Relationship between depression and frailty in older adults: A systematic review and meta-analysis

Ageing Research Reviews

Volumn 36, Issue , 2017, Pages 78-87

  Soysal, Pinar ^a   Veronese, Nicola ^b,c   Thompson, Trevor ^d   Kahl, Kai G ^e   Fernandes, Brisa S ^f,g   Prina, A Matthew ^h   Solmi, Marco ^c,i,j   Schofield, Patricia ^k   Koyanagi, Ai ^l,m   Tseng, Ping Tao ⁿ   Lin, Pao Yao ^o,p   Chu, Che Sheng ^q   Cosco, Theodore D ^r,s   Cesari, Matteo ^t,u   Carvalho, Andre F ^v   Stubbs, Brendon ^h,k,w  

^a Kayseri Education and Research Hospital   (Turkey)

^b CNR   (Italy)

^c Institute of Clinical Research and Education in Medicine (IREM)   (Italy)

^d UNIVERSITY OF GREENWICH   (United Kingdom)

^e HANNOVER MEDICAL SCHOOL   (Germany)

^f BARWON HEALTH   (Australia)

^g FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^h KING'S COLLEGE LONDON   (United Kingdom)

ⁱ UNIVERSITY OF PADOVA   (Italy)

^j Local Social Sanitary Unit   (Italy)

^k ANGLIA RUSKIN UNIVERSITY   (United Kingdom)

^l UNIVERSITY OF BARCELONA   (Spain)

^m CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

ⁿ Tsyr Huey (Loving) Mental Hospital   (Taiwan)

^o CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^p CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^q KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^r UNIVERSITY COLLEGE LONDON   (United Kingdom)

^s UNIVERSITY OF OXFORD   (United Kingdom)

^t UNIVERSITÉ PAUL SABATIER   (France)

^u TOULOUSE UNIVERSITY HOSPITAL   (France)

^v FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^w SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST   (United Kingdom)

more..

Author keywords

Depression; Frail; Geriatrics; Meta analysis; Older adults; Psychiatry

Indexed keywords

AGED; AGING; BIBLIOGRAPHIC DATABASE; CROSS-SECTIONAL STUDY; DATA EXTRACTION; DEPRESSION; DISEASE ASSOCIATION; EMBASE; FRAILTY; GERIATRIC DEPRESSION SCALE; HUMAN; INCIDENCE; LONGITUDINAL STUDY; MAJOR DEPRESSION; MEDLINE; MENTAL PATIENT; META ANALYSIS; MULTICENTER STUDY (TOPIC); NEWCASTLE-OTTAWA SCALE; ODDS RATIO; OUTCOME ASSESSMENT; PREVALENCE; PSYCHOMETRY; PSYCINFO; PUBLISHING; REVIEW; RISK FACTOR; STATISTICAL ANALYSIS; SYSTEMATIC REVIEW; FRAIL ELDERLY; PSYCHOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CROSS-SECTIONAL STUDIES; DEPRESSION; FRAIL ELDERLY; FRAILTY; HUMANS; INCIDENCE; PREVALENCE; RISK FACTORS;

EID: 85016610031     PISSN: 15681637     EISSN: 18729649     Source Type: Journal    
DOI: 10.1016/j.arr.2017.03.005     Document Type: Review

References (63)

