Depression and frailty in later life: A synthetic review

International Journal of Geriatric Psychiatry

Volumn 27, Issue 9, 2012, Pages 879-892

  Mezuk, Briana ^a   Edwards, Lauren ^a   Lohman, Matt ^a   Choi, Moon ^a   Lapane, Kate ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

aging; comorbidity; depression; disability; frailty

Indexed keywords

ANTIDEPRESSANT AGENT;

BODY WEIGHT; CLINICAL FEATURE; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; DAILY LIFE ACTIVITY; DEPRESSION; DISEASE ASSOCIATION; ETHNIC DIFFERENCE; FRAIL ELDERLY; HIGH RISK POPULATION; HUMAN; MEDLINE; PHYSICAL DISABILITY; POPULATION RESEARCH; PSYCHOPHARMACOTHERAPY; REVIEW; RISK ASSESSMENT; RISK FACTOR; SOCIAL SUPPORT; STUDY DESIGN; SYMPTOMATOLOGY; SYSTEMATIC REVIEW; VULNERABLE POPULATION;

AGED; AGED, 80 AND OVER; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DEPRESSIVE DISORDER; EMPIRICAL RESEARCH; FEMALE; FRAIL ELDERLY; HUMANS; MALE; RISK FACTORS;

EID: 84864691275     PISSN: 08856230     EISSN: 10991166     Source Type: Journal    
DOI: 10.1002/gps.2807     Document Type: Review

References (92)

