메뉴 건너뛰기




Volumn 7, Issue , 2017, Pages

Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition and Alter the Epigenome and Metabolome

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E4;

EID: 85014959369     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep43701     Document Type: Article
Times cited : (73)

References (52)
  • 1
    • 2542502430 scopus 로고    scopus 로고
    • ApoE genotype accounts for the vast majority of AD risk and AD pathology
    • Raber, J., Huang, Y. & Ashford, J. W. ApoE genotype accounts for the vast majority of AD risk and AD pathology. Neurobiol Aging. 25, 641-50 (2004).
    • (2004) Neurobiol Aging. , vol.25 , pp. 641-650
    • Raber, J.1    Huang, Y.2    Ashford, J.W.3
  • 2
    • 77956130453 scopus 로고    scopus 로고
    • Worldwide allele frequencies of the human apolipoprotein e gene: Climate, local adaptations, and evolutionary history
    • Eisenberg, D. T., Kuzawa, C. W. & Hayes, M. G. Worldwide allele frequencies of the human apolipoprotein E gene: climate, local adaptations, and evolutionary history. Am J Phys. Anthropol. 143, 100-11 (2010).
    • (2010) Am J Phys. Anthropol. , vol.143 , pp. 100-111
    • Eisenberg, D.T.1    Kuzawa, C.W.2    Hayes, M.G.3
  • 3
    • 37149036580 scopus 로고    scopus 로고
    • Detrimental effects of apolipoprotein E4: Potential therapeutic targets in AD
    • Mahley, R. W., Huang, Y. & Weisgraber, K. H. Detrimental effects of apolipoprotein E4: potential therapeutic targets in AD. Curr Alzheimer Res. 4, 537-540 (2007).
    • (2007) Curr Alzheimer Res. , vol.4 , pp. 537-540
    • Mahley, R.W.1    Huang, Y.2    Weisgraber, K.H.3
  • 4
    • 66349121082 scopus 로고    scopus 로고
    • Apolipoprotein e knock-out and knock-in mice: Atherosclerosis, metabolic syndrome, and beyond
    • Pendse, A. A., Arbones-Mainar, J. M., Johnson, L. A., Altenburg, M. K. & Maeda, N. Apolipoprotein E knock-out and knock-in mice: atherosclerosis, metabolic syndrome, and beyond. J Lipid Res. 50, S178-S182 (2009).
    • (2009) J Lipid Res. , vol.50 , pp. S178-S182
    • Pendse, A.A.1    Arbones-Mainar, J.M.2    Johnson, L.A.3    Altenburg, M.K.4    Maeda, N.5
  • 5
    • 33845341470 scopus 로고    scopus 로고
    • Impact of recent increase in incidence on future diabetes burden: U.S. 2005-2050
    • Narayan, K. M., Boyle, J. P., Geiss, L. S., Saaddine, J. B. & Tompson, T. J. Impact of recent increase in incidence on future diabetes burden: U.S., 2005-2050. Diabetes Care. 29, 2114-2116 (2006).
    • (2006) Diabetes Care , vol.29 , pp. 2114-2116
    • Narayan, K.M.1    Boyle, J.P.2    Geiss, L.S.3    Saaddine, J.B.4    Tompson, T.J.5
  • 6
    • 84888402101 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies
    • Gudala, K., Bansal, D., Schifano, F. & Bhansali, A. Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies. J Diabetes Investig. 4, 640-50 (2013).
    • (2013) J Diabetes Investig. , vol.4 , pp. 640-650
    • Gudala, K.1    Bansal, D.2    Schifano, F.3    Bhansali, A.4
  • 7
    • 84863002952 scopus 로고    scopus 로고
    • Cognitive function and decline in obesity
    • Sellbom, K. S. & Gunstad, J. Cognitive function and decline in obesity. J. Alzheimers Dis. 30, S89-S95 (2012).
    • (2012) J. Alzheimers Dis. , vol.30 , pp. S89-S95
    • Sellbom, K.S.1    Gunstad, J.2
  • 9
    • 84859718265 scopus 로고    scopus 로고
    • Demonstrated brain insulin resistance in AD patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
    • Talbot, K. et al. Demonstrated brain insulin resistance in AD patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest. 122, 1316-38 (2012).
