Gender Dysphoria and Autism Spectrum Disorder: A Systematic Review of the Literature

Sexual Medicine Reviews

Volumn 4, Issue 1, 2016, Pages 3-14

  Glidden, Derek ^a   Bouman, Walter Pierre ^a   Jones, Bethany A ^a,b   Arcelus, Jon ^a,c  

^a Nottingham Centre for Gender Dysphoria   (United Kingdom)

^b LOUGHBOROUGH UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Autism; Autism Spectrum Disorder; Gender Dysphoria; Systematic Review; Transgender; Transsexualism

Indexed keywords

AUTISM; CHILD BEHAVIOR; DISEASE ASSOCIATION; EVIDENCE BASED MEDICINE; GENDER DYSPHORIA; GENDER IDENTITY; HUMAN; MOTIVATION; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; REVIEW; SEX DIFFERENCE; SOCIAL COGNITION; SOCIAL INTERACTION; SYSTEMATIC REVIEW; TRANSGENDER; ADOLESCENT; COMORBIDITY; FEMALE; LITERATURE; MALE; PREVALENCE;

ADOLESCENT; AUTISM SPECTRUM DISORDER; COMORBIDITY; FEMALE; GENDER DYSPHORIA; GENDER IDENTITY; HUMANS; MALE; PREVALENCE; REVIEW LITERATURE AS TOPIC;

EID: 84979798857     PISSN: 20500513     EISSN: 20500521     Source Type: Journal    
DOI: 10.1016/j.sxmr.2015.10.003     Document Type: Review

References (72)

