Platelets activate a pathogenic response to blood-stage Plasmodium infection but not a protective immune response

Blood

Volumn 129, Issue 12, 2017, Pages 1669-1679

  Gramaglia, Irene ^a   Velez, Joyce ^a   Combes, Valery ^a,b   Grau, Georges E R ^a,c   Wree, Melanie ^d   Van Der Heyde, Henri C ^a  

^a La Jolla Infectious Disease Institute   (United States)

^b UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CEREBRAL MALARIA; CONTROLLED STUDY; ERYTHROCYTE; MOUSE; NONHUMAN; PARASITE IMMUNITY; PARASITEMIA; PLASMODIUM BERGHEI; PLASMODIUM CHABAUDI; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTOPENIA; ANIMAL; BLOOD; CELL CULTURE; CELLULAR IMMUNITY; HUMAN; IMMUNOLOGY; MALARIA; MALARIA, CEREBRAL; PARASITOLOGY; PHYSIOLOGY; THROMBOCYTE;

CD40 ANTIGEN;

ANIMALS; ANTIGENS, CD40; BLOOD PLATELETS; CELLS, CULTURED; ERYTHROCYTES; HUMANS; IMMUNITY, CELLULAR; MALARIA; MALARIA, CEREBRAL; MICE; PLASMODIUM CHABAUDI;

EID: 85016303233     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2016-08-733519     Document Type: Article

References (24)

1. van der Heyde HC, Nolan J, Combes V, Gramaglia I, Grau GE. A unified hypothesis for the genesis of cerebral malaria: sequestration, inflammation and hemostasis leading to microcirculatory dysfunction. Trends Parasitol. 2006;22(11):503-508.
2. Francischetti IM, Seydel KB, Monteiro RQ. Blood coagulation, inflammation, and malaria. Microcirculation. 2008;15(2):81-107.
3. McMorran BJ, Wieczorski L, Drysdale KE, et al. Platelet factor 4 and Duffy antigen required for platelet killing of Plasmodium falciparum. Science. 2012;338(6112):1348-1351.
4. McMorran BJ, Marshall VM, de Graaf C, et al. Platelets kill intraerythrocytic malarial parasites and mediate survival to infection. Science. 2009; 323(5915):797-800.
5. Peyron F, Polack B, Lamotte D, Kolodie L, Ambroise-Thomas P. Plasmodium falciparum growth inhibition by human platelets in vitro. Parasitology. 1989;99(Pt 3):317-322.
6. Greenbaum DC, FitzGerald GA. Platelets, pyrexia, and plasmodia. N Engl J Med. 2009; 361(5):526-528.
7. Grau GE, Tacchini-Cottier F, Vesin C, et al. TNFinduced microvascular pathology: active role for platelets and importance of the LFA-1/ICAM-1 interaction. Eur Cytokine Netw. 1993;4(6): 415-419.
8. van der Heyde HC, Gramaglia I, Sun G, Woods C. Platelet depletion by anti-CD41 (alphaIIb) mAb injection early but not late in the course of disease protects against Plasmodium berghei pathogenesis by altering the levels of pathogenic cytokines. Blood. 2005;105(5):1956-1963.
9. White NJ, Turner GD, Medana IM, Dondorp AM, Day NP. The murine cerebral malaria phenomenon. Trends Parasitol. 2010;26(1):11-15.
10. Craig AG, Grau GE, Janse C, et al; participants of the Hinxton Retreat meeting on Animal Models for Research on Severe Malaria. The role of animal models for research on severe malaria. PLoS Pathog. 2012;8(2):e1002401.
11. van der Heyde HC, Huszar D, Woodhouse C, Manning DD, Weidanz WP. The resolution of acute malaria in a definitive model of B cell deficiency, the JHD mouse. J Immunol. 1994; 152(9):4557-4562.
12. Gramaglia I, Sahlin H, Nolan JP, Frangos JA, Intaglietta M, van der Heyde HC. Cell- rather than antibody-mediated immunity leads to the development of profound thrombocytopenia during experimental Plasmodium berghei malaria. J Immunol. 2005;175(11):7699-7707.
13. Gramaglia I, Sobolewski P, Meays D, et al. Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria. Nat Med. 2006;12(12):1417-1422.
14. Chang WL, Jones SP, Lefer DJ, et al. CD8(1)-T-cell depletion ameliorates circulatory shock in Plasmodium berghei-infected mice. Infect Immun. 2001;69(12):7341-7348.
15. Daily JP, Le Roch KG, Sarr O, et al. In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins. J Infect Dis. 2005;191(7):1196-1203.
16. Trager W. A new method for intraerythrocytic cultivation of malaria parasites (Plasmodium coatneyi and P. falciparum). J Protozool. 1971; 18(2):239-242.
17. Grun JL, Weidanz WP. Immunity to Plasmodium chabaudi adami in the B-cell-deficient mouse. Nature. 1981;290(5802):143-145.
18. Roberts DW, Weidanz WP. T-cell immunity to malaria in the B-cell deficient mouse. Am J Trop Med Hyg. 1979;28(1):1-3.
19. Piguet PF, Kan CD, Vesin C, Rochat A, Donati Y, Barazzone C. Role of CD40-CVD40L in mouse severe malaria. Am J Pathol. 2001;159(2):733-742.
20. Aggrey AA, Srivastava K, Ture S, Field DJ, Morrell CN. Platelet induction of the acute-phase response is protective in murine experimental cerebral malaria. J Immunol. 2013;190(9):4685-4691.
21. Chotivanich K, Sritabal J, Udomsangpetch R, et al. Platelet-induced autoagglutination of Plasmodium falciparum-infected red blood cells and disease severity in Thailand. J Infect Dis. 2004;189(6):1052-1055.
22. Elzey BD, Sprague DL, Ratliff TL. The emerging role of platelets in adaptive immunity. Cell Immunol. 2005;238(1):1-9.
23. Elzey BD, Ratliff TL, Sowa JM, Crist SA. Platelet CD40L at the interface of adaptive immunity. Thromb Res. 2011;127(3):180-183.
24. Elzey BD, Schmidt NW, Crist SA, et al. Plateletderived CD154 enables T-cell priming and protection against Listeria monocytogenes challenge. Blood. 2008;111(7):3684-3691.