A Targeted and Stable Polymeric Nanoformulation Enhances Systemic Delivery of mRNA to Tumors

Molecular Therapy

Volumn 25, Issue 1, 2017, Pages 92-101

  Chen, Qixian ^a,b   Qi, Ruogu ^c   Chen, Xiyi ^d   Yang, Xi ^e   Wu, Sudong ^f   Xiao, Haihua ^c   Dong, Wenfei ^a  

^a SUZHOU INSTITUTE OF BIOMEDICAL ENGINEERING AND TECHNOLOGY   (China)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

^d DALIAN MEDICAL UNIVERSITY   (China)

^e SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^f NINGBO INSTITUTE OF MATERIALS TECHNOLOGY AND ENGINEERING   (China)

Author keywords

gene expression; mRNA delivery; polymeric micelle; thermo responsive; tumor targeting

Indexed keywords

COPOLYMER; LIGAND; MACROGOL; MESSENGER RNA; NUCLEASE; PLASMID DNA; POLY(N ISOPROPYLACRYLAMIDE); POLYLYSINE; RIBONUCLEASE; MACROGOL DERIVATIVE; NANOPARTICLE; POLYMER;

ANIMAL EXPERIMENT; ARTICLE; ATOMIC FORCE MICROSCOPY; CONTROLLED STUDY; CROSS LINKING; FEMALE; GENE DELIVERY SYSTEM; GENE EXPRESSION; HYDROPHILICITY; HYDROPHOBICITY; IN VIVO STUDY; INCUBATION TIME; MOUSE; NONHUMAN; OXIDATION REDUCTION STATE; PHOTON CORRELATION SPECTROSCOPY; THERMODYNAMICS; TRANSMISSION ELECTRON MICROSCOPY; CELL SURVIVAL; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; DRUG FORMULATION; GENETICS; HUMAN; METABOLISM; NEOPLASM; PATHOLOGY; SYNTHESIS; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL SURVIVAL; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; HUMANS; LIGANDS; NANOPARTICLES; NEOPLASMS; POLYETHYLENE GLYCOLS; POLYLYSINE; POLYMERS; RNA, MESSENGER;

EID: 85016330478     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1016/j.ymthe.2016.10.006     Document Type: Article

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