Frailty predicts new and persistent depressive symptoms among community-dwelling older adults: Findings from singapore longitudinal aging study

Journal of the American Medical Directors Association

Volumn 15, Issue 1, 2014, Pages 76.e7-76.e12

  Feng, Liang ^a   Nyunt, Ma Shwe Zin ^a   Feng, Lei ^a   Yap, Keng Bee ^b   Ng, Tze Pin ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b ALEXANDRA HOSPITAL   (Singapore)

Author keywords

Comorbidity; Depression; Outcome; Physical frailty; Risk factor

Indexed keywords

ADULT; AGED; ARTICLE; COMORBIDITY; CROSS-SECTIONAL STUDY; DEMOGRAPHY; DEPRESSION; FEMALE; FOLLOW UP; FRAIL ELDERLY; GERIATRIC DEPRESSION SCALE; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PHENOTYPE; SINGAPORE;

COMORBIDITY; DEPRESSION; OUTCOME; PHYSICAL FRAILTY; RISK FACTOR;

AGED; AGED, 80 AND OVER; CROSS-SECTIONAL STUDIES; DEPRESSION; FATIGUE; FEMALE; FRAIL ELDERLY; HUMANS; LINEAR MODELS; LONGITUDINAL STUDIES; MALE; PROSPECTIVE STUDIES; RISK FACTORS; SINGAPORE;

EID: 84890754905     PISSN: 15258610     EISSN: 15389375     Source Type: Journal    
DOI: 10.1016/j.jamda.2013.10.001     Document Type: Article

References (50)

