Conjugation of cRGD peptide to chlorophyll a based photosensitizer (HPPH) alters its pharmacokinetics with enhanced tumor-imaging and photosensitizing (PDT) efficacy

Molecular Pharmaceutics

Volumn 8, Issue 4, 2011, Pages 1186-1197

  Srivatsan, Avinash ^a   Ethirajan, Manivannan ^a   Pandey, Suresh K ^a   Dubey, Shipra ^a   Zheng, Xiang ^a   Liu, Ting Hsiu ^b   Shibata, Masayuki ^b   Missert, Joseph ^a   Morgan, Janet ^b   Pandey, Ravindra K ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

cRGD; cyclic Arg Gly Asp; HPPH; photodynamic therapy; photosensitizer

Indexed keywords

3 (1' HEXYLOXYETHYL) 3 DEVINYLPYROPHEOPHORBIDE A; 3 (1' HEXYLOXYETHYL) 3 DEVINYLPYROPHEOPHORBIDE A ARGINYLGLYCYLASPARTIC ACID CONJUGATE; ARGININE; ARGINYLGLYCYLASPARTIC ACID; ASPARTIC ACID; CHLOROPHYLL A; PHOTOSENSITIZING AGENT; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CELL LINE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG CONJUGATION; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; FLUORESCENCE IMAGING; MOLECULAR IMAGING; MOLECULAR MODEL; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PHOTOSENSITIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; TUMOR CELL; TUMOR IMAGING;

CELL LINE, TUMOR; CHLOROPHYLL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; INTEGRIN ALPHAVBETA3; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; OLIGOPEPTIDES; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS;

EID: 79961069148     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200018y     Document Type: Article

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