Systematic review of systematic reviews of non-pharmacological interventions to treat behavioural disturbances in older patients with dementia. the SENATOR-OnTop series

BMJ Open

Volumn 7, Issue 3, 2017, Pages

  Abraha, Iosief ^a   Rimland, Joseph M ^a   Trotta, Fabiana Mirella ^a   Dell'Aquila, Giuseppina ^a   Cruz Jentoft, Alfonso ^b   Petrovic, Mirko ^c   Gudmundsson, Adalsteinn ^d   Soiza, Roy ^e   O'Mahony, Denis ^f   Guaita, Antonio ^g   Cherubini, Antonio ^a  

^a INRCA   (Italy)

^b HOSPITAL RAMÓN Y CAJAL   (Spain)

^c GHENT UNIVERSITY   (Belgium)

^d LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^e WOODEND HOSPITAL   (United Kingdom)

^f UNIVERSITY COLLEGE CORK   (Ireland)

^g 'Golgi Cenci' Foundation   (Italy)

Author keywords

Alzheimer's disease; Behavioral and psychological symptoms in dementia; BPSD; Non pharmacological intervention

Indexed keywords

ACUPRESSURE; AGED; AGITATION; ALTERNATIVE MEDICINE; ANIMAL ASSISTED THERAPY; ANXIETY; AROMATHERAPY; ASSISTED LIVING FACILITY; BEHAVIOR DISORDER; BEHAVIOUR MANAGEMENT TECHNIQUE; CAREGIVER BASED INTERVENTION; CHECKLIST; COGNITIVE THERAPY; COMMUNICATION SKILL; DANCE THERAPY; DEMENTIA; DINING ROOM ENVIRONMENT BASED INTERVENTION; FAMILY COUNSELING; HOME CARE; HORTICULTURAL THERAPY; HUMAN; INTENSIVE CARE UNIT; KINESIOTHERAPY; MASSAGE; MUSIC THERAPY; PERSON CENTRED CARE; PHOTOTHERAPY; PHYSICAL MEDICINE; PSYCHOTHERAPY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REMINISCENCE THERAPY; RESIDENTIAL CARE; REVIEW; SENSORY GARDEN; SENSORY STIMULATION; SHIATSU; SIMULATED PRESENCE THERAPY; SNOEZELEN MULTISENSORY STIMULATION THERAPY; STAFF TRAINING; SYSTEMATIC REVIEW; SYSTEMATIC REVIEW (TOPIC); TOUCH THERAPY; TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION; VALIDATION THERAPY; COMPLICATION; LITERATURE; PHYSIOTHERAPY; PROCEDURES; PSYCHOLOGY; RESTLESSNESS; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ANXIETY; COGNITIVE THERAPY; COMPLEMENTARY THERAPIES; DEMENTIA; HOME CARE SERVICES; HUMANS; PHOTOTHERAPY; PHYSICAL THERAPY MODALITIES; PSYCHOMOTOR AGITATION; REVIEW LITERATURE AS TOPIC;

EID: 85015751619     PISSN: None     EISSN: 20446055     Source Type: Journal    
DOI: 10.1136/bmjopen-2016-012759     Document Type: Review

References (222)

