Systematic drug repositioning through mining adverse event data in ClinicalTrials.gov

PeerJ

Volumn 2017, Issue 3, 2017, Pages

  Su, Eric Wen ^a   Sanger, Todd M ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

ClinicalTrials.gov; Drug repositioning; Drug repurposing; Indication discovery; Text mining

Indexed keywords

ALISKIREN; CLOPIDOGREL; DACLIZUMAB; DENOSUMAB; IVABRADINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHYTOMENADIONE; SIMVASTATIN; TELMISARTAN; UNCLASSIFIED DRUG; V501 VACCINE; VIRUS VACCINE; VORAPAXAR;

ALGORITHM; ARTICLE; BIOINFORMATICS; BLADDER CANCER; BREAST CANCER; COLON CANCER; DATA MINING; DISEASE ONTOLOGY; DRUG REPOSITIONING; HUMAN; LUNG TUMOR; MELANOMA; NON SMALL CELL LUNG CANCER; PANCREAS CARCINOMA; RECTUM CANCER; STOMACH CANCER; UTERINE CERVIX DYSPLASIA;

EID: 85016037007     PISSN: None     EISSN: 21678359     Source Type: Journal    
DOI: 10.7717/peerj.3154     Document Type: Article

References (24)

1. Ashburn TT, Thor KB. 2004. Drug repositioning: identifying and developing new uses for existing drugs. Nature Reviews Drug Discovery 3:673-683 DOI 10.1038/nrd1468.
2. Bandy J, Milward D, McQuay S. 2009. Mining protein-protein interactions from published literature using Linguamatics I2E. Methods in Molecular Biology 563:3-13 DOI 10.1007/978-1-60761-175-2_1.
3. Coelho ED, Arrais JP, Oliveira JL. 2016. Computational discovery of putative leads for drug repositioning through drug-target interaction prediction. PLOS Computational Biology 12:e1005219 DOI 10.1371/journal.pcbi.1005219.
4. Cormack J, Nath C, Milward D, Raja K, Jonnalagadda SR. 2015. Agile text mining for the 2014 i2b2/UTHealth Cardiac risk factors challenge. Journal of Biomedical Informatics 58(Suppl):S120-S127 DOI 10.1016/j.jbi.2015.06.030.
5. Firnhaber C, Zungu K, Levin S, Michelow P, Montaner LJ, McPhail P, Williamson AL, Allan BR, Van der Horst C, Rinas A, Sanne I. 2009. Diverse and high prevalence of human papillomavirus associated with a significant high rate of cervical dysplasia in human immunodeficiency virus-infected women in Johannesburg, South Africa. Acta Cytologica 53:10-17 DOI 10.1159/000325079.
6. Galijatovic-Idrizbegovic A, Miller JE, Cornell WD, Butler JA, Wollenberg GK, Sistare FD, DeGeorge JJ. 2016. Role of chronic toxicology studies in revealing new toxicities. Regulatory Toxicology and Pharmacology 82:94-98 DOI 10.1016/j.yrtph.2016.10.010.
7. Hodos RA, Kidd BA, Shameer K, Readhead BP, Dudley JT. 2016. In silico methods for drug repurposing and pharmacology. Wiley Interdisciplinary Reviews: Systems Biology and Medicine 8:186-210 DOI 10.1002/wsbm.1337.
8. Hu J, Zhang LC, Song X, Lu JR, Jin Z. 2015. KRT6 interacting with notch1 contributes to progression of renal cell carcinoma, and aliskiren inhibits renal carcinoma cell lines proliferation in vitro. International Journal of Clinical and Experimental Pathology 8:9182-9188.
9. Juanola-Falgarona M, Salas-Salvado J, Martinez-Gonzalez MA, Corella D, Estruch R, Ros E, Fito M, Aros F, Gomez-Gracia E, Fiol M, Lapetra J, Basora J, Lamuela-Raventos RM, Serra-Majem L, Pinto X, Munoz MA, Ruiz-Gutierrez V, Fernandez-Ballart J, Bullo M. 2014. Dietary intake of vitamin K is inversely associated with mortality risk. Journal of Nutrition 144:743-750 DOI 10.3945/jn.113.187740.
