Pathophysiology of the gut and the microbiome in the host response

Pediatric Critical Care Medicine

Volumn 18, Issue 3, 2017, Pages S46-S49

  Lyons, John D ^a   Coopersmith, Craig M ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Intestinal barrier; Microbiome; Multiple organ dysfunction syndrome; Pediatrics

Indexed keywords

ARTICLE; BACTERIAL TRANSLOCATION; CRITICAL ILLNESS; DIGESTIVE SYSTEM FUNCTION DISORDER; DISEASE ASSOCIATION; HUMAN; IMMUNE RESPONSE; INTESTINE EPITHELIUM; INTESTINE FLORA; MULTIPLE ORGAN FAILURE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; CHILD; INTESTINE MUCOSA; MICROBIOLOGY; PEDIATRICS; PHYSIOLOGY;

BACTERIAL TRANSLOCATION; CHILD; CRITICAL ILLNESS; GASTROINTESTINAL MICROBIOME; HUMANS; INTESTINAL MUCOSA; MULTIPLE ORGAN FAILURE; PEDIATRICS;

EID: 85016501374     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/PCC.0000000000001046     Document Type: Article

References (27)

1. Helander HF, Fandriks L: Surface area of the digestive tract-revisited. Scand J Gastroenterol 2014; 49:681-689
2. Sekirov I, Russell SL, Antunes LC, et al: Gut microbiota in health and disease. Physiol Rev 2010; 90:859-904
3. Mittal R, Coopersmith CM: Redefining the gut as the motor of critical illness. Trends Mol Med 2014; 20:214-223
4. Reintam Blaser A, Poeze M, Malbrain ML, et al; Gastro-Intestinal Failure Trial Group: Gastrointestinal symptoms during the first week of intensive care are associated with poor outcome: A prospective multicentre study. Intensive Care Med 2013; 39:899-909
5. Piton G, Belon F, Cypriani B, et al: Enterocyte damage in critically ill patients is associated with shock condition and 28-day mortality. Crit Care Med 2013; 41:2169-2176
6. Moore FA, Moore EE, Poggetti R, et al: Gut bacterial translocation via the portal vein: A clinical perspective with major torso trauma. J Trauma 1991; 31:629-636
7. Deitch EA: Gut-origin sepsis: Evolution of a concept. Surgeon 2012; 10:350-356
8. Senthil M, Brown M, Xu DZ, et al: Gut-lymph hypothesis of systemic inflammatory response syndrome/multiple-organ dysfunction syndrome: Validating studies in a porcine model. J Trauma 2006; 60:958-965
9. Reino DC, Pisarenko V, Palange D, et al: Trauma hemorrhagic shockinduced lung injury involves a gut-lymph-induced TLR4 pathway in mice. PLoS One 2011; 6:e14829
10. Reino DC, Palange D, Feketeova E, et al: Activation of toll-like receptor 4 is necessary for trauma hemorrhagic shock-induced gut injury and polymorphonuclear neutrophil priming. Shock 2012; 38:107-114
11. Dominguez JA, Xie Y, Dunne WM, et al: Intestine-specific Mttp deletion decreases mortality and prevents sepsis-induced intestinal injury in a murine model of Pseudomonas aeruginosa pneumonia. PLoS One 2012; 7:e49159
12. Liang Z, Xie Y, Dominguez JA, et al: Intestine-specific deletion of microsomal triglyceride transfer protein increases mortality in aged mice. PLoS One 2014; 9:e101828
13. Hotchkiss RS, Swanson PE, Freeman BD, et al: Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 1999; 27:1230-1251
14. Coopersmith CM, Stromberg PE, Dunne WM, et al: Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumoniainduced sepsis. JAMA 2002; 287:1716-1721
15. Coopersmith CM, Chang KC, Swanson PE, et al: Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice. Crit Care Med 2002; 30:195-201
16. Clark JA, Gan H, Samocha AJ, et al: Enterocyte-specific epidermal growth factor prevents barrier dysfunction and improves mortality in murine peritonitis. Am J Physiol Gastrointest Liver Physiol 2009; 297:G471-G479
17. Fink MP: Intestinal epithelial hyperpermeability: Update on the pathogenesis of gut mucosal barrier dysfunction in critical illness. Curr Opin Crit Care 2003; 9:143-151
18. Zahs A, Bird MD, Ramirez L, et al: Inhibition of long myosin lightchain kinase activation alleviates intestinal damage after binge ethanol exposure and burn injury. Am J Physiol Gastrointest Liver Physiol 2012; 303:G705-G712
19. Qin X, Caputo FJ, Xu DZ, et al: Hydrophobicity of mucosal surface and its relationship to gut barrier function. Shock 2008; 29:372-376
20. Schmid-Schonbein GW, DeLano FA, Penn AH, et al: An elementary analysis of physiologic shock and multi-organ failure: The autodigestion hypothesis. Conf Proc IEEE Eng Med Biol Soc 2012; 2012:3114-3115
21. Bo L, Li J, Tao T, et al: Probiotics for preventing ventilator-associated pneumonia. Cochrane Database Syst Rev 2014; 10:CD009066
22. Barraud D, Bollaert PE, Gibot S: Impact of the administration of probiotics on mortality in critically ill adult patients: A meta-analysis of randomized controlled trials. Chest 2013; 143:646-655
23. Taur Y, Jenq RR, Perales MA, et al: The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation. Blood 2014; 124:1174-1182
24. van Nood E, Vrieze A, Nieuwdorp M, et al: Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med 2013; 368:407-415
25. Price R, MacLennan G, Glen J; SuDDICU Collaboration: Selective digestive or oropharyngeal decontamination and topical oropharyngeal chlorhexidine for prevention of death in general intensive care: Systematic review and network meta-analysis. BMJ 2014; 348:g2197
26. Babrowski T, Romanowski K, Fink D, et al: The intestinal environment of surgical injury transforms Pseudomonas aeruginosa into a discrete hypervirulent morphotype capable of causing lethal peritonitis. Surgery 2013; 153:36-43
27. Zaborin A, Defazio JR, Kade M, et al: Phosphate-containing polyethylene glycol polymers prevent lethal sepsis by multidrug-resistant pathogens. Antimicrob Agents Chemother 2014; 58:966-977