1. Prince M, Bryce R, Albanese E, et al. The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement 2013;9:63-75. e2.
2. Grasset L, Brayne C, Joly P, et al. Trends in dementia incidence: evolution over a 10-year period in France. Alzheimers Dement 2016;12:272-80.
3. Rattinger GB, Fauth EB, Behrens S, et al. Closer caregiver and care-recipient relationships predict lower informal costs of dementia care: the Cache County Dementia Progression Study. Alzheimers Dement 2016;12:917-24.
4. Wimo A, Jönsson L, Bond J, et al. The worldwide economic impact of dementia 2010. Alzheimers Dement 2013;9: 1-11. e3.
5. Finkel SI, Costa e Silva J, Cohen G, et al. Behavioral and psychological signs and symptoms of dementia: a consensus statement on current knowledge and implications for research and treatment. Int Psychogeriatr 1996;8(Suppl 3):497-500.
6. Lyketsos CG, Carrillo MC, Ryan JM, et al. Neuropsychiatric symptoms in Alzheimer's disease. Alzheimers Dement 2011;7:532-9.
7. Geda YE, Schneider LS, Gitlin LN, et al. Neuropsychiatric symptoms in Alzheimer's disease: past progress and anticipation of the future. Alzheimers Dement 2013;9:602-8.
8. Ismail Z, Smith EE, Geda Y, et al. Neuropsychiatric symptoms as early manifestations of emergent dementia: provisional diagnostic criteria for mild behavioral impairment. Alzheimers Dement 2016;12:195-202.
9. Kales HC, Gitlin LN, Lyketsos CG. Assessment and management of behavioral and psychological symptoms of dementia. BMJ 2015;350:h369.
10. Petrovic M, Hurt C, Collins D, et al. Clustering of behavioural and psychological symptoms in dementia (BPSD): a European Alzheimer's disease consortium (EADC) study. Acta Clin Belg 2007;62:426-32.
11. Pawucka U, Brzyski P, Kubicz D, et al. The determinants of behavioral symptoms in long-term care facility residents. Eur Geriatr Med 2016;7:157-62.
12. Savva GM, Zaccai J, Matthews FE, et al. Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population. Br J Psychiatry 2009;194:212-19.
13. Hendriks SA, Smalbrugge M, Galindo-Garre F, et al. From admission to death: prevalence and course of pain, agitation, shortness of breath, treatment of these symptoms in nursing home residents with dementia. J Am Med Dir Assoc 2015;16:475-81.
14. Ryu SH, Katona C, Rive B, et al. Persistence of and changes in neuropsychiatric symptoms in Alzheimer disease over 6 months: the LASER-AD study. Am J Geriatr Psychiatry 2005;13:976-83.
15. Givens JL, Jones RN, Mazor KM, et al. Development and psychometric properties of the family distress in advanced dementia scale. J Am Med Dir Assoc 2015;16:775-80.
16. Wetzels RB, Zuidema SU, de Jonghe JF, et al. Determinants of quality of life in nursing home residents with dementia. Dement Geriatr Cogn Disord 2010;29:189-97.
17. Gaugler JE, Yu F, Krichbaum K, et al. Predictors of nursing home admission for persons with dementia. Med Care 2009;47: 191-8.
18. Cabrera E, Sutcliffe C, Verbeek H, et al. Non-pharmacological interventions as a best practice strategy in people with dementia living in nursing homes. A systematic review. Eur Geriatr Med 2015;6:134-50.
19. Cammisuli DM, Danti S, Bosinelli F, et al. Non-pharmacological interventions for people with Alzheimer's disease: a critical review of the scientific literature from the last ten years. Eur Geriatr Med 2016;7:57-64.
20. Howard R, McShane R, Lindesay J, et al. Donepezil and memantine for moderate-to-severe Alzheimer's disease. N Engl J Med 2012;366:893-903.
21. Olin J, Schneider L. Galantamine for Alzheimer's disease. Cochrane Database Syst Rev 2002(3):CD001747.
22. Locca JF, Büla CJ, Zumbach S, et al. Pharmacological treatment of behavioral and psychological symptoms of dementia (BPSD) in nursing homes: development of practice recommendations in a Swiss canton. J Am Med Dir Assoc 2008;9:439-48.
23. Porsteinsson AP, Drye LT, Pollock BG, et al. Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial. JAMA 2014;311:682-91.
24. Bierman EJ, Comijs HC, Gundy CM, et al. The effect of chronic benzodiazepine use on cognitive functioning in older persons: good, bad or indifferent Int J Geriatr Psychiatry 2007;22:1194-200.
25. Maher AR, Maglione M, Bagley S, et al. Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis. JAMA 2011;306:1359-69.
26. Berry SD, Placide SG, Mostofsky E, et al. Antipsychotic and benzodiazepine drug changes affect acute falls risk differently in the nursing home. J Gerontol A Biol Sci Med Sci 2016;71:273-8.
27. Howard RJ, Juszczak E, Ballard CG, et al. Donepezil for the treatment of agitation in Alzheimer's disease. N Engl J Med 2007;357:1382-92.
28. Matsunaga S, Kishi T, Iwata N. Memantine monotherapy for Alzheimer's disease: a systematic review and meta-analysis. PLoS ONE 2015;10:e0123289.
29. Seitz DP, Brisbin S, Herrmann N, et al. Efficacy and feasibility of nonpharmacological interventions for neuropsychiatric symptoms of dementia in long term care: a systematic review. J Am Med Dir Assoc 2012;13:503-06. e2.
30. Zetteler J. Effectiveness of simulated presence therapy for individuals with dementia: a systematic review and meta-analysis. Aging Ment Health 2008;12:779-85.
31. O'Neil ME, Freeman M, Portland V. A systematic evidence review of non-pharmacological interventions for behavioral symptoms of dementia. Washington (DC): Department of Veterans Affairs, 2011.
32. Abraha I, Trotta F, Rimland JM, et al. Efficacy of non-pharmacological interventions to prevent and treat Delirium in older patients: a systematic overview. The SENATOR project ONTOP Series. PLoS ONE 2015;10:e0123090.