10. Kesic V, Petkovic S, Milacic D. 1990. Smoking and nonmalignant changes in the uterine cervix. Srpski Arhiv Za Celokupno Lekarstvo 118:201-204.
11. Li J, Chen L, Yu P, Liu B, Zhu J, Yang Y. 2014. Telmisartan exerts anti-tumor effects by activating peroxisome proliferator-activated receptor-gamma in human lung adeno- carcinoma A549 cells. Molecules 19:2862-2876 DOI 10.3390/molecules19032862.
12. Li J, Lu Z. 2012. Systematic identification of pharmacogenomics information from clini- cal trials. Journal of Biomedical Informatics 45:870-878 DOI 10.1016/j.jbi.2012.04.005.
13. Li J, Zheng S, Chen B, Butte AJ, Swamidass SJ, Lu Z. 2016. A survey of current trends in computational drug repositioning. Briefings in Bioinformatics 17:2-12 DOI 10.1093/bib/bbv020.
14. Mullen J, Cockell SJ, Tipney H, Woollard PM, Wipat A. 2016. Mining integrated semantic networks for drug repositioning opportunities. PeerJ 4:e1558 DOI 10.7717/peerj.1558.
15. Nugent T, Plachouras V, Leidner JL. 2016. Computational drug repositioning based on side-effects mined from social media. PeerJ Computer Science 2:e46 DOI 10.7717/peerj-cs.46.
16. Pu Z, Zhu M, Kong F. 2016. Telmisartan prevents proliferation and promotes apop- tosis of human ovarian cancer cells through upregulating PPARgamma and downregulating MMP9 expression. Molecular Medicine Reports 13:555-559 DOI 10.3892/mmr.2015.4512.
17. Qosa H, Mohamed LA, Al Rihani SB, Batarseh YS, Duong QV, Keller JN, Kaddoumi A. 2016. High-throughput screening for identification of blood-brain barrier integrity enhancers: a drug repurposing opportunity to rectify vascular amyloid toxicity. Journal of Alzheimer's Disease 53(4):1499-1516 DOI 10.3233/jad-151179.
18. Sheskin J. 1965. Thalidomide in the treatment of lepra reactions. Clinical Pharmacology and Therapeutics 6:303-306 DOI 10.1002/cpt196563303.
19. Tari LB, Patel JH. 2014. Systematic drug repurposing through text mining. Methods in Molecular Biology 1159:253-267 DOI 10.1007/978-1-4939-0709-0_14.
20. Wei G, Wang M, Carr BI. 2010. Sorafenib combined vitamin K induces apoptosis in human pancreatic cancer cell lines through RAF/MEK/ERK and c-Jun NH2-terminal kinase pathways. Journal of Cellular Physiology 224:112-119 DOI 10.1002/jcp.22099.
21. Wu CH, Bai LY, Tsai MH, Chu PC, Chiu CF, Chen MY, Chiu SJ, Chiang JH, Weng JR. 2016a. Pharmacological exploitation of the phenothiazine antipsychotics to develop novel antitumor agents-A drug repurposing strategy. Scientific Reports 6 DOI 10.1038/srep27540.
22. Wu M, Sirota M, Butte AJ, Chen B. 2015. Characteristics of drug combination therapy in oncology by analyzing clinical trial data on ClinicalTrials.gov. Pacific Symposium on Biocomputing 2015:68-79.
23. Wu TT, Niu HS, Chen LJ, Cheng JT, Tong YC. 2016b. Increase of human prostate cancer cell (DU145) apoptosis by telmisartan through PPAR-delta pathway. European Journal of Pharmacology 775:35-42 DOI 10.1016/j.ejphar.2016.02.017.
24. Zheng C, Guo Z, Huang C, Wu Z, Li Y, Chen X, Fu Y, Ru J, Ali Shar P, Wang Y, Wang Y. 2015. Large-scale direct targeting for drug repositioning and discovery. Scientific Reports 5 DOI 10.1038/srep11970.