White matter repair after extracellular vesicles administration in an experimental animal model of subcortical stroke

Scientific Reports

Volumn 7, Issue , 2017, Pages

  Otero Ortega, Laura ^a   Laso García, Fernando ^a   Del Carmen Gómez De Frutos, María ^a   Rodríguez Frutos, Berta ^a   Pascual Guerra, Jorge ^a   Fuentes, Blanca ^a   Díez Tejedor, Exuperio ^a   Gutiérrez Fernández, María ^a  

^a HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CALCIUM BINDING PROTEIN; CD81 ANTIGEN; CD81 PROTEIN, RAT; NERVE PROTEIN; PDCD6IP PROTEIN, RAT; PROTEOME;

ANIMAL; AXON; BRAIN; CEREBROVASCULAR ACCIDENT; CHEMISTRY; CONNECTOME; CONVALESCENCE; DISEASE MODEL; EXOSOME; GENE EXPRESSION REGULATION; GENETICS; INTRAVENOUS DRUG ADMINISTRATION; MALE; MESENCHYMAL STROMA CELL; METABOLISM; NERVE CELL PLASTICITY; NERVE REGENERATION; PATHOLOGY; PHYSIOLOGY; RAT; SECRETION (PROCESS); SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION; TRANSPLANTATION; ULTRASTRUCTURE; WHITE MATTER;

ANIMALS; AXONS; BIOMARKERS; BRAIN; CALCIUM-BINDING PROTEINS; CONNECTOME; DISEASE MODELS, ANIMAL; EXTRACELLULAR VESICLES; GENE EXPRESSION REGULATION; INJECTIONS, INTRAVENOUS; MALE; MESENCHYMAL STROMAL CELLS; NERVE REGENERATION; NERVE TISSUE PROTEINS; NEURONAL PLASTICITY; PROTEOME; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; STROKE; TETRASPANIN 28; TISSUE DISTRIBUTION; WHITE MATTER;

EID: 85015433259     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep44433     Document Type: Article

References (36)

