scopus 로고    scopus 로고
    • Tau: the center of a signaling nexus in Alzheimer’s disease
    • PID: 26903798
    • Khan SS, Bloom GS (2016) Tau: the center of a signaling nexus in Alzheimer’s disease. Front Neurosci 10:31
    • (2016) Front Neurosci , vol.10 , pp. 31
    • Khan, S.S.1    Bloom, G.S.2
  • 5
    • 73649112749 scopus 로고    scopus 로고
    • Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3cXhslSjtb0%3D, PID: 19815707
    • Deng Y, Li B, Liu Y, Iqbal K, Grundke-Iqbal I, Gong CX (2009) Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer’s disease. Am J Pathol 175:2089–2098
    • (2009) Am J Pathol , vol.175 , pp. 2089-2098
    • Deng, Y.1    Li, B.2    Liu, Y.3    Iqbal, K.4    Grundke-Iqbal, I.5    Gong, C.X.6
  • 6
    • 42249107130 scopus 로고    scopus 로고
    • Brain insulin, energy and glucose homeostasis; genes, environment and metabolic pathologies
    • COI: 1:CAS:528:DC%2BD1cXls1Sjs78%3D, PID: 18407262
    • Gerozissis K (2008) Brain insulin, energy and glucose homeostasis; genes, environment and metabolic pathologies. Eur J Pharmacol 585:38–49
    • (2008) Eur J Pharmacol , vol.585 , pp. 38-49
    • Gerozissis, K.1
  • 7
    • 15244351255 scopus 로고    scopus 로고
    • Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer’s disease–is this type 3 diabetes?
    • COI: 1:CAS:528:DC%2BD2MXhvVSrtL8%3D, PID: 15750215
    • Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R et al (2005) Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer’s disease–is this type 3 diabetes? J Alzheimers Dis 7:63–80
    • (2005) J Alzheimers Dis , vol.7 , pp. 63-80
    • Steen, E.1    Terry, B.M.2    Rivera, E.J.3    Cannon, J.L.4    Neely, T.R.5    Tavares, R.6
  • 8
    • 84873266979 scopus 로고    scopus 로고
    • Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer s disease - protocol for a controlled, randomized double-blinded trial
    • PID: 23158895
    • Egefjord L, Gejl M, Møller A, Brændgaard H, Gottrup H, Antropova O et al (2012) Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer s disease - protocol for a controlled, randomized double-blinded trial. Dan Med J 59:A4519
    • (2012) Dan Med J , vol.59 , pp. A4519
    • Egefjord, L.1    Gejl, M.2    Møller, A.3    Brændgaard, H.4    Gottrup, H.5    Antropova, O.6
  • 9
    • 84962229876 scopus 로고    scopus 로고
    • The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy
    • COI: 1:CAS:528:DC%2BC28XjtFSmsA%3D%3D, PID: 26746341
    • Hansen HH, Barkholt P, Fabricius K, Jelsing J, Terwel D, Pyke C et al (2016) The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy. Brain Res 1634:158–170
    • (2016) Brain Res , vol.1634 , pp. 158-170
    • Hansen, H.H.1    Barkholt, P.2    Fabricius, K.3    Jelsing, J.4    Terwel, D.5    Pyke, C.6
  • 10
    • 84897003731 scopus 로고    scopus 로고
    • Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress
    • COI: 1:CAS:528:DC%2BC2cXptVGmsQ%3D%3D, PID: 24112036
    • Sharma MK, Jalewa J, Hölscher C (2014) Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress. J Neurochem 128:459–471
    • (2014) J Neurochem , vol.128 , pp. 459-471
    • Sharma, M.K.1    Jalewa, J.2    Hölscher, C.3
  • 12
    • 84892690389 scopus 로고    scopus 로고
    • The neuroprotection of liraglutide on Alzheimer-like learning and memory impairment by modulating the hyperphosphorylation of tau and neurofilament proteins and insulin signaling pathways in mice
    • PID: 24008687
    • Xiong H, Zheng C, Wang J, Song J, Zhao G, Shen H et al (2013) The neuroprotection of liraglutide on Alzheimer-like learning and memory impairment by modulating the hyperphosphorylation of tau and neurofilament proteins and insulin signaling pathways in mice. J Alzheimers Dis 37:623–635
