메뉴 건너뛰기




Volumn 355, Issue 6330, 2017, Pages

An adipo-biliary-uridine axis that regulates energy homeostasis

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; GLUCOSE; URIDINE; GLUCOSE BLOOD LEVEL; LEPTIN;

EID: 85015341564     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf5375     Document Type: Article
Times cited : (104)

References (47)
  • 1
    • 0032992733 scopus 로고    scopus 로고
    • Uridine and its nucleotides: Biological actions, therapeutic potentials
    • pmid: 10354618
    • G. P. Connolly, J. A. Duley, Uridine and its nucleotides: Biological actions, therapeutic potentials. Trends Pharmacol. Sci. 20, 218-225 (1999). doi: 10.1016/S0165-6147(99)01298-5; pmid: 10354618
    • (1999) Trends Pharmacol. Sci. , vol.20 , pp. 218-225
    • Connolly, G.P.1    Duley, J.A.2
  • 2
    • 79960620585 scopus 로고    scopus 로고
    • Biochemistry of uridine in plasma
    • pmid: 21689643
    • T. Yamamoto et al., Biochemistry of uridine in plasma. Clin. Chim. Acta 412, 1712-1724 (2011). doi: 10.1016/j.cca.2011.06.006; pmid: 21689643
    • (2011) Clin. Chim. Acta , vol.412 , pp. 1712-1724
    • Yamamoto, T.1
  • 3
    • 0037130273 scopus 로고    scopus 로고
    • Homeostatic control of uridine and the role of uridine phosphorylase: A biological and clinical update
    • pmid: 12084455
    • G. Pizzorno et al., Homeostatic control of uridine and the role of uridine phosphorylase: A biological and clinical update. Biochim. Biophys. Acta 1587, 133-144 (2002). doi: 10.1016/S0925-4439(02)00076-5; pmid: 12084455
    • (2002) Biochim. Biophys. Acta , vol.1587 , pp. 133-144
    • Pizzorno, G.1
  • 4
    • 0019519002 scopus 로고
    • Novel single-pass exchange of circulating uridine in rat liver
    • pmid: 7256279
    • T. Gasser, J. D. Moyer, R. E. Handschumacher, Novel single-pass exchange of circulating uridine in rat liver. Science 213, 777-778 (1981). doi: 10.1126/science.7256279; pmid: 7256279
    • (1981) Science , vol.213 , pp. 777-778
    • Gasser, T.1    Moyer, J.D.2    Handschumacher, R.E.3
  • 5
    • 0031745059 scopus 로고    scopus 로고
    • Discrete roles of hepatocytes and nonparenchymal cells in uridine catabolism as a component of its homeostasis
    • pmid: 9696700
    • M. P. Liu, L. Beigelman, E. Levy, R. E. Handschumacher, G. Pizzorno, Discrete roles of hepatocytes and nonparenchymal cells in uridine catabolism as a component of its homeostasis. Am. J. Physiol. 274, G1018-G1023 (1998). pmid: 9696700
    • (1998) Am. J. Physiol. , vol.274 , pp. G1018-G1023
    • Liu, M.P.1    Beigelman, L.2    Levy, E.3    Handschumacher, R.E.4    Pizzorno, G.5
  • 6
    • 0029930340 scopus 로고    scopus 로고
    • Pyrimidines and CNS regulation
    • pmid: 8936346
    • G. P. Connolly, H. A. Simmonds, J. A. Duley, Pyrimidines and CNS regulation. Trends Pharmacol. Sci. 17, 106-107 (1996). doi: 10.1016/0165-6147(96)20001-X; pmid: 8936346
    • (1996) Trends Pharmacol. Sci. , vol.17 , pp. 106-107
    • Connolly, G.P.1    Simmonds, H.A.2    Duley, J.A.3
  • 7
    • 84958212031 scopus 로고    scopus 로고
    • Chronic uridine administration induces fatty liver and pre-diabetic conditions in mice
    • pmid: 26789264
    • Y. Urasaki, G. Pizzorno, T. T. Le, Chronic uridine administration induces fatty liver and pre-diabetic conditions in mice. PLOS ONE 11, e0146994 (2016). doi: 10.1371/journal.pone.0146994; pmid: 26789264
