Elevated adenosine monophosphate deaminase activity in Alzheimer's disease brain

Neurobiology of Aging

Volumn 19, Issue 5, 1998, Pages 385-391

  Sims, Brian ^a   Powers, Richard E ^b   Sabina, Richard L ^c   Theibert, Anne B ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Adenosine monophosphate deaminase (EC 3.5.4.6); Alzheimer's disease; Ammonia; Brain; Hyperammonemia; Postmortem

Indexed keywords

ADENOSINE MONOPHOSPHATE DEAMINASE; AMMONIA; MESSENGER RNA;

ADULT; AGED; ALZHEIMER DISEASE; AMMONIA FORMATION; ARTICLE; AUTOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; HYPERAMMONEMIA; IMMUNOBLOTTING; MALE; PATHOGENESIS; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; AMMONIA; AMP DEAMINASE; BRAIN; CEREBELLUM; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MALE; MIDDLE AGED; OCCIPITAL LOBE; RNA, MESSENGER; TEMPORAL LOBE;

EID: 0032411240     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(98)00083-9     Document Type: Article

References (58)

1. Adolfsson, R; Gottfries, C. G.; Oreland, L.; Winblad, B. Increased activity of brain and platelet monoamine oxidase in dementia of Alzheimer type. Life Sci. 27:1029-1034; 1980.
2. Branconnier, R. J.; Dessain, E. C.; McNiff, M. E.; Cole, J. O. Blood ammonia and Alzheimer's disease. Am. J. Psychiatry 143:1313; 1986.
3. Brion, J. P. The neurobiology of Alzheimer's disease. Acta Clin. Belg. 51:80-90; 1996.
4. Cairns, N. J.; Chadwick, A.; Luthert, P. J.; Lantos, P. L. Astrocytosis, β A4-protein deposition and paired helical filament formation in Alzheimer's disease. J. Neurol. Sci. 112:68-75; 1992.
5. Cooper, A. J. L.; Mora, S. N.; Cruz, N. F.; Gelbard, A. S. Cerebral ammonia metabolism in hyperammonemic rats. J. Neurochem. 44: 1716-1723; 1985.
6. 13N-labeled ammonia in rat brain. J. Biol. Chem. 254:4982-4992; 1979.
7. Cooper, A. J. L.; Plum, F. Biochemistry and physiology of brain ammonia. Physiol. Rev. 67:440-519; 1987.
8. Fisman, M.; Ball, M.; Blume, W. Hyperammonemia and Alzheimer's disease. J. Am. Geriatr. Soc. 37:1102; 1989.
9. Fisman, M.; Gordon, B.; Feleki, V.; Helmes, E.; Appell, J.; Rabheru, K. Hyperammonemia in Alzheimer's disease. Am. J. Psychiatry 142:71-73; 1985.
10. Fukautani, Y.; Cairns, N. J.; Rossor, M. N.; Lantos, P. L. Purkinje cell loss and astrocytosis in the familial and sporadic Alzheimer's disease. Neurosci. Lett. 214:33-6; 1996.
11. Geddes, J. W.; Cotman, C. W. Plasticity, pathology and Alzheimer's disease. Neurobiol. Aging 10:571-573; 1989.
12. Gibson, G. E; Sheu, K.-F. R.; Blass, J. P. Reduced activities of thiamine dependent enzymes in the brains and peripheral tissues of patients with Alzheimer's disease. Arch. Neurol. 45:836-840; 1988.
13. Gunnersen, D.; Haley, B. Detection of glutamine synthetase in the cerebrospinal fluid of Alzheimer diseased patients: A potential diagnostic biochemical marker. Proc. Natl. Acad. Sci. USA 89:11949-11953; 1992.
14. Hoyer, S.; Nitsch, R.; Oesterreich, K. Ammonia is endogenously generated in the presence of presumed and verified dementia of Alzheimer type. Neurosci. Lett. 117:358-362; 1990.
15. Hoyer, S. Possible role of ammonia in the brain in dementia of Alzheimer type. Hepatic encephalopathy, hyperammonemia, and ammonia toxicity. New York: Plenum Press; 1994:197-204.
16. Ito, K.; Yamamoto, H.; Mizugaki, M. Purification and general properties of AMP deaminase from sheep brain. J. Biochem. 103:259-262; 1988.
17. Johnson, G. V. W.; Cox, T. M.; Lockhart, J. P.; Zinnerman, M. D.; Miller, M. L.; Powers, R. E. Transglutaminase activity is increased in Alzheimer's disease brain. Brain Res. 751:323-329; 1997.