1. Diagnostic and statistical manual of mental disorders (fifth edition) 2013, American Psychiatric Association, American Psychiatric Association, Washington, DC.
2. Ahmad S., Barrett J., Beaini A.Y., Bouman W.P., Davies A., Greener H.M., et al. Gender dysphoria services: a guide for general practitioners and other healthcare staff. Sex Relation Ther 2013, 28:173.
3. Coleman E., Bockting W., Botzer M., Cohen-Kettenis P., DeCuypere G., Feldman J., et al. Standards of care for the health of transsexual, transgender, and gender-nonconforming people, version 7. Int J Transgend 2012, 13:165.
4. Wylie K., Barrett J., Besser M., Bouman W.P., Bridgman M., Clayton A., et al. Good practice guidelines for the assessment and treatment of adults with gender dysphoria. Sex Relation Ther 2012, 29:154.
5. The ICD-10 classification of mental and behaviour disorders 1992, World Health Organisation, World Health Organisation, Geneva. 10th ed.
6. Drescher J., Cohen-Kettenis P., Winter S. Minding the body: situating gender identity diagnoses in the ICD-11. Int Rev Psychiarty 2012, 24:568.
7. Diagnostic and statistical manual of mental disorders (fourth edition, text revision) 2000, American Psychiatric Association, American Psychiatric Association, Washington DC.
8. Wålinder J. Incidence and sex ratio of transsexualism in Sweden. Br J Psychiatry 1971, 119:195.
9. Tsoi W.F. The prevalence of transsexualism is Singapore. Acta Psychiatr Scand 1988, 78:501.
10. Zucker K.J., Lawrence A.A. Epidemiology of gender identity disorder: recommendations for standards of care for the World Professional Association for Transgender Health. Int J Transgend 2009, 11:8.
11. Arcelus J., Bouman W.P., Van De Noortgate W., Claes L., Witcomb G.L., Fernandez-Aranda F. Systematic review and meta-analysis of prevalence studies in transsexualism. Eur Psychiatry 2015, 30:807.
12. De Vries A.L., Noens I.L., Cohen-Kettenis P.T., van Berchelaer-Onnes I.A., Doreleijers T.A. Autism spectrum disorders in gender dysphoric children and adolescents. J Autism Dev Disord 2010, 40:930.
13. Jacobs L.A., Rachlin K., Erickson-Schroth L., Jansson A. Gender dysphoria and co-occurring autism spectrum disorders: review, case examples and treatment considerations. LGBT Health 2014, 1:277.
14. Van Caenegem E., Wierck K., Elaut E., Buysse A., Dewaele A., Van Nieuwerburgh F., et al. Prevalence of gender nonconformity in Flanders, Belgium. Arch Sex Behav 2015, 44:1281.
15. Bloomberg S.J., Bramlet M.D., Kogan M.D., Schieve L.A., Jones J.R., Lu M.C. Changes in prevalence of parent-reported autism spectrum disorder in school-aged U.S. children 2007-2012. Natl Health Stat Rep 2013, 65:1.
16. Pasterski V., Gilligan L., Curtis R. Traits of autism spectrum disorders in adults with gender dysphoria. Arch Sex Behav 2014, 43:387.
17. Robinow O. Paraphilia and transgenderism: a connection with Asperger's disorder?. Sexual Relation Ther 2009, 24:143.
18. Van Schalkwyk G.I., Klingensmith K., Volkmar F.R. Gender identity and autism spectrum disorders. Yale J Biol Med 2015, 88:81.
19. Wood E., Halder N. Gender disorders in learning disability-a systematic review. Tizard Learn Disabil Rev 2014, 19:158.
20. Moher D., Liberati A., Tetzlaff J., Altman D.G. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement. PLoS Med 2009, 6:e1000097. PRISMA Group.
21. Williams P.G., Allard A., Sears L. Case study: cross-gender preoccupations in two male children with autism. J Autism Dev Disord 1996, 26:635.
22. Landén M., Rasmussen P. Gender identity disorder in a girl with autism-a case report. Eur Child Adolesc Psychitry 1997, 6:170.
23. Mukaddes N.M. Gender identity problems in autistic children. Child Care Health Dev 2002, 24:529.
24. Perera H., Gadambanathan T., Weerasiri S. Gender identity disorder presenting in a girl with Asperger's disorder and obsessive compulsive disorder. Ceylon Med J 2003, 48:57.
25. Galluci G., Hackerman F., Schmidt C.W. Gender identity disorder in an adult male with Asperger's syndrome. Sex Disabil 2005, 23:35.