1. Sozmen, E. G., Kolekar, A., Havton, L. A., & Carmichael, S. T. A white matter stroke model in the mouse: axonal damage, progenitor responses and MRI correlates. J Neurosci Methods. 180, 261-72 (2009
2. Matute, C., Domercq, M., Perez-Samartin, A., & Ransom, B. R. Protecting white matter from stroke injury. Stroke. 44, 1204-1211 (2013
3. Leu, S. et al. Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats. J Transl Med. 8, 63 (2010
4. Gutierrez-Fernandez, M. et al. Comparison between xenogeneic and allogeneic adipose mesenchymal stem cells in the treatment of acute cerebral infarct: proof of concept in rats. J Transl Med. 1, 13: 46 (2015
5. Otero-Ortega, L. et al. White matter injury restoration after stem cell administration in subcortical ischemic stroke. Stem Cell Res Ther. 6, 121 (2015
6. Gutierrez-Fernandez, M. et al. Functional recovery after hematic administration of allogenic mesenchymal stem cells in acute ischemic stroke in rats. Neuroscience. 175, 394-405 (2011
7. Doeppner, T. R. et al. EVs improve post-stroke neuroregeneration and prevent postischemic immunosuppression. Stem Cells Transl Med. 4, 1131-43 (2015
8. Xu, W., Yang, Z., & Lu, N. From pathogenesis to clinical application: insights into EVs as transfer vectors in cancer. J Exp Clin Cancer Res. 35, 156 (2016
9. Marote, A., Teixeira, F. G., Mendes-Pinheiro, B., & Salgado, A. J. MSC-Derived EVs: Cell-Secreted Nanovesicles with Regenerative Potential. Front Pharmacol. 7, 231 (2016
10. Lee, M. et al. Adipose-derived stem cell EVs alleviate pathology of amyotrophic lateral sclerosis in vitro. Biochem Biophys Res Commun. In press (2016
11. Xin, H. et al. MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of EVs-enriched extracellular particles. Stem Cells. 31, 2737-46 (2013
12. Guihong, Li. et al. Bone marrow mesenchymal stem cell therapy in ischemic stroke: mechanisms of action and treatment optimization strategies. Neural Regen Res. 6, 1015-1024 (2016
13. Eckert, A M. et al. Evidence for high translational potential of mesenchymal stromal cell therapy to improve recovery from ischemic stroke J Cereb Blood Flow Metab. 9, 1322-1334 (2013
14. Walker, P. A. et al. Bone marrow-derived stromal cell therapy for traumatic brain injury is neuroprotective via stimulation of nonneurologic organ systems. Surgery. 152, 790-3 (2012
15. Suzuki, E. et al. Stem cell-derived EVs as a therapeutic tool for cardiovascular disease. World J Stem Cells. 8, 297-305 (2016
16. Beer, L., Mildner, M., Gyongyosi, M., & Ankersmit, H. J. Peripheral blood mononuclear cell secretome for tissue repair. Apoptosis. In press (2016
17. Hu, L. et al. EVs derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts. Sci Rep. In press (2016
18. Chen, T. et al. Porcine milk-derived EVs promote proliferation of intestinal epithelial cells. Sci Rep. 6, 33862 (2016
19. Ellwanger, J. H. et al. EVs are possibly used as a tool of immune regulation during the dendritic cell-based immune therapyagainst HIV-I. Med Hypotheses. 95, 67-70 (2016
20. Xin, H. et al. EVs-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth. Stem Cells. 30, 1556-64 (2012
21. Zhang, Y. et al. Effect of EVs derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury. J Neurosurg. 122, 856-67 (2015
22. Xin, H., Li, Y., Cui, Y., Yang, J. J., Zhang, Z. G., & Chopp, M. Systemic administration of EVs released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats. J Cereb Blood Flow Metab. 33, 1711-5 (2013
23. Zhang, Y. et al. 5Systemic administration of cell-free EVs generated by human bone marrow derived mesenchymal stem cells cultured under 2D and 3D conditions improves functional recovery in rats after traumatic brain injury. Neurochem Int. In press (2016
24. Ramos-Cejudo, J. et al. Brain-derived neurotrophic factor administration mediated oligodendrocyte differentiation and myelin formation in subcortical ischemic stroke. Stroke. 46, 221-8 (2015
25. Rodriguez-Frutos, B. et al. Enhanced brain-derived neurotrophic factor delivery by ultrasound and microbubbles promotes white matter repair after stroke. Biomaterials. 100, 41-52 (2016
26. Baracskay, K. L. et al. NG2-positive cells generate A2B5-positive oligodendrocyte precursor cells. Glia. 55, 1001-1010 (2007
27. Back, S. A., Riddle, A., & McClure, M. M. Maturation-dependent vulnerability of perinatal white matter in premature birth. Stroke. 38, 724-30 (2007
28. Kalani, A., Chaturvedi, P., Kamat, P. K., Maldonado, C., Bauer, P., Joshua, I. G., Tyagi, S. C., & Tyagi, N. Curcumin-loaded embryonic stem cell EVs restored neurovascular unit following ischemia-reperfusion injury. Int J Biochem Cell Biol. 79: 360-369 (2016
29. Stroke Therapy Academic Industry Roundtable (STAIR). Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke. 12, 2752-8 (1999
30. Lapchak, P. A., Zhang, J. H., & Noble-Haeusslein, L. J. RIGOR guidelines: escalating STAIR and STEPS for effective translational research. Transl Stroke Res. 4, 279-85 (2013
31. Rogers, D. C., Campbell, C. A., Stretton, J. L., & Mackay, K. B. Correlation between motor impairment and infarct volume after permanent and transient middle cerebral artery occlusion in the rat. Stroke 28, 2060-2065 (1997
32. Sozmen, E. G., Hinman, J. D., & Carmichael, S. T. Models that matter: white matter stroke models. Neurotherapeutics. 9, 349-58 (2012
33. Barratt, H. E., Lanman, T. A., & Carmichael, S. T. Mouse intracerebral hemorrhage models produce different degrees of initial and delayed damage, axonal sprouting, and recovery. J Cereb Blood Flow Metab. 9, 1463-71 (2014
34. Wi?niewski, J. R., Zougman, A., Nagaraj, N., & Mann, M. Universal sample preparation method for proteome analysis. Nat Methods 5, 359-362 (2009
35. Navarro, P. et al. General Statistical framework for quantitative proteomics by stable isotope labeling. J Proteome Res. 3, 1234-1247 (2014
36. Eden, E. et al. GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists. BMC Bioinformatics. 10-48 (2009