    • (2013) J Alzheimers Dis , vol.37 , pp. 623-635
    • Xiong, H.1    Zheng, C.2    Wang, J.3    Song, J.4    Zhao, G.5    Shen, H.6
  • 13
    • 84974559551 scopus 로고    scopus 로고
    • In Alzheimer’s disease, six-month treatment with GLP-1 analogue prevents decline of brain glucose metabolism: randomized, placebo-controlled, double-blind clinical trial
    • PID: 27252647
    • Gejl M, Gjedde A, Egefjord L, Møller A, Hansen SB, Vang K et al (2016) In Alzheimer’s disease, six-month treatment with GLP-1 analogue prevents decline of brain glucose metabolism: randomized, placebo-controlled, double-blind clinical trial. Front Aging Neurosci 8:108
    • (2016) Front Aging Neurosci , vol.8 , pp. 108
    • Gejl, M.1    Gjedde, A.2    Egefjord, L.3    Møller, A.4    Hansen, S.B.5    Vang, K.6
  • 14
    • 0042697305 scopus 로고    scopus 로고
    • Triple-transgenic model of Alzheimer’s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction
    • COI: 1:CAS:528:DC%2BD3sXmsFOksro%3D, PID: 12895417
    • Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R et al (2003) Triple-transgenic model of Alzheimer’s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39:409–421
    • (2003) Neuron , vol.39 , pp. 409-421
    • Oddo, S.1    Caccamo, A.2    Shepherd, J.D.3    Murphy, M.P.4    Golde, T.E.5    Kayed, R.6
  • 15
    • 84978869488 scopus 로고    scopus 로고
    • Traumatic brain injury accelerates amyloid-beta deposition and impairs spatial learning in the triple-transgenic mouse model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC28XhtFKku7rF, PID: 27373531
    • Shishido H, Kishimoto Y, Kawai N, ToyotaY, Ueno M, Kubota T et al (2016) Traumatic brain injury accelerates amyloid-beta deposition and impairs spatial learning in the triple-transgenic mouse model of Alzheimer’s disease. Neurosci Lett 629:62–67
    • (2016) Neurosci Lett , vol.629 , pp. 62-67
    • Shishido, H.1    Kishimoto, Y.2    Kawai, N.3    Toyota, Y.4    Ueno, M.5    Kubota, T.6
  • 16
    • 84897834287 scopus 로고    scopus 로고
    • Evaluation of neuroprotective effect of glucagon-like peptide 1 analogs using neuroimaging
    • PID: 24529526
    • Femminella GD, Edison P (2014) Evaluation of neuroprotective effect of glucagon-like peptide 1 analogs using neuroimaging. Alzheimers Dement 10:S55–S61
    • (2014) Alzheimers Dement , vol.10 , pp. S55-S61
    • Femminella, G.D.1    Edison, P.2
  • 17
    • 33846461062 scopus 로고    scopus 로고
    • Morris water maze: procedures for assessing spatial and related forms of learning and memory
    • PID: 17406317
    • Vorhees CV, Williams MT (2006) Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 1:848–858
    • (2006) Nat Protoc , vol.1 , pp. 848-858
    • Vorhees, C.V.1    Williams, M.T.2
  • 18
    • 0043198343 scopus 로고    scopus 로고
    • Modern statistical methods for handling missing repeated measurements in obesity trial data: beyond LOCF
    • COI: 1:STN:280:DC%2BD3szotVymsQ%3D%3D, PID: 12916818
    • Gadbury GL, Coffey CS, Allison DB (2003) Modern statistical methods for handling missing repeated measurements in obesity trial data: beyond LOCF. Obes Rev 4:175–184
    • (2003) Obes Rev , vol.4 , pp. 175-184
    • Gadbury, G.L.1    Coffey, C.S.2    Allison, D.B.3
  • 19
    • 79955749452 scopus 로고    scopus 로고
    • The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3MXls1Olt7w%3D, PID: 21525299
    • McClean PL, Parthsarathy V, Faivre E, Hölscher C (2011) The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer’s disease. J Neurosci 31:6587–6594
    • (2011) J Neurosci , vol.31 , pp. 6587-6594
    • McClean, P.L.1    Parthsarathy, V.2    Faivre, E.3    Hölscher, C.4
  • 20