33. Vélez-Diáz-Pallarés M, Lozano-Montoya I, Correa-Pérez A, et al. Non-pharmacological interventions to prevent or treat pressure ulcers in older patients: Clinical practice recommendations. The SENATOR-ONTOP series. Eur Geriatr Med 2016;7:142-8.
34. Lozano-Montoya I, Velez-Diaz-Pallares M, Abraha I, et al. Nonpharmacologic interventions to prevent pressure ulcers in older patients: an overview of systematic reviews (the software ENgine for the assessment and optimization of drug and non-drug therapy in older peRsons [SENATOR] definition of optimal evidence-based non-drug therapies in older people [ONTOP] series). J Am Med Dir Assoc 2016;17:370 e1-70 e10.
35. Velez-Diaz-Pallares M, Lozano-Montoya I, Abraha I, et al. Nonpharmacologic interventions to heal pressure ulcers in older patients: an overview of systematic reviews (the SENATORONTOP series). J Am Med Dir Assoc 2015;16:448-69.
36. Rimland JM, Dell'Aquila G, O'Mahony D, et al. Meta-analysis of multifactorial interventions to prevent falls of older adults in care facilities. J Am Geriatr Soc 2015;63:1972-3.
37. Rimland JM, Abraha I, Dell'Aquila G, et al. Effectiveness of non-pharmacological interventions to prevent falls in older people: a systematic overview. The SENATOR Project ONTOP Series. PLoS ONE 2016;11:e0161579.
38. Abraha I, Cruz-Jentoft A, Soiza RL, et al. Evidence of and recommendations for non-pharmacological interventions for common geriatric conditions: the SENATOR-ONTOP systematic review protocol. BMJ Open 2015;5:e007488.
39. Shea BJ, Grimshaw JM, Wells GA, et al. Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol 2007;7:10.
40. Savovic J, Jones HE, Altman DG, et al. Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials. Ann Intern Med 2012;157:429-38.
41. Abraha I, Cherubini A, Cozzolino F, et al. Deviation from intention to treat analysis in randomised trials and treatment effect estimates: meta-epidemiological study. BMJ 2015;350:h2445.
42. Chan AW, Hróbjartsson A, Haahr MT, et al. Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles. JAMA 2004;291:2457-65.
43. Guyatt GH, Oxman AD, Vist G, et al. GRADE guidelines: 4. Rating the quality of evidence-study limitations (risk of bias). J Clin Epidemiol 2011;64:407-15.
44. Robinson N, Lorenc A, Liao X. The evidence for Shiatsu: a systematic review of Shiatsu and acupressure. BMC Complement Altern Med 2011;11:88.
45. Lin LC, Yang MH, Kao CC, et al. Using acupressure and Montessori-based activities to decrease agitation for residents with dementia: a cross-over trial. J Am Geriatr Soc 2009;57:1022-9.
46. Nguyen QA, Paton C. The use of aromatherapy to treat behavioural problems in dementia. Int J Geriatr Psychiatry 2008;23:337-46.
47. Fung JKKM, Tsang HWH, Chung RCK. A systematic review of the use of aromatherapy in treatment of behavioral problems in dementia. Geriatr Gerontol Int 2012;12:372-82.
48. Forrester LT, Maayan N, Orrell M, et al. Aromatherapy for dementia. Cochrane Database Syst Rev 2014;(2):CD003150.
49. Fu CY, Moyle W, Cooke M. A randomised controlled trial of the use of aromatherapy and hand massage to reduce disruptive behaviour in people with dementia. BMC Complement Altern Med 2013;13:165.
50. Lin PW, Chan WC, Ng BF, et al. Efficacy of aromatherapy (Lavandula angustifolia) as an intervention for agitated behaviours in Chinese older persons with dementia: a cross-over randomized trial. Int J Geriatr Psychiatry 2007;22:405-10.
51. O'Connor DW, Eppingstall B, Taffe J, et al. A randomized, controlled cross-over trial of dermally-applied lavender (Lavandula angustifolia) oil as a treatment of agitated behaviour in dementia. BMC Complement Altern Med 2013;13:315.
52. Smallwood J, Brown R, Coulter F, et al. Aromatherapy and behaviour disturbances in dementia: a randomized controlled trial. Int J Geriatr Psychiatry 2001;16:1010-13.
53. Ballard CG, O'Brien JT, Reichelt K, et al. Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa. J Clin Psychiatry 2002;63:553-8.
54. Burns A, Perry E, Holmes C, et al. A double-blind placebo-controlled randomized trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer's disease. Dement Geriatr Cogn Disord 2011;31:158-64.
55. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatr 2003;74:863-6.
56. Burleigh S, Armstrong C. On the scent of a useful therapy. J Dement Care 1997;5:21-3.
57. Gray SG, Clair AA. Influence of aromatherapy on medication administration to residential-care residents with dementia and behavioral challenges. Am J Alzheimers Dis Other Demen 2002;17:169-74.
58. Holmes C, Hopkins V, Hensford C, et al. Lavender oil as a treatment for agitated behaviour in severe dementia: a placebo controlled study. Int J Geriatr Psychiatry 2002;17:305-8.
59. Jimbo D, Kimura Y, Taniguchi M, et al. Effect of aromatherapy on patients with Alzheimer's disease. Psychogeriatrics 2009;9:173-9.
60. Kilstoff K, Chenoweth L. New approaches to health and well-being for dementia day-care clients, family carers and day-care staff. Int J Nurs Pract 1998;4:70-83.
61. Cameron H, du Toit S, Richard G, et al. Using lemon balm oil to reduce aggression and agitation in dementia: results of a pilot study. J Dement Care 2011;19:36-8.
62. Cohen-Mansfield J. Nonpharmacologic interventions for inappropriate behaviors in dementia: a review, summary, critique. Am J Geriatr Psychiatry 2001;9:361-81.
63. Viggo Hansen N, Jørgensen T, ∅rtenblad L. Massage and touch for dementia. Cochrane Database Syst Rev 2006;(4):CD004989.
64. Remington R. Calming music and hand massage with agitated elderly. Nurs Res 2002;51:317-23.
65. Moyle W, Murfield JE, O'Dwyer S, et al. The effect of massage on agitated behaviours in older people with dementia: a literature review. J Clin Nurs 2013;22:601-10.
