Metabolic Adaptations in Pregnancy: A Review

Annals of Nutrition and Metabolism

Volumn 70, Issue 1, 2017, Pages 59-65

  Zeng, Zhandong ^a   Liu, Fengli ^a   Li, Shixian ^a  

^a XUZHOU CHILDREN S HOSPITAL   (China)

Author keywords

Fetus; Metabolic adaptations; Pregnancy

Indexed keywords

CHOLESTEROL; FATTY ACID; GLUCOSE; GLUCOSE TRANSPORTER; HORMONE; KETONE BODY;

ADAPTATION; CATABOLISM; CLINICAL TRIAL; FETUS GROWTH; HUMAN; HYPERLIPIDEMIA; LACTATION; METABOLISM; PREGNANCY; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW; FEMALE; FETOMATERNAL TRANSFUSION; FETUS DEVELOPMENT; INFANT NUTRITION; MATERNAL NUTRITION; NEWBORN;

FEMALE; FETAL DEVELOPMENT; HUMANS; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; INFANT, NEWBORN; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; MATERNAL-FETAL EXCHANGE; PREGNANCY;

EID: 85015654073     PISSN: 02506807     EISSN: 14219697     Source Type: Journal    
DOI: 10.1159/000459633     Document Type: Review

References (55)

1. Wang Q, Liu C, Zhang Z: Transthyretin and normal human pregnancy: mini review. Crit Rev Eukaryot Gene Expr 2016; 26: 273-277.
2. Herrera E: Lipid metabolism in pregnancy and its consequences in the fetus and newborn. Endocrine 2002; 19: 43-55.
3. Villar J, Cogswell M, Kestler E, Castillo P, Menendez R, Repke JT: Effect of fat and fatfree mass deposition during pregnancy on birth weight. Am J Obstet Gynecol 1992; 167: 1344-1352.
4. Murphy SP, Abrams BF: Changes in energy intakes during pregnancy and lactation in a national sample of US women. Am J Public Health 1993; 83: 1161-1163.
5. Palacín M, Lasunción MA, Asunción M, Herrera E: Circulating metabolite utilization by periuterine adipose tissue in situ in the pregnant rat. Metabolism 1991; 40: 534-539.
6. Alvarez JJ, Montelongo A, Iglesias A, Lasunción MA, Herrera E: Longitudinal study on lipoprotein profile, high density lipoprotein subclass, and postheparin lipases during gestation in women. J Lipid Res 1996; 37: 299-308.
7. Thenen SW, Mayer J: Adipose tissue glycerokinase activity in genetic and acquired obesity in rats and mice. Proc Soc Exp Biol Med 1975; 148: 953-957.
8. Martineau MG, Raker C, Dixon PH, Chambers J, Machirori M, King NM, Hooks ML, Manoharan R, Chen K, Powrie R, Williamson C: The metabolic profile of intrahepatic cholestasis of pregnancy is associated with impaired glucose tolerance, dyslipidemia, and increased fetal growth. Diabetes Care 2015; 38: 243-248.
9. Pujol E, Proenza A, Lladó I, Roca P: Pregnancy effects on rat adipose tissue lipolytic capacity are dependent on anatomical location. Cell Physiol Biochem 2005;16:229-236.
10. Zorzano A, Lasuncion MA, Herrera E: Role of the availability of substrates on hepatic and renal gluconeogenesis in the fasted late pregnant rat. Metabolism 1986; 35: 297-303.
11. Ricciolini R, Scalibastri M, Carminati P, Arduini A: The effect of pivalate treatment of pregnant rats on body mass and insulin levels in the adult offspring. Life Sci 2001;69:1733-1738.
12. Gu DS, Shambaugh GE 3rd, Metzger BE, Unterman TG, Radosevich JA: Retardation of fetal brain cell growth during maternal starvation: circulating factors versus altered cellular response. Neurochem Res 1992; 17: 529-537.
13. Spracklen CN, Smith CJ, Saftlas AF, Robinson JG, Ryckman KK: Maternal hyperlipidemia and the risk of preeclampsia: a meta-analysis. Am J Epidemiol 2014;180:346-358.
14. Iglesias A, Montelongo A, Herrera E, Lasuncion MA: Changes in cholesteryl ester transfer protein activity during normal gestation and postpartum. Clin Biochem 1994; 27: 63-68.
15. Tabas I: Consequences of cellular cholesterol accumulation: basic concepts and physiological implications. J Clin Invest 2002; 110: 905-911.
16. Nowaczyk MJ, Farrell SA, Sirkin WL, Velsher L, Krakowiak PA, Waye JS, Porter FD: Smith-Lemli-Opitz (RHS) syndrome: holoprosencephaly and homozygous IVS8-1G->C genotype. Am J Med Genet 2001; 103: 75-80.
