An elementary analysis of physiologic shock and multi-organ failure: The Autodigestion Hypothesis

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

Volumn , Issue , 2012, Pages 3114-3115

  Schmid Schonbein, Geert W ^a   Delano, Frank A ^a   Penn, Alexander H ^a   Kistler, Erik ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BREAKDOWN PRODUCTS; DIGESTIVE ENZYMES; ELEMENTARY ANALYSIS; FOOD DIGESTION; MULTIORGAN FAILURE; ORGAN FAILURE; SMALL INTESTINE; THERAPEUTIC INTERVENTION;

ENZYMES; PHYSIOLOGY;

SAFETY ENGINEERING;

ARTICLE; ENZYMOLOGY; HUMAN; INTESTINE; MULTIPLE ORGAN FAILURE; PANCREAS; SHOCK;

HUMANS; INTESTINES; MULTIPLE ORGAN FAILURE; PANCREAS; SHOCK;

EID: 84882950339     PISSN: 1557170X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/EMBC.2012.6346623     Document Type: Conference Paper

References (7)

1. E. B. Kistler, T. E. Hugli, G. W. Schmid-Schönbein, "The pancreas as a source of cardiovascular cell activating factors," Microcirculation, vol.7, 2000, pp. 183-192.
2. H. Mitsuoka, E. B. Kistler, G. W. Schmid-Schönbein, "Generation of in vivo activating factors in the ischemic intestine by pancreatic enzymes," Proc. Nat. Acad. Sci. U.S.A., vol. 97, 2000, pp.1772-1777.
3. F. Fitzal, F. A. DeLano, C. Young, H. S. Rosário, G. W. Schmid-Schönbein, "Pancreatic protease inhibition during shock attenuates cell activation and peripheral inflammation," J. Vasc. Res., vol. 39, 2002, pp.320-329.
4. F. Fitzal, F. A. DeLano, C. Young, G. W. Schmid-Schönbein, "Delayed intestinal protease inhibition after intestinal ischemia and reperfusion improves early symptoms of shock," Arch. Surg, vol. 139, 2004, pp.1008-1016.
5. A. H. Penn, T. E. Hugli, G. W. Schmid-Schönbein, "Pancreatic enzymes generate cytotoxic mediators in the intestine," Shock, vol. 27, 2007, pp. 296-304.
6. H. D. Kim, D. J. Malinoski, B. Borazjani, M. S. Patel, J. Chen, J. Slone, X. M. T. Nguyen, E. Steward, G. W. Schmid-Schönbein, D. B. Hoyt, "Inhibition of intraluminal pancreatic enzymes with nafamostat mesilate improves clinical outcomes after hemorrhagic shock in swine," Journal of Trauma, Injury, Infection and Critical Care, vol. 68, 2010, pp. 1078-1083.
7. M. Chang, E. Kistler, G. W. Schmid-Schönbein, "Disruption of the intestinal mucin layer during ischemia allows early entry of digestive enzymes into the intestinal wall," Shock, vol. 37, 2012, pp. 297-305.