Increase of human prostate cancer cell (DU145) apoptosis by telmisartan through PPAR-delta pathway

European Journal of Pharmacology

Volumn 775, Issue , 2016, Pages 35-42

  Wu, Tony Tong Lin ^a,b   Niu, Ho Shan ^c   Chen, Li Jen ^c   Cheng, Juei Tang ^d,e   Tong, Yat Ching ^f  

^a KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c TZU CHI COLLEGE OF TECHNOLOGY   (Taiwan)

^d CHI MEI MEDICAL CENTER   (Taiwan)

^e CHANG JUNG CHRISTIAN UNIVERSITY   (Taiwan)

^f NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Peroxisome proliferator activated receptor; Prostate cancer; Telmisartan

Indexed keywords

3 [(4 ANILINO 2 METHOXYPHENYL)SULFAMOYL] 2 THENOIC ACID METHYL ESTER; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; SMALL INTERFERING RNA; TELMISARTAN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; BENZOIC ACID DERIVATIVE; SULFONE; THIOPHENE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL SURVIVAL; CELL VIABILITY ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DU145 CELL LINE; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; GENE SILENCING; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROSTATE CANCER CELL LINE; PROTEIN EXPRESSION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENETICS; METABOLISM; PROSTATE TUMOR; TUMOR CELL LINE;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZIMIDAZOLES; BENZOATES; CELL LINE, TUMOR; HUMANS; MALE; PPAR DELTA; PROSTATIC NEOPLASMS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SULFONES; THIOPHENES;

EID: 84959527220     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2016.02.017     Document Type: Article

References (31)

