Replacing d-Glucosamine with Its l-Enantiomer in Glycosylated Antitumor Ether Lipids (GAELs) Retains Cytotoxic Effects against Epithelial Cancer Cells and Cancer Stem Cells

Journal of Medicinal Chemistry

Volumn 60, Issue 5, 2017, Pages 2142-2147

  Ogunsina, Makanjuola ^a   Samadder, Pranati ^a   Idowu, Temilolu ^a   Arthur, Gilbert ^a   Schweizer, Frank ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1 O HEXADECYL 2 O METHYL 3 O (4' BENZYL 2',6' DIAMINO 2',6' DIDEOXY ALPHA LEVO GLUCOPYRANOSYL) SN GLYCEROL; 1 O HEXADECYL 2 O METHYL 3 O (4' BENZYL 2',6' DIAMINO 2',6' DIDEOXY BETA LEVO GLUCOPYRANOSYL) SN GLYCEROL; ANTINEOPLASTIC AGENT; CISPLATIN; DOXORUBICIN; ETHER LIPID; GLUCOSAMINE DERIVATIVE; GLYCOSYLATED ANTITUMOR ETHER LIPID; SALINOMYCIN; UNCLASSIFIED DRUG; GLUCOSAMINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER CELL LINE; CANCER REGRESSION; CANCER STEM CELL; CELL KILLING; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; ENANTIOMER; EPITHELIAL CANCER CELL LINE; GLYCOSYLATION; HUMAN; HUMAN CELL; MTS ASSAY; SYNTHESIS; CHEMISTRY; EPITHELIUM; METABOLISM; NEOPLASM; PATHOLOGY; STEREOISOMERISM;

EPITHELIUM; GLUCOSAMINE; GLYCOSYLATION; HUMANS; NEOPLASMS; NEOPLASTIC STEM CELLS; STEREOISOMERISM;

EID: 85015081962     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b01773     Document Type: Article

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