Ultrafine carbon particles promote rotenone-induced dopamine neuronal loss through activating microglial NADPH oxidase

Toxicology and Applied Pharmacology

Volumn 322, Issue , 2017, Pages 51-59

  Wang, Yinxi ^a   Liu, Dan ^a   Zhang, Huifeng ^a   Wang, Yixin ^a   Wei, Ling ^b   Liu, Yutong ^c   Liao, Jieying ^d   Gao, Hui Ming ^e   Zhou, Hui ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b Beijing Center for Physical and Chemical Analysis   (China)

^c BEIJING NORMAL UNIVERSITY   (China)

^d INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^e NANJING UNIVERSITY   (China)

Author keywords

NADPH oxidase; Neuroinflammation; Parkinson's disease; Particulate matter; Rotenone; Ultrafine carbon black

Indexed keywords

DOPAMINE; ENVIRONMENTAL CHEMICAL; GLYCOPROTEIN GP 91; PROTEIN P40; PROTEIN P47; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; ROTENONE; SUPEROXIDE; TYROSINE 3 MONOOXYGENASE; ULTRAFINE CARBON PARTICLE; UNCLASSIFIED DRUG; SILICONE DERIVATIVE; SOOT; ULTRAFINE;

ARTICLE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; GENE DELETION; GLIA; GLIAL CELL CULTURE; IMMUNOCHEMISTRY; MESENCEPHALON; MICROGLIA; MOUSE; NERVE CELL CULTURE; NEUROPATHOLOGY; NEUROTOXICITY; NEUROTOXICOLOGY; NONHUMAN; PARKINSON DISEASE; RAT; 129 MOUSE; ANIMAL; C57BL MOUSE; CELL CULTURE; COCULTURE; DOSE RESPONSE; DRUG EFFECTS; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; NERVE CELL; PATHOLOGY; PHYSIOLOGY; SOOT; SPRAGUE DAWLEY RAT; TOXICITY;

ANIMALS; CELLS, CULTURED; COCULTURE TECHNIQUES; DOPAMINERGIC NEURONS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ENZYME ACTIVATION; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICROGLIA; NADPH OXIDASE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; ROTENONE; SILICONES; SOOT;

EID: 85014956428     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2017.03.005     Document Type: Article

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