17. Edison RJ, Berg K, Remaley A, Kelley R, Rotimi C, Stevenson RE, Muenke M: Adverse birth outcome among mothers with low serum cholesterol. Pediatrics 2007; 120: 723-733.
18. Mueckler M, Thorens B: The SLC2 (GLUT) family of membrane transporters. Mol Aspects Med 2013; 34: 121-138.
19. Jansson T, Wennergren M, Illsley NP: Glucose transporter protein expression in human placenta throughout gestation and in intrauterine growth retardation. J Clin Endocrinol Metab 1993; 77: 1554-1562.
20. Baumann MU, Schneider H, Malek A, Palta V, Surbek DV, Sager R, Zamudio S, Illsley NP: Regulation of human trophoblast GLUT1 glucose transporter by insulin-like growth factor I (IGF-I). PLoS One 2014; 9:e106037.
21. Baumann NA, Sullivan DP, Ohvo-Rekila H, Simonot C, Pottekat A, Klaassen Z, Beh CT, Menon AK: Transport of newly synthesized sterol to the sterol-enriched plasma membrane occurs via nonvesicular equilibration. Biochemistry 2005; 44: 5816-5826.
22. Liu B, Xu Y, Zhang Y, Cai J, Deng L, Yang J, Zhou Y, Long Y, Zhang J, Wang Z: Early diagnosis of gestational diabetes mellitus (EDoGDM) study: a protocol for a prospective, longitudinal cohort study. BMJ Open 2016; 6:e012315.
23. Mennitti LV, Oliveira JL, Morais CA, Estadella D, Oyama LM, Oller do Nascimento CM, Pisani LP: Type of fatty acids in maternal diets during pregnancy and/or lactation and metabolic consequences of the offspring. J Nutr Biochem 2015; 26: 99-111.
24. Mccoy MG, Sun GS, Marchadier D, Maugeais C, Glick JM, Rader DJ: Characterization of the lipolytic activity of endothelial lipase. J Lipid Res 2002; 43: 921-929.
25. Gauster M, Hiden U, Blaschitz A, Frank S, Lang U, Alvino G, Cetin I, Desoye G, Wadsack C: Dysregulation of placental endothelial lipase and lipoprotein lipase in intrauterine growth-restricted pregnancies. J Clin Endocrinol Metab 2007; 92: 2256-2263.
26. Kazantzis M, Stahl A: Fatty acid transport proteins, implications in physiology and disease. Biochim Biophys Acta 2012; 1821: 852-857.
27. Larque E, Demmelmair H, Klingler M, De Jonge S, Bondy B, Koletzko B: Expression pattern of fatty acid transport protein-1 (FATP-1), FATP-4 and heart-fatty acid binding protein (H-FABP) genes in human term placenta. Early Hum Dev 2006; 82: 697-701.
28. Lager S, Powell TL: Regulation of nutrient transport across the placenta. J Pregnancy 2012; 2012: 179827.
29. Dietschy JM, Turley SD, Spady DK: Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans. J Lipid Res 1993; 34: 1637-1659.
30. De Groot LJ: Fetal and neonatal cholesterol metabolism; in De Groot LJ, Chrousos G, Dungan K, Feingold KR, Grossman A, Hershman JM, Koch C, Korbonits M, McLachlan R, New M, Purnell J, Rebar R, Singer F, Vinik A (eds): Endotext [Internet]. South Dartmouth, MDText.com, Inc., 2000-2016.
31. Weaver DD, Solomon BD, Akin-Samson K, Kelley RI, Muenke M: Cyclopia (synophthalmia) in Smith-Lemli-Opitz syndrome: first reported case and consideration of mechanism. Am J Med Genet C Semin Med Genet 2010; 154C: 142-145.
32. Wadsack C, Hammer A, Levak-Frank S, Desoye G, Kozarsky KF, Hirschmugl B, Sattler W, Malle E: Selective cholesteryl ester uptake from high density lipoprotein by human first trimester and term villous trophoblast cells. Placenta 2003; 24: 131-143.
33. Mahley RW, Rall SC Jr: Apolipoprotein E: far more than a lipid transport protein. Annu Rev Genomics Hum Genet 2000; 1: 507-537.
34. Witsch-Baumgartner M, Gruber M, Kraft HG, Rossi M, Clayton P, Giros M, Haas D, Kelley RI, Krajewska-Walasek M, Utermann G: Maternal apo E genotype is a modifier of the Smith-Lemli-Opitz syndrome. J Med Genet 2004; 41: 577-584.
35. Madsen EM, Lindegaard ML, Andersen CB, Damm P, Nielsen LB: Human placenta secretes apolipoprotein B-100-containing lipoproteins. J Biol Chem 2004; 279: 55271-55276.
36. Lanthaler B, Steichen-Gersdorf E, Kollerits B, Zschocke J, Witsch-Baumgartner M: Maternal ABCA1 genotype is associated with severity of Smith-Lemli-Opitz syndrome and with viability of patients homozygous for null mutations. Eur J Hum Genet 2013; 21: 286-293.