    • (2012) J Clin Invest. , vol.122 , pp. 1316-1338
    • Talbot, K.1
  • 10
    • 70949097121 scopus 로고    scopus 로고
    • Presence of the APOE epsilon4 allele modifes the relationship between T2D and cognitive performance: The Maine-Syracuse Study
    • Dore, G. A., Elias, M. F., Robbins, M. A., Elias, P. K. & Nagy, Z. Presence of the APOE epsilon4 allele modifes the relationship between T2D and cognitive performance: the Maine-Syracuse Study. Diabetologia. 52, 2551-60 (2009).
    • (2009) Diabetologia. , vol.52 , pp. 2551-2560
    • Dore, G.A.1    Elias, M.F.2    Robbins, M.A.3    Elias, P.K.4    Nagy, Z.5
  • 11
    • 0036227542 scopus 로고    scopus 로고
    • Honolulu-Asia Aging Study. T2D, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study
    • Peila, R., Rodriguez, B. L. & Launer, L. J. Honolulu-Asia Aging Study. T2D, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study. Diabetes. 51, 1256-62 (2002).
    • (2002) Diabetes , vol.51 , pp. 1256-1262
    • Peila, R.1    Rodriguez, B.L.2    Launer, L.J.3
  • 12
    • 0347719366 scopus 로고    scopus 로고
    • Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia
    • Reiman, E. M. et al. Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia. Proc Natl Acad Sci USA 101, 284-9 (2004).
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 284-289
    • Reiman, E.M.1
  • 13
    • 84856606017 scopus 로고    scopus 로고
    • Terapeutic targets of brain insulin resistance in sporadic AD
    • de la Monte, S. M. Terapeutic targets of brain insulin resistance in sporadic AD. Front Biosci (Elite Ed) 4, 1582-1605 (2012).
    • (2012) Front Biosci (Elite Ed) , vol.4 , pp. 1582-1605
    • De La Monte, S.M.1
  • 14
    • 84941001029 scopus 로고    scopus 로고
    • Diferential Effects of Meal Challenges on Cognition, Metab olism, and Biomarkers for Apolipoprotein e ϵ 4 Carriers and Adults with Mild Cognitive Impairment
    • Hanson, A. J. et al. Diferential Effects of Meal Challenges on Cognition, Metab olism, and Biomarkers for Apolipoprotein E ϵ 4 Carriers and Adults with Mild Cognitive Impairment. J Alzheimers Dis. 48, 205-18 (2015).
    • (2015) J Alzheimers Dis. , vol.48 , pp. 205-218
    • Hanson, A.J.1
  • 15
    • 0037452760 scopus 로고    scopus 로고
    • Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly
    • Convit, A., Wolf, O. T., Tarshish, C. & de Leon, M. J. Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly. Proc Natl Acad Sci USA 100, 2019-22 (2003).
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2019-2022
    • Convit, A.1    Wolf, O.T.2    Tarshish, C.3    De Leon, M.J.4
  • 16
    • 84961208212 scopus 로고    scopus 로고
    • Apolipoprotein e Genotype and Sex Infuence Glucose Tolerance in Older Adults: A Cross-Sectional Study
    • Hanson, A. J., Banks, W. A., Hernandez Saucedo, H. & Craf, S. Apolipoprotein E Genotype and Sex Infuence Glucose Tolerance in Older Adults: A Cross-Sectional Study. Dement Geriatr Cogn Dis Extra. 6, 78-89 (2016).
    • (2016) Dement Geriatr Cogn Dis Extra. , vol.6 , pp. 78-89
    • Hanson, A.J.1    Banks, W.A.2    Hernandez Saucedo, H.3    Craf, S.4
  • 17
    • 0035676137 scopus 로고    scopus 로고
    • Associations between apolipoprotein e phenotype, glucose metabolism and cognitive function in men. An explorative study in a population sample
    • Helkala, E. L. et al. Associations between apolipoprotein E phenotype, glucose metabolism and cognitive function in men. An explorative study in a population sample. Diabet Med. 18, 991-7 (2001).
    • (2001) Diabet Med. , vol.18 , pp. 991-997
    • Helkala, E.L.1
  • 18
    • 84931301395 scopus 로고    scopus 로고
    • DNA methylation as a diagnostic and therapeutic target in the battle against T2D
    • Rönn, T. & Ling, C. DNA methylation as a diagnostic and therapeutic target in the battle against T2D. Epigenomics. 7, 451-60 (2015).
    • (2015) Epigenomics , vol.7 , pp. 451-460
    • Rönn, T.1    Ling, C.2
  • 19
    • 84925604811 scopus 로고    scopus 로고
    • Role of Tet1 and 5-hydroxymethylcytosine in cocaine action
    • Feng, J. et al. Role of Tet1 and 5-hydroxymethylcytosine in cocaine action. Nat Neurosci. 18, 536-44 (2015).
