A competitive inhibitory circuit for selection of active and passive fear responses

Nature

Volumn 542, Issue 7639, 2017, Pages 96-99

  Fadok, Jonathan P ^a   Krabbe, Sabine ^a   Markovic, Milica ^a,b   Courtin, Julien ^a   Xu, Chun ^a   Massi, Lema ^a   Botta, Paolo ^a,b,c   Bylund, Kristine ^a   Müller, Christian ^a   Kovacevic, Aleksandar ^a   Tovote, Philip ^a   Lüthi, Andreas ^a,b  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c CHAMPALIMAUD CENTRE FOR THE UNKNOWN   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; SOMATOSTATIN;

BEHAVIORAL RESPONSE; CELLS AND CELL COMPONENTS; EVOLUTIONARY BIOLOGY; FREEZING; GENE EXPRESSION; INHIBITOR; LABORATORY METHOD; NERVOUS SYSTEM; NEUROLOGY; PROTEIN;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CENTRAL NUCLEUS (AMYGDALA); CONDITIONING; CONTROLLED STUDY; DEFENSIVE BEHAVIOR; FEAR; FEAR CONDITIONING TEST; FLIGHT; FREEZING BEHAVIOR; IN VIVO STUDY; MALE; MOUSE; NERVE CELL; NONHUMAN; OPTOGENETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABIES; THREAT; WHITE NOISE; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CATALEPSY; CYTOLOGY; ESCAPE BEHAVIOR; LOCOMOTION; METABOLISM; NERVE CELL INHIBITION; NERVE TRACT; PHYSIOLOGY; PSYCHOLOGY;

MUS; RODENTIA;

ANIMALS; CENTRAL AMYGDALOID NUCLEUS; CORTICOTROPIN-RELEASING HORMONE; ESCAPE REACTION; FEAR; FREEZING REACTION, CATALEPTIC; LOCOMOTION; MALE; MICE; MICE, INBRED C57BL; MODELS, NEUROLOGICAL; NEURAL INHIBITION; NEURAL PATHWAYS; NEURONS; OPTOGENETICS; SOMATOSTATIN;

EID: 85016164005     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature21047     Document Type: Article

References (38)

