CNT1, concentrative nucleoside transporter 1

xPharm: The Comprehensive Pharmacology Reference

Volumn , Issue , 2007, Pages 1-4

  Cass, Carol E ^a   Baldwin, Stephen A ^b   Young, James ^c  

^a CROSS CANCER INSTITUTE   (Canada)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84883970640     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-008055232-3.60461-1     Document Type: Chapter

References (16)

1. del Santos B., Tarafa G., Felipe A., Casado F.J., Pastor-Anglada M. Developmental regulation of the concentrative nucleoside transporters CNT1 and CNT2 in rat liver. J. Hepatol. 2001, 34:873-880.
2. Duflot S., Calvo M., Casado F.J., Enrich C., Pastor-Anglada M. Concentrative nucleoside transporter (rCNT1) is targeted to the apical membrane through the hepatic transcytotic pathway. Exp. Cell Res. 2002, 281:77-85.
3. +-nucleoside cotransporters rCNT1. J. Biol. Chem. 2001, 276:27981-27988.
4. Huang Q.Q., Yao S.Y.M., Ritzel M.W., Paterson A.R.P., Cas C.E., Young J.D. Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein. J. Biol. Chem. 1994, 269:17757-17760.
5. +-nucleoside cotransporters hCNT1 and hCNT2. J. Biol. Chem. 1999, 274:24475-24484.
6. Mackey J.R., Baldwin S.A., Young J.D., Cass C.E. Nucleoside transport and its significance for anticancer drug resistance. Drug Resistance Updates 1998, 1:310-324.
7. Mackey J.R., Yao S.Y.M., Smith K.M., Karpinski E., Baldwin S.A., Cass C.E., Young J.D. Gemcitabine transport in Xenopus oocytes expressing recombinant plasma membrane nucleoside transporters. J. Natl. Cancer Inst. 1999, 91:1876-1881.
8. Mangravite L.M., Lipschutz J.H., Mostov K.E., Giacomini K.M. Localization of GFP-tagged concentrative nucleoside transporters in a renal polarized epithelial cell line. Am. J. Physiol. Renal Physiol. 2001, 280:F879-F885.
9. +-nucleoside cotransporter from pig kidney, pkCNT1. Biochim. Biophys. Acta. 1998, 1415:266-269.
10. +-nucleoside cotransporter (hCNT1). Am. J. Physiol. Cell Physiol. 1997, 272:C707-C714.
11. Soler C., Garcia-Manteiga J., Valdes R., Xaus J., Comalada M., Casado F.J., Pastor-Anglada M., Celada A., Felipe A. Macrophages require different nucleoside transport systems for proliferation and activation. FASEB J. 2001, 15:1979-1988.
12. Soler C., Valdes R., Garcia-Manteiga J., Xaus J., Comalada M., Casado F.J., Modplell M., Nicholson B., MacLeod C., Felipe A., Celada A., Pastor-Anglada M. Lipopolysaccharide-induced apoptosis of macrophages determines the up-regulation of concentrative nucleoside transporters CNT1 and CNT2 through tumor necrosis factor-alpha-dependent and-independent mechanisms. J. Biol. Chem. 2001, 276:30043-30049.
13. Valdes R., Casado F.J., Pastor-Anglada M. Cell cycle-dependent regulation of rCNT1,a concentrative nucleoside transporter involved in the uptake of cell-cycle-dependent nucleoside-derived anticancer drugs. Biochem. Biophys. Res. Commun. 2002, 296:575-579.
14. Yao S.Y.M., Cass C.E., Young J.D. Transport of the antiviral nucleoside analogs 3?-azido-3?-deoxythymidine (AZT) and 2?,3?-deoxycytidine (ddC) by a recombinant nucleoside transporter (rCNT1) expressed in Xenopus oocytes. Mol. Pharmacol. 1996, 50:388-393.
15. Yao S.Y.M., Ng A.M.L., Sundaram M., Cass C.E., Baldwin S.A., Young J.D. Transport of antiviral 3?-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine(NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes. Mol. Membr. Biol. 2001, 18:161-167.
16. Yao S.Y.M., Cass C.E., Young J.D. The Xenopus oocyte expression system for the cDNA cloning and characterization of plasma membrane transport protiens. Membrane Transport Proteins: A Practical Approach 2000, 47-78. Oxford University Press, Oxford. S.A. Baldwin (Ed.).