    • (2015) Nat Neurosci. , vol.18 , pp. 536-544
    • Feng, J.1
  • 20
    • 85007593378 scopus 로고    scopus 로고
    • Proton irradiation Induces Persistent and Tissue-Specific DNA Methylation Changes in the Lef Ventricle and Hippocampus
    • Impey, S., Pelz, C., Tafessu, A., Marzulla, T., Turker, M. & Raber, J. Proton irradiation Induces Persistent and Tissue-Specific DNA Methylation Changes in the Lef Ventricle and Hippocampus. BMC Genomics. 17, 273 (2016).
    • (2016) BMC Genomics. , vol.17 , pp. 273
    • Impey, S.1    Pelz, C.2    Tafessu, A.3    Marzulla, T.4    Turker, M.5    Raber, J.6
  • 21
    • 84876685184 scopus 로고    scopus 로고
    • Epigenetic methylations and their connections with metabolism
    • Chiacchiera, F., Piunti, A. & Pasini, D. Epigenetic methylations and their connections with metabolism. Cell Mol Life Sci. 70, 1495-508 (2013).
    • (2013) Cell Mol Life Sci. , vol.70 , pp. 1495-1508
    • Chiacchiera, F.1    Piunti, A.2    Pasini, D.3
  • 22
    • 85014889027 scopus 로고    scopus 로고
    • Amelioration of Metabolic Syndrome-Associated Cognitive Impairments in Mice via a Reduction in Dietary Fat Content or Infusion of Non-Diabetic Plasma
    • Johnson, L. A. et al. Amelioration of Metabolic Syndrome-Associated Cognitive Impairments in Mice via a Reduction in Dietary Fat Content or Infusion of Non-Diabetic Plasma. EBioMedicine. 26, 42 (2015).
    • (2015) EBioMedicine. , vol.26 , pp. 42
    • Johnson, L.A.1
  • 23
    • 84938236312 scopus 로고    scopus 로고
    • Streptozotocin induced Alzheimer's disease like changes and the underlying neural degeneration and regeneration mechanism
    • Kamat, P. K. Streptozotocin induced Alzheimer's disease like changes and the underlying neural degeneration and regeneration mechanism. Neural Regen Res. 10, 1050-1052 (2015).
    • (2015) Neural Regen Res. , vol.10 , pp. 1050-1052
    • Kamat, P.K.1
  • 26
    • 84950992864 scopus 로고    scopus 로고
    • Initiative. Regional brain hypometabolism is unrelated to regional amyloid plaque burden
    • Altmann, A., Ng, B., Landau, S. M., Jagust, W. J., Greicius, M. D. & Neuroimaging, A. D. Initiative. Regional brain hypometabolism is unrelated to regional amyloid plaque burden. Brain. 138, 3734-46 (2015).
    • (2015) Brain , vol.138 , pp. 3734-3746
    • Altmann, A.1    Ng, B.2    Landau, S.M.3    Jagust, W.J.4    Greicius, M.D.5    Neuroimaging, A.D.6
  • 27
    • 84892772159 scopus 로고    scopus 로고
    • Reduced phosphorylation of brain insulin receptor substrate and Akt proteins in apolipoprotein-E4 targeted replacement mice
    • Ong, Q. R., Chan, E. S., Lim, M. L., Cole, G. M. & Wong, B. S. Reduced phosphorylation of brain insulin receptor substrate and Akt proteins in apolipoprotein-E4 targeted replacement mice. Sci Rep. 4, 3754 (2014).
    • (2014) Sci Rep. , vol.4 , pp. 3754
    • Ong, Q.R.1    Chan, E.S.2    Lim, M.L.3    Cole, G.M.4    Wong, B.S.5
  • 28
    • 84976407005 scopus 로고    scopus 로고
    • A ltered Energ y Met ab olism Pathways in the Posterior Cingulate in Young Adult Ap olip oprotein e ϵ 4 C arriers
    • Perkins, M. et al. A ltered Energ y Met ab olism Pathways in the Posterior Cingulate in Young Adult Ap olip oprotein E ϵ 4 C arriers. J. Alzheimers Dis. 53, 95-106 (2016).
    • (2016) J. Alzheimers Dis. , vol.53 , pp. 95-106
    • Perkins, M.1
  • 29
    • 84919714337 scopus 로고    scopus 로고
    • The APOE genotype: Modification of therapeutic responses in AD
    • Hanson, A. J., Craf, S. & Banks, W. A. The APOE genotype: modification of therapeutic responses in AD. Curr Pharm Des. 21, 114-20 (2015).