1. Katz I.R. Depression and frailty: The need for interdisciplinary research. Am J Geriatr Psychiatry 2004, 12:1-6.
2. Stone R., Cafferata G.L., Sangl J. Caregivers of the frail elderly: A national profile. Gerontologist 1987, 29:616-626.
3. Yang Y., George L.K. Functional disability, disability transitions, and depressive symptoms in late life. JAging Health 2005, 17:263-292.
4. Fried L.P., Tangen C.M., Walston J., et al. Cardiovascular Health Study Collaborative Research Group: Frailty in older adults: Evidence for a phenotype. JGerontol A Biol Sci Med Sci 2001, 56:M146-M156.
5. Ensrud K.E., Ewing S.K., Taylor B.C., et al. Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. Arch Intern Med 2008, 168:382-389.
6. Avila-Funes J.A., Helmer C., Amieva H., et al. Frailty among community-dwelling elderly people in France: The three-city study. JGerontol A Biol Sci Med Sci 2008, 63:1089-1096.
7. Feng L., Yap K.B., Kua E.H., Ng T.P. Depressive symptoms, physician visits and hospitalization among community-dwelling older adults. Int Psychogeriatr 2009, 21:568-575.
8. Penninx B.W., Guralnik J.M., Ferrucci L., et al. Depressive symptoms and physical decline in community-dwelling older persons. JAMA 1998, 279:1720-1726.
9. Simonsick E.M., Wallace R.B., Blazer D.G., Berkman L.F. Depressive symptomatology and hypertension-associated morbidity and mortality in older adults. Psychosom Med 1995, 57:427-435.
10. Djernes J.K. Prevalence and predictors of depression in populations of elderly: A review. Acta Psychiatr Scand 2006, 113:372-387.
11. Gobbens R.J., Luijkx K.G., Wijnen-Sponselee M.T., Schols J.M. Towards an integral conceptual model of frailty. JNutr Health Aging 2010, 14:175-181.
12. Mezuk B., Lohman M., Dumenci L., Lapane K.L. Are depression and frailty overlapping syndromes in mid- and late-life? A latent variable analysis. Am J Geriatr Psychiatry 2013, 21:560-569.
13. Mezuk B., Edwards L., Lohman M., et al. Depression and frailty in later life: A synthetic review. Int J Geriatr Psychiatry 2012, 27:879-892.
14. Newsom J.T., Schulz R. Social support as a mediator in the relation between functional status and quality of life in older adults. Psychol Aging 1996, 11:34-44.
15. Chang S.S., Weiss C.O., Xue Q.L., Fried L.P. Patterns of comorbid inflammatory diseases in frail older women: The Women's Health and Aging Studies I and II. JGerontol A Biol Sci Med Sci 2010, 65:407-413.
16. Chen C.Y., Wu S.C., Chen L.J., Lue B.H. The prevalence of subjective frailty and factors associated with frailty in Taiwan. Arch Gerontol Geriatr 2010, 50:S43-S47.
17. Ní Mhaoláin A.M., Fan C.W., Romero-Ortuno R., et al. Frailty, depression, and anxiety in later life. Int Psychogeriatr 2012, 24:1265-1274.
18. Schieman S., Plickert G. Functional limitations and changes in levels of depression among older adults: A multiple-hierarchy stratification perspective. JGerontol B Psychol Sci Soc Sci 2007, 62:S36-S42.
19. Chang M., Phillips C., Coppin A.K., et al. An association between incident disability and depressive symptoms over 3 years of follow-up among older women. Aging Clin Exp Res 2009, 21:191-197.
20. Ng T.P., Niti M., Chiam P.C., Kua E.H. Prevalence and correlates of functional disability in multiethnic elderly Singaporeans. JAm Geriatr Soc 2006, 54:21-29.
21. Yesavage J. Geriatric Depression Scale. Psychopharmacol Bull 1988, 24:709-711.
22. Nyunt M.S., Fones C., Niti M., Ng T.P. Criterion-based validity and reliability of the Geriatric Depression Screening Scale (GDS-15) in a large validation sample of community-living Asian older adults. Aging Mental Health 2009, 13:376-382.
23. Broekman B.F., Nyunt S.Z., Niti M., et al. Differential item functioning of the Geriatric Depression Scale in an Asian population. JAffect Disord 2008, 108:285-290.
24. Tinetti M.E. Performance-oriented assessment of mobility problems in elderly patients. JAm Geriatr Soc 1986, 34:119-126.
25. Ware J.E., Kosinski M., Keller S.D. SF-12®: How to Score the SF-12 ® Physical and Mental Health Summary Scales 1998, QualityMetric Incorporated, Lincoln, RI. Third Edition.
26. Ng T.P., Niti M., Chiam P.C., et al. Ethnic and educational differences in cognitive test performance on mini-mental state examination in Asians. Am J Geriatr Psychiatry 2007, 15:130-139.
27. Ng T.P., Niti M., Chiam P.C., Kua E.H. Physical and cognitive domains of the Instrumental Activities of Daily Living: Validation in a multiethnic population of Asian older adults. JGerontol A Biol Sci Med Sci 2006, 61:726-735.
28. Han B. Improvement in depressive symptoms and changes in self-rated health among community-dwelling disabled older adults. Aging Ment Health 2006, 10:599-605.
29. Gayman M.D., Turner R.J., Cui M. Physical limitations and depressive symptoms: Exploring the nature of the association. JGerontol B Psychol Sci Soc Sci 2008, 63:219-228.
30. Ormel J., Rijdijk F.V., Sullivan M., et al. Temporal and reciprocal relationship between IADL/ADL disability and depressive symptoms in late life. JGerontol B Psychol Sci Soc Sci 2002, 57:338-347.
31. Barry L.C., Allore H.G., Bruce M.L., Gill T.M. Longitudinal association between depressive symptoms and disability burden among older persons. JGerontol B Psychol Sci Soc Sci 2009, 64:1325-1332.
32. Lakey S.L., LaCroix A.Z., Gray S.L., et al. Antidepressant use, depressive symptoms, and incident frailty in women aged 65 and older from the Women's Health Initiative Observational Study. JAm Geriatr Soc 2012, 60:854-861.
33. Ostir G.V.G.V., Ottenbacher K.J., Markides K.S. Onset of frailty in older adults and the protective role of positive affect. Psychol Aging 2004, 19:402-408.
34. Xue Q.L., Fried L.P., Glass T.A., et al. Life-space constriction, development of frailty, and the competing risk of mortality. Am J Epidemiol 2008, 167:240.
35. Park-Lee E., Fredman L., Hochberg M., Faulkner K. Positive affect and incidence of frailty in elderly women caregivers and noncaregivers: Results of Caregiver-Study of Osteoporotic Fractures. JAm Geriatr Soc 2009, 57:627-633.
36. Taylor M.G., Lynch S.M. Trajectories of impairment, social support, and depressive symptoms in later life. JGerontol B Psychol Sci Soc Sci 2004, 59:S238-S246.
37. Schmidt H.D., Shelton R.C., Duman R.S. Functional biomarkers of depression: Diagnosis, treatment, and pathophysiology. Neuropsychopharmacology 2011, 36:2375-2394.
38. Walston J., Hadley E.C., Ferrucci L., et al. Research agenda for frailty in older adults: Toward a better understanding of physiology and etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. JAm Geriatr Soc 2006, 54:991-1001.
39. Leng S., Bandeen-Roche K., Huang Y., et al. Total and differential white blood cell counts and their associations with circulating interleukin-6 levels in community-dwelling older women. JGerontol A Biol Sci Med Sci 2005, 60A:M195-M199.
40. Hubbard R.E., O'Mahony M.S., Savva G.M., et al. Inflammation and frailty measures in older people. JCell Mol Med 2009, 13:3103-3109.
41. Schaap L.A., Pluijm S.M., Deeg D.J., Visser M. Inflammatory markers and loss of muscle mass (sarcopenia) and strength. Am J Med 2006, 119:526.e9-526.e17.
42. Schaap L.A., Pluijm S.M., Deeg D.J., et al. Health ABC Study. Higher inflammatory marker levels in older persons: Associations with 5-year change in muscle mass and muscle strength. JGerontol A Biol Sci Med Sci 2009, 64:1183-1189.
43. Lindqvist D., Janelidze S., Hagell P., et al. Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity. Biological Psychiatry 2009, 66:287-292.
44. Howren M.B., Lamkin D.M., Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: A meta-analysis. Psychosom Med 2009, 71:171-186.
45. Mezuk B., Eaton W.W., Golden S.H., et al. Depression, antidepressants, and bone mineral density in a population-based cohort. JGerontol A Med Sci Biol Sci 2008, 63:1410-1415.
46. Ensrud K.E., Blackwell T., Mangione C.M. Central nervous system-active medications and risk for falls in older women. JAm Geriatr Soc 2002, 50:1629-1637.
47. Takkouche B., Montes Martinez A., Gill S., Etminan M. Psychotropic medications and the risk of fracture: A meta-analysis. Drug Saf 2007, 30:171-184.
48. Blazer D.G., Hybels C.F., Pieper C.F. The association of depression and mortality in elderly persons: A case for multiple, independent pathways. JGerontol A Biol Sci Med Sci 2001, 56:M505-M509.
49. Cronin-Stubbs D., de Leon C.F., Beckett L.A., et al. Six-year effect of depressive symptoms on the course of physical disability in community-living older adults. Arch Intern Med 2000, 160:3074-3080.
50. St John P.D., Montgomery P.R. Depressive symptoms in older people predict nursing home admission. JAm Geriatr Soc 2006, 54:1794-1795.