Antipsychotic and Benzodiazepine Drug Changes Affect Acute Falls Risk Differently in the Nursing Home

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 71, Issue 2, 2016, Pages 273-278

  Berry, Sarah D ^a,b   Placide, Sebastian G ^b   Mostofsky, Elizabeth ^a   Zhang, Yuqing ^c   Lipsitz, Lewis A ^a,b   Mittleman, Murray A ^a   Kiel, Douglas P ^a,b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b Hebrew Senior Life   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antipsychotic; Benzodiazepine; Drug change; Falls; Nursing home

Indexed keywords

BENZODIAZEPINE DERIVATIVE; NEUROLEPTIC AGENT;

AGED; CROSSOVER PROCEDURE; DOSE RESPONSE; FALLING; FEMALE; HUMAN; MALE; NURSING HOME; STATISTICS AND NUMERICAL DATA;

ACCIDENTAL FALLS; AGED; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; NURSING HOMES;

EID: 84961656585     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glv091     Document Type: Conference Paper

References (27)

1. Rubenstein LZ, Josephson KR, Robbins AS. Falls in the nursing home. Ann Intern Med. 1994;121:442-451.
2. Thapa PB, Brockman KG, Gideon P, Fought RL, Ray WA. Injurious falls in nonambulatory nursing home residents: A comparative study of circumstances, incidence, and risk factors. J Am Geriatr Soc. 1996;44:273-278.
3. Neuman MD, Silber JH, Magaziner JS, Passarella MA, Mehta S, Werner RM. Survival and functional outcomes after hip fracture among nursing home residents. JAMA Intern Med. 2014;174:1273-1280.
4. Hien le TT, Cumming RG, Cameron ID, et al. Atypical antipsychotic medications and risk of falls in residents of aged care facilities. J Am Geriatr Soc. 2005;53:1290-1295.
5. Chatterjee S, Chen H, Johnson ML, Aparasu RR. Risk of falls and fractures in older adults using atypical antipsychotic agents: A propensity score-adjusted, retrospective cohort study. Am J Geriatr Pharmacother. 2012;10:83-94.
6. Fraser LA, Liu K, Naylor KL, et al. Falls and fractures with atypical antipsychotic medication use: A population-based cohort study. JAMA Intern Med 2015; 175:450-452.
7. Mustard CA, Mayer T. Case-control study of exposure to medication and the risk of injurious falls requiring hospitalization among nursing home residents. Am J Epidemiol. 1997;145:738-745.
8. Jalbert JJ, Eaton CB, Miller SC, Lapane KL. Antipsychotic use and the risk of hip fracture among older adults afflicted with dementia. J Am Med Dir Assoc. 2010;11:120-127.
9. Liperoti R, Onder G, Lapane KL, et al. Conventional or atypical antipsychotics and the risk of femur fracture among elderly patients: results of a case-control study. J Clin Psychiatry. 2007;68:929-934.
10. Rigler SK, Shireman TI, Cook-Wiens GJ, et al. Fracture risk in nursing home residents initiating antipsychotic medications. J Am Geriatr Soc. 2013;61:715-722.
11. Ray WA, Thapa PB, Gideon P. Benzodiazepines and the risk of falls in nursing home residents. J Am Geriatr Soc. 2000;48:682-685.
12. Granek E, Baker SP, Abbey H, et al. Medications and diagnoses in relation to falls in a long-term care facility. J Am Geriatr Soc. 1987;35:503-511.
13. Ray WA, Griffin MR, Downey W. Benzodiazepines of long and short elimination half-life and the risk of hip fracture. JAMA. 1989;262:3303-3307.
14. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2012;60:616-631.
15. Stevenson DG, Decker SL, Dwyer LL, et al. Antipsychotic and benzodiazepine use among nursing home residents: findings from the 2004 National Nursing Home Survey. Am J Geriatr Psychiatry. 2010;18:1078-1092.
16. Maclure M. The case-crossover design: A method for studying transient effects on the risk of acute events. Am J Epidemiol. 1991;133:144-153.
17. Morris JN, Hawes C, Fries BE, et al. Designing the national resident assessment instrument for nursing homes. Gerontologist. 1990;30:293-307.
18. Hartmaier SL, Sloane PD, Guess HA, Koch GG, Mitchell CM, Phillips CD. Validation of the Minimum Data Set Cognitive Performance Scale: agreement with the Mini-Mental State Examination. J Gerontol A Biol Sci Med Sci. 1995;50:M128-M133.
19. Morris JN, Fries BE, Morris SA. Scaling ADLs within the MDS. J Gerontol A Biol Sci Med Sci. 1999;54:M546-M553.
20. Fries BE, Simon SE, Morris JN, Flodstrom C, Bookstein FL. Pain in U.S. nursing homes: validating a pain scale for the minimum data set. Gerontologist. 2001;41:173-179.
21. Koehler M, Rabinowitz T, Hirdes J, et al. Measuring depression in nursing home residents with the MDS and GDS: an observational psychometric study. BMC Geriatr. 2005;5:1.
22. Huybrechts KF, Rothman KJ, Silliman RA, Brookhart MA, Schneeweiss S. Risk of death and hospital admission for major medical events after initiation of psychotropic medications in older adults admitted to nursing homes. CMAJ. 2011;183:E411-E419.
23. Thapa PB, Gideon P, Fought RL, Ray WA. Psychotropic drugs and risk of recurrent falls in ambulatory nursing home residents. Am J Epidemiol. 1995;142:202-211.
24. Rothberg MB, Herzig SJ, Pekow PS, Avrunin J, Lagu T, Lindenauer PK. Association between sedating medications and delirium in older inpatients. J Am Geriatr Soc. 2013;61:923-930.
25. de Groot MH, van Campen JP, Moek MA, Tulner LR, Beijnen JH, Lamoth CJ. The effects of fall-risk-increasing drugs on postural control: A literature review. Drugs Aging. 2013;30:901-920.
26. Berry SD, Zhang Y, Lipsitz LA, Mittleman MA, Solomon DH, Kiel DP. Antidepressant prescriptions: an acute window for falls in the nursing home. J Gerontol A Biol Sci Med Sci. 2011;66:1124-1130.
27. Berry SD, Lee Y, Cai S, Dore DD. Nonbenzodiazepine sleep medication use and hip fractures in nursing home residents. JAMA Intern Med. 2013;173:754-761.