37. Yeşilkaya E, Karaer K, Bideci A, Camurdan O, Perçin EF, Cinaz P: Dubowitz syndrome: a cholesterol metabolism disorder? Genet Couns 2008;19:287-290.
38. Alonso De La Torre SR, Serrano MA, Medina JM: Carrier-mediated beta-D-hydroxybutyrate transport in brush-border membrane vesicles from rat placenta. Pediatr Res 1992; 32: 317-323.
39. Ville D, Chiron C, Laschet J, Dulac O: The ketogenic diet can be used successfully in combination with corticosteroids for epileptic encephalopathies. Epilepsy Behav 2015; 48: 61-65.
40. Tatone EH, Duffield TF, Capel MB, DeVries TJ, LeBlanc SJ, Gordon JL: A randomized controlled trial of dexamethasone as an adjunctive therapy to propylene glycol for treatment of hyperketonemia in postpartum dairy cattle. J Dairy Sci 2016; 99: 8991-9000.
41. Jansson T: Amino acid transporters in the human placenta. Pediatr Res 2001; 49: 141-147.
42. Zhang L, Song X, Zhou L, Liang G, Xu H, Wang F, Huang F, Jiang G: Accumulation of intestinal tissue 3-deoxyglucosone attenuated GLP-1 secretion and its insulinotropic effect in rats. Diabetol Metab Syndr 2016; 8: 78.
43. Catalano PM, Hoegh M, Minium J, Huston-Presley L, Bernard S, Kalhan S, Hauguel-De Mouzon S: Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism. Diabetologia 2006; 49: 1677-1685.
44. Godsland IF: Effects of postmenopausal hormone replacement therapy on lipid, lipoprotein, and apolipoprotein (A) concentrations: analysis of studies published from 1974-2000. Fertil Steril 2001; 75: 898-915.
45. Calan OG, Akan P, Cataler A, Dogan C, Kocturk S: Amyloid beta peptides affect pregnenolone and pregnenolone sulfate levels in PC-12 and SH-SY5Y cells depending on cholesterol. Neurochem Res 2016; 41: 1700-1712.
46. Xue W, Deng Y, Wang YF, Sun AJ: Effect of half-dose and standard-dose conjugated equine estrogens combined with natural progesterone or dydrogesterone on components of metabolic syndrome in healthy postmenopausal women: a randomized controlled trial. Chin Med J (Engl) 2016; 129: 2773-2779.
47. Newbern D, Freemark M: Placental hormones and the control of maternal metabolism and fetal growth. Curr Opin Endocrinol Diabetes Obes 2011; 18: 409-416.
48. Sitruk-Ware R: Progestins and cardiovascular risk markers. Steroids 2000; 65: 651-658.
49. Wu Z, Bidlingmaier M, Friess SC, Kirk SE, Buchinger P, Schiessl B, Strasburger CJ: A new nonisotopic, highly sensitive assay for the measurement of human placental growth hormone: development and clinical implications. J Clin Endocrinol Metab 2003; 88: 804-811.
50. Barbour LA, Mccurdy CE, Hernandez TL, Kirwan JP, Catalano PM, Friedman JE: Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes. Diabetes Care 2007; 30(suppl 2): S112-S119.
51. Skvarca A, Tomazic M, Blagus R, Krhin B, Janez A: Adiponectin/leptin ratio and insulin resistance in pregnancy. J Int Med Res 2013; 41: 123-128.
52. Zhang EE, Liu Y, Dentin R, Pongsawakul PY, Liu AC, Hirota T, Nusinow DA, Sun X, Landais S, Kodama Y, Brenner DA, Montminy M, Kay SA: Cryptochrome mediates circadian regulation of camp signaling and hepatic gluconeogenesis. Nat Med 2010; 16: 1152-1156.
53. Kirwan JP, Hauguel-De Mouzon S, Lepercq J, Challier JC, Huston-Presley L, Friedman JE, Kalhan SC, Catalano PM: TNF-alpha is a predictor of insulin resistance in human pregnancy. Diabetes 2002; 51: 2207-2213.
54. Cseh K, Winkler G, Melczer Z, Baranyi E: The role of tumour necrosis factor (TNF)-alpha resistance in obesity and insulin resistance. Diabetologia 2000; 43: 525.
55. Shao J, Catalano PM, Yamashita H, Ruyter I, Smith S, Youngren J, Friedman JE: Decreased insulin receptor tyrosine kinase activity and plasma cell membrane glycoprotein-1 overexpression in skeletal muscle from obese women with gestational diabetes mellitus (GDM): evidence for increased serine/threonine phosphorylation in pregnancy and GDM. Diabetes 2000; 49: 603-610.