    • (2016) PLOS ONE , vol.11 , pp. e0146994
    • Urasaki, Y.1    Pizzorno, G.2    Le, T.T.3
  • 8
    • 0023626609 scopus 로고
    • Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites
    • pmid:3664929
    • G. J. Peters et al., Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites. Cancer Chemother. Pharmacol. 20, 101-108 (1987). doi: 10.1007/BF00253962; pmid:3664929
    • (1987) Cancer Chemother. Pharmacol. , vol.20 , pp. 101-108
    • Peters, G.J.1
  • 9
    • 0023216368 scopus 로고
    • Effect of pyrimidine nucleosides on body temperatures of man and rabbit in relation to pharmacokinetic data
    • pmid: 3151015
    • G. J. Peters et al., Effect of pyrimidine nucleosides on body temperatures of man and rabbit in relation to pharmacokinetic data. Pharm. Res. 4, 113-119 (1987). doi: 10.1023/A:1016410817898; pmid: 3151015
    • (1987) Pharm. Res. , vol.4 , pp. 113-119
    • Peters, G.J.1
  • 10
    • 84941360332 scopus 로고    scopus 로고
    • Hypothalamic UDP increases in obesity and promotes feeding via P2Y6-dependent activation of AgRP neurons
    • pmid: 26359991
    • S. M. Steculorum et al., Hypothalamic UDP increases in obesity and promotes feeding via P2Y6-dependent activation of AgRP neurons. Cell 162, 1404-1417 (2015). doi: 10.1016/j.cell.2015.08.032; pmid: 26359991
    • (2015) Cell , vol.162 , pp. 1404-1417
    • Steculorum, S.M.1
  • 11
    • 84984564001 scopus 로고    scopus 로고
    • Is increased antidepressant exposure a contributory factor to the obesity pandemic?
    • pmid: 26978741
    • S. H. Lee, G. Paz-Filho, C. Mastronardi, J. Licinio, M. L. Wong, Is increased antidepressant exposure a contributory factor to the obesity pandemic? Transl. Psychiatry 6, e759 (2016). doi: 10.1038/tp.2016.25; pmid: 26978741
    • (2016) Transl. Psychiatry , vol.6 , pp. e759
    • Lee, S.H.1    Paz-Filho, G.2    Mastronardi, C.3    Licinio, J.4    Wong, M.L.5
  • 13
    • 0033405291 scopus 로고    scopus 로고
    • Torpor in mice is induced by both leptin-dependent and -independent mechanisms
    • pmid: 10588755
    • O. Gavrilova et al., Torpor in mice is induced by both leptin-dependent and -independent mechanisms. Proc. Natl. Acad. Sci. U.S.A. 96, 14623-14628 (1999). doi: 10.1073/pnas.96.25.14623; pmid: 10588755
    • (1999) Proc. Natl. Acad. Sci. U.S.A , vol.96 , pp. 14623-14628
    • Gavrilova, O.1
  • 14
    • 0015151785 scopus 로고
    • Aspartate transcarbamylase. Interaction with the transition state analogue N-(phosphonacetyl)-L-aspartate
    • pmid: 4943676
    • K. D. Collins, G. R. Stark, Aspartate transcarbamylase. Interaction with the transition state analogue N-(phosphonacetyl)-L-aspartate. J. Biol. Chem. 246, 6599-6605 (1971). pmid: 4943676
    • (1971) J. Biol. Chem. , vol.246 , pp. 6599-6605
    • Collins, K.D.1    Stark, G.R.2
  • 15
    • 0014896767 scopus 로고
    • Regulation of pyrimidine and arginine biosynthesis in mammals
    • pmid: 4941903
    • M. E. Jones, Regulation of pyrimidine and arginine biosynthesis in mammals. Adv. Enzyme Regul. 9, 19-49 (1970). doi: 10.1016/S0065-2571(71)80036-5; pmid: 4941903
    • (1970) Adv. Enzyme Regul , vol.9 , pp. 19-49
    • Jones, M.E.1
  • 16
    • 0028155759 scopus 로고
