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Volumn 6, Issue 5, 2017, Pages 440-446

Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice

Author keywords

Diabetes; Dyslipidemia; Glucose homeostasis; Obesity; Pharmacotherapy; Sex differences

Indexed keywords

GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1;

EID: 85014827561     PISSN: None     EISSN: 22128778     Source Type: Journal    
DOI: 10.1016/j.molmet.2017.02.002     Document Type: Article
Times cited : (92)

References (33)
  • 1
    • 84906882822 scopus 로고    scopus 로고
    • Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013
    • [1] Ng, M., Fleming, T., Robinson, M., Thomson, B., Graetz, N., Margono, C., et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 384 (2014), 766–781.
    • (2014) Lancet , vol.384 , pp. 766-781
    • Ng, M.1    Fleming, T.2    Robinson, M.3    Thomson, B.4    Graetz, N.5    Margono, C.6
  • 2
    • 84899898677 scopus 로고    scopus 로고
    • The direct and indirect costs of both overweight and obesity: a systematic review
    • [2] Dee, A., Kearns, K., O'Neill, C., Sharp, L., Staines, A., O'Dwyer, V., et al. The direct and indirect costs of both overweight and obesity: a systematic review. BMC Research Notes, 7, 2014, 242.
    • (2014) BMC Research Notes , vol.7 , pp. 242
    • Dee, A.1    Kearns, K.2    O'Neill, C.3    Sharp, L.4    Staines, A.5    O'Dwyer, V.6
  • 5
    • 85010930965 scopus 로고    scopus 로고
    • Evolution of pharmacological obesity treatments: focus on adverse side-effect profiles
    • [5] Krentz, A.J., Fujioka, K., Hompesch, M., Evolution of pharmacological obesity treatments: focus on adverse side-effect profiles. Diabetes, Obesity and Metabolism 18 (2016), 558–570.
    • (2016) Diabetes, Obesity and Metabolism , vol.18 , pp. 558-570
    • Krentz, A.J.1    Fujioka, K.2    Hompesch, M.3
  • 7
    • 78651361894 scopus 로고    scopus 로고
    • Cost-effectiveness of bariatric surgery for severely obese adults with diabetes
    • [7] Hoerger, T.J., Zhang, P., Segel, J.E., Kahn, H.S., Barker, L.E., Couper, S., Cost-effectiveness of bariatric surgery for severely obese adults with diabetes. Diabetes Care 33 (2010), 1933–1939.
    • (2010) Diabetes Care , vol.33 , pp. 1933-1939
    • Hoerger, T.J.1    Zhang, P.2    Segel, J.E.3    Kahn, H.S.4    Barker, L.E.5    Couper, S.6
  • 10
    • 84866706026 scopus 로고    scopus 로고
    • Female mice are protected against high-fat diet induced metabolic syndrome and increase the regulatory T cell population in adipose tissue
    • [10] Pettersson, U.S., Walden, T.B., Carlsson, P.O., Jansson, L., Phillipson, M., Female mice are protected against high-fat diet induced metabolic syndrome and increase the regulatory T cell population in adipose tissue. PLoS One, 7, 2012, e46057.
    • (2012) PLoS One , vol.7 , pp. e46057
    • Pettersson, U.S.1    Walden, T.B.2    Carlsson, P.O.3    Jansson, L.4    Phillipson, M.5
  • 11
    • 61849113209 scopus 로고    scopus 로고
    • Differential susceptibility to obesity between male, female and ovariectomized female mice
    • [11] Hong, J., Stubbins, R.E., Smith, R.R., Harvey, A.E., Nunez, N.P., Differential susceptibility to obesity between male, female and ovariectomized female mice. Nutrition Journal, 8, 2009, 11.
    • (2009) Nutrition Journal , vol.8 , pp. 11
    • Hong, J.1    Stubbins, R.E.2    Smith, R.R.3    Harvey, A.E.4    Nunez, N.P.5
  • 12
    • 0003828657 scopus 로고    scopus 로고
    • Exploring the biological contributions to human health: does sex matter?
    • National Academies Press Washington (DC)
    • [12] Wizemann, T.M., Pardue, M.L., Exploring the biological contributions to human health: does sex matter?. 2001, National Academies Press, Washington (DC).
    • (2001)
    • Wizemann, T.M.1    Pardue, M.L.2
  • 13
    • 64549132904 scopus 로고    scopus 로고
    • Sex differences in the regulation of body weight
    • [13] Shi, H., Clegg, D.J., Sex differences in the regulation of body weight. Physiology& Behavior 97 (2009), 199–204.
    • (2009) Physiology& Behavior , vol.97 , pp. 199-204
    • Shi, H.1    Clegg, D.J.2
  • 15
    • 0031760880 scopus 로고    scopus 로고
    • Age and sex distribution of suspected adverse drug reactions to newly marketed drugs in general practice in England: analysis of 48 cohort studies
