Hypersensitive termination of the hypoxic response by a disordered protein switch

Nature

Volumn 543, Issue 7645, 2017, Pages 447-451

  Berlow, Rebecca B ^a   Dyson, H Jane ^a   Wright, Peter E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

E1A ASSOCIATED P300 PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTRINSICALLY DISORDERED PROTEIN; PROTEIN; PROTEIN CITED2; PROTEIN TAZ1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; CITED2 PROTEIN, HUMAN; HIF1A PROTEIN, HUMAN; HISTONE ACETYLTRANSFERASE PCAF; OXYGEN; PROTEIN BINDING; REPRESSOR PROTEIN; TRANSACTIVATOR PROTEIN;

CELLS AND CELL COMPONENTS; CYTOLOGY; GENE EXPRESSION; HYPOXIA; OXYGEN; PHYSIOLOGICAL RESPONSE; PROTEIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; GENE EXPRESSION; HYPOXIA; MOLECULAR MECHANICS; NEGATIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN SECRETION; TRANSCRIPTION INITIATION; ALLOSTERISM; AMINO ACID SEQUENCE; BINDING COMPETITION; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGICAL FEEDBACK; PROTEIN DOMAIN; PROTEIN MOTIF;

ALLOSTERIC REGULATION; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING, COMPETITIVE; FEEDBACK, PHYSIOLOGICAL; HUMANS; HYPOXIA; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTRINSICALLY DISORDERED PROTEINS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; OXYGEN; P300-CBP TRANSCRIPTION FACTORS; PROTEIN BINDING; PROTEIN DOMAINS; REPRESSOR PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTIONAL ACTIVATION;

EID: 85015440189     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature21705     Document Type: Article

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