    • 84959036980 scopus 로고    scopus 로고
    • Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss
    • COI: 1:CAS:528:DC%2BC28XislyksLw%3D, PID: 26888634
    • Di J, Cohen LS, Corbo CP, Phillips GR, ElIdrissi A, Alonso AD (2016) Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss. Sci Rep 6:20833
    • (2016) Sci Rep , vol.6 , pp. 20833
    • Di, J.1    Cohen, L.S.2    Corbo, C.P.3    Phillips, G.R.4    ElIdrissi, A.5    Alonso, A.D.6
  • 21
    • 42649141628 scopus 로고    scopus 로고
    • Decreased presence of perforated synapses in a triple-transgenic mouse model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD1cXlt1ansLg%3D, PID: 18328008
    • Bertoni-Freddari C, Sensi SL, Giorgetti B, Balietti M, Di Stefano G, Canzoniero LM et al (2008) Decreased presence of perforated synapses in a triple-transgenic mouse model of Alzheimer’s disease. Rejuvenation Res 11:309–313
    • (2008) Rejuvenation Res , vol.11 , pp. 309-313
    • Bertoni-Freddari, C.1    Sensi, S.L.2    Giorgetti, B.3    Balietti, M.4    Di Stefano, G.5    Canzoniero, L.M.6
  • 22
    • 17044439021 scopus 로고    scopus 로고
    • Alzheimer’s disease: a-beta, tau and synaptic dysfunction
    • COI: 1:CAS:528:DC%2BD2MXjtVylsb8%3D, PID: 15823755
    • LaFerla FM, Oddo S (2005) Alzheimer’s disease: a-beta, tau and synaptic dysfunction. Trends Mol Med 11:170–176
    • (2005) Trends Mol Med , vol.11 , pp. 170-176
    • LaFerla, F.M.1    Oddo, S.2
  • 23
    • 84899940393 scopus 로고    scopus 로고
    • Deregulation of brain insulin signaling in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC2cXmvFCnsL4%3D, PID: 24652456
    • Chen Y, Deng Y, Zhang B, Gong CX (2014) Deregulation of brain insulin signaling in Alzheimer’s disease. Neurosci Bull 30:282–294
    • (2014) Neurosci Bull , vol.30 , pp. 282-294
    • Chen, Y.1    Deng, Y.2    Zhang, B.3    Gong, C.X.4
  • 24
    • 84965162519 scopus 로고    scopus 로고
    • Subcutaneous administration of liraglutide ameliorates learning and memory impairment by modulating tau hyperphosphorylation via the glycogen synthase kinase-3β pathway in an amyloid β protein induced alzheimer disease mouse model
    • COI: 1:CAS:528:DC%2BC28XntlSqsrk%3D, PID: 27131827
    • Qi L, Ke L, Liu X, Liao L, Ke S, Liu X et al (2016) Subcutaneous administration of liraglutide ameliorates learning and memory impairment by modulating tau hyperphosphorylation via the glycogen synthase kinase-3β pathway in an amyloid β protein induced alzheimer disease mouse model. Eur J Pharmacol 783:23–32
    • (2016) Eur J Pharmacol , vol.783 , pp. 23-32
    • Qi, L.1    Ke, L.2    Liu, X.3    Liao, L.4    Ke, S.5    Liu, X.6
  • 25
    • 84979210794 scopus 로고    scopus 로고
    • Long-term treatment with liraglutide, a glucagon-like peptide-1 (GLP-1) Receptor agonist, has no effect on β-amyloid plaque load in two transgenic APP/PS1 mouse models of Alzheimer’s disease
    • PID: 27421117
    • Hansen HH, Fabricius K, Barkholt P, Kongsbak-Wismann P, Schlumberger C, Jelsing J et al (2016) Long-term treatment with liraglutide, a glucagon-like peptide-1 (GLP-1) Receptor agonist, has no effect on β-amyloid plaque load in two transgenic APP/PS1 mouse models of Alzheimer’s disease. PLoS ONE 11(7):e0158205
    • (2016) PLoS ONE , vol.11 , Issue.7
    • Hansen, H.H.1    Fabricius, K.2    Barkholt, P.3    Kongsbak-Wismann, P.4    Schlumberger, C.5    Jelsing, J.6
  • 26
    • 85007593139 scopus 로고    scopus 로고
    • Liraglutide promotes improvements in objective measures of cognitive dysfunction in individuals with mooddisorders: a pilot, open-label study
    • COI: 1:CAS:528:DC%2BC28Xhs1GnsrnF, PID: 27721184
