Synthesis of antimitotic thioglycosides: In vitro and in vivo evaluation of their anticancer activity

Journal of Medicinal Chemistry

Volumn 54, Issue 19, 2011, Pages 6949-6955

  García Álvarez, Isabel ^a   Groult, Hugo ^b,e   Casas, Josefina ^c   Barreda Manso, M Asunción ^a,d   Yanguas Casás, Natalia ^a,d   Nieto Sampedro, Manuel ^a,d   Romero Ramírez, Lorenzo ^a,d   Fernández Mayoralas, Alfonso ^b  

^a HOSPITAL NACIONAL DE PARAPLÉJICOS   (Spain)

^b INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

^c INSTITUTE OF ADVANCED CHEMISTRY OF CATALONIA IQAC CSIC   (Spain)

^d INSTITUTO CAJAL   (Spain)

^e HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA N ACETYLGLUCOSAMINIDASE; ANTIMITOTIC AGENT; GLYCOSPHINGOLIPID; N ACETYL BETA GLUCOSAMINIDASE; THIOGLYCOSIDE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; GLIOMA; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; LUNG CARCINOMA; MASS SPECTROMETRY; NONHUMAN; PHOSPHOLIPID METABOLISM; TUMOR VOLUME; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; ANTIMITOTIC AGENTS; BETA-N-ACETYLHEXOSAMINIDASES; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; GLYCOLIPIDS; HUMANS; HYDROLYSIS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOGLUCOSIDES; THIOGLYCOSIDES; TRANSPLANTATION, HETEROLOGOUS; TUMOR BURDEN;

EID: 80053926325     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200961q     Document Type: Article

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