1. Abellan van Kan, G., Rolland, Y., Bergman, H., et al. The I.A.N.A Task Force on frailty assessment of older people in clinical practice. J. Nutr. Health Aging, 12, 2008, 29e37.
2. Almeida, O.P., Hankey, G.J., Yeap, B.B., Golledge, J., Norman, P.E., Flicker, L., Depression, frailty, and all-cause mortality: a cohort study of men older than 75 years. J. Am. Med. Dir. Assoc. 16 (2015), 296–300, 10.1016/j.jamda.2014.10.023.
3. Almeida, O.P., McCaul, K., Hankey, G.J., Yeap, B.B., Golledge, J., Norman, P.E., Flicker, L., Duration of diabetes and its association with depression in later life: the Health in Men Study (HIMS). Maturitas 86 (2016), 3–9, 10.1016/j.maturitas.2016.01.003.
4. Anand, A., Gunn, A.D., Barkay, G., Karne, H.S., Nurnberger, J.I., Mathew, S.J., Ghosh, S., Early antidepressant effect of memantine during augmentation of lamotrigine inadequate response in bipolar depression: a double-blind, randomized, placebo-controlled trial. Bipolar Disord. 14 (2012), 64–70, 10.1111/j.1399- 5618.2011.00971.x.
5. Badalà, F., Nouri-mahdavi, K., Raoof, D.A., NIH public access. Computer (Long. Beach. Calif.) 144 (2008), 724–732, 10.1038/jid.2014.371.
6. Benraad, C.E.M., Kamerman-Celie, F., van Munster, B.C., Oude Voshaar, R.C., Spijker, J., Olde Rikkert, M.G.M., Geriatric characteristics in randomised controlled trials on antidepressant drugs for older adults: a systematic review. Int. J. Geriatr. Psychiatry 31 (2016), 990–1003, 10.1002/gps.4443.
7. Belvederi, M. Murri, Pariante, C., Mondelli, V., Masotti, M., Atti, A.R., Mellacqua, Z., Antonioli, M., Ghio, L., Menchetti, M., Zanetidou, S., Innamorati, M., Amore, M., HPA axis and aging in depression: systematic review and meta-analysis. Psychoneuroendocrinology 41 (2014), 46–62, 10.1016/j.psyneuen.2013.12.004.
8. Bortolato, B., Miskowiak, K.W., Köhler, C.A., Maes, M., Fernandes, B.S., Berk, M., Carvalho, A.F., Cognitive remission: a novel objective for the treatment of major depression?. BMC Med., 22(14:9), 2016, 10.1186/s12916-016-0560-3.
9. Brouwer-Brolsma, E.M., van de Rest, O., Tieland, M., van der Zwaluw, N.L., Steegenga, W.T., Adam, J.J., van Loon, L.J., Feskens, E.J., de Groot, L.C., Serum 25-hydroxyvitamin D is associated with cognitive executive function in Dutch prefrail and frail elderly: a cross-sectional study exploring the associations of 25-hydroxyvitamin D with glucose metabolism, cognitive performance and depression. J. Am. Med. Dir. Assoc., 06, 2013, 010.
10. Brown, P.J., Roose, S.P., Fieo, R., Liu, X., Rantanen, T., Sneed, J.R., Rutherford, B.R., Devanand, D.P., Avlund, K., Frailty and depression in older adults: a high-risk clinical population. Am. J. Geriatr. Psychiatry 22 (2014), 1083–1095, 10.1016/j.jagp.2013.04.010.
11. Brown, P.J., Rutherford, B.R., Yaffe, K., Tandler, J.M., Ray, J.L., Pott, E., Chung, S., Roose, S.P., The depressed frail phenotype: The clinical manifestation of increased biological aging. Am. J. Geriatr. Psychiatry. 24:11 (2016), 1084–1094, 10.1016/j.jagp.2016.06.005.
12. Buigues, C., Padilla-Sánchez, C., Garrido, J.F., Navarro-Martínez, R., Ruiz-Ros, V., Cauli, O., The relationship between depression and frailty syndrome: a systematic review. Aging Ment. Health 19 (2015), 762–772, 10.1080/13607863.2014.967174.
13. Burnam, M.A., Wells, K.B., Leake, B., Landsverk, J., Development of a brief screening instrument for detecting depressive disorders. Med Care 26:8 (1988), 775–789.
14. Chang, S.S., Weiss, C.O., Xue, Q.L., Fried, L.P., Patterns of comorbid inflammatory diseases in frail older women: the women's health and aging studies I and II. J. Gerontol. Ser. A- Biol. Sci. Med. Sci. 65 (2010), 407–413, 10.1093/gerona/glp181.
15. Clegg, A., Young, J., Iliffe, S., Rikkert, M.O., Rockwood, K., Frailty in elderly people. Lancet 381 (2013), 752–762, 10.1016/S0140-6736(12) 62167-9.