66. Holliday-Welsh DM, Gessert CE, Renier CM. Massage in the management of agitation in nursing home residents with cognitive impairment. Geriatr Nurs 2009;30:108-17.
67. Forbes D, Blake Catherine M, Thiessen Emily J, et al. Light therapy for improving cognition, activities of daily living, sleep, challenging behaviour, psychiatric disturbances in dementia. Cochrane Database Syst Rev 2014;(2):CD003946.
68. Ancoli-Israel S, Martin JL, Gehrman P, et al. Effect of light on agitation in institutionalized patients with severe Alzheimer disease. Am J Geriatr Psychiatry 2003;11:194-203.
69. Burns A, Allen H, Tomenson B, et al. Bright light therapy for agitation in dementia: a randomized controlled trial. Int Psychogeriatr 2009;21:711-21.
70. Dowling GA, Mastick J, Hubbard EM, et al. Effect of timed bright light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease. Int J Geriatr Psychiatry 2005;20: 738-43.
71. Riemersma-van der Lek RF, Swaab DF, Twisk J, et al. Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial. JAMA 2008;299:2642-55.
72. Chaudhury H, Hung L, Badger M. The role of physical environment in supporting person-centered dining in long-term care: a review of the literature. Am J Alzheimers Dis Other Demen 2013;28: 491-500.
73. Barrick AL, Sloane PD, Williams CS, et al. Impact of ambient bright light on agitation in dementia. Int J Geriatr Psychiatry 2010;25: 1013-21.
74. Padilla R. Effectiveness of environment-based interventions for people with Alzheimer's disease and related dementias. Am J Occup Ther 2011;65:514-22.
75. Hickman SE, Barrick AL, Williams CS, et al. The effect of ambient bright light therapy on depressive symptoms in persons with Dementia. J Am Geriatr Soc 2007;55:1817-24.
76. Whear R, Coon JT, Bethel A, et al. What is the impact of using outdoor spaces such as gardens on the physical and mental well-being of those with dementia A systematic review of quantitative and qualitative evidence. J Am Med Dir Assoc 2014;15:697-705.
77. Luk KY, Lai KYC, Li CC, et al. The effect of horticultural activities on agitation in nursing home residents with dementia. Int J Geriatr Psychiatry 2011;26:435-6.
78. Gonzalez MT, Kirkevold M. Benefits of sensory garden and horticultural activities in dementia care: a modified scoping review. J Clin Nurs 2014;23:2698-715.
79. Connell BR, Sanford JA, Lewis D. Therapeutic effects of an outdoor activity program on nursing home residents with dementia. J Hous Elderly 2007;21:194-209.
80. Chatterton WB, Baker F Morgan K. The singer or the singing: who sings individually to persons with dementia and what are the effects Am J Alzheimers Dis Other Demen 2010;25:641-9.
81. McDermott OC, Crellin N, Ridder HM, et al. Music therapy in dementia: a narrative synthesis systematic review. Int J Geriatr Psychiatry 2013;28:781-94.
82. Ueda TS, Suzukamo Y, Sato, M, et al. Effects of music therapy on behavioral and psychological symptoms of dementia: a systematic review and meta-analysis. Ageing Res Rev 2013;12:628-41.
83. Vasionyte IM, Madison G. Musical intervention for patients with dementia: a meta-analysis. J Clin Nurs 2013;22:1203-16.
84. Wall M, Duffy A. The effects of music therapy for older people with dementia. Br J Nurs 2010;19:108-13.
85. Whear R, Abbott R, Thompson-Coon J, et al. Effectiveness of mealtime interventions on behavior symptoms of people with dementia living in care homes: a systematic review. J Am Med Dir Assoc 2014;15:185-93.
86. Groene RW. Effectiveness of music therapy 1:1 intervention with individuals having senile dementia of the Alzheimer's type. J Music Ther 1993;30:138-57.
87. Guétin S, Portet F, Picot MC, et al. Effect of music therapy on anxiety and depression in patients with Alzheimer's type dementia: randomised, controlled study. Dement Geriatr Cogn Disord 2009;28:36-46.
88. Ledger AJ, Baker FA. An investigation of long-term effects of group music therapy on agitation levels of people with Alzheimer's disease. Aging Ment Health 2007;11:330-8.
89. Miura H, Kanayama Y, Mogi N, et al. Effect and significance of music therapy on elderly persons with mild dementia. 2005;5:48-57.
90. Sung HC, Chang AM, Abbey J. The effects of preferred music on agitation of older people with dementia in Taiwan. Int J Geriatr Psychiatry 2006;21:999-1000.
91. Sung HC, Chang AM, Lee W-L. A preferred music listening intervention to reduce anxiety in older adults with dementia in nursing homes. J Clin Nurs 2010;19:1056-64.
92. Suzuki M, Kanamori M, Nagasawa S, et al. Music therapy-induced changes in behavioral evaluations, saliva chromogranin a and immunoglobulin a concentrations in elderly patients with senile dementia. Geriatr Gerontol Int 2007;7:61-71.
93. Tuet RWK, Lam LCW. A preliminary study of the effects of music therapy on agitation in Chinese patients with dementia. Hong Kong J Psychiatry 2006;16:87-91.
94. Ikeda M, Suzuki M, Sawai D, et al. Effects of nursing intervention using rhythmic exercise for patients with severe senile dementia. Nurs Res 2006;39:301-13.
95. Mihara B, Hosoya M, Mihara Y, et al. The effect of music therapy for elderly with dementia: a comparative study between large group and small group sessions. Japanese J Music Ther 2004;4:208-16.
96. Raglio A, Bellelli G, Traficante D, et al. Efficacy of music therapy in the treatment of behavioral and psychiatric symptoms of dementia. Alzheimer Dis Assoc Disord 2008;22:158-62.
97. Sung HC, Chang SM, Lee WL, et al. The effects of group music with movement intervention on agitated behaviours of institutionalized elders with dementia in Taiwan. Complement Ther Med 2006;14:113-19.
