Behavioral improvements in a valproic acid rat model of autism following vitamin D supplementation

Psychiatry Research

Volumn 253, Issue , 2017, Pages 28-32

  Du, Lin ^a   Zhao, Guolian ^a   Duan, Zipeng ^a   Li, Fan ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

Autism; Behavior; Rat; Valproic acid; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; SODIUM CHLORIDE; VALPROIC ACID; VITAMIN D; 25-HYDROXYVITAMIN D; TRANQUILIZER;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTISM; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG RESPONSE; EXPERIMENTAL TEST; FEMALE; GROOMING; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; NEWBORN; NONHUMAN; OLFACTORY DISHABITUATION; OLFACTORY HABITUATION; PERINATAL PERIOD; PRENATAL EXPOSURE; RAT; SINGLE DRUG DOSE; SMELLING; SOCIAL INTERACTION; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; CHEMICALLY INDUCED; DIETARY SUPPLEMENT; DISEASE MODEL; DRUG EFFECTS; HUMAN RELATION; ODOR; PREGNANCY; SOCIAL BEHAVIOR; TANDEM MASS SPECTROMETRY; WISTAR RAT;

ANIMALS; ANTIMANIC AGENTS; AUTISTIC DISORDER; BEHAVIOR, ANIMAL; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; FEMALE; INTERPERSONAL RELATIONS; MALE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, WISTAR; SMELL; SOCIAL BEHAVIOR; TANDEM MASS SPECTROMETRY; VALPROIC ACID; VITAMIN D;

EID: 85015444513     PISSN: 01651781     EISSN: 18727123     Source Type: Journal    
DOI: 10.1016/j.psychres.2017.03.003     Document Type: Article

References (35)