26. Lemaire M., Thomazeau B., Bonnet-Brilhault F. Gender identity disorder and autism spectrum disorder in a 23 year old female. Arch Sex Behav 2014, 43:395.
27. Kraemer B., Delsignore A., Gundelfinger R., Schnyder U., Hepp U. Comorbidity of Asperger syndrome and gender identity disorder. Eur Child Adolesc Psychiatry 2005, 14:292.
28. Abelson A.G. The development of gender identity in the autistic child. Child Care Health Dev 1981, 7:347.
29. VanderLaan D.P., Leef J.H., Wood H., Hughes S.K., Zucker K.J. Autism spectrum disorder risk factors and autistic traits in gender dysphoric children. J Autism Dev Disord 2015, 6:1742.
30. Kaltiala-Heino R., Sumia M., Työläjärvi M., Lindberg N. Two years of gender identity service for minors: overrepresentation of natal girls with severe problems in adolescent development. Child Adolesc Ment Health 2015, 9:9.
31. Jones R.M., Wheelwright S., Farrell K., Martin E., Green R., Di Ceglie D., et al. Brief report: female-to-male transsexual people and autistic traits. J Autism Dev Disord 2012, 42:301.
32. Bejerot S., Eriksson J.M. Sexuality and gender role in autism spectrum disorder: a case control study. PLoS One 2014, 9:1.
33. Skagerberg E., Di Ceglie D., Carmichael P. Brief report: autistic features in children and adolescents with gender dysphoria. J Autism Dev Disord 2015, 45:2628.
34. Constantino J.N., Gruber C.P. Social Responsiveness Scale (SRS) 2005, Western Psychological Services, Los Angeles, CA.
35. Di Ceglie D., Skagerberg E., Baron-Cohen S., Auyeung B. Empathising and systemising in adolescents with gender dysphoria. Opticon 2014, 16:1.
36. VanderLaan D.P., Postema L., Wood H., Singh D., Fantus S., Hyun J., et al. Do children with gender dysphoria have intense/obsessional interests?. J Sex Res 2015, 52:213.
37. Strang F.J., Kenworthy L., Dominska A., Sokoloff J., Kenealy E.L., Berl M., et al. Increased gender variance in autism spectrum disorders and attention deficit hyperactivity disorder. Arch Sex Behav 2014, 43:1525.
38. Paluszny M., Beit-Hallahmi B., Catford J.C., Cooley R., Dull C., Guiora A.Z. Gender identity and its measurement in young children. Compr Psychiat 1973, 14:281.
39. Gesell A., Halverson H.M., Thompson H., Ilg F.L., Costner B.M., Ames L.B., et al. The first five years of life: a guide to the study of the preschool child 1940, Harper, New York.
40. Zucker K.J., Bradley S.J. Gender identity disorder and psychosexual problems in children and adolescents 1995, Guilford, New York.
41. Cohen-Kettenis P., Pfäfflin F. Transgenderism and intersexuality in childhood and adolescence 2003, Sage, Thousand Oaks, CA.
42. Wallien M.S.C., Cohen-Kettenis P.T. Psychosexual outcomes of gender dysphoric children. J Am Acad Child Adolesc Psychiatry 2008, 47:1413.
43. Fombonne E. Epidemiology of autistic disorder and other pervasive developmental disorders. J Clin Psychiatry 2005, 66:3.
44. Wing L., Leekam S.R., Libby S.J., Gould J., Larcombe M. The diagnostic interview for social and communication disorders: background, inter-rater reliability and clinical use. J Child Psychol Psychiatry 2002, 43:307.
45. Le Couteur A., Rutter M., Lord C., Rios P., Robertson S., Holdgrafer M., et al. Autism Diagnostic Interview: a standardized investigator-based instrument. J Autism Dev Disord 1989, 19:363.
46. Lord C., Rutter M., Le Couteur A. Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 1994, 24:659.
47. Lord C., Rutter M., DiLavore P., Risi S. Autism Diagnostic Observation Schedule. ADOS Manual 2002, Western Psychological Services, Los Angeles.
48. Johnson L.L., Bradley S.J., Birkenfeld-Adams A.S., Kuksis M.A.R., Maing D.M., Mitchell J.N., et al. A parent-report gender identity questionnaire for children. Arch Sex Behav 2005, 33:105.
49. Wigham S., McConachie H., Tandos J., Le Couteur A. The reliability and validity of the Social Responsiveness Scale in a UK general child population. Res Dev Disabil 2012, 33:944. Gateshead Millennium Study Core Team.