    • Mansur RB, Ahmed J, Cha DS, Woldeyohannes HO, Subramaniapillai M, Lovshin J et al (2017) Liraglutide promotes improvements in objective measures of cognitive dysfunction in individuals with mooddisorders: a pilot, open-label study. J Affect Disord 207:114–120
    • (2017) J Affect Disord , vol.207 , pp. 114-120
    • Mansur, R.B.1    Ahmed, J.2    Cha, D.S.3    Woldeyohannes, H.O.4    Subramaniapillai, M.5    Lovshin, J.6
  • 27
    • 84890808796 scopus 로고    scopus 로고
    • Subcutaneous administration of liraglutide ameliorates Alzheimer-associated tau hyperphosphorylation in rats with type 2 diabetes
    • PID: 23948890
    • Yang Y, Zhang J, Ma D, Zhang M, Hu S, Shao S et al (2013) Subcutaneous administration of liraglutide ameliorates Alzheimer-associated tau hyperphosphorylation in rats with type 2 diabetes. J Alzheimers Dis 37:637–648
    • (2013) J Alzheimers Dis , vol.37 , pp. 637-648
    • Yang, Y.1    Zhang, J.2    Ma, D.3    Zhang, M.4    Hu, S.5    Shao, S.6
  • 28
    • 84855548096 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains
    • COI: 1:CAS:528:DC%2BC38Xks1KhtA%3D%3D, PID: 22115895
    • Li L, Zhang ZF, Hölscher C, Gao C, Jiang YH, Liu YZ (2012) (Val(8)) glucagon-like peptide-1 prevents tau hyperphosphorylation, impairment of spatial learning and ultra-structural cellular damage induced by streptozotocin in rat brains. Eur J Pharmacol 674(2–3):280–286
    • (2012) Eur J Pharmacol , vol.674 , Issue.2-3 , pp. 280-286
    • Li, L.1    Zhang, Z.F.2    Hölscher, C.3    Gao, C.4    Jiang, Y.H.5    Liu, Y.Z.6
  • 29
    • 84940909497 scopus 로고    scopus 로고
    • Neurofilament light gene deletion exacerbates amyloid, dystrophic neurite, and synaptic pathology in the APP/PS1 transgenic model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC2MXht1GrurjM, PID: 26344875
    • Fernandez-Martos CM, King AE, Atkinson RA, Woodhouse A, Vickers JC (2015) Neurofilament light gene deletion exacerbates amyloid, dystrophic neurite, and synaptic pathology in the APP/PS1 transgenic model of Alzheimer’s disease. Neurobiol Aging 36:2757–2767
    • (2015) Neurobiol Aging , vol.36 , pp. 2757-2767
    • Fernandez-Martos, C.M.1    King, A.E.2    Atkinson, R.A.3    Woodhouse, A.4    Vickers, J.C.5
  • 30
    • 57049125529 scopus 로고    scopus 로고
    • Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: parallels with Alzheimer’s disease and correction by insulin
    • COI: 1:CAS:528:DC%2BD1cXhsVarurfF, PID: 18627032
    • Jolivalt CG, Lee CA, Beiswenger KK, Smith JL, Orlov M, Torrance MA et al (2008) Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: parallels with Alzheimer’s disease and correction by insulin. J Neurosci Res 86:3265–3274
    • (2008) J Neurosci Res , vol.86 , pp. 3265-3274
    • Jolivalt, C.G.1    Lee, C.A.2    Beiswenger, K.K.3    Smith, J.L.4    Orlov, M.5    Torrance, M.A.6
  • 31
    • 37249040432 scopus 로고    scopus 로고
    • Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms
    • COI: 1:CAS:528:DC%2BD1cXmtlU%3D, PID: 18077675
    • Planel E, Tatebayashi Y, Miyasaka T, Liu L, Wang L, Herman M et al (2007) Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms. J Neurosci 27:13635–13648
    • (2007) J Neurosci , vol.27 , pp. 13635-13648
    • Planel, E.1    Tatebayashi, Y.2    Miyasaka, T.3    Liu, L.4    Wang, L.5    Herman, M.6
  • 32
    • 84930672166 scopus 로고    scopus 로고
    • Compromised MAPK signaling in human diseases: an update
    • COI: 1:CAS:528:DC%2BC2MXivFantrc%3D, PID: 25690731
    • Kim EK, Choi EJ (2015) Compromised MAPK signaling in human diseases: an update. Arch Toxicol 89:867–882
    • (2015) Arch Toxicol , vol.89 , pp. 867-882
    • Kim, E.K.1    Choi, E.J.2
  • 33
    • 84859726053 scopus 로고    scopus 로고
    • An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease- associated Abeta oligomers