1. Baird, G., Simonoff, E., Pickles, A., Chandler, S., Loucas, T., Meldrum, D., et al. Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special needs and Autism Project (SNAP). Lancet 368 (2006), 210–215.
2. Bolivar, V.J., Walters, S.R., Phoenix, J.L., Assessing autism-like behavior in mice: variations in social interactions among inbred strains. Behav. Brain Res. 176 (2007), 21–26.
3. Bromley, R.L., Mawer, G., Clayton-Smith, J., Baker, G.A., Liverpool and Manchester Neurodevelopment Group, Autism spectrum disorders following in utero exposure to antiepileptic drugs. Neurology 71 (2008), 1923–1924.
4. Bromley, R.L., Mawer, G.E., Briggs, M., Cheyne, C., Clayton-Smith, J., Garcia-Finana, M., et al. The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs. J. Neurol. Neurosurg. Psychiatry 84 (2013), 637–643.
5. Brugha, T.S., McManus, S., Bankart, J., Scott, F., Purdon, S., Smith, J., et al. Epidemiology of autism spectrum disorders in adults in the community in England. Arch. Gen. Psychiatry 68 (2011), 459–465.
6. Christianson, A.L., Chesler, N., Kromberg, J.G., Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs. Dev. Med. Child Neurol. 36 (1994), 361–369.
7. Currenti, S.A., Understanding and determining the etiology of autism. Cell Mol. Neurobiol. 30 (2010), 161–171.
8. DeLuca, H.F., Is there more to learn about functional vitamin D metabolism*. J. Steroid Biochem. Mol. Biol. 148 (2015), 3–6.
9. Feng, J., Shan, L., Du, L., Wang, B., Li, H., Wang, W., Clinical improvement following vitamin D3 supplementation in autism spectrum disorder. Nutr Neurosci., 2016 (Epub).
10. Fernell, E., Bejerot, S., Westerlund, J., Miniscalco, C., Simila, H., Eyles, D., et al. Autism spectrum disorder and low vitamin D at birth: a sibling control study. Mol. Autism, 6, 2015, 3.
11. Foley, K.A., Ossenkopp, K.P., Kavaliers, M., Macfabe, D.F., Pre- and neonatal exposure to lipopolysaccharide or the enteric metabolite, propionic acid, alters development and behavior in adolescent rats in a sexually dimorphic manner. PLoS One, 9, 2014, e87072.
12. Glidden, D., Bouman, W.P., Jones, B.A., Arcelus, J., Gender dysphoria and autism spectrum disorder: a systematic review of the literature. Sex. Med. Rev. 4 (2016), 3–14.
13. Herscovitch, K., Dauletbaev, N., Lands, L.C., Vitamin D as an anti-microbial and anti-inflammatory therapy for Cystic Fibrosis. Paediatr. Respir. Rev. 15 (2014), 154–162.
14. Hollocks, M.J., Jones, C.R., Pickles, A., Baird, G., Happe, F., Charman, T., et al. The association between social cognition and executive functioning and symptoms of anxiety and depression in adolescents with autism spectrum disorders. Autism Res. 7 (2014), 216–228.
15. Iwata, K., Matsuzaki, H., Takei, N., Manabe, T., Mori, N., Animal models of autism: an epigenetic and environmental viewpoint. J. Cent. Nerv. Syst. Dis. 2 (2010), 37–44.
16. Jia, F., Wang, B., Shan, L., Xu, Z., Staal, W.G., Du, L., Core symptoms of autism improved after vitamin D supplementation. Pediatrics 135 (2015), e196–e198.
17. Komulainen, T., Lodge, T., Hinttala, R., Bolszak, M., Pietila, M., Koivunen, P., et al. Sodium valproate induces mitochondrial respiration dysfunction in HepG2 in vitro cell model. Toxicology 331 (2015), 47–56.
18. Lewis, M.H., Tanimura, Y., Lee, L.W., Bodfish, J.W., Animal models of restricted repetitive behavior in autism. Behav. Brain Res. 176 (2007), 66–74.
19. Löscher, W., Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy. CNS Drugs 16 (2002), 669–694.
20. Martin, H.G., Manzoni, O.J., Late onset deficits in synaptic plasticity in the valproic acid rat model of autism. Front. Cell Neurosci., 8, 2014, 23.
21. McGrath, J., Feron, F., Eyles, D., Mackay-Sim, A., Vitamin D: the neglected neurosteroid*. Trends Neurosci. 24 (2001), 570–572.
22. Phiel, C.J., Zhang, F., Huang, E.Y., Guenther, M.G., Lazar, M.A., Klein, P.S., Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J. Biol. Chem. 276 (2001), 36734–36741.
23. Ramagopalan, S.V., Heger, A., Berlanga, A.J., Maugeri, N.J., Lincoln, M.R., Burrell, A., et al. A chip-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Genome Res. 20 (2010), 1352–1360.
24. Saad, K., Abdel-Rahman, A.A., Elserogy, Y.M., Al-Atram, A.A., Cannell, J.J., Bjorklund, G., et al. Vitamin D status in autism spectrum disorders and the efficacy of vitamin D supplementation in autistic children. Nutr. Neurosci. 19 (2015), 346–351.
25. Sadamatsu, M., Kanai, H., Xu, X., Liu, Y., Kato, N., Review of animal models for autism: implication of thyroid hormone. Congenit. Anom. 46 (2006), 1–9.
26. Samuel, S., Sitrin, M.D., Vitamin D's role in cell proliferation and differentiation. Nutr. Rev. 66 (2008), S116–S124.
27. Schneider, T., Przewlocki, R., Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism. Neuropsychopharmacology 30 (2005), 80–89.
28. Scott, D.F., The History of Epileptic Therapy: An Account of How Medication was Developed. (1. publ. ed.), 1993, Parthenon Publ. Group, Carnforth u.a., 131 (ISBN 9781850703914).
29. Selim, M.E., Al-Ayadhi, L.Y., Possible ameliorative effect of breastfeeding and the uptake of human colostrum against coeliac disease in autistic rats. World J. Gastroenterol. 19 (2013), 3281–3290.
30. Semple, B.D., Blomgren, K., Gimlin, K., Ferriero, D.M., Noble-Haeusslein, L.J., Brain development in rodents and humans: identifying benchmarks of maturation and vulnerability to injury across species. Prog. Neurobiol. 106–107 (2013), 1–16.
31. Seuter, S., Heikkinen, S., Carlberg, C., Chromatin acetylation at transcription start sites and vitamin D receptor binding regions relates to effects of 1alpha, 25-dihydroxyvitamin D3 and histone deacetylase inhibitors on gene expression. Nucleic Acids Res. 41 (2013), 110–124.
32. Shirazi, H.A., Rasouli, J., Ciric, B., Rostami, A., Zhang, G.X., 1,25-Dihydroxyvitamin D3 enhances neural stem cell proliferation and oligodendrocyte differentiation. Exp. Mol. Pathol. 98 (2015), 240–245.
33. Stack, C.M., Lim, M.A., Cuasay, K., Stone, M.M., Seibert, K.M., Spivak-Pohis, I., et al. Deficits in social behavior and reversal learning are more prevalent in male offspring of VIP deficient female mice. Exp. Neurol. 211 (2008), 67–84.
34. Verrotti, A., Agostinelli, S., Parisi, P., Chiarelli, F., Coppola, G., Nonalcoholic fatty liver disease in adolescents receiving valproic acid. Epilepsy Behav. 20 (2011), 382–385.
35. Vinten, J., Bromley, R.L., Taylor, J., Adab, N., Kini, U., Baker, G.A., et al. The behavioral consequences of exposure to antiepileptic drugs in utero. Epilepsy Behav. 14 (2009), 197–201.