    • Potential adaptations to acute hypoxia: Hct, stress proteins, and set point for temperature regulation
    • pmid: 8203641
    • K. P. Mayfield, E. J. Hong, K. M. Carney, L. G. D'Alecy, Potential adaptations to acute hypoxia: Hct, stress proteins, and set point for temperature regulation. Am. J. Physiol. 266, R1615-R1622 (1994). pmid: 8203641
    • (1994) Am. J. Physiol. , vol.266 , pp. R1615-R1622
    • Mayfield, K.P.1    Hong, E.J.2    Carney, K.M.3    D'Alecy, L.G.4
  • 17
    • 0025248418 scopus 로고
    • Indirect calorimetry: Methodological and interpretative problems
    • pmid: 2180312
    • D. C. Simonson, R. A. DeFronzo, Indirect calorimetry: Methodological and interpretative problems. Am. J. Physiol. 258, E399-E412 (1990). pmid: 2180312
    • (1990) Am. J. Physiol. , vol.258 , pp. E399-E412
    • Simonson, D.C.1    DeFronzo, R.A.2
  • 18
    • 84856340680 scopus 로고    scopus 로고
    • The respiratory exchange ratio is associated with fitness indicators both in trained and untrained men: A possible application for people with reduced exercise tolerance
    • pmid: 21157516
    • A. Ramos-Jiménez et al., The respiratory exchange ratio is associated with fitness indicators both in trained and untrained men: A possible application for people with reduced exercise tolerance. Clin. Med. Circ. Respirat. Pulm. Med. 2, 1-9 (2008). pmid: 21157516
    • (2008) Clin. Med. Circ. Respirat. Pulm. Med. , vol.2 , pp. 1-9
    • Ramos-Jiménez, A.1
  • 19
    • 84903382613 scopus 로고    scopus 로고
    • Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding
    • pmid: 24880214
    • J. G. Kim et al., Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. Nat. Neurosci. 17, 908-910 (2014). doi: 10.1038/nn.3725; pmid: 24880214
    • (2014) Nat. Neurosci , vol.17 , pp. 908-910
    • Kim, J.G.1
  • 20
    • 0023020613 scopus 로고
    • Caloric intake and sympathetic nervous system activity. Implications for blood pressure regulation and thermogenesis
    • pmid: 3531416
    • L. Landsberg, J. B. Young, Caloric intake and sympathetic nervous system activity. Implications for blood pressure regulation and thermogenesis. J. Clin. Hypertens. 2, 166-171 (1986). pmid: 3531416
    • (1986) J. Clin. Hypertens , vol.2 , pp. 166-171
    • Landsberg, L.1    Young, J.B.2
  • 21
    • 50649088582 scopus 로고    scopus 로고
    • Beta-aminoisobutyric acid prevents diet-induced obesity in mice with partial leptin deficiency
    • pmid: 19186330
    • K. Begriche et al., Beta-aminoisobutyric acid prevents diet-induced obesity in mice with partial leptin deficiency. Obesity 16, 2053-2067 (2008). doi: 10.1038/oby.2008.337; pmid: 19186330
    • (2008) Obesity , vol.16 , pp. 2053-2067
    • Begriche, K.1
  • 22
    • 0019483866 scopus 로고
    • Salvage of circulating pyrimidine nucleosides in the rat
    • pmid: 7248957
    • J. D. Moyer, J. T. Oliver, R. E. Handschumacher, Salvage of circulating pyrimidine nucleosides in the rat. Cancer Res. 41, 3010-3017 (1981). pmid: 7248957
    • (1981) Cancer Res. , vol.41 , pp. 3010-3017
    • Moyer, J.D.1    Oliver, J.T.2    Handschumacher, R.E.3
  • 23
    • 0015128127 scopus 로고
    • Rates of formation of blood-borne uridine and cytidine in dogs
    • pmid: 5570345
    • J. Tseng, J. Barelkovski, E. Gurpide, Rates of formation of blood-borne uridine and cytidine in dogs. Am. J. Physiol. 221, 869-878 (1971). pmid: 5570345