1. Alexopoulos GS, Abrams RC, Young RC, Shamoian CA,. 1988. Cornell Scale for Depression in Dementia. Biol Psych 23: 271-284.
2. Andersen K, Lolk A, Kraugh-Sorensen P, et al., 2005. Depression and the risk of Alzheimer disease. Epidemiology 16: 233-238.
3. Atkinson HH, Rosano C, Simonsick EM, et al., 2007. Cognitive function, gait speed decline, and comorbidities: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci 62: 844-850.
4. Avlund K,. 2006. Factors underlying tiredness in older adults. Aging Clin Exp 18: 16-25.
5. Avlund K, Rantanen T, Schroll M,. 2006. Tiredness and subsequent disability in older adults: the role of walking limitations. J Gerontol A Med Sci Bio Sci 61: 1201-1205.
6. Bandeen-Roche K, Xue QL, Ferrucci L, et al., 2006. Phenotype of frailty: characterization in the women's health and aging studies. J Gerontol A Med Sci Bio Sci 61: 262-266.
7. Barry LC, Allore HG, Bruce ML, Gill TM,. 2009. Longitudinal association between depressive symptoms and disability burden among older persons. J Gerontol B Psychol Sci Soc Sci 64: 1325-1332.
8. Birrer RB, Vemuri SP,. 2004. Depression in later life: a diagnostic and therapeutic challenge. Am Fam Phys 69: 2375-2382.
9. Blyth FM, Rochat S, Cumming RG, et al., 2008. Pain, frailty and comorbidity on older men: the CHAMP study. Pain 140: 224-230.
10. Breslau J, Aguilar S, Kendler KS, et al., 2006. Specifying race-ethnic differences for psychiatric disorder in a USA national sample. Psychol Med 36: 57-68.
11. Broe GA, Jorm AF, Creasey H, et al., 1999. Impact of chronic systemic and neurological disorders on disability, depression, and life satisfaction. Int J Geriatr Psychiatry 14: 497-499.
12. Bruce ML,. 2001. Depression and disability in later life. Am J Geriatr Psych 9: 102-112.
13. Buchner DM,. 1996. Factors associated with changes in gait speed in older adults. J Gerontol: Med Sci 51A: 297-302.
14. Chang M, Phillips C, Coppin AK, et al., 2009. An association between incident disability and depressive symptoms over 3 years of follow-up among older women. Aging Clin Exp Res 21 (2): 191-197.
15. Chang SS, Weiss CO, Xue QL, Fried LP,. 2010. Patterns of comorbid inflammatory diseases in frail older women: the Women's Health and Aging Studies I and II. J Gerontol A Biol Sci Med Sci 65 (4): 407-413.
16. Chen CY, Wu SC, Chen LJ, Lue BH,. 2010. The prevalence of subjective frailty and factors associated with frailty in Taiwan. Arch Gerontol Geriatr 50: S43-S47.
17. Cigolle CT, Ofstedal MB, Tian Z, Blaum CS,. 2009. Comparing models of frailty: the Health and Retirement Study. J Am Geriatr Soc 57: 830-839.
18. Committee on a National Research Agenda on Aging. 1991. Extending Life, Enhancing Life: A National Research Agenda on Aging. National Academy Press: Washington, DC.
19. Cummings SM, Neff JA, Husaini BA,. 2003. Functional impairment as a predictor of depressive symptomatology: the role of race, religiosity, and social support. Health Soc Work 28: 23-32.
20. Davidson H, Feldman PH, Crawford S,. 1994. Measuring depressive symptoms in the frail elderly. J Gerontol 49: 159-164.
21. Deshpande N, Metter EJ, Bandinelli S, et al., 2008. Psychological, physical, and sensory correlates of fear of falling and consequent activity restriction in the elderly: the InCHIANTI study. Am J Phys Med Rehabil 87: 354-362.
22. Dowrick C, Peveler R, Lloyd H,. 2005. Somatic symptoms and depression: diagnostic confusion and clinical neglect. Br J Gen Pract 55: 829-230.
23. Eaton WW, Hall ALF, MacDonald R, McKibben J,. 2007. Case Identification in psychiatric epidemiology: a review. Int Rev Psychiatry 19: 497-507.
24. Ensrud KE, Blackwell T, Mangione CM,. 2002. Central nervous system-active medications and risk for falls in older women. J Am Geriatr Soc 50: 1629-1637.
25. Ensrud KE, Ewing SK, Fredman L, et al., 2010. Circulating 25-hydroxyvitamin D levels and frailty status in older women. J Clin Endocrinol Metab 95: 5266-5273.
26. Ensrud KE, Ewing SK, Taylor BC, et al., 2007. Frailty and risk of falls, fracture, and mortality in older women: the study of osteoporotic fractures. J Gerontol A Med Sci Biol Sci 62: 744-751.
27. Fairhall N, Aggar C, Kirrle SE, et al., 2008. Frailty Intervention Trial. BMC Geriatr 8: 27.
28. Fialova D, Onder G,. 2009. Medication errors in elderly people: contributing factors and future perspectives. Br J Clin Pharmacolog 67: 641-645.
29. Fiske A, O'Riley AA,. 2008. Depression in late life. In, J Hunsley, and, EJ Mash, (eds.), A Guide to Assessments that Work. Oxford University Press: New York, NY, 138-157.
30. Fitzpatrick AL, Buchanan CK, Nahin RL, et al., 2007. Associations of gait speed and other measures of physical function with cognition in a healthy cohort of elderly persons. J Gerontol A Biol Sci Med Sci 62: 1244-1251.
31. Fried LP, Tangen CM, Walston J, et al., 2001. Frailty in older adults: evidence for a phenotype. J Gerontol A Med Sci Biol Sci 56: 46-56.
32. Frisoli A, Chaves PH, Ingham SJ, Fried LP,. 2011. Severe osteopenia and osteoporosis, sarcopenia, and frailty status in community-dwelling older women: results from the Women's Health and Aging Study (WHAS) II. Bone 48: 952-957.
