Effects of obesity on IL-33/ST2 system in heart, adipose tissue and liver: study in the experimental model of Zucker rats

Experimental and Molecular Pathology

Volumn 102, Issue 2, 2017, Pages 354-359

  Ragusa, Rosetta ^a   Cabiati, Manuela ^b   Guzzardi, Maria Angela ^b   D'Amico, Andrea ^a,c   Giannessi, Daniela ^b   Del Ry, Silvia ^b   Caselli, Chiara ^b  

^a SCUOLA SUPERIORE SANT ANNA   (Italy)

^b INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

^c Harvard University   (United States)

Author keywords

Inflammation; Interleukin 33; Obesity; Suppression of tumorigenicity 2

Indexed keywords

GLUCOSE; INSULIN; INTERLEUKIN 1 RECEPTOR LIKE 1 PROTEIN; INTERLEUKIN 33; MESSENGER RNA; NATRIURETIC FACTOR; INTERLEUKIN 1 RECEPTOR; ST2 PROTEIN, RAT; TRANSCRIPTOME;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HEART; HEART DISEASE; HEART STRESS; INFLAMMATION; INSULIN BLOOD LEVEL; LIVER; MALE; MOLECULAR MECHANICS; NONHUMAN; OBESITY; PROTEIN EXPRESSION; RAT; ZUCKER RAT; ANIMAL; CARDIAC MUSCLE; DISEASE MODEL; GENETICS; METABOLISM; PATHOLOGY;

ADIPOSE TISSUE; ANIMALS; DISEASE MODELS, ANIMAL; INTERLEUKIN-33; LIVER; MALE; MYOCARDIUM; OBESITY; RATS, ZUCKER; RECEPTORS, INTERLEUKIN-1; RNA, MESSENGER; TRANSCRIPTOME;

EID: 85015321313     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2017.03.002     Document Type: Article

References (32)