18. Jolly, D. J.; Okayama, H.; Berg, P.; Esty, A. C.; Filpula, D.; Bohlen, P.; Johnson, G. G.; Shively, J. E.; Hunkapillar, T.; Friedmann, T. Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase. Proc. Natl. Acad. Sci. USA 80:477-81; 1983.
19. Krieg, P. A.; Melton, D. A. In vitro RNA synthesis with SP6 RNA polymerase. Methods Enzymol. 155:397-415; 1987.
20. Le Prince, G.; Delaers, P.; Pages, C.; Lefrancois, T.; Touret, M.; Salanon, M.; Tardy, M. Glutamine synthetase (GS) expression is reduced in senile dementia of the Alzheimer type. Neurochem. Res. 20:859-862; 1995.
21. Lockwood, A. H. Hepatic encephalopathy and other neurological disorders associated with gastrointestinal disease, second edition. New York: Churchill Livingstone; 1994:247-258.
22. Lowenstein, J. M. The purine nucleotide cycle revised. Int. J. Sports Med. 11:S37-S46; 1990.
23. Mahnke-Zizelman D. K.; Sabina R. L. Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene exhibiting alternatively spliced 5′-exons. J. Biol. Chem. 267:20866-77; 1992.
24. Mahnke-Zizelman, D. K.; Eddy, R.; Shows, T. B.; Sabina, R. L. Characterization of the human AMPD3 gene reveals that 5′ exon usage is subject to transcriptional control by three tandem promoters and alternative splicing. Biochim. Biophys. Acta 1306:75-92; 1996.
25. Mahnke-Zizelman, D. K.; Van den Bergh, F.; Bausch-Jurken, M. T.; Eddy, R.; Sait, S.; Shows, T. B.; Sabina, R. L. Cloning, sequence and characterization of the human AMPD2 g, sequence and characterization of the human AMPD2 gene: Evidence for transcriptional regulation by two closely spaced promoters. Biochim. Biophys. Acta 1308:122-32; 1996.
26. Mancardi, G. L.; Liwnicz, B. H.; Mandybur, T. I. Fibrous astrocytes in Alzheimer's disease and senile dementia of Alzheimer's type. Acta Neuropathologica 61:76-80; 1983.
27. Mandybur, T. I.; Chuirazzi, C. C. Astrocytes and the plaques of Alzheimer's disease. Neurology 40:635-639; 1990.
28. Marquetant, R.; Sabina, R.; Holmes, E. Identification of a noncatalytic domain in AMP deaminase that influences binding to myosin. Biochemistry 28:8744-8749; 1989.
29. Merkler, D. J.; Schramm, V. L. Catalytic mechanism of yeast adenosine 5′-monophosphate deaminase. Zinc content, substrate specificity, pH studies, and solvent isotope effects. Biochemistry 32: 5792-9; 1993.
30. Morisaki, T.; Sabina, R. L.; Holmes, E. W. Adenylate deaminase, a multigene family in humans and rats. J. Biol. Chem. 265:11482-11486; 1990.
31. Miulli, D. E.; Norwell, D. Y.; Schwartz, F. N. Plasma concentrations of glutamate and its metabolites in patients with Alzheimer' s disease. J. Am. Geriatr. Soc. 93:670-676; 1993.
32. Mousseau, D. D.; Butterworth, R. F. Current theories on the pathogenesis of hepatic encephalopathy. Proc. Soc. Exp. Biol. Med. 206: 329-344; 1994.
33. Mrak R. E.; Sheng J. G.; Griffin W. S. Glial cytokines in Alzheimer's disease: Review and pathogenic implications. Hum. Pathol. 26:816-23; 1995.
34. Nixon, R. A.; Cataldo, A. M.; Paskevich, P. A.; Hamilton, D. J.; Wheelock, T. R.; Kanaley-Andrews, L. The lysosomal system in neurons: Involvement at multiple stages of Alzheimer's disease pathogenesis. Ann. N.Y. Acad. Sci. 674:65-88; 1992.
35. Norenberg, M. D. The role of astrocytes in hepatic encephalopathy. Neurochem. Pathol. 6:13-33; 1987.
36. Ogasawara, N.; Goto, H.; Watanabe, T. Isozymes of rat brain AMP-deaminase: Developmental changes and characterizations of five forms. FEBS Lett. 58:245-248; 1975.