    • (1971) Am. J. Physiol. , vol.221 , pp. 869-878
    • Tseng, J.1    Barelkovski, J.2    Gurpide, E.3
  • 24
    • 0023729427 scopus 로고
    • Biochemistry and clinical activity of N-(phosphonacetyl)-L-aspartate: A review
    • pmid: 3293772
    • J. L. Grem, S. A. King, P. J. O'Dwyer, B. Leyland-Jones, Biochemistry and clinical activity of N-(phosphonacetyl)-L-aspartate: A review. Cancer Res. 48, 4441-4454 (1988). pmid: 3293772
    • (1988) Cancer Res. , vol.48 , pp. 4441-4454
    • Grem, J.L.1    King, S.A.2    O'Dwyer, P.J.3    Leyland-Jones, B.4
  • 25
    • 22544456545 scopus 로고    scopus 로고
    • Fat apoptosis through targeted activation of caspase 8: A new mouse model of inducible and reversible lipoatrophy
    • pmid: 15965483
    • U. B. Pajvani et al., Fat apoptosis through targeted activation of caspase 8: A new mouse model of inducible and reversible lipoatrophy. Nat. Med. 11, 797-803 (2005). doi: 10.1038/nm1262; pmid: 15965483
    • (2005) Nat. Med. , vol.11 , pp. 797-803
    • Pajvani, U.B.1
  • 26
    • 58749091644 scopus 로고    scopus 로고
    • Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy
    • pmid: 19187773
    • V. A. Cortés et al., Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy. Cell Metab. 9, 165-176 (2009). doi: 10.1016/j.cmet.2009.01.002; pmid: 19187773
    • (2009) Cell Metab. , vol.9 , pp. 165-176
    • Cortés, V.A.1
  • 27
    • 84893059416 scopus 로고    scopus 로고
    • Thermometry, calorimetry, and mean body temperature during heat stress
    • pmid: 24265242
    • G. P. Kenny, O. Jay, Thermometry, calorimetry, and mean body temperature during heat stress. Compr. Physiol. 3, 1689-1719 (2013). doi: 10.1002/cphy.c130011; pmid: 24265242
    • (2013) Compr. Physiol. , vol.3 , pp. 1689-1719
    • Kenny, G.P.1    Jay, O.2
  • 28
    • 0019447089 scopus 로고
    • Diet-induced changes in sympathoadrenal activity: Implications for thermogenesis
    • pmid: 7017328
    • L. Landsberg, J. B. Young, Diet-induced changes in sympathoadrenal activity: Implications for thermogenesis. Life Sci. 28, 1801-1819 (1981). doi: 10.1016/0024-3205(81)90352-0; pmid: 7017328
    • (1981) Life Sci. , vol.28 , pp. 1801-1819
    • Landsberg, L.1    Young, J.B.2
  • 29
    • 84890561808 scopus 로고    scopus 로고
    • Bile formation and secretion
    • pmid: 23897680
    • J. L. Boyer, Bile formation and secretion. Compr. Physiol. 3, 1035-1078 (2013). pmid: 23897680
    • (2013) Compr. Physiol. , vol.3 , pp. 1035-1078
    • Boyer, J.L.1
  • 30
    • 84947610783 scopus 로고    scopus 로고
    • Bile acid-activated receptors, intestinal microbiota, and the treatment of metabolic disorders
    • pmid: 26481828
    • S. Fiorucci, E. Distrutti, Bile acid-activated receptors, intestinal microbiota, and the treatment of metabolic disorders. Trends Mol. Med. 21, 702-714 (2015). doi: 10.1016/j.molmed.2015.09.001; pmid: 26481828
    • (2015) Trends Mol. Med. , vol.21 , pp. 702-714
    • Fiorucci, S.1    Distrutti, E.2
  • 31
    • 0015862254 scopus 로고
    • Purine nucleotide biosynthesis in gastrointestinal mucosa
    • pmid: 4354798
    • A. M. Mackinnon, D. J. Deller, Purine nucleotide biosynthesis in gastrointestinal mucosa. Biochim. Biophys. Acta 319, 1-4 (1973). doi: 10.1016/0005-2787(73)90034-8; pmid: 4354798