98. Choi AN, Lee MS, Cheong KJ, et al. Effects of group music intervention on behavioral and psychological symptoms in patients with dementia: a pilot-controlled trial. Int J Neurosci 2009;119:471-81.
99. Goka F. The effects of combined music and reminiscence therapy for small groups of the elderly with senile dementia of Alzheimer type, the efficacy of the evaluation method. Japanese J Music Ther 2005;5:25-38.
100. Raglio A, Bellelli G, Traficante D, et al. Efficacy of music therapy treatment based on cycles of sessions: a randomised controlled trial. Aging Ment Health 2010;14:900-4.
101. Smith GH. A comparison of the effects of three treatment interventions on cognitive functioning of Alzheimer patients. Music Ther 1986;6:41-56.
102. Suzuki M, Kanamori M, Watanabe M, et al. Behavioral and endocrinological evaluation of music therapy for elderly patients with dementia. Nurs Health Sci 2004;6:11-18.
103. Van de Winckel A, Feys H, De Weerdt W, et al. Cognitive and behavioural effects of music-based exercises in patients with dementia. Clin Rehabil 2004;18:253-60.
104. Svansdottir HB, Snaedal J. Music therapy in moderate and severe dementia of Alzheimer's type: a case-control study. Int Psychogeriatr 2006;18:613-21.
105. Clark ME, Lipe AW, Bilbrey M. Use of music to decrease aggressive behaviors in people with dementia. J Gerontol Nurs 1998;24:10-17.
106. Cooke M, Moyle W, Shum D, et al. A randomized controlled trial exploring the effect of music on quality of life and depression in older people with Dementia. J Health Psychology 2010;15:765-76.
107. Nair B, Heim C, Krishnan C, et al. The effect of Baroque music on behavioural disturbances in patients with dementia. Australas J Ageing 2011;30:11-15.
108. Raglio A, Oasi O, Gianotti M, et al. Effects of music therapy on psychological symptoms and heart rate variability in patients with dementia. A pilot study. Current Aging Sci 2010:242-6.
109. Irish M, Cunningham CJ, Walsh JB, et al. Investigating the enhancing effect of music on autobiographical memory in mild Alzheimer's disease. Dement Geriatr Cogn Disord 2006;22:108-20.
110. Denney A. Quiet music. An intervention for mealtime agitation J Gerontol Nurs 1997;23:16-23.
111. Hicks-Moore SL. Relaxing music at mealtime in nursing homes: effects on agitated patients with dementia. J Gerontol Nurs 2005;31:26-32.
112. Ragneskog H, Kihlgren M, Karlsson I, et al. Dinner music for demented patients: analysis of video-recorded observations. Clin Nurs Res 1996;5:262-77. Discussion 78-82.
113. Thomas DW, Smith M. The effect of music on caloric consumption among nursing home residents with Dementia of the Alzheimer's type. Act Adapt Aging 2009;33:1-16.
114. Kiepe MS, Barbara S, Thomas K. Effects of dance therapy and ballroom dances on physical and mental illnesses: a systematic review. Arts Psychotherapy 2012;39:404-11.
115. Guzman-Garcia A, Hughes JC, James IA, et al. Dancing as a psychosocial intervention in care homes: a systematic review of the literature. Int J Geriatr Psychiatry 2013;28:914-24.
116. Hokkanen L, Rantala L, Remes AM, et al. Dance and movement therapeutic methods in management of dementia: a randomized, controlled study. J Am Geriatr Soc 2008;56:771-2.
117. Chung JC, Lai CK, Chung PM, et al. Snoezelen for dementia. Cochrane Database Syst Rev 2002;(4):CD003152.
118. Baker R, Bell S, Baker E, et al. A randomized controlled trial of the effects of multi-sensory stimulation (MSS) for people with dementia. Br J Clin Psychology 2001;40:81-96.
119. Baker R. & Dowling Z. (1995) INTERACT. A New Measure of Response to Multi-Sensory Environments. Research Publication. Research and Development Support Unit, Poole Hospital, Dorset.
120. Baker R, Holloway J, Holtkamp CCM, et al. Effects of multi-sensory stimulation for people with dementia. J Adv Nurs 2003;43:465-77.
121. van Weert JC, van Dulmen AM, Spreeuwenberg PM, et al. Effects of snoezelen, integrated in 24 h dementia care, on nurse-patient communication during morning care. Patient Educ Couns 2005;58:312-26.
122. van Weert JC, van Dulmen AM, Spreeuwenberg PM, et al. Behavioral and mood effects of Snoezelen integrated into 24-hour dementia care. J Am Geriatr Soc 2005;53:24-33.
123. Bi X, Lv H, Chen BL, et al. Effects of transcutaneous electrical nerve stimulation on pain in patients with spinal cord injury: a randomized controlled trial. J Phys Ther Sci 2015;27:23-5.
124. Salami O, Lyketsos C, Rao V. Treatment of sleep disturbance in Alzheimer's dementia. Int J Geriatr Psychiatry 2011;26:771-82.
125. Cameron M, Lonergan E, Lee H. Transcutaneous electrical nerve stimulation (TENS) for dementia. Cochrane Database Syst Rev 2003(3):CD004032.
126. Scherder E, Knol D, van Someren E, et al. Effects of low-frequency cranial electrostimulation on the rest-activity rhythm and salivary cortisol in Alzheimer's disease. Neurorehabil Neural Repair 2003;17:101-8.
127. Scherder EJ, Bouma A, Steen L. Influence of transcutaneous electrical nerve stimulation on memory in patients with dementia of the Alzheimer type. J Clin Exp Neuropsychol 1992;14: 951-60.
128. Scherder EJ, Deijen JB, Vreeswijk SH, et al. Cranial electrostimulation (CES) in patients with probable Alzheimer's disease. Behav Brain Res 2002;128:215-17.
129. Scherder EJ, Van Someren EJ, Bouma A, et al. Effects of transcutaneous electrical nerve stimulation (TENS) on cognition and behaviour in aging. Behav Brain Res 2000;111:223-5.
130. Scherder EJ, Van Someren EJ, Swaab DF. Transcutaneous electrical nerve stimulation (TENS) improves the rest-activity rhythm in midstage Alzheimer's disease. Behav Brain Res 1999;101:105-7.