16. Collard, R.M., Boter, H., Schoevers, R.A., Oude Voshaar, R.C., Prevalence of frailty in community-dwelling older persons: a systematic review. J. Am. Geriatr. Soc. 60 (2012), 1487–1492, 10.1111/j.1532-5415.2012.04054.x.
17. Collard, R.M., Comijs, H.C., Naarding, P., Oude Voshaar, R.C., Physical frailty: vulnerability of patients suffering from late-life depression. Aging Ment. Health 18 (2014), 570–578, 10.1080/13607863.2013.827628.
18. de Albuquerque Sousa, Patrício, Dias, R.C., Maciel álvaro, C.C., Guerra, R.O., Frailty syndrome and associated factors in community-dwelling elderly in Northeast Brazil. Arch. Gerontol. Geriatr., 2012, 54, 10.1016/j.archger.2011.08.010.
19. Dent, E., Hoogendijk, E.O., Psychosocial factors modify the association of frailty with adverse outcomes: a prospective study of hospitalised older people. BMC Geriatr., 14, 2014, 108, 10.1186/1471-2318-14-108.
20. Drey, M., Pfeifer, K., Sieber, C.C., Bauer, J.M., The Fried frailty criteria as inclusion criteria for a randomized controlled trial: personal experience and literature review. Gerontology 57:1 (2011), 11–18, 10.1159/000313433.
21. Duval, S., Tweedie, R., Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56 (2000), 455–463, 10.1111/j.0006- 341x.2000.00455.x.
22. Feng, L., Nyunt, M.S.Z., Feng, L., Yap, K.B., Ng, T.P., Frailty predicts new and persistent depressive symptoms among community-dwelling older adults: findings from singapore longitudinal aging study. J. Am. Med. Dir. Assoc., 15, 2014, 10.1016/j.jamda.2013.10.001.
23. Fried, L.P., Tangen, C.M., Walston, J., Newman, A.B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W.J., Burke, G., McBurnie, M.A., Frailty in older adults: evidence for a phenotype. J. Gerontol. A Biol. Sci. Med. Sci. 56 (2001), M146–M156.
24. Fugate Woods, N., LaCroix, A.Z., Gray, S.L., Aragaki, A., Cochrane, B.B., Brunner, R.L., Masaki, K., Murray, A., Newman, A.B., Frailty: emergence and consequences in women aged 65 and older in the women's health initiative observational study. J. Am. Geriatr. Soc. 53 (2005), 1321–1330, 10.1111/j.1532- 5415.2005.53405.x.
25. Hajek, A., Brettschneider, C., Posselt, T., Lange, C., Mamone, S., Wiese, B., Weyerer, S., Werle, J., Fuchs, A., Pentzek, M., Stein, J., Luck, T., Bickel, H., Mosch, E., Heser, K., Jessen, F., Maier, W., Scherer, M., Riedel-Heller, S.G., Konig, H.-H., Predictors of frailty in old age – results of a longitudinal study. J. Nutr. Health Aging 20 (2016), 952–957, 10.1007/s12603-015-0634-5.
26. Hare, D.L., Toukhsati, S.R., Johansson, P., Jaarsma, T., Depression and cardiovascular disease: a clinical review. Eur. Heart J. 35 (2014), 1365–1372, 10.1093/eurheartj/eht462.
27. Higgins, J.P.T., Thompson, S.G., Quantifying heterogeneity in a meta-analysis. Stat. Med. 21 (2002), 1539–1558, 10.1002/sim.1186.
28. Ioannidis, J.P., Lau, J., Pooling research results: benefits and limitations of meta- analysis. Jt. Comm. J. Qual. Improv. 25:9 (1999), 462–469.
29. Jarschik, P., Nunin, C., Botigu, T., Escobar, M.A., Lavedan, A., Viladrosa, M., Prevalence of frailty and factors associated with frailty in the elderly population of Lleida Spain: the FRALLE survey. Arch. Gerontol. Geriatr. 55 (2012), 625–631, 10.1016/j.archger.2012.07.002.
30. Jung, H., Jang, I., Lee, Y.S., Lee, C.K., Cho, E., Kang, W.Y., Kim, D.H., Prevalence of frailty and aging-related health conditions in older koreans in rural communities: a cross-sectional analysis of the aging study of pyeongchang rural area. J. Korean Med. Sci., 2016, 345–352, 10.3346/jkms.2016.31.3.345.
31. Katz, I.R., Depression and frailty: the need for multidisciplinary research. Am. J. Geriatr. Psychiatry 12 (2004), 1–6.
32. Kroenke, K., Spitzer, R.L., Williams, J.B., The PHQ-9: validity of a brief depression severity measure. J. Gen. Intern. Med. 16:9 (2001), 606–613.
33. Lakey, S.L., Lacroix, A.Z., Gray, S.L., Borson, S., Williams, C.D., Calhoun, D., Goveas, J.S., Smoller, J.W., Ockene, J.K., Masaki, K.H., Coday, M.E., Rosal, M.C., Woods, N.F., Antidepressant use, depressive symptoms, and incident frailty in women aged 65 and older from the Women'S Health Initiative Observational Study. J. Am. Geriatr. Soc. 60 (2012), 854–861, 10.1111/j.1532-5415.2012.03940.x.