    • [15] Martin, R.M., Biswas, P.N., Freemantle, S.N., Pearce, G.L., Mann, R.D., Age and sex distribution of suspected adverse drug reactions to newly marketed drugs in general practice in England: analysis of 48 cohort studies. British Journal of Clinical Pharmacology 46 (1998), 505–511.
    • (1998) British Journal of Clinical Pharmacology , vol.46 , pp. 505-511
    • Martin, R.M.1    Biswas, P.N.2    Freemantle, S.N.3    Pearce, G.L.4    Mann, R.D.5
  • 16
    • 84900526349 scopus 로고    scopus 로고
    • Policy: NIH to balance sex in cell and animal studies
    • [16] Clayton, J.A., Collins, F.S., Policy: NIH to balance sex in cell and animal studies. Nature 509 (2014), 282–283.
    • (2014) Nature , vol.509 , pp. 282-283
    • Clayton, J.A.1    Collins, F.S.2
  • 17
    • 84861890043 scopus 로고    scopus 로고
    • Outstanding Scientific Achievement Award Lecture 2011: defeating diabesity: the case for personalized combinatorial therapies
    • [17] Tschöp, M.H., DiMarchi, R.D., Outstanding Scientific Achievement Award Lecture 2011: defeating diabesity: the case for personalized combinatorial therapies. Diabetes 61 (2012), 1309–1314.
    • (2012) Diabetes , vol.61 , pp. 1309-1314
    • Tschöp, M.H.1    DiMarchi, R.D.2
  • 19
    • 84925282923 scopus 로고    scopus 로고
    • A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
    • [19] Finan, B., Yang, B., Ottaway, N., Smiley, D.L., Ma, T., Clemmensen, C., et al. A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents. Nature Medicine 21 (2015), 27–36.
    • (2015) Nature Medicine , vol.21 , pp. 27-36
    • Finan, B.1    Yang, B.2    Ottaway, N.3    Smiley, D.L.4    Ma, T.5    Clemmensen, C.6
  • 20
    • 84907683220 scopus 로고    scopus 로고
    • Variations in body weight, food intake and body composition after long-term high-fat diet feeding in C57BL/6J mice
    • [20] Yang, Y., Smith, D.L. Jr., Keating, K.D., Allison, D.B., Nagy, T.R., Variations in body weight, food intake and body composition after long-term high-fat diet feeding in C57BL/6J mice. Obesity (Silver Spring) 22 (2014), 2147–2155.
    • (2014) Obesity (Silver Spring) , vol.22 , pp. 2147-2155
    • Yang, Y.1    Smith, D.L.2    Keating, K.D.3    Allison, D.B.4    Nagy, T.R.5
  • 21
    • 0344683235 scopus 로고    scopus 로고
    • National research council (US) committee for the update of the Guide for the Care and use of laboratory Animals. Guide for the Care and use of laboratory Animals
    • Available from: Accessed 23 January 2017
    • [21] National Institutes of Health, National research council (US) committee for the update of the Guide for the Care and use of laboratory Animals. Guide for the Care and use of laboratory Animals. 2011, 10.17226/12910 Available from: https://www.ncbi.nlm.nih.gov/books/NBK54050/ Accessed 23 January 2017.
    • (2011)
    • National Institutes of Health1
  • 22
    • 84897909191 scopus 로고    scopus 로고
    • GLP-1/glucagon coagonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet
    • [22] Clemmensen, C., Chabenne, J., Finan, B., Sullivan, L., Fischer, K., Kuchler, D., et al. GLP-1/glucagon coagonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet. Diabetes 63 (2014), 1422–1427.
    • (2014) Diabetes , vol.63 , pp. 1422-1427
    • Clemmensen, C.1    Chabenne, J.2    Finan, B.3    Sullivan, L.4    Fischer, K.5    Kuchler, D.6
  • 23
    • 0021813187 scopus 로고
    • Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • [23] Matthews, D.R., Hosker, J.P., Rudenski, A.S., Naylor, B.A., Treacher, D.F., Turner, R.C., Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 (1985), 412–419.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 24
    • 38449108309 scopus 로고    scopus 로고
    • Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice
    • [24] Hofmann, S.M., Perez-Tilve, D., Greer, T.M., Coburn, B.A., Grant, E., Basford, J.E., et al. Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice. Diabetes 57 (2008), 5–12.
    • (2008) Diabetes , vol.57 , pp. 5-12
    • Hofmann, S.M.1    Perez-Tilve, D.2    Greer, T.M.3    Coburn, B.A.4    Grant, E.5    Basford, J.E.6
  • 25