    • COI: 1:CAS:528:DC%2BC38Xlt1egtbc%3D, PID: 22476196
    • Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H et al (2012) An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease- associated Abeta oligomers. J Clin Invest 122(4):1339–1353
    • (2012) J Clin Invest , vol.122 , Issue.4 , pp. 1339-1353
    • Bomfim, T.R.1    Forny-Germano, L.2    Sathler, L.B.3    Brito-Moreira, J.4    Houzel, J.C.5    Decker, H.6
  • 34
    • 43049118551 scopus 로고    scopus 로고
    • Differential activation of mitogen-activated protein kinase signaling pathways in the hippocampus of CRND8 transgenic mouse, a model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD1cXlvVWns7o%3D, PID: 18406062
    • Giovannini MG, Cerbai F, Bellucci A, Melani C, Grossi C, Bartolozzi C et al (2008) Differential activation of mitogen-activated protein kinase signaling pathways in the hippocampus of CRND8 transgenic mouse, a model of Alzheimer’s disease. Neuroscience 153:618–633
    • (2008) Neuroscience , vol.153 , pp. 618-633
    • Giovannini, M.G.1    Cerbai, F.2    Bellucci, A.3    Melani, C.4    Grossi, C.5    Bartolozzi, C.6
  • 35
    • 78650309919 scopus 로고    scopus 로고
    • Treadmill exercise represses neuronal cell death in an aged transgenic mousemodel of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3cXhs1Wmt7vE, PID: 20969897
    • Um HS, Kang EB, Koo JH, Kim HT, Jin-Lee, Kim EJ et al (2011) Treadmill exercise represses neuronal cell death in an aged transgenic mousemodel of Alzheimer’s disease. Neurosci Res 69:161–173
    • (2011) Neurosci Res , vol.69 , pp. 161-173
    • Um, H.S.1    Kang, E.B.2    Koo, J.H.3    Kim, H.T.4    Jin-Lee5    Kim, E.J.6
  • 36
    • 84962030767 scopus 로고    scopus 로고
    • C-Jun N-terminal Kinase (JNK) signaling as a therapeutic target for Alzheimer’s disease
    • PID: 26793112
    • Yarza R, Vela S, Solas M, Ramirez MJ (2015) c-Jun N-terminal Kinase (JNK) signaling as a therapeutic target for Alzheimer’s disease. Front Pharmacol 6:321
    • (2015) Front Pharmacol , vol.6 , pp. 321
    • Yarza, R.1    Vela, S.2    Solas, M.3    Ramirez, M.J.4
  • 37
    • 57349101675 scopus 로고    scopus 로고
    • A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
    • COI: 1:CAS:528:DC%2BD1cXhsVGltb%2FM, PID: 19056984
    • Sabio G, Das M, Mora A, Zhang Z, Jun JY, Ko HJ et al (2008) A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 322:1539–1543
    • (2008) Science , vol.322 , pp. 1539-1543
    • Sabio, G.1    Das, M.2    Mora, A.3    Zhang, Z.4    Jun, J.Y.5    Ko, H.J.6
  • 38
    • 84940737313 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptors sensitize a MAPK-linked toxicity pathway on prolonged exposure to beta-amyloid
    • COI: 1:CAS:528:DC%2BC2MXhsVSlurzK, PID: 26139609
    • Arora K, Cheng J, Nichols RA (2015) Nicotinic acetylcholine receptors sensitize a MAPK-linked toxicity pathway on prolonged exposure to beta-amyloid. J Biol Chem 290:21409–21420
    • (2015) J Biol Chem , vol.290 , pp. 21409-21420
    • Arora, K.1    Cheng, J.2    Nichols, R.A.3
  • 39
    • 35448930622 scopus 로고    scopus 로고
    • Evidence of Abeta- and transgene-dependent defects in ERK-CREB signaling in Alzheimer’s models
    • COI: 1:CAS:528:DC%2BD2sXhtl2jurnF, PID: 17760871
    • Ma QL, Harris-White ME, Ubeda OJ, Simmons M, Beech W, Lim GP et al (2007) Evidence of Abeta- and transgene-dependent defects in ERK-CREB signaling in Alzheimer’s models. J Neurochem 103:1594–1607
    • (2007) J Neurochem , vol.103 , pp. 1594-1607
    • Ma, Q.L.1    Harris-White, M.E.2    Ubeda, O.J.3    Simmons, M.4    Beech, W.5    Lim, G.P.6


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