34. Liberati, A., Altman, D.G., Tetzlaff, J., Mulrow, C., Gøtzsche, P.C., Ioannidis, J.P.A., Clarke, M., Devereaux, P.J., Kleijnen, J., Moher, D., The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med., 6, 2009, 10.1371/journal.pmed.1000100 (e1000100).
35. Lohman, M., Dumenci, L., Mezuk, B., Sex differences in the construct overlap of frailty and depression: evidence from the health and retirement study. J. Am. Geriatr. Soc. 62 (2014), 500–505, 10.1111/jgs.12689.
36. Lohman, M., Dumenci, L., Mezuk, B., Depression and frailty in late life: evidence for a common vulnerability. J. Gerontol. -Ser. B Psychol. Sci. Soc. Sci. 71 (2016), 630–640, 10.1093/geronb/gbu180.
37. Lohman, L., Construct overlap between depression and frailty in later life: evidence from the health and retirement study. Compr. Psychiatry, 2013, 10.1016/j.comppsych.2012.07.032.
38. Matheus, H.L. Arts, Collard, R.M., Comijs, H.C., Zuidersma, M., de Rooij, S.E., Naarding, P., Oude Voshaar, R.C., Physical frailty and cognitive functioning in depressed older adults: findings from the NESDO study. J. Am. Med. Dir. Assoc. 17 (2016), 36–43, 10.1016/j.jamda.2015.07.016.
39. Makizako, H., Shimada, H., Doi, T., Yoshida, D., Anan, Y., Tsutsumimoto, K., Uemura, K., Liu- Ambrose, T., Park, H., Lee, S., Suzuki, T., Physical frailty predicts incident depressive symptoms in elderly people: prospective findings from the Obu Study of Health Promotion for the Elderly. J. Am. Med. Dir. Assoc. 16 (2015), 194–199, 10.1016/j.jamda.2014.08.017.
40. McAdams-DeMarco, M.A., Ying, H., Olorundare, I., King, E.A., Haugen, C., Buta, B., Gross, A.L., Kalyani, R., Desai, N.M., Dagher, N.N., Lonze, B.E., Montgomery, R.A., Bandeen-Roche, K., Walston, J.D., Segev, D.L., Individual frailty components and mortality In kidney transplant recipients. Transplantation, 2016, 1, 10.1097/tp.0000000000001546.
41. Mezuk, B., Edwards, L., Lohman, M., Choi, M., Lapane, K., Depression and frailty in later life: a synthetic review. Int. J. Geriatr. Psychiatry 27 (2012), 879–892, 10.1002/gps.2807.
42. Mezuk, B., Lohman, M., Dumenci, L., Lapane, K.L., Are depression and frailty overlapping syndromes in mid- and late-life? A latent variable analysis. Am. J. Geriatr. Psychiatry 21 (2013), 560–569, 10.1016/j.jagp.2012.12.019.
43. Monin, J., Doyle, M., Levy, B., Schulz, R., Fried, T., Kershaw, T., Spousal associations between frailty and depressive symptoms: longitudinal findings from the cardiovascular health study. J. Am. Geriatr. Soc. 64 (2016), 824–830, 10.1111/jgs.14023.
44. Newberg, A.R., Davydow, D.S., Lee, H.B., Cerebrovascular disease basis of depression: post-stroke depression and vascular depression. Int. Rev. Psychiatry 18 (2006), 433–441, 10.1080/09540260600935447.
45. Paulson, D., Lichtenberg, P.A., Vascular depression: an early warning sign of frailty. Aging Ment. Health 17 (2013), 85–93, 10.1080/13607863.2012.692767.
46. Pegorari, M.S., Tavares, D.M.D.S., Factors associated with the frailty syndrome in elderly individuals living in the urban area. Rev. Lat. Am. Enfermagem 22 (2014), 874–882, 10.1590/0104- 1169.0213.2493.
47. Potter, G.G., McQuoid, D.R., Whitson, H.E., Steffens, D.C., Physical frailty in late-life depression is associated with deficits in speed-dependent executive functions. Int. J. Geriatr. Psychiatry 31 (2016), 466–474, 10.1002/gps.4351.
48. Radloff, L.S., The CES-D scale: a self-report depression scale for research in the general population. Appl. Psychol. Meas. 1 (1977), 385–401, 10.1177/014662167700100306.
49. Rockwood, K., Song, X., MacKnight, C., Bergman, H., Hogan, D.B., McDowell, I., Mitnitski, A., A global clinical measure of fitness and frailty in elderly people. CMAJ 173:5 (2005), 489–495.