    • (1973) Biochim. Biophys. Acta , vol.319 , pp. 1-4
    • Mackinnon, A.M.1    Deller, D.J.2
  • 32
    • 0028072440 scopus 로고
    • Uptake, transport and metabolism of exogenous nucleosides in intestinal epithelial cell cultures
    • pmid: 7931703
    • Y. He, I. R. Sanderson, W. A. Walker, Uptake, transport and metabolism of exogenous nucleosides in intestinal epithelial cell cultures. J. Nutr. 124, 1942-1949 (1994). pmid: 7931703
    • (1994) J. Nutr. , vol.124 , pp. 1942-1949
    • He, Y.1    Sanderson, I.R.2    Walker, W.A.3
  • 35
    • 84857893793 scopus 로고    scopus 로고
    • Structural determinants for rCNT2 sorting to the plasma membrane of polarized and non-polarized cells
    • pmid: 22136384
    • I. Pinilla-Macua, F. J. Casado, M. Pastor-Anglada, Structural determinants for rCNT2 sorting to the plasma membrane of polarized and non-polarized cells. Biochem. J. 442, 517-525 (2012). doi: 10.1042/BJ20110605; pmid: 22136384
    • (2012) Biochem. J , vol.442 , pp. 517-525
    • Pinilla-Macua, I.1    Casado, F.J.2    Pastor-Anglada, M.3
  • 36
    • 84910625940 scopus 로고    scopus 로고
    • 649, are important for maturation and sorting to the plasma membrane
    • pmid: 25315414
    • 649, are important for maturation and sorting to the plasma membrane. FEBS Lett. 588, 4382-4389 (2014). doi: 10.1016/j.febslet.2014.10.006; pmid: 25315414
    • (2014) FEBS Lett. , vol.588 , pp. 4382-4389
    • Pinilla-Macua, I.1    Claudio-Montero, A.2    Pastor-Anglada, M.3
  • 37
    • 58249095954 scopus 로고    scopus 로고
    • A splice variant of the SLC28A3 gene encodes a novel human concentrative nucleoside transporter-3 (hCNT3) protein localized in the endoplasmic reticulum
    • pmid: 18827020
    • E. Errasti-Murugarren, M. Molina-Arcas, F. J. Casado, M. Pastor-Anglada, A splice variant of the SLC28A3 gene encodes a novel human concentrative nucleoside transporter-3 (hCNT3) protein localized in the endoplasmic reticulum. FASEB J. 23, 172-182 (2009). doi: 10.1096/fj.08-113902; pmid: 18827020
    • (2009) FASEB J , vol.23 , pp. 172-182
    • Errasti-Murugarren, E.1    Molina-Arcas, M.2    Casado, F.J.3    Pastor-Anglada, M.4
  • 38
    • 78649526985 scopus 로고    scopus 로고
    • Uridine metabolism in HIV-1-infected patients: Effect of infection, of antiretroviral therapy and of HIV-1/ART-associated lipodystrophy syndrome
    • pmid: 21085568
    • P. Domingo et al., Uridine metabolism in HIV-1-infected patients: Effect of infection, of antiretroviral therapy and of HIV-1/ART-associated lipodystrophy syndrome. PLOS ONE 5, e13896 (2010). doi: 10.1371/journal.pone.0013896; pmid: 21085568
    • (2010) PLOS ONE , vol.5 , pp. e13896
    • Domingo, P.1
  • 39
    • 0032543680 scopus 로고    scopus 로고
    • A nutrientsensing pathway regulates leptin gene expression in muscle and fat
    • pmid: 9641678
    • J. Wang, R. Liu, M. Hawkins, N. Barzilai, L. Rossetti, A nutrientsensing pathway regulates leptin gene expression in muscle and fat. Nature 393, 684-688 (1998). doi: 10.1038/31474; pmid: 9641678
    • (1998) Nature , vol.393 , pp. 684-688
    • Wang, J.1    Liu, R.2    Hawkins, M.3    Barzilai, N.4    Rossetti, L.5
  • 40
    • 76149141225 scopus 로고    scopus 로고
    • Metabolism and circadian rhythms - Implications for obesity