1. Gross, C. T., Canteras, N. S. The many paths to fear. Nat. Rev. Neurosci. 13, 651-658 (2012).
2. Blanchard, D. C., Blanchard, R. J. in Handbook of Anxiety and Fear Vol. 17 Handbook of Behavioral Neuroscience (eds R. J. Blanchard, D. C. Blanchard, G. Griebel & D. Nutt) Ch. 2. 4, 63-79 (Academic Press, 2008).
3. Anderson, D. J., Adolphs, R. A framework for studying emotions across species. Cell 157, 187-200 (2014).
4. Fanselow, M. S. Conditioned and unconditional components of post-shock freezing. Pavlov. J. Biol. Sci. 15, 177-182 (1980).
5. Tovote, P., Fadok, J. P., Lüthi, A. Neuronal circuits for fear and anxiety. Nat. Rev. Neurosci. 16, 317-331 (2015).
6. Davis, M. in The Amygdala (ed. J. P. Aggleton) Ch. 6, 213-288 (Oxford University Press, 2000).
7. Tsetsenis, T., Ma, X. H., Lo Iacono, L., Beck, S. G., Gross, C. Suppression of conditioning to ambiguous cues by pharmacogenetic inhibition of the dentate gyrus. Nat. Neurosci. 10, 896-902 (2007).
8. Perusini, J. N., Fanselow, M. S. Neurobehavioral perspectives on the distinction between fear and anxiety. Learn. Mem. 22, 417-425 (2015).
9. Maren, S. Neurobiology of Pavlovian fear conditioning. Annu. Rev. Neurosci. 24, 897-931 (2001).
10. LeDoux, J. E. Emotion circuits in the brain. Annu. Rev. Neurosci. 23, 155-184 (2000).
11. Haubensak, W., et al. Genetic dissection of an amygdala microcircuit that gates conditioned fear. Nature 468, 270-276 (2010).
12. Roberts, G. W., Woodhams, P. L., Polak, J. M., Crow, T. J. Distribution of neuropeptides in the limbic system of the rat: the amygdaloid complex. Neuroscience 7, 99-131 (1982).
13. Swanson, L. W., Sawchenko, P. E., Rivier, J., Vale, W. W. Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study. Neuroendocrinology 36, 165-186 (1983).
14. Li, H., et al. Experience-dependent modification of a central amygdala fear circuit. Nat. Neurosci. 16, 332-339 (2013).
15. Viviani, D., et al. Oxytocin selectively gates fear responses through distinct outputs from the central amygdala. Science 333, 104-107 (2011).
16. Ciocchi, S., et al. Encoding of conditioned fear in central amygdala inhibitory circuits. Nature 468, 277-282 (2010).
17. Penzo, M. A., Robert, V., Li, B. Fear conditioning potentiates synaptic transmission onto long-range projection neurons in the lateral subdivision of central amygdala. J. Neurosci. 34, 2432-2437 (2014).
18. Gozzi, A., et al. A neural switch for active and passive fear. Neuron 67, 656-666 (2010).
19. Yu, K., Garcia da Silva, P., Albeanu, D. F., Li, B. Central amygdala somatostatin neurons gate passive and active defensive behaviors. J. Neurosci. 36, 6488-6496 (2016).
20. Nelson, A. B., Kreitzer, A. C. Reassessing models of basal ganglia function and dysfunction. Annu. Rev. Neurosci. 37, 117-135 (2014).
21. Isosaka, T., et al. Htr2a-expressing cells in the central amygdala control the hierarchy between innate and learned fear. Cell 163, 1153-1164 (2015).
22. Penzo, M. A., et al. The paraventricular thalamus controls a central amygdala fear circuit. Nature 519, 455-459 (2015).
23. Tovote, P., et al. Midbrain circuits for defensive behaviour. Nature 534, 206-212 (2016).
24. Beyeler, A., et al. Divergent routing of positive and negative information from the amygdala during memory retrieval. Neuron 90, 348-361 (2016).
25. Xu, C., et al. Distinct hippocampal pathways mediate dissociable roles of context in memory retrieval. Cell 167, 961-972. e16 (2016).
26. Ciocchi, S., Passecker, J., Malagon-Vina, H., Mikus, N., Klausberger, T. Brain computation. Selective information routing by ventral hippocampal CA1 projection neurons. Science 348, 560-563 (2015).
27. Bittencourt, A. S., Carobrez, A. P., Zamprogno, L. P., Tufik, S., Schenberg, L. C. Organization of single components of defensive behaviors within distinct columns of periaqueductal gray matter of the rat: role of N-methyl-d-aspartic acid glutamate receptors. Neuroscience 125, 71-89 (2004).
28. De Oca, B. M., DeCola, J. P., Maren, S., Fanselow, M. S. Distinct regions of the periaqueductal gray are involved in the acquisition and expression of defensive responses. J. Neurosci. 18, 3426-3432 (1998).
29. Canteras, N. S., Graeff, F. G. Executive and modulatory neural circuits of defensive reactions: implications for panic disorder. Neurosci. Biobehav. Rev. 46, 352-364 (2014).
30. Pitman, R. K., et al. Biological studies of post-traumatic stress disorder. Nat. Rev. Neurosci. 13, 769-787 (2012).
31. Paxinos, G., Franklin, K. B. J. The Mouse Brain in Stereotaxic Coordinates. (Academic, 2001).
32. Taniguchi, H., et al. A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex. Neuron 71, 995-1013 (2011).
33. Seidler, B., et al. A Cre-loxP-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors. Proc. Natl Acad. Sci. USA 105, 10137-10142 (2008).
34. Fenno, L. E., et al. Targeting cells with single vectors using multiple-feature Boolean logic. Nat. Methods 11, 763-772 (2014).
35. Herry, C., et al. Switching on and off fear by distinct neuronal circuits. Nature 454, 600-606 (2008).
36. Wolff, S. B., et al. Amygdala interneuron subtypes control fear learning through disinhibition. Nature 509, 453-458 (2014).
37. Preibisch, S., Saalfeld, S., Tomancak, P. Globally optimal stitching of tiled 3D microscopic image acquisitions. Bioinformatics 25, 1463-1465 (2009).
38. Ollion, J., Cochennec, J., Loll, F., Escudé, C., Boudier, T. TANGO: a generic tool for high-throughput 3D image analysis for studying nuclear organization. Bioinformatics 29, 1840-1841 (2013).