1. Abbasi, F., Brown, B.W. Jr., Lamendola, C., McLaughlin, T., Reaven, G.M., Relationship between obesity, insulin resistance, and coronary heart disease risk. J. Am. Coll. Cardiol. 40:5 (2002), 937–943.
2. Bastien, M., Poirier, P., Lemieux, I., Després, J.P., Overview of epidemiology and contribution of obesity to cardiovascular disease. Prog. Cardiovasc. Dis. 56:4 (2014), 369–381.
3. Bustin, S.A., Benes, V., GArson, J.A., Hellemans, J., Kubista, M., Muller, R., Nolan, T., Pfaffi, M.W., Shipley, G.L., Vandesompele, J., Wittwer, C.T., The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin. Chem. 55:4 (2009), 611–622.
4. Cabiati, M., Raucci, S., Caselli, C., Guzzardi, M.A., D'Amico, A., Prescimone, T., Giannessi, D., Del Ry, S., Tissue-specific selection of stable reference genes for real-time PCR normalization in an obese rat model. J. Mol. Endocrinol. 48:3 (2012), 251–260.
5. Cabiati, M., Raucci, S., Liistro, T., Belcastro, E., Prescimone, T., Caselli, C., Matteucci, M., Iozzo, P., Mattii, L., Giannessi, D., Del Ry, S., Impact of obesity on the expression profile of natriuretic peptide system in a rat experimental model. PLoS One, 8(8), 2013, e72959.
6. Caselli, C., Inflammation in cardiac disease: focus on interleukin-33/ST2 pathway. Inflamm. Cell Signal., 1, 2014, e149, 10.14800/ics.149.
7. Frisbee, J.C., Delp, M.D., Vascular function in the metabolic syndrome and the effects on skeletal muscle perfusion: lessons from the obese Zucker rat. Essays Biochem. 42 (2006), 145–161.
8. Guiducci, L., Liistro, T., Burchielli, S., Panetta, D., Bonora, D., Di Cecco, P., Bucci, M., Moehrs, S., Del Guerra, A., Salvadori, P.A., Iozzo, P., Contribution of organ blood flow, intrinsic tissue clearance and glycemia to the regulation of glucose use in obese and type 2 diabetic rats: a PET study. Nutr. Metab. Cardiovasc. Dis. 21:9 (2011), 726–732.
9. Haraldsen, G., Balogh, J., Polheimer, J., Kuchler, A.M., Interleukin-33-cytokine of dual function or novel alarmin?. Trends Immunol. 30:5 (2009), 227–233.
10. Hedayat, M., Mahmoudi, M.J., Rezaei Rose, N.R., Proinflammatory cyokines in heart failure: double-edged swords. Heart Fail. Rev. 15:6 (2010), 543–562.
11. Johnson, F.K., Johnson, R.A., Durante, W., Jackson, K.E., Stevenson, B.K., Peyton, K.J., Metabolic syndrome increases endogenous carbon monoxide production to promote hypertension and endothelial dysfunction in obese Zucker rat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 290:3 (2006), R601–R608.
12. Jugdutt, B.I., Preventing adverse remodeling and rupture during healing after myocardial infarction in mice and humans. Circulation 122:2 (2010), 103–105.
13. Ky, B., French, B., McCloskey, K., Rame, J.E., McIntosh, E., Shahi, P., Dries, D.L., Tang, W.H., Wu, A.H., Fang, J.C., Boxer, R., Sweitzer, N.K., Levy, W.C., Goldberg, L.R., Jessup, M., Cappola, T.P., High-sensitivity ST2 for prediction of adverse outcomes in chronic heart failure. Circ. Heart Fail. 4:2 (2011), 180–187.
14. 85Kr. J Appl Phisiol. 23:5 (1967), 621–630.
15. Liew, F.Y., Pitman, N.I., McInnes, I.B., Disease-associated functions of IL-33: the new kid in the IL-1 family. Nat. Rev. Immunol. 10:2 (2010), 103–110.
16. Martìnez-Martìnez, E., Cachofeiro, V., Rousseau, E., Alvarez, V., Calvier, L., Fernández-Celis, A., Leroy, C., Miana, M., Jurado-López, R., Briones, A.M., Jaisser, F., Zannad, F., Rossignol, P., López-Andrés, N., Interleukin-33/ST2 system attenuates aldosterone-induced adipogenesis and inflammation. Mol. Cell. Endocrinol. 411 (2015), 20–27.
17. Mathieu, P., Poirier, P., Pibarot, P., Lemieux, I., Després, J.P., Visceral obesity: the link among inflammation, hypertension, and cardiovascular disease. Hypertension 53:4 (2009), 577–584.
18. Miller, A.M., Liew, F.Y., The IL-33/ST2 pathway—a new therapeutic target in cardiovascular disease. Pharmacol. Ther. 131:2 (2011), 179–186.
19. Miller, A.M., Asquith, D.L., Hueber, A.J., Anderson, L.A., Holmes, W.M., McKenzie, A.N., Xu, D., Sattar, N., McInnes, I.B., Liew, F.Y., IL-33 induces protectiv effects in adipose tissue inflammation during obesity in mice. Circ. Res. 107:5 (2010), 650–658.
20. Miyashita, K., Itoh, H., Tsujimoto, H., Tamura, N., Fukunaga, Y., Sone, M., Yamahara, K., Taura, D., Inuzuka, M., Sonoyama, T., Nakao, K., Natriuretic peptides/cGMP/cGMP-dependent protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity. Diabetes 58:12 (2009), 2880–2892.
21. Reichenbach, D.K., Schwarze, V., Matta, B.M., Tkachev, V., Lieberknecht, E., Liu, Q., Koehn, B.H., Pfeifer, D., Taylor, P.A., Prinz, G., Dierbach, H., Stickel, N., Beck, Y., Warncke, M., Junt, T., Schmitt-Graeff, A., Nakae, S., Follo, M., Wertheimer, T., Schwab, L., Devlin, J., Watkins, S.C., Duyster, J., Ferrara, J.L., Turnquist, H.R., Zeiser, R., Blazar, B.R., The IL-33/ST2 axis augments effector T-cell responses during acute GVHD. Blood 125:20 (2015), 3183–3192.
22. Salas, A., The IL-33/ST2 axis: yet another therapeutic target in inflammatory bowel disease?. Gut 62:10 (2013), 1392–1393 Oct.
23. Sanada, S., Hakuno, D., Higgins, L.J., Schreiter, E.R., McKenzie, A.N.J., Lee, R.T., IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system. J. Clin. Invest. 117:6 (2007), 1538–1549.
24. Seki, K., Sanada, S., Kudinova, A.Y., Steinhauser, M.L., Handa, V., Gannon, J., Lee, R.T., Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signaling.Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signaling. Circ. Heart Fail. 2:6 (2009), 684–691.
25. Tago, K., Noda, T., Hayakawa, M., Iwahana, H., Yangisawa, K., Yashiro, T., Tominaga, S., Tissue distribution and subcellular localization of variant form of the human ST2 gene product, ST2V. Biochem. Biophys. Red. Commun. 285:5 (2001), 1377–1383.
26. Van de Voorder, J., Pauwels, B., Boydens, C., Decaluwe, K., Adipocytokines in relation to cardiovascular disease. Metabolism 62:11 (2013), 1513–1521.
27. Van Gaal, L.F., Mertens, I.L., De Block, C.E., Mechanisms linking obesity with cardiovascular disease. Nature 444:7121 (2006), 875–880.
28. Vandesomepele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A., Speleman, F., Accurate normalization of rel-time PCR quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol., 3(7), 2002, RESEARCH0034.
29. Weinberg, E.O., Shimpo, M., Hurwitz, S., Tominaga, S., Rouleau, J.L., Lee, R.T., Identification of serum soluble ST2 receptor as a novel heart failure biomarker. Circulation 107 (2003), 721–726.
30. Zhang, J., Ramadan, A.M., Griesenauer, B., Li, W., Turner, M.J., Liu, C., Kapur, R., Hanenberg, H., Blazar, B.R., Tawara, I., Paczesny, S., ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease. Sci. Transl. Med., 7(308), 2015, 308ra160, 10.1126/scitranslmed.aab0166.
31. Zeyda, M., Wernly, B., Demyanets, S., Kaun, C., Hammerle, M., Hantusch, B., Schranz, M., Neuhofer, A., Itariu, B.K., Keck, M., Prager, G., Wojta, J., Stulnig, T.M., Severe obesity increases adipose tissuue expression of interleukin-33 and its receptor ST2, both predominantly detectable in endotelial cells of human adipose tissue. Int. J. Obes. (Lond) 37:5 (2013), 658–665.
32. Zhao, Q., Chen, G., Role of IL-33 and its receptor in T cell-mediated autoimmune diseases. Biomed. Res. Int., 2014, 2014, 587376, 10.1155/2014/587376.