    • (2015) Curr Pharm Des. , vol.21 , pp. 114-120
    • Hanson, A.J.1    Craf, S.2    Banks, W.A.3
  • 30
    • 84867537286 scopus 로고    scopus 로고
    • Combination of apolipoprotein E4 and high carbohydrate diet reduces hippocampal BDNF and arc levels and impairs memory in young mice
    • Maioli, S. et al. Combination of apolipoprotein E4 and high carbohydrate diet reduces hippocampal BDNF and arc levels and impairs memory in young mice. J Alzheimers Dis. 32, 341-55 (2012).
    • (2012) J Alzheimers Dis. , vol.32 , pp. 341-355
    • Maioli, S.1
  • 31
    • 79951824233 scopus 로고    scopus 로고
    • ϵ 3 and ϵ 4 alleles of human APOE diferentially afect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice
    • To, A. W., Ribe, E. M., C huang, T. T., S chroeder, J. E. & L ovestone, S.Te ϵ 3 and ϵ 4 alleles of human APOE diferentially afect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice. PLoS One. 6, e16991 (2011).
    • (2011) PLoS One. , vol.6 , pp. e16991
    • To, A.W.1    Ribe, E.M.2    Huang T T, C.3    Chroeder J E, S.4    Ovestone S Te, L.5
  • 33
    • 77954842819 scopus 로고    scopus 로고
    • Quantification of the sixth DNA base hydroxymethylcytosine in the brain
    • Münzel, M. et al. Quantification of the sixth DNA base hydroxymethylcytosine in the brain. Angew Chem Int Ed Engl. 49, 5375-7 (2010).
    • (2010) Angew Chem Int Ed Engl. , vol.49 , pp. 5375-5377
    • Münzel, M.1
  • 34
    • 79952483902 scopus 로고    scopus 로고
    • Western diet consumption and cognitive impairment: Links to hippocampal dysfunction and obesity
    • Kanoski, S. E. & Davidson, T. L. Western diet consumption and cognitive impairment: links to hippocampal dysfunction and obesity. Physiol. Behav. 103, 59-68 (2011).
    • (2011) Physiol. Behav. , vol.103 , pp. 59-68
    • Kanoski, S.E.1    Davidson, T.L.2
  • 35
    • 84920394792 scopus 로고    scopus 로고
    • Deregulation of purine metabolism in AD
    • Ansoleaga, B. et al. Deregulation of purine metabolism in AD. Neurobiol Aging. 36, 68-80 (2015).
    • (2015) Neurobiol Aging. , vol.36 , pp. 68-80
    • Ansoleaga, B.1
  • 36
    • 84878638145 scopus 로고    scopus 로고
    • Pharmacometabolomics Research Network. Alterations in metabolic pathways and networks in AD
    • Kaddurah-Daouk, R. et al. Pharmacometabolomics Research Network. Alterations in metabolic pathways and networks in AD. Transl. Psychiatr. 3, e244 (2013).
    • (2013) Transl. Psychiatr. , vol.3 , pp. e244
    • Kaddurah-Daouk, R.1
  • 37
    • 0032411240 scopus 로고    scopus 로고
    • Elevated adenosine monophosphate deaminase activity in AD brain
    • Sims, B., Powers, R. E., Sabina, R. L. & Teibert, A. B. Elevated adenosine monophosphate deaminase activity in AD brain. Neurobiol Aging. 19, 385-91 (1998).
    • (1998) Neurobiol Aging. , vol.19 , pp. 385-391
    • Sims, B.1    Powers, R.E.2    Sabina, R.L.3    Teibert, A.B.4
  • 38
    • 0017275451 scopus 로고
    • The effect of hypoxia on the pentose phosphate pathway in brain
    • Hakim, A. M., Moss, G. & Gollomp, S. M. The effect of hypoxia on the pentose phosphate pathway in brain. J Neurochem. 26, 683-688 (1976).
    • (1976) J Neurochem. , vol.26 , pp. 683-688
    • Hakim, A.M.1    Moss, G.2    Gollomp, S.M.3
  • 40
    • 84876136764 scopus 로고    scopus 로고
    • Cerebrovascular effects of apolipoprotein E: Implications for Alzheimer disease
    • Zlokovic, B. V. Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease. JAMA Neurol. 70, 440-4 (2013).