1. M.O. Andersen, K.A. Howard, S.R. Paludan, F. Besenbacher, and J. Kjems Delivery of siRNA from lyophilized polymeric surfaces Biomaterials 29 2008 506 512
2. J.O. Ban, J.H. Oh, S.M. Son, D. Won, H.S. Song, S.B. Han, D.C. Moon, K.W. Kang, M.J. Song, and J.T. Hong Troglitazone, a PPAR agonist, inhibits human prostate cancer cell growth through inactivation of NFkappaB via suppression of GSK-3beta expression Cancer Biol. Ther. 12 2011 288 296
3. S.C. Benson, H.A. Pershadsingh, C.I. Ho, A. Chittiboyina, P. Desai, M. Pravenec, N. Qi, J. Wang, M.A. Avery, and T.W. Kurtz Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity Hypertension 43 2004 993 1002
4. J. Berger, and D.E. Moller The mechanisms of action of PPARs Annu. Rev. Med. 53 2002 409 435
5. A. Calastretti, G. Gatti, C. Quaresmini, and A. Bevilacqua Down-modulation of Bcl-2 sensitizes PTEN-mutated prostate cancer cells to starvation and taxanes Prostate 74 2014 1411 1422
6. X. Feng, Z. Luo, L. Ma, S. Ma, D. Yang, Z. Zhao, Z. Yan, H. He, T. Cao, D. Liu, and Z. Zhu Angiotensin II receptor blocker telmisartan enhances running endurance of skeletal muscle through activation of the PPAR-delta/AMPK pathway J. Cell Mol. Med. 15 2011 1572 1581
7. K. Funao, M. Matsuyama, Y. Kawahito, H. Sano, J. Chargui, J.L. Touraine, T. Nakatani, and R. Yoshimura Telmisartan is a potent target for prevention and treatment in human prostate cancer Oncol. Rep. 20 2008 295 300
8. H. He, D. Yang, L. Ma, Z. Luo, S. Ma, X. Feng, T. Cao, Z. Yan, D. Liu, M. Tepel, and Z. Zhu Telmisartan prevents weight gain and obesity through activation of peroxisome proliferator-activated receptor-delta-dependent pathways Hypertension 55 2010 869 879
9. M. Kaur, R.K. Bhatia, R.R. Pissurlenkar, E.C. Coutinho, U.K. Jain, O.P. Katare, R. Chandra, and J. Madan Telmisartan complex augments solubility, dissolution and drug delivery in prostate cancer cells Carbohydr. Polym. 101 2014 614 622
10. N. Koyama, Y. Nishida, T. Ishii, T. Yoshida, Y. Furukawa, and H. Narahara Telmisartan induces growth inhibition, DNA double-strand breaks and apoptosis in human endometrial cancer cells PLoS One 9 2014 e93050
11. H. Kurokawa, S. Sugiyama, T. Nozaki, K. Sugamura, K. Toyama, J. Matsubara, K. Fujisue, K. Ohba, H. Maeda, M. Konishi, E. Akiyama, H. Sumida, Y. Izumiya, O. Yasuda, S. Kim-Mitsuyama, and H. Ogawa Telmisartan enhances mitochondrial activity and alters cellular functions in human coronary artery endothelial cells via AMP-activated protein kinase pathway Atherosclerosis 239 2015 375 385
12. L.D. Lee, B. Mafura, J.C. Lauscher, H. Seeliger, M.E. Kreis, and J. Grone Antiproliferative and apoptotic effects of telmisartan in human colon cancer cells Oncol. Lett. 8 2014 2681 2686
13. M. Matsuyama, K. Funao, K. Kuratsukuri, T. Tanaka, Y. Kawahito, H. Sano, J. Chargui, J.L. Touraine, N. Yoshimura, and R. Yoshimura Telmisartan inhibits human urological cancer cell growth through early apoptosis Exp. Ther. Med. 1 2010 301 306
14. A.A. Metwally, and I.S. Blagbrough Self-assembled lipoplexes of short Interfering RNA (siRNA) using spermine-based fatty acid amide guanidines: effect on gene silencing efficiency Pharmaceutics 3 2011 406 424
15. K. Mori, B. Le Goff, C. Charrier, S. Battaglia, D. Heymann, and F. Redini DU145 human prostate cancer cells express functional receptor activator of NFkappaB: new insights in the prostate cancer bone metastasis process Bone 40 2007 981 990
16. E. Mueller, P. Sarraf, P. Tontonoz, R.M. Evans, K.J. Martin, M. Zhang, C. Fletcher, S. Singer, and B.M. Spiegelman Terminal differentiation of human breast cancer through PPAR gamma Mol. Cell 1 1998 465 470
17. N.P. Nunez, H. Liu, and G.G. Meadows PPAR-gamma ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells Cancer Lett. 236 2006 133 141
18. M.K. Pant, A. Abughaban, and J.B. Aragon-Ching Advances in systemic therapies for metastatic castration-resistant prostate cancer Future Oncol. 10 2014 2213 2226
19. J.M. Peters, J.E. Foreman, and F.J. Gonzalez Dissecting the role of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) in colon, breast, and lung carcinogenesis Cancer Metastas-. Rev. 30 2011 619 640
20. R. Rodriguez-Calvo, L. Serrano, T. Coll, N. Moullan, R.M. Sanchez, M. Merlos, X. Palomer, J.C. Laguna, L. Michalik, W. Wahli, and M. Vazquez-Carrera Activation of peroxisome proliferator-activated receptor beta/delta inhibits lipopolysaccharide-induced cytokine production in adipocytes by lowering nuclear factor-kappaB activity via extracellular signal-related kinase 1/2 Diabetes 57 2008 2149 2157
21. S. Rogenhofer, J. Ellinger, P. Kahl, C. Stoehr, A. Hartmann, D. Engehausen, W.F. Wieland, S.C. Muller, F. Hofstadter, and B. Walter Enhanced expression of peroxisome proliferate-activated receptor gamma (PPAR-gamma) in advanced prostate cancer Anticancer Res. 32 2012 3479 3483
22. P.O. Rujitanaroj, B. Jao, J. Yang, F. Wang, J.M. Anderson, J. Wang, and S.Y. Chew Controlling fibrous capsule formation through long-term down-regulation of collagen type I (COL1A1) expression by nanofiber-mediated siRNA gene silencing Acta Biomater. 9 2013 4513 4524
23. F. Sanchis-Gomar, and G. Lippi Telmisartan as metabolic modulator: a new perspective in sports doping? J. Strength Cond. Res. 26 2012 608 610
24. D.A. Scudiero, R.H. Shoemaker, K.D. Paull, A. Monks, S. Tierney, T.H. Nofziger, M.J. Currens, D. Seniff, and M.R. Boyd Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines Cancer Res. 48 1988 4827 4833
25. Y. Segawa, R. Yoshimura, T. Hase, T. Nakatani, S. Wada, Y. Kawahito, T. Kishimoto, and H. Sano Expression of peroxisome proliferator-activated receptor (PPAR) in human prostate cancer Prostate 51 2002 108 116
26. Y. Shi, M. Hon, and R.M. Evans The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling Proc. Natl. Acad. Sci. USA 99 2002 2613 2618
27. A. Shiota, M. Shimabukuro, D. Fukuda, T. Soeki, H. Sato, E. Uematsu, Y. Hirata, H. Kurobe, H. Sakaue, Y. Nakaya, H. Masuzaki, and M. Sata Activation of AMPK-Sirt1 pathway by telmisartan in white adipose tissue: a possible link to anti-metabolic effects Eur. J. Pharm. 692 2012 84 90
28. K.R. Stone, D.D. Mickey, H. Wunderli, G.H. Mickey, and D.F. Paulson Isolation of a human prostate carcinoma cell line (DU 145) Int. J. Cancer 21 1978 274 281
29. S. Xu, H. Song, M. Huang, K. Wang, C. Xu, and L. Xie Telmisartan inhibits the proinflammatory effects of homocysteine on human endothelial cells through activation of the peroxisome proliferator-activated receptor-delta pathway Int. J. Mol. Med. 34 2014 828 834
30. L. Yang, J. Zhou, Q. Ma, C. Wang, K. Chen, W. Meng, Y. Yu, Z. Zhou, and X. Sun Knockdown of PPAR delta gene promotes the growth of colon cancer and reduces the sensitivity to bevacizumab in nude mice model PLoS One 8 2013 e60715
31. X. Zuo, M. Xu, J. Yu, Y. Wu, M.J. Moussalli, G.C. Manyam, S.I. Lee, S. Liang, M. Gagea, J.S. Morris, R.R. Broaddus, and I. Shureiqi Potentiation of colon cancer susceptibility in mice by colonic epithelial PPAR-delta/beta overexpression J. Natl. Cancer Inst. 106 2014 52 dju0 52