131. Van Someren EJ, Scherder EJ, Swaab DF. Transcutaneous electrical nerve stimulation (TENS) improves circadian rhythm disturbances in Alzheimer disease. Alzheimer Dis Assoc Disord 1998;12:114-18.
132. Hozumi S, Hori H, Okawa M, et al. Favorable effect of transcranial electrostimulation on behavior disorders in elderly patients with dementia: a double-blind study. Int J Neurosci 1996;88:1-10.
133. Woods B, Aguirre E, Spector AE, et al. Cognitive stimulation to improve cognitive functioning in people with dementia. Cochrane Database Syst Rev 2012;(2):CD005562.
134. Aguirre E, Woods RT, Spector A, et al. Cognitive stimulation for dementia: a systematic review of the evidence of effectiveness from randomised controlled trials. Ageing Res Rev 2013;12:253-62.
135. Alves J, Magalhaes R, Thomas RE, et al. Is there evidence for cognitive intervention in Alzheimer disease A systematic review of efficacy, feasibility, cost-effectiveness. Alzheimer Dis Assoc Disord 2013;27:195-203.
136. Carrion C, Aymerich M, Baillés E, et al. Cognitive psychosocial intervention in dementia: a systematic review. Dement Geriatr Cogn Disord 2013;36:363-75.
137. Yu F, Rose KM, Burgener SC, et al. Cognitive training for earlystage Alzheimer's disease and dementia. J Gerontol Nurs 2009;35:23-9.
138. Olazarán J, Reisberg B, Clare L, et al. Nonpharmacological therapies in Alzheimer's disease: a systematic review of efficacy. Dement Geriatr Cogn Disord 2010;30:161-78.
139. Zientz J, Rackley A, Chapman SB, et al. Evidence-based practice recommendations for dementia: educating caregivers on Alzheimer's disease and training communication strategies. J Med Speech Lang Pathol 2007;15:liii-lxiv.
140. Baines S, Saxby P, Ehlert K. Reality orientation and reminiscence therapy. A controlled cross-over study of elderly confused people. Br J Psychiatry 1987;151:222-31.
141. Ferrario E, Cappa G, Molaschi M, et al. Reality orientation therapy in institutionalized elderly patients: preliminary results. Arch Gerontol Geriatr 1991;12:139-42.
142. Onder G, Zanetti O, Giacobini E, et al. Reality orientation therapy combined with cholinesterase inhibitors in Alzheimer's disease: randomised controlled trial. Br J Psychiatry 2005;187:450-5.
143. Robichaud L, Hebert R, Desrosiers J. Efficacy of a sensory integration program on behaviors of inpatients with dementia. Am J Occup Ther 1994;48:355-60.
144. Kim SY, Yoo EY, Jung MY, et al. A systematic review of the effects of occupational therapy for persons with dementia: a meta-analysis of randomized controlled trials. NeuroRehabilitation 2012;31: 107-15.
145. Kurz AF, Leucht S, Lautenschlager NT. The clinical significance of cognition-focused interventions for cognitively impaired older adults: a systematic review of randomized controlled trials. Int Psychogeriatr 2011;23:1364-75.
146. Blake M. Group reminiscence therapy for adults with dementia: a review. Br J Community Nurs 2013;18:228-33.
147. Subramaniam P, Woods B. The impact of individual reminiscence therapy for people with dementia: systematic review. Expert Rev Neurother 2012;12:545-55.
148. Deponte A, Missan R. Effectiveness of validation therapy (VT) in group: preliminary results. Arch Gerontol Geriatr 2007;44:113-17.
149. Wang JJ, Yen M, OuYang WC. Group reminiscence intervention in Taiwanese elders with dementia. Arch Gerontol Geriatr 2009;49:227-32.
150. Haight BK, Gibson F, Michel Y. The Northern Ireland life review/life storybook project for people with dementia. Alzheimers Dement 2006;2:56-8.
151. Morgan S, Woods R. Life review with people with dementia in care homes: a preliminary randomized controlled trial. 2010;1:43-60.
152. Lai CK, Chi I, Kayser-Jones J. A randomized controlled trial of a specific reminiscence approach to promote the well-being of nursing home residents with dementia. Int Psychogeriatr 2004;16:33-49.
153. Haslam C, Haslam SA, Jetten J, et al. The social treatment: the benefits of group interventions in residential care settings. Psychol Aging 2010;25:157-67.
154. Politis AM, Vozzella S, Mayer LS, et al. A randomized, controlled, clinical trial of activity therapy for apathy in patients with dementia residing in long-term care. Int J Geriatr Psychiatry 2004;19:1087-94.
155. Neal M, Barton Wright P. Validation therapy for dementia. Cochrane Database Syst Rev 2003(3):CD001394.
156. Peoples. Validation therapy, versus reality orientation as treatment for disorientated institutionalised elderly [Masters dissertation]. Akron: College of Nursing, University of Akron, 1982.
157. Robb SS, Stegman CE, Wolanin MO. No research versus research with compromised results: a study of validation therapy. Nurs Res 1986;35:113-18.
158. Toseland RW, Diehl M, Freeman K, et al. The impact of validation group therapy on nursing home residents with dementia. J Appl Gerontol 1997;16:31-50.
159. Vasse E, Vernooij-Dassen M, Spijker A, et al. A systematic review of communication strategies for people with dementia in residential and nursing homes. Int Psychogeriatr 2010;22:189-200.
160. Cohen-Mansfield J. Agitated behaviors in the elderly. II. Preliminary results in the cognitively deteriorated. J Am Geriatr Soc 1986;34:722-7.
161. Abraha I, Rimland JM, Lozano-Montoya I, et al. simulated presence therapy for dementia: a systematic review protocol. BMJ Open 2016;6:e011007.
162. Kverno KS, Black BS, Nolan MT. Research on treating neuropsychiatric symptoms of advanced dementia with non-pharmacological strategies, 1998-2008: a systematic literature review. Int Psychogeriatr 2009;21:825-43.