    • (2013) JAMA Neurol. , vol.70 , pp. 440-444
    • Zlokovic, B.V.1
  • 41
    • 84870937275 scopus 로고    scopus 로고
    • APOE genotype afects the pre-synaptic compartment of glutamatergic nerve terminals
    • Dumanis, S. B., DiBattista, A. M., Miessau, M., Moussa, C. E. & Rebeck, G. W. APOE genotype afects the pre-synaptic compartment of glutamatergic nerve terminals. J Neurochem. 124, 4-14 (2013).
    • (2013) J Neurochem. , vol.124 , pp. 4-14
    • Dumanis, S.B.1    DiBattista, A.M.2    Miessau, M.3    Moussa, C.E.4    Rebeck, G.W.5
  • 42
    • 77955350021 scopus 로고    scopus 로고
    • ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling
    • Chen, Y., Durakoglugil, M. S., Xian, X. & Herz, J. ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling. Proc Natl Acad Sci USA 107, 12011-6 (2010).
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 12011-12016
    • Chen, Y.1    Durakoglugil, M.S.2    Xian, X.3    Herz, J.4
  • 43
    • 0022480081 scopus 로고
    • Increased cerebral glucose-6-phosphate dehydrogenase activity in AD may refect oxidative stress
    • Martins, R. N., Harper, C. G., Stokes, G. B. & Masters, C. L. Increased cerebral glucose-6-phosphate dehydrogenase activity in AD may refect oxidative stress. J. Neurochem. 46, 1042-1045 (1986).
    • (1986) J. Neurochem. , vol.46 , pp. 1042-1045
    • Martins, R.N.1    Harper, C.G.2    Stokes, G.B.3    Masters, C.L.4
  • 44
    • 0032917662 scopus 로고    scopus 로고
    • The activity of the pentose phosphate pathway is increased in response to oxidative stress in AD
    • Palmer, A. M. The activity of the pentose phosphate pathway is increased in response to oxidative stress in AD. J. Neural Transm. 106, 317-28 (1999).
    • (1999) J. Neural Transm. , vol.106 , pp. 317-328
    • Palmer, A.M.1
  • 45
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg, O. On the origin of cancer cells. Science 123, 309-314 (1956).
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 47
    • 77958453314 scopus 로고    scopus 로고
    • Spatial correlation between brain aerobic glycolysis and A-beta deposition
    • Vlassenko, A. G. et al. Spatial correlation between brain aerobic glycolysis and A-beta deposition. Proc Natl Acad Sci USA 41, 17763-17767 (2010).
    • (2010) Proc Natl Acad Sci USA , vol.41 , pp. 17763-17767
    • Vlassenko, A.G.1
  • 48
    • 83755180492 scopus 로고    scopus 로고
    • Metabolome in progression to AD
    • Orešič, M. et al. Metabolome in progression to AD. Transl. Psychiatry. 1, e57 (2011).
    • (2011) Transl. Psychiatry. , vol.1 , pp. e57
    • Orešič, M.1
  • 49
    • 84976275057 scopus 로고    scopus 로고
    • Metabolic shifs toward fatty-acid usage and increased thermogenesis are associated with impaired adipogenesis in mice expressing human APOE4
    • Arbones-Mainar, J. M. et al. Metabolic shifs toward fatty-acid usage and increased thermogenesis are associated with impaired adipogenesis in mice expressing human APOE4. Int. J. Obes. 40, 1574-1581 (2016).
    • (2016) Int. J. Obes. , vol.40 , pp. 1574-1581
    • Arbones-Mainar, J.M.1
  • 51
    • 84883153448 scopus 로고    scopus 로고
    • Simultaneous, untargeted metabolic profling of polar and nonpolar metabolites by LC-Q-TOF mass spectrometry
    • Kirkwood, J. S., Maier, C. & Stevens, J. F.Simultaneous, untargeted metabolic profling of polar and nonpolar metabolites by LC-Q-TOF mass spectrometry. Curr. Protoc. Toxicol. 4, 39 (2013).
    • (2013) Curr. Protoc. Toxicol. , vol.4 , pp. 39
    • Kirkwood, J.S.1    Maier, C.2    Stevens, J.F.3
  • 52
    • 77956550520 scopus 로고    scopus 로고
    • MetPA: A web-based metabolomics tool for pathway analysis and visualization
    • Xia, J. & Wishart, D. S. MetPA: a web-based metabolomics tool for pathway analysis and visualization. Bioinformatics 26, 2342-2344 (2010).
    • (2010) Bioinformatics , vol.26 , pp. 2342-2344
    • Xia, J.1    Wishart, D.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.