33. Gagne JJ, Patrick AR, Mogun H, Solomon DH,. 2011. Antidepressants and fracture risk in older adults: a comparative safety analysis. Clin Pharmacol Therapy 89: 880-887.
34. Gallo JJ, Rabins PV,. 1999. Depression without sadness: alternative presentations of depression in late life. Am Fam Phys 60: 820-826.
35. Gallo JJ, Anthony JC, Muthen BO,. 1994. Age differences in the symptoms of depression: a latent trait analysis. J Gerontology 49: 251-264.
36. Gayman MD, Turner RJ, Cui M,. 2008. Physical limitations and depressive symptoms: exploring the nature of the association. J Gerontol B Psychol Sci Soc Sci 63: 219-228.
37. Gitlin LN, Hauck WW, Dennis MP, Schulz R,. 2007. Depressive symptoms in older African-American and white adults with functional difficulties: the role of control strategies. J Am Geriatr Soc 55: 1023-1030.
38. Guarnacia PJ, Angel R, Worobey JL,. 1989. The factor structure of the CES-D in the Hispanic Health and Nutrition Examination Survey: the influences of ethnicity, gender and language. Soc Sci Med 29: 85-94.
39. Hajjar I, Yang F, Sorond F, et al., 2009. A novel aging phenotype of slow gait, impaired executive function, and depressive symptoms: relationship to blood pressure and other cardiovascular risks. J Gerontol A Med Sci Bio Sci 64A: 994-1001.
40. Han B,. 2006. Improvement in depressive symptoms and changes in self-rated health among community-dwelling disabled older adults Aging Ment Health 10: 599-605.
41. Hebert R, Braybe C, Spiegelhalter D,. 1999. Factors associated with functional decline and improvement in a very elderly community-dwelling population. Am J Epidemiol 150: 501-510.
42. Hybels CF, Blazer DG, Pieper CF,. 2001. Toward a threshold for subthreshold depression: an analysis of correlates of depression by severity of symptoms using data from an elderly community sample. Gerontologist 41: 357-365.
43. Jang Y, Haley WE, Small BJ, Mortimer JA,. 2002. The role of mastery and social resources in the associations between disability and depression in later life. Gerontologist 42: 807-813.
44. Jang Y, Kim G, Chriboga DA,. 2006. Health perception and depressive symptoms among older Korean Americans. J Cross Cult Gerontol 21: 91-102.
45. Jongenelis K, Pot AM, Eisses AM, et al., 2004. Prevalence and risk indicators of depression in elderly nursing home patients: the AGED study. J Affect Disord 83: 135-142.
46. Katon W, Sullivan MD,. 1990. Depression and chronic medical illness. J Clin Psychiatry 51: 3-11.
47. Katz IR,. 1996. On the inseparability of mental and physical health in aged persons: lessons from depression and medical comorbidity. Am J Geriatr Psychiatry 4: 1-16.
48. Katz IR,. 2004. Depression and frailty: the need for interdisciplinary research. Am J Geriatr Psychiatry 12: 1-6.
49. Katz IR, Parmelee PA, Beaston-Wimmer P, Smith BD,. 1994. Association of antidepressants and other medications with mortality in the residential-care elderly. J Geriatr Psych Neurol 7: 221-226.
50. Kennedy GJ, Kelman HR, Thomas C,. 1991. Persistence and remission of depressive symptoms in late life. Am J Psychiatry 148: 174-178.
51. Landi F, Onder G, Cesari M, et al., 2005. Pain and its relation to depressive symptoms in frail older people living in the community: an observational study: Silver Network Home Care Project. J Pain Symptom Manage 29: 255-262.
52. Lang IA, Hubbard RE, Andrew MK, et al., 2009. Neighborhood deprivation, individual socioeconomic status, and frailty in older adults. J Am Geriatr Soc 57: 1776-1780.
53. Laursen TM, Munk-Olsen T, Nordentoft M, and, Mortensen PB,. 2007. Increased mortality among patients admitted with major psychiatric disorders: a register-based study comparing mortality in unipolar depressive disorder, bipolar affective disorder, schizoaffective disorder, and schizophrenia. J Clin Psych 68: 899-907.
54. Mehta KM, Yaffe K, Covinsky KE,. 2002. Cognitive impairment, depressive symptoms, and functional decline in older people. J Am Geriatr Soc 50: 1045-1050.
55. Mezuk B, Eaton WW,. 2010. Approaches to measuring multi-dimensional constructs across the life course: operationalizing depression over the lifespan. In:, Tucker E, Viswanathan M, Walford G, (eds). The Handbook of Measurement. SAGE, Inc: London, 239-264.
56. Mezuk B, Golden SH,. 2009. A link between depression and bone metabolism: what are the implications for treatment? Exp Rev Endocrinol Metab 4: 199-202.
57. Mezuk B, Eaton WW, Golden SH, et al., 2008. Depression, antidepressants, and bone mineral density in a population-based cohort. J Gerontol A Med Sci Biol Sci 63: 1410-1415.
58. Mirowsky J, Ross C,. 1992. Age and depression. J Health Soc Behav 33 (3): 187-205.
59. Mottram P, Wilson K, Strobl J,. 2006. Antidepressants for depressed elderly. Cochrane Database Syst Rev 25: CD003491.
60. Needham B, Hill TD,. 2010. Do gender differences in mental health contribute to gender differences in physical health? Soc Sci Med 71: 1472-1479.
61. Newsom JT, Schulz R,. 1996. Social support as a mediator in the relation between functional status and quality of life in older adults Psychol Aging 11: 34-44.
62. Onishi J, Umegai H, Suzuki Y,. et al. 2004. The relationship between functional disability and depressive mood in Japanese older adult inpatients. J Geriatr Psychiatry Neurol 17: 93-98.