    • pmid: 19854863
    • O. Froy, Metabolism and circadian rhythms - implications for obesity. Endocr. Rev. 31, 1-24 (2010). doi: 10.1210/er.2009-0014; pmid: 19854863
    • (2010) Endocr. Rev. , vol.31 , pp. 1-24
    • Froy, O.1
  • 41
    • 84859459231 scopus 로고    scopus 로고
    • Coordination of the transcriptome and metabolome by the circadian clock
    • pmid: 22431615
    • K. L. Eckel-Mahan et al., Coordination of the transcriptome and metabolome by the circadian clock. Proc. Natl. Acad. Sci. U.S.A. 109, 5541-5546 (2012). doi: 10.1073/pnas.1118726109; pmid: 22431615
    • (2012) Proc. Natl. Acad. Sci. U.S.A , vol.109 , pp. 5541-5546
    • Eckel-Mahan, K.L.1
  • 42
    • 84860659169 scopus 로고    scopus 로고
    • Shedding pounds after going under the knife: Guts over glory-why diets fail
    • pmid: 22561823
    • R. Larder, S. O'Rahilly, Shedding pounds after going under the knife: Guts over glory-why diets fail. Nat. Med. 18, 666-667 (2012). doi: 10.1038/nm.2747; pmid: 22561823
    • (2012) Nat. Med. , vol.18 , pp. 666-667
    • Larder, R.1    O'Rahilly, S.2
  • 43
    • 85002860439 scopus 로고    scopus 로고
    • Body temperature regulation in diabetes
    • pmid: 27227101
    • G. P. Kenny, R. J. Sigal, R. McGinn, Body temperature regulation in diabetes. Temperature 3, 119-145 (2016). doi: 10.1080/23328940.2015.1131506; pmid: 27227101
    • (2016) Temperature , vol.3 , pp. 119-145
    • Kenny, G.P.1    Sigal, R.J.2    McGinn, R.3
  • 44
    • 50949114536 scopus 로고    scopus 로고
    • PANIC-ATTAC: A mouse model for inducible and reversible beta-cell ablation
    • pmid: 18469203
    • Z. V. Wang et al., PANIC-ATTAC: A mouse model for inducible and reversible beta-cell ablation. Diabetes 57, 2137-2148 (2008). doi: 10.2337/db07-1631; pmid: 18469203
    • (2008) Diabetes , vol.57 , pp. 2137-2148
    • Wang, Z.V.1
  • 45
    • 0030945932 scopus 로고    scopus 로고
    • A new, efficient, two step procedure for the preparation of the antineoplastic agent sparfosic acid
    • A. D. Morris, A. A. Cordi, A new, efficient, two step procedure for the preparation of the antineoplastic agent sparfosic acid. Synth. Commun. 27, 1259-1266 (1997). doi: 10.1080/00397919708003363
    • (1997) Synth. Commun. , vol.27 , pp. 1259-1266
    • Morris, A.D.1    Cordi, A.A.2
  • 46
    • 84924857231 scopus 로고    scopus 로고
    • Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration
    • pmid:25339419
    • R. Ye et al., Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration. eLife 3, (2014).doi:10.7554/eLife.03851; pmid:25339419
    • (2014) eLife , vol.3
    • Ye, R.1
  • 47
    • 84907190268 scopus 로고    scopus 로고
    • Diurnal variation in insulin sensitivity of glucose metabolism is associated with diurnal variations in whole-body and cellular fatty acid metabolism in metabolically normal women
    • pmid: 24878055
    • J. Yoshino et al., Diurnal variation in insulin sensitivity of glucose metabolism is associated with diurnal variations in whole-body and cellular fatty acid metabolism in metabolically normal women. J. Clin. Endocrinol. Metab. 99, E1666-E1670 (2014). doi: 10.1210/jc.2014-1579; pmid: 24878055
    • (2014) J. Clin. Endocrinol. Metab. , vol.99 , pp. E1666-E1670
    • Yoshino, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.