163. Teri L, Logsdon RG, McCurry SM. Nonpharmacologic treatment of behavioral disturbance in dementia. Med Clin North Am 2002;86:641-56. viii.
164. Teri L, Gibbons LE, McCurry SM, et al. Exercise plus behavioral management in patients with Alzheimer disease: a randomized controlled trial. JAMA 2003;290:2015-22.
165. Proctor R, Burns A, Powell HS, et al. Behavioural management in nursing and residential homes: a randomised controlled trial. Lancet 1999;354:26-9.
166. Teri L, Huda P, Gibbons L, et al. STAR: a dementia-specific training program for staff in assisted living residences. Gerontologist 2005;45:686-93.
167. McCurry SM, Gibbons LE, Logsdon RG, et al. Nighttime insomnia treatment and education for Alzheimer's disease: a randomized, controlled trial. J Am Geriatr Soc 2005;53:793-802.
168. Gitlin LN, Winter L, Dennis MP, et al. A biobehavioral home-based intervention and the well-being of patients with dementia and their caregivers: the COPE randomized trial. JAMA 2010;304:983-91.
169. Beck CK, Vogelpohl TS, Rasin JH, et al. Effects of behavioral interventions on disruptive behavior and affect in demented nursing home residents. Nurs Res 2002;51:219-28.
170. Suhr J. Progressive muscle relaxation in the management of behavioural disturbance in Alzheimer's disease. Neuropsychol Rehabil 1999;9:31-44.
171. McCallion P, Toseland RW, Freeman K. An evaluation of a family visit education program. J Am Geriatr Soc 1999;47:203-14.
172. Livingston G, Kelly L, Lewis-Holmes E, et al. A systematic review of the clinical effectiveness and cost-effectiveness of sensory, psychological and behavioural interventions for managing agitation in older adults with dementia. Health Technol Assess 2014;18:1-226. v-vi.
173. Gormley N, Lyons D, Howard R. Behavioural management of aggression in dementia: a randomized controlled trial. Age Ageing 2001;30:141-5.
174. Teri L, Logsdon RG, Peskind E, et al. Treatment of agitation in AD: a randomized, placebo-controlled clinical trial. Neurology 2000;55:1271-8.
175. Bourgeois MS, Burgio LD, Schulz R, et al. Modifying repetitive verbalizations of community-dwelling patients with AD. Gerontologist 1997;37:30-9.
176. Moniz Cook ED, Swift K, James I, et al. Functional analysis-based interventions for challenging behaviour in dementia. Cochrane Database Syst Rev 2012;(2):CD006929.
177. Mador JE, Giles L, Whitehead C, et al. A randomized controlled trial of a behavior advisory service for hospitalized older patients with confusion. Int J Geriatr Psychiatry 2004;19:858-63.
178. Burgio L, Stevens A, Guy D, et al. Impact of two psychosocial interventions on white and African American family caregivers of individuals with dementia. Gerontologist 2003;43:568-79.
179. Chenoweth L, King MT, Jeon Y-H, et al. Caring for Aged Dementia Care Resident Study (CADRES) of person-centred care, dementia-care mapping, usual care in dementia: a cluster-randomised trial. Lancet Neurol 2009;8:317-25.
180. Farran CJ, Gilley DW, McCann JJ, et al. Psychosocial interventions to reduce depressive symptoms of dementia caregivers: a randomized clinical trial comparing two approaches. J Mental Health Aging 2004;10:337-50.
181. Fossey J, Ballard C, Juszczak E, et al. Effect of enhanced psychosocial care on antipsychotic use in nursing home residents with severe dementia: cluster randomised trial. BMJ 2006;332:756-61.
182. Gitlin LN, Winter L, Corcoran M, et al. Effects of the home environmental skill-building program on the caregiver-care recipient dyad: 6-month outcomes from the Philadelphia REACH Initiative. Gerontologist 2003;43:532-46.
183. Gonyea JG, O'Connor MK, Boyle PA. Project CARE: a randomized controlled trial of a behavioral intervention group for Alzheimer's disease caregivers. Gerontologist 2006;46:827-32.
184. Huang HL, Shyu YI, Chen MC, et al. A pilot study on a home-based caregiver training program for improving caregiver self-efficacy and decreasing the behavioral problems of elders with dementia in Taiwan. Int J Geriatr Psychiatry 2003;18:337-45.
185. Losada Baltar A, Izal Fernandez de Troconiz M, Montorio Cerrato I, et al. [Differential efficacy of two psychoeducational interventions for dementia family caregivers]. Rev Neurol 2004;38:701-8.
186. Moniz-Cook E, Elston C, Gardiner E, et al. Can training community mental health nurses to support family carers reduce behavioural problems in dementia An exploratory pragmatic randomised controlled trial. Int J Geriatr Psychiatry 2008;23:185-91.
187. Zarit SH, Anthony CR, Boutselis M. Interventions with care givers of dementia patients: comparison of two approaches. Psychol Aging 1987;2:225-32.
188. Gitlin LN, Winter L, Dennis MP, et al. Targeting and managing behavioral symptoms in individuals with dementia: a randomized trial of a nonpharmacological intervention. J Am Geriatr Soc 2010;58:1465-74.
189. Finnema E, Droës RM, Ettema T, et al. The effect of integrated emotion-oriented care versus usual care on elderly persons with dementia in the nursing home and on nursing assistants: a randomized clinical trial. Int J Geriatr Psychiatry 2005;20: 330-43.
190. Schrijnemaekers V, van Rossum E, Candel M, et al. Effects of emotion-oriented care on elderly people with cognitive impairment and behavioral problems. Int J Geriatr Psychiatry 2002;17:926-37.
191. Brodaty H, Arasaratnam C. Meta-analysis of nonpharmacological interventions for neuropsychiatric symptoms of dementia. Am J Psychiatry 2012;169:946-53.
192. Eggenberger E, Heimerl K, Bennett MI. Communication skills training in dementia care: a systematic review of effectiveness, training content, didactic methods in different care settings. Int Psychogeriatr 2013;25:345-58.