50. Baron-Cohen S., Richler J., Bisarya D., Gurunathan N., Wheelwright S. The Autistic Spectrum Quotient (AQ): evidence from Asperger syndrome/high functioning autism, males and females, scientists and mathematicians. J Autism Dev Disord 2001, 31:5.
51. Wheelwright S., Baron-Cohen S., Goldenfield N., Delaney J., Fine D.R.S. Predicting autistic spectrum quotient from systemizing quotient-revised and empathy quotient. J Autism Dev Disord 2006, 1079:47.
52. Bem S. The measurement of psychological androgyny. J Consult Clin Psychol 1974, 42:155.
53. Baron-Cohen S. The extreme male brain theory of autism. Trend Cogn Sci 2002, 6:248.
54. Baron-Cohen S., Lombardo M.V., Auyeung B., Ashwin E., Chakrabarti B., Knickmeyer R. Why are autism spectrum conditions more prevalent in males?. PLoS Biol 2011, 9:e1001081.
55. Baron-Cohen S., Cassidy S., Auyeung B., Allison C., Achoukhi M., Robertson S., et al. Attenuation of typical sex differences in 800 adults with autism vs. 3,900 controls. PLoS One 2014, 9:e102251.
56. Auyeung B., Baron-Cohen S., Ashwin E., Knickmeyer R., Taylor K., Hackett G. Fetal testosterone and autistic traits. Br J Psychol 2009, 100:1.
57. Baron-Cohen S., Lutchmaya S., Knickmeyer R.C. Prenatal testosterone in mind: amniotic fluid studies 2004, MIT Press, Cambridge, MA.
58. Knickmeyer R., Baron-Cohen S., Raggatt P., Taylor K., Hackett G. Fetal testosterone and empathy. Horm Behav 2006, 49:282.
59. Geier A.D., Geier R.M. A prospective assessment of androgen levels in patients with autistic spectrum disorders: biochemical underpinnings and suggested therapies. Neuroendocrinol Lett 2007, 28:565.
60. Ingudomnukul E., Baron-Cohen S., Wheelwright S., Knickmeyer R. Elevated rates of testosterone-related disorders in women with autism spectrum conditions. Horm Behav 2007, 51:597.
61. Cohen-Kettenis P.T. Gender change in 46,XY persons with 5α-reductase-2 deficiency and 17β-hydroxysteroid dehydrogenase-3 deficiency. Arch Sex Behav 2005, 34:399.
62. Dessens A.B., Slijper F.M.E., Drop S.L.S. Gender dysphoria and gender change in chromosomal females with congenital adrenal hyperplasia. Arch Sex Behav 2005, 34:389.
63. Mazur T. Gender dysphoria and gender change in androgen insensitivity or micropenis. Arch Sex Behav 2005, 34:411.
64. Meyer-Bahlburg H.F.L. Gender identity outcome in female-raised 46,XY persons with penile agenesis, cloacal exstrophy of the bladder, or penile ablation. Arch Sex Behav 2005, 34:423.
65. Grandin T. Thinking in pictures 1996, Vintage Books, Vancouver, WA.
66. Fonagy P., Target M. Early intervention and the development of self-regulation. Psychoanal Inq 2002, 22:307.
67. Baron-Cohen S. Theory of mind and autism: a fifteen year review. Understanding other minds: perspectives from developmental cognitive neuroscience 2000, 3-30. Oxford University Press, New York. 2nd ed. S. Baron-Cohen, H. Tager-Flusberg, D.J. Cohen (Eds.).
68. Coates S. Developmental research on childhood gender identity disorder. Identity, gender and sexuality, 150 years after Freud 2006, International Psychoanalytic Association, London. P. Fonagy, R. Krause, B. Leutzinger (Eds.).
69. Zucker KJ, Leef JH, Wood H, Hughes SK, Wasserman L, Vanderlaan DP. LinkedIn? On the relation between gender dysphoria and traits of autism spectrum disorder in children. Paper presented at the International Academy of Sex Research. August 2015; Toronto, Canada.
70. Aitken M., Steensma T.D., Blanchard R., VanderLaan D.P., Wood H., Fuentes A., et al. Evidence for an altered sex ratio in clinic-referred adolescents with gender dysphoria. J Sex Med 2015, 12:756.
71. De Vries ALC, Kreukels BPC, T'Sjoen G, Ålgars M, Mattila A. Increase of referrals to gender identity clinics: a European trend? In: Transgender Healthcare in Europe. Book of Abstracts. Ghent, Belgium: European Professional Association of Transgender Health (EPATH); 2015. p. 10. Accessed April 8, 2015. http://epath.eu/wp-content/uploads/2014/07/EPATH-2015-Book-of-Abstracts.pdf.
72. Keuzenkamp S., Kuyper L. Acceptance of LGBT individuals in the Netherlands 2013 2013, The Netherlands Institute of Social Research (ED), The Hague.