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • [25] Kleiner, D.E., Brunt, E.M., Van Natta, M., Behling, C., Contos, M.J., Cummings, O.W., et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41 (2005), 1313–1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3    Behling, C.4    Contos, M.J.5    Cummings, O.W.6
  • 26
    • 84919674550 scopus 로고    scopus 로고
    • Hypothalamic PGC-1alpha protects against high-fat diet exposure by regulating ERalpha
    • [26] Morselli, E., Fuente-Martin, E., Finan, B., Kim, M., Frank, A., Garcia-Caceres, C., et al. Hypothalamic PGC-1alpha protects against high-fat diet exposure by regulating ERalpha. Cell Reports 9 (2014), 633–645.
    • (2014) Cell Reports , vol.9 , pp. 633-645
    • Morselli, E.1    Fuente-Martin, E.2    Finan, B.3    Kim, M.4    Frank, A.5    Garcia-Caceres, C.6
  • 27
    • 0025341763 scopus 로고
    • Fasting serum insulin concentration and early insulin response as risk determinants for developing diabetes
    • [27] Lundgren, H., Bengtsson, C., Blohme, G., Lapidus, L., Waldenstrom, J., Fasting serum insulin concentration and early insulin response as risk determinants for developing diabetes. Diabetic Medicine 7 (1990), 407–413.
    • (1990) Diabetic Medicine , vol.7 , pp. 407-413
    • Lundgren, H.1    Bengtsson, C.2    Blohme, G.3    Lapidus, L.4    Waldenstrom, J.5
  • 28
    • 84877264082 scopus 로고    scopus 로고
    • Female mice are more susceptible to nonalcoholic fatty liver disease: sex-specific regulation of the hepatic AMP-activated protein kinase-plasminogen activator inhibitor 1 cascade, but not the hepatic endotoxin response
    • [28] Spruss, A., Henkel, J., Kanuri, G., Blank, D., Puschel, G.P., Bischoff, S.C., et al. Female mice are more susceptible to nonalcoholic fatty liver disease: sex-specific regulation of the hepatic AMP-activated protein kinase-plasminogen activator inhibitor 1 cascade, but not the hepatic endotoxin response. Molecular Medicine 18 (2012), 1346–1355.
    • (2012) Molecular Medicine , vol.18 , pp. 1346-1355
    • Spruss, A.1    Henkel, J.2    Kanuri, G.3    Blank, D.4    Puschel, G.P.5    Bischoff, S.C.6
  • 29
    • 84904382730 scopus 로고    scopus 로고
    • High fat diet feeding results in gender specific steatohepatitis and inflammasome activation
    • [29] Ganz, M., Csak, T., Szabo, G., High fat diet feeding results in gender specific steatohepatitis and inflammasome activation. World Journal of Gastroenterology 20 (2014), 8525–8534.
    • (2014) World Journal of Gastroenterology , vol.20 , pp. 8525-8534
    • Ganz, M.1    Csak, T.2    Szabo, G.3
  • 30
    • 84948456496 scopus 로고    scopus 로고
    • Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: a comparison with vitamin E
    • [30] Ni, Y., Nagashimada, M., Zhuge, F., Zhan, L., Nagata, N., Tsutsui, A., et al. Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: a comparison with vitamin E. Scientific Reports, 5, 2015, 17192.
    • (2015) Scientific Reports , vol.5 , pp. 17192
    • Ni, Y.1    Nagashimada, M.2    Zhuge, F.3    Zhan, L.4    Nagata, N.5    Tsutsui, A.6
  • 31
    • 13444282229 scopus 로고    scopus 로고
    • Liver enzyme alteration: a guide for clinicians
    • [31] Giannini, E.G., Testa, R., Savarino, V., Liver enzyme alteration: a guide for clinicians. CMAJ 172 (2005), 367–379.
    • (2005) CMAJ , vol.172 , pp. 367-379
    • Giannini, E.G.1    Testa, R.2    Savarino, V.3
  • 32
    • 79959518258 scopus 로고    scopus 로고
    • Assessment of different bariatric surgeries in the treatment of obesity and insulin resistance in mice
    • [32] Yin, D.P., Gao, Q., Ma, L.L., Yan, W., Williams, P.E., McGuinness, O.P., et al. Assessment of different bariatric surgeries in the treatment of obesity and insulin resistance in mice. Annals of Surgery 254 (2011), 73–82.
    • (2011) Annals of Surgery , vol.254 , pp. 73-82
    • Yin, D.P.1    Gao, Q.2    Ma, L.L.3    Yan, W.4    Williams, P.E.5    McGuinness, O.P.6
  • 33
    • 84949756400 scopus 로고    scopus 로고
    • Gastric bypass surgery but not caloric restriction improves reproductive function in obese mice
    • [33] Frank, A.P., Zechner, J.F., Clegg, D.J., Gastric bypass surgery but not caloric restriction improves reproductive function in obese mice. Obesity Surgery 26 (2016), 467–473.
    • (2016) Obesity Surgery , vol.26 , pp. 467-473
    • Frank, A.P.1    Zechner, J.F.2    Clegg, D.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.