KRT6 interacting with notch 1 contributes to progression of renal cell carcinoma, and aliskiren inhibits renal carcinoma cell lines proliferation in vitro

International Journal of Clinical and Experimental Pathology

Volumn 8, Issue 8, 2015, Pages 9182-9188

  Hu, Jing ^a   Zhang, Li Chao ^a   Song, Xu ^a   Lu, Jian Rao ^a   Jin, Zhu ^a  

^a SHANGHAI SEVENTH PEOPLE S HOSPITAL   (China)

Author keywords

Aliskiren; KRT6; Notch1; Renal carcinoma

Indexed keywords

ALISKIREN; AMIDE; CYTOKERATIN 6; FUMARIC ACID DERIVATIVE; NOTCH1 RECEPTOR; SMALL INTERFERING RNA;

APOPTOSIS; CELL PROLIFERATION; DISEASE COURSE; DRUG EFFECTS; FEMALE; GENE SILENCING; GENETICS; HUMAN; KIDNEY CARCINOMA; KIDNEY TUMOR; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; UPREGULATION;

AMIDES; APOPTOSIS; CARCINOMA, RENAL CELL; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE PROGRESSION; FEMALE; FUMARATES; GENE SILENCING; HUMANS; KERATIN-6; KIDNEY NEOPLASMS; MALE; MIDDLE AGED; RECEPTOR, NOTCH1; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 85012982863     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Slaby O, Jancovicova J, Lakomy R, Svoboda M, Poprach A, Fabian P, Kren L, Michalek J and Vyzula R. Expression of miRNA-106b in conventional renal cell carcinoma is a potential marker for prediction of early metastasis after nephrectomy. J Exp Clin Cancer Res 2010; 29: 90.
2. Ho TH, Liu XD, Huang Y, Warneke CL, Johnson MM, Hoang A, Tamboli P, Wang F and Jonasch E. The impact of FGFR1 and FRS2alpha expression on sorafenib treatment in metastatic renal cell carcinoma. BMC Cancer 2015; 15: 304.
3. Zhang JT, Chen KP, Guan T and Zhang S. Effect of aliskiren on cardiovascular outcomes in patients with prehypertension: a meta-analysis of randomized controlled trials. Drug Des Devel Ther 2015; 9: 1963-1971.
4. Wang W, Qiu L, Howard A, Solis N, Li C, Wang X, Kopp JB and Levi M. Protective effects of aliskiren and valsartan in mice with diabetic nephropathy. J Renin Angiotensin Aldosterone Syst 2014; 15: 384-395.
5. Miyajima A, Yazawa S, Kosaka T, Tanaka N, Shirotake S, Mizuno R, Kikuchi E and Oya M. Prognostic Impact of Renin-Angiotensin System Blockade on Renal Cell Carcinoma After Surgery. Ann Surg Oncol 2015; [Epub ahead of print].
6. McKay RR, Rodriguez GE, Lin X, Kaymakcalan MD, Hamnvik OP, Sabbisetti VS, Bhatt RS, Simantov R and Choueiri TK. Angiotensin System Inhibitors and Survival Outcomes in Patients with Metastatic Renal Cell Carcinoma. Clin Cancer Res 2015; 21: 2471-9.
7. Araujo WF, Naves MA, Ravanini JN, Schor N and Teixeira VP. Renin-angiotensin system (RAS) blockade attenuates growth and metastatic potential of renal cell carcinoma in mice. Urol Oncol 2015; 33: 389.e1-7.
8. Arumugam A, Weng Z, Chaudhary SC, Afaq F, Elmets CA and Athar M. Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch. Biochem Biophys Res Commun 2014; 451: 394-401.
9. Ai Q, Ma X, Huang Q, Liu S, Shi T, Zhang C, Zhu M, Zhang Y, Wang B, Ni D, Li H, Zheng T and Zhang X. High-level expression of Notch1 increased the risk of metastasis in T1 stage clear cell renal cell carcinoma. PLoS One 2012; 7: e35022.
10. Radtke F and Raj K. The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer 2003; 3: 756-767.
11. Lever AF, Hole DJ, Gillis CR, McCallum IR, McInnes GT, MacKinnon PL, Meredith PA, Murray LS, Reid JL and Robertson JW. Do inhibitors of angiotensin-I-converting enzyme protect again-st risk of cancer? Lancet 1998; 352: 179-184.
12. de Araujo Junior RF, Leitao Oliveira AL, de Melo Silveira RF, de Oliveira Rocha HA, de Franca Cavalcanti P and de Araujo AA. Telmisartan induces apoptosis and regulates Bcl-2 in human renal cancer cells. Exp Biol Med (Maywood) 2015; 240: 34-44.
13. Fan L, Feng Y, Wan HY, Ni L, Qian YR, Guo Y, Xiang Y and Li QY. Hypoxia induces dysregulation of local renin-angiotensin system in mouse Lewis lung carcinoma cells. Genet Mol Res 2014; 13: 10562-10573.
14. Shibayama Y, Fujimori T, Nguyen G, Hirose T, Totsune K, Ichihara A, Kitada K, Nakano D, Kobori H, Kohno M, Masaki T, Suzuki Y, Yachida S and Nishiyama A. (Pro)renin receptor is crucial for Wnt/beta-catenin-dependent genesis of pancreatic ductal adenocarcinoma. Sci Rep 2015; 5: 8854.
15. Inanc M, Ozkan M, Karaca H, Berk V, Bozkurt O, Duran AO, Ozaslan E, Akgun H, Tekelioglu F and Elmali F. Cytokeratin 5/6, c-Met expressions, and PTEN loss prognostic indicators in triple-negative breast cancer. Med Oncol 2014; 31: 801.
16. Fichtenbaum EJ, Marsh WL Jr and Zynger DL. CK5, CK5/6, and double-stains CK7/CK5 and p53/CK5 discriminate in situ vs invasive urothelial cancer in the prostate. Am J Clin Pathol 2012; 138: 190-197.