37. Ogasawara, N.; Goto, H.; Yamada, Y.; Watanbe, T.; Asano, T. AMP-deaminase isozymes in human tissues. Biochim. Biophys. Acta 714:298-306; 1982.
38. Raabe, W. A.; Onstad, G. R. Ammonia and methionine sulfoxime intoxication. Brain Res. 242:291-298; 1982.
39. Ratnakumari, L.; Qureshi I. A.; Butterworth, R. F. Evidence for cholinergic neuronal loss in brain in congenital ornithine transcarbamylase deficiency. Neurosci. Lett. 178:63-65; 1994.
40. Ratnakumari, L.; Qureshi, I. A.; Maysinger, D.; Butterworth, R. F. Developmental deficiency of the cholinergic system in congenital hyperammonemic spf mice: Effect of acetyl-1-carnitine. J. Pharmacol. Exp. Ther. 274:437-443; 1995.
41. Reyes, M. G; Faraldi, F; Chandran, R.; Verano, A.; Levi, A. C. Histopathology of the substantia nigra in Alzheimer's disease. Panminerva Med. 38:8-14; 1996.
42. Sabina R. L.; Morisaki T.; Clarke P.; Eddy R.; Shows T. B.; Morton C. C.; Holmes E. W. Characterization of the human and rat myoadenylate deaminase genes. J. Biol. Chem. 265:9423-33; 1990.
43. Seiler, N. Is ammonia a pathogenetic factor in Alzheimer's disease? Neurochem. Res. 18:235-245; 1993.
44. Seiler N. An ammonia hypothesis of Alzheimer disease. Adv. Exp. Med. Biol. 420:235-55; 1997.
45. Selkoe, D. J. The molecular pathology of Alzheimer's disease. Neuron 6:487-498; 1991.
46. Siman, R.; Greenberg, B. D. Alzheimer's disease. Neurotherapeutics, emerging strategies. Totowa: Humana Press; 1996:389-428.
47. Smith, C. D.; Carney, J. M.; Stark-Reed, P. E.; Oliver, C. N.; Stadtman, E. R.; Floyd, R. A.; Markesbery, W. R. Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer's disease. Proc. Natl. Acad. Sci. USA 88:10540-10543; 1991.
48. Spychala, J.; Marszalek, J. Regulatory properties of AMP-deaminases from rat tissues. J. Biochem. 23:1155-1159; 1991.
49. Szerb, J. C.; Butterworth, R. F. Effect of ammonium ions on synaptic transmission in the mammalian central nervous system. Prog. Neurobiol. 39:135-153; 1992.
50. Tovmasian, E. K.; Hairapetian, R. L.; Bykova, E. V.; Severin, Jr., S. E.; Haroutunian, A. V. Phosphorylation of the skeletal muscle AMP-deaminase by protein kinase C. FEB 259:321-323; 1990.
51. Theibert, A. B.; Estevez, V. A.; Marecek, J. F.; Prestwich, G. D.; Snyder, S. H. Photoaffinity labeling and characterization of isolated inositol 1,3,4,5-tetrakisphosphate- and inositol hexakisphosphate-binding proteins. J. Biol. Chem. 267:9071-9079; 1992.
52. Van den Bergh, F.; Sabina, R. L. Characterization of human AMP deaminase 2 (AMPD2) gene expression reveals alternative transcripts encoding variable N-terminal extensions of isoform. Biochem. J. 312:401-10; 1995.
53. Vettenranta K.; Raivio K. O. Key enzymes of purine degradation and reutilization in human fetal liver and brain. Biol. Neonate 58:311-7; 1990.
54. Weil-Malherbe, H.; Drysdale, A. C. Ammonia formation in brain-III. The role of the protein amide groups and of hexosamines. J. Neurochem. 1:250-255; 1957.
55. Yankner, B. A. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 16:921-932; 1996.
56. Yoshino, M.; Miyajma, E.; Tsushima, K. Inhibition of AMP deaminase of bovine brain and liver by fatty acyl-CoA derivatives. FEBS Lett. 72:143-146; 1976.
57. Yoshino, M.; Murakami, K. AMP deaminase reaction as a control system of glycolysis in yeast. J. Biol. Chem. 260:4729-4732; 1985.
58. Zoref-Shani, E.; Bromberg, Y.; Lilling, G.; Gozes, I.; Brosh, S.; Sidi, Y. Developmental changes in purine nucleotide metabolism in cultured rat astroglia. Int. J. Dev. Neurosci. 13:887-96; 1995.