193. Teri L, McCurry SM, Logsdon R, et al. Training community consultants to help family members improve dementia care: a randomized controlled trial. Gerontologist 2005;45:802-11.
194. Burgio LD, Stevens A, Burgio KL, et al. Teaching and maintaining behavior management skills in the nursing home. Gerontologist 2002;42:487-96.
195. Burgio LD, Allen-Burge R, Roth DL, et al. Come talk with me: improving communication between nursing assistants and nursing home residents during care routines. Gerontologist 2001;41:449-60.
196. Done DJ, Thomas JA. Training in communication skills for informal carers of people suffering from dementia: a cluster randomized clinical trial comparing a therapist led workshop and a booklet. Int J Geriatr Psychiatry 2001;16:816-21.
197. Magai C, Cohen CI, Gomberg D. Impact of training dementia caregivers in sensitivity to nonverbal emotion signals. Int Psychogeriatr 2002;14:25-38.
198. Staal JA, Sacks A, Matheis R, et al. The effects of Snoezelen (multi-sensory behavior therapy) and psychiatric care on agitation, apathy, activities of daily living in dementia patients on a short term geriatric psychiatric inpatient unit. Int J Psychiatry Med 2007;37:357-70.
199. Clare L, Linden DE, Woods RT, et al. Goal-oriented cognitive rehabilitation for people with early-stage Alzheimer disease: a single-blind randomized controlled trial of clinical efficacy. Am J Geriatr Psychiatry 2010;18:928-39.
200. Gitlin LN, Winter L, Burke J, et al. Tailored activities to manage neuropsychiatric behaviors in persons with dementia and reduce caregiver burden: a randomized pilot study. Am J Geriatr Psychiatry 2008;16:229-39.
201. Gitlin LN, Corcoran M, Winter L, et al. A randomized, controlled trial of a home environmental intervention: effect on efficacy and upset in caregivers and on daily function of persons with dementia. Gerontologist 2001;41:4-14.
202. Gaugler JE, Kane RL. Families and assisted living. Gerontologist 2007;47(suppl 1):83-99.
203. Collet J, de Vugt ME, Verhey FR, et al. Efficacy of integrated interventions combining psychiatric care and nursing home care for nursing home residents: a review of the literature. Int J Geriatr Psychiatry 2010;25:3-13.
204. Zimmerman S, Anderson WL, Brode S, et al. Systematic review: effective characteristics of nursing homes and other residential long-term care settings for people with dementia. J Am Geriatr Soc 2013;61:1399-409.
205. Whall AL, Black ME, Groh CJ, et al. The effect of natural environments upon agitation and aggression in late stage dementia patients. Am J Alzheimers Dis Other Demen 1997;12:216-20.
206. Hicks-Moore SL, Robinson BA. Favorite music and hand massage: two interventions to decrease agitation in residents with dementia. Dementia 2008;7:95-108.
207. Potter R, Ellard D, Rees K, et al. A systematic review of the effects of physical activity on physical functioning, quality of life and depression in older people with dementia. Int J Geriatr Psychiatry 2011;26:1000-11.
208. Thuné-Boyle IC, Iliffe S, et al. The effect of exercise on behavioral and psychological symptoms of dementia: towards a research agenda. Int Psychogeriatr 2012;24:1046-57.
209. Burgener SC, Yang Y, Gilbert R, et al. The effects of a multimodal intervention on outcomes of persons with early-stage dementia. Am J Alzheimers Dis Other Demen 2008;23:382-94.
210. Rolland Y, Pillard F, Klapouszczak A, et al. Exercise program for nursing home residents with Alzheimer's disease: a 1-year randomized, controlled trial. J Am Geriatr Soc 2007;55:158-65.
211. Steinberg M, Leoutsakos JM, Podewils LJ, et al. Evaluation of a home-based exercise program in the treatment of Alzheimer's disease: the Maximizing Independence in Dementia (MIND) study. Int J Geriatr Psychiatry 2009;24:680-5.
212. Bernabei V, De Ronchi D, La Ferla T, et al. Animal-assisted interventions for elderly patients affected by dementia or psychiatric disorders: a review. J Psychiatr Res 2013;47:762-73.
213. Churchill M, Safaoui J, McCabe BW, et al. Using a therapy dog to alleviate the agitation and desocialization of people with Alzheimer's disease. J Psychosoc Nurs Ment Health Serv 1999;37:16-22.
214. McCabe BW, Baun MM, Speich D, et al. Resident dog in the Alzheimer's special care unit. West J Nurs Res 2002;24:684-96.
215. Richeson NE. Effects of animal-assisted therapy on agitated behaviors and social interactions of older adults with dementia. Am J Alzheimers Dis Other Demen 2003;18:353-8.
216. Libin A, Cohen-Mansfield J. Therapeutic robocat for nursing home residents with dementia: preliminary inquiry. Am J Alzheimers Dis Other Demen 2004;19:111-16.
217. Motomura N, Yagi T, Ohyama H. Animal assisted therapy for people with dementia. Psychogeriatrics 2004;4:40-2.
218. Sellers DM. The evaluation of an animal assisted therapy intervention for elders with dementia in long-term care. Act Adapt Aging 2006;30:61-77.
219. Brush JA, Meehan RA, Calkins MP. Using the environment to improve intake for people with dementia. Alzheimer's Care Today 2002;3:330-8.
220. Koss E, Gilmore G. Environmental interventions and functional ability of AD patients. In: Vellas, B., Fitten, J. and Frisoni, G. eds. Research and practice in Alzheimer's disease. Paris: Springer, 1998:185-191.
221. Frisoni GB, Gozzetti A, Bignamini V, et al. Special care units for dementia in nursing homes: a controlled study of effectiveness. Arch Gerontol Geriatr 1998;26:215-24.
222. Fontana Gasio P, Kraüchi K, Cajochen C, et al. Dawn-dusk simulation light therapy of disturbed circadian rest-activity cycles in demented elderly. Exp Gerontol 2003;38:207