50. Rodda, J., Walker, Z., Carter, J., Depression in older adults. BMJ, 343, 2011, 10.1136/bmj.d5219.
51. Sanchez-Garcia, S., Sanchez-Arenas, R., Garcia-Pereira, C., Rosas-Carrasco, O., Avila-Funes, J.A., Ruiz-Arregui, L., Juarez- Cedillo, T., Frailty among community- dwelling elderly Mexican people: prevalence and association with sociodemographic characteristics, health state and the use of health services. Geriatr. Gerontol. Int. 14 (2014), 395–402, 10.1111/ggi.12114.
52. Schuch, F.B., Deslandes, A.C., Stubbs, B., Gosmann, N.P., Silva, C.T., Fleck, M.P., Neurobiological effects of exercise on major depressive disorder: a systematic review. Neurosci. Biobehav. Rev. 61 (2016), 1–11, 10.1016/j.neubiorev.2015.11.012.
53. Schuch, F.B., Vancampfort, D., Rosenbaum, S., Richards, J., Ward, P.B., Veronese, N., Solmi, M., Cadore, E.L., Stubbs, B., Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias. Rev. Bras. Psiquiatr. 38:3 (2016), 247–254, 10.1590/1516-4446-2016- 1915.
54. Soysal, P., Stubbs, B., Lucato, P., Luchini, C., Solmi, M., Peluso, R., Sergi, G., Isik, A.T., Manzato, E., Maggi, S., Maggio, M., Prina, A.M., Cosco, T.D., Wu, Y.-T., Veronese, N., Inflammation and frailty in the elderly: a systematic review and meta-analysis. Ageing Res. Rev. 31 (2016), 1–8, 10.1016/j.arr.2016.08.006.
55. Soysal Pinar, Isik Ahmet Turan, Carvalho Andre F., Fernandes Brisa S., Solmi Marco, Schofield Patricia, Veronese Nicola, Stubbs Brendon, 2017. Oxidative stress and frailty: A systematic review and synthesis of the best evidence. http://dx.doi.org/10.1016/j.maturitas.2017.01.006 (in press).
56. von Elm, E., Altman, D.G., Egger, M., Pocock, S.J., Gøtzsche, P.C., Vandenbroucke, J.P., for the STROBE Initiative, The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guildelines for reporting observational studies. J. Clin. Epidemiol. 61 (2008), 344–349, 10.1016/j.jclinepi.2007.11.008.
57. von Zerssen, D., Berger, M., Dose, M., Doerr, P., Krieg, C., Bossert, S., Riemann, D., Pirke, K.M., Dolhofer, R., Müller, O.A., The nature of neuroendocrine abnormalities in depression: a controversial issue in contemporary psychiatry. Psychiatr. Dev. 4 (1986), 237–256.
58. Vaughan, L., Corbin, A.L., Goveas, J.S., Depression and frailty in later life: a systematic review. Clin. Interv. Aging 10 (2015), 1947–1958, 10.2147/CIA.S69632.
59. Veronese, N., Stubbs, B., Fontana, L., Trevisan, C., Bolzetta, F., Rui, M., Sartori, De, Musacchio, L., Zambon, E., Maggi, S., Perissinotto, S., Corti, E., Crepaldi, M.C., Manzato, G., Sergi, E., A comparison of objective physical performance tests and future mortality in the elderly people. J. Gerontol. A. Biol. Sci. Med. Sci.(July 28), 2016, 10.1093/gerona/glw139 pii: glw139.
60. Wells, G., Shea, B., O'Connell, D., Peterson, J., Welch, V., Losos, M., Tugwell, P., The Newcastle- Ottawa Scale (NOS) for Assessing the Quality If Nonrandomized Studies in Meta- Analyses. 2012, 10.2307/632432 (Available from URL: http//www.ohrid.ca/programs/clinicalepidemiology/oxford.asp).
61. Wittchen, H.U., Robins, L.N., Cottler, L.B., Sartorius, N., Burke, J.D., Regier, D., Cross-cultural feasibility, reliability and sources of variance of the Composite International Diagnostic Interview (CIDI). The multicentre WHO/ADAMHA field trials. Br. J. Psychiatry: J. Ment. Sci., 645–653, 1991, 658 159(Journal Article).
62. Woods, N.F., LaCroix, A.Z., Gray, S.L., Aragaki, A., Cochrane, B.B., Brunner, R.L., Masaki, K., Murray, A., Newman, A.B., Frailty: emergence and consequences in women aged 65 and older in the Women's Health Initiative observational study. J. Am. Geriatr. Soc. 53 (2005), 1321–1330, 10.1111/j.1532- 5415.2005.53405.x.
63. Ylli, A., Miszkurka, M., Phillips, S.P., Guralnik, J., Deshpande, N., Zunzunegui, M.V., Clinically relevant depression in old age: An international study with populations from Canada, Latin America and Eastern Europe. Psychiatry Res. 30:241 (2016), 236–241, 10.1016/j.psychres.2016.04.096.