63. Ormel J, Rijdijk FV, Sullivan M,. et al. 2002. Temporal and reciprocal relationship between IADL/ADL disability and depressive symptoms in late life. J Gerontol B Psychol Sci Soc Sci 57: 338-347.
64. Ostir GVGV, Ottenbacher KJ, Markides KS,. 2004. Onset of frailty in older adults and the protective role of positive affect. Psychol Aging 19: 402-408.
65. Park-Lee E, Fredman L, Hochberg M, Faulkner K,. 2009. Positive affect and incidence of frailty in elderly women caregivers and non-caregivers: results of Caregiver-Study of Osteoporotic Fractures. J Am Geriatr Soc 57: 627-633.
66. Parmelee PA, Lawton MP, Katz IR,. 1998. The structure of depression among elderly institution residents: affective and somatic correlates of physical frailty. J Gerontol A Biol Sci Med Sci 53: 155-162.
67. Pijpers E, Ferreira I, Van de Laar RJ, et al., 2009. Predicting mortality of psychogeriatric patients: a simple prognostic frailty risk score. Postgrad Med J 85: 464-469.
68. Prince MJ, Harwood RH, Blizard RA, et al., 1997. Impairment, disability and handicap as risk factors for depression in old age: the Gospel Oak Project V. Psychol Med 27: 311-321.
69. Rantanen T, Penninx BW, Masaki K, et al., 2000. Depressed mood and body mass index as predictors of muscle strength decline in old men. J Am Geriatr Soc 48: 613-617.
70. Rocchiccioli JT, Sanford JT,. 2009. Revisiting geriatric failure to thrive: a complex and compelling clinical condition. J Gerontol Nurs 34: 18-24.
71. Rockwood K, Fox RA, Stolee P,. 1994. Frailty in elderly people: an evolving concept. Can Med Assoc J 150: 489-495.
72. Rockwood K, Howlett SE, MacKnight C, et al., 2004. Prevalence, attributes, and outcomes of fitness and frailty in community-dwelling older adults: report from the Canadian study of health and aging. J Gerontol A Bio Sci Med Sci 59: 1310-1317.
73. Rovner BW, German PS, Brant LJ, et al., 1991. Depression and mortality in nursing homes. JAMA 265: 993-996.
74. Sarkisian CA, Liu H, Gutierrez PR, et al., 2000. Modifiable risk factors predict functional decline among older women: a prospectively validated clinical prediction tool. The study of osteoporotic fractures research group. J Am Geriatr Soc 48: 170-178.
75. Schieman S, Plickert G,. 2007. Functional limitations and changes in levels of depression among older adults: a multiple-hierarchy stratification perspective. J Gerontol B Psychol Sci Soc Sci 62: S36-S42.
76. Schnittker J,. 2005. When mental health becomes health: age and the shifting meaning of self-evaluations of general health. Milbank Q 83: 397-423.
77. Schulz R, Williamson GM,. 1993. Psychosocial and behavioral dimensions of physical frailty. J Gerontol 48: 39-43.
78. Schwartzbaum J, Ahlbom A, Feychting M,. 2003. Berkson's bias reviewed. Euro J Epidemiol 18: 1109-1112.
79. Simon GE, Von Korff M, Piccinelli M, et al., 1999. An international study of the relation between somatic symptoms and depression. NEJM 341: 1329-1335.
80. Smith Barusch A, Rogers A, Abu-Bader SH,. 1999. Depressive symptoms in the frail elderly: physical and psycho-social correlates. Int J Aging Hum Dev 49: 107-125.
81. Stek ML, Gussekloo J, Beekman AT, et al., 2004. Prevalence, correlates and recognition of depression in the oldest old: the Leiden 85-plus study. J Affect Disord 78: 193-200.
82. Strawbridge WJ, Shema SJ, Balfour JL, et al., 1998. Antecedents of frailty over three decades in an older cohort. J Gerontol B Psych Sci Soc Sci 53B: 9-16.
83. Takkouche B, Montes-Martinez A, Gill S, and, Etminan M,. 2007. Psychotropic medications and the risk of fracture: a meta-analysis. Drug Saf 30: 171-184.
84. Taylor MG, Lynch SM,. 2004. Trajectories of impairment, social support, and depressive symptoms in later life J Gerontol B Psychol Sci Soc Sci 59: S238-S246.
85. Tinetti ME, Inouye SK, Gill TM, Douchette JT,. 1995. Shared risk factors for falls, incontinence, and functional dependence. Unifying the approach to geriatric syndromes. JAMA 273: 1348-1353.
86. Vaillant GE,. 1998. Natural history of male psychological health: relationship of mood disorder vulnerability to physical health. Am J Psychiatry 155: 184-191.
87. Wada T, Ishine M, Ishimoto Y, et al., 2008. Community-dwelling elderly fallers in Japan are older, more disabled, and more depressed than nonfallers. J Am Geriatr Soc 56: 1570-1571.
88. Whooley MA, Kip KE, Cauley JA, et al., 1999. Depression, falls, and risk of fracture in older women. Arch Intern Med 159: 484-490.
89. Woods NF, La Croix AZ, Gray SL, et al., 2005. Frailty: emergence and consequences in women aged 65 and older in the Women's Health Initiative Observational Study. J Am Geriatr Soc 53: 1321-1330.
90. Xue QL, Fried LP, Glass TA, et al., 2008. Life-space constriction, development of frailty, and the competing risk of mortality. Am J Epidemiol 167: 240.
91. Yang Y, George LK,. 2005. Functional disability, disability transitions, and depressive symptoms in late life. J Aging Health 17: 263-292.
92. Yesavage JA, Brink TL, Rose TL, et al., 1983. Development and validation of a geriatric depression screening scale: a preliminary report. J Psych Res 17: 37-49.