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Volumn 2, Issue 3, 2015, Pages 236-247

GHK-Cu may prevent oxidative stress in skin by regulating copper and modifying expression of numerous antioxidant genes

Author keywords

Copper peptides; Dichloromethane; Ferritin iron oxidation; Gene expression; Gene profiling; GHK; Glycyl L histidyl L lysine; Reactive carbonyl species; Reactive oxygen species

Indexed keywords


EID: 85014486567     PISSN: None     EISSN: 20799284     Source Type: Journal    
DOI: 10.3390/cosmetics2030236     Document Type: Review
Times cited : (29)

References (64)
  • 1
    • 0035095323 scopus 로고    scopus 로고
    • Antioxidants in health and disease
    • Young, I.S.; Woodside, J.V. Antioxidants in health and disease. J. Clin. Pathol. 2001, 54, 176-186
    • (2001) J. Clin. Pathol , vol.54 , pp. 176-186
    • Young, I.S.1    Woodside, J.V.2
  • 2
    • 84899581041 scopus 로고    scopus 로고
    • The role of antioxidants in skin cancer prevention and treatment
    • Godic, A.; Poljsak, B.; Adamic, M.; Dahmane, R. The role of antioxidants in skin cancer prevention and treatment. Oxid. Med. Cell. Longev. 2014, 2014, doi:10.1155/2014/860479
    • (2014) Oxid. Med. Cell. Longev , vol.2014
    • Godic, A.1    Poljsak, B.2    Adamic, M.3    Dahmane, R.4
  • 3
    • 33748750998 scopus 로고    scopus 로고
    • Dual effects of antioxidants in neurodegeneration: Direct neuroprotection against oxidative stress and indirect protection via suppression of glia-mediated inflammation
    • Wang, J.Y.; Wen, L.L.; Huang, Y.N.; Chen, Y.T.; Ku, M.C. Dual effects of antioxidants in neurodegeneration: Direct neuroprotection against oxidative stress and indirect protection via suppression of glia-mediated inflammation. Curr. Pharm. Des. 2006, 12, 3521-3533
    • (2006) Curr. Pharm. Des , vol.12 , pp. 3521-3533
    • Wang, J.Y.1    Wen, L.L.2    Huang, Y.N.3    Chen, Y.T.4    Ku, M.C.5
  • 4
    • 46849097170 scopus 로고    scopus 로고
    • The human tri-peptide GHK and tissue remodeling
    • Pickart, L. The human tri-peptide GHK and tissue remodeling. J. Biomater. Sci. Polym. Ed. 2008, 19, 969-988
    • (2008) J. Biomater. Sci. Polym. Ed , vol.19 , pp. 969-988
    • Pickart, L.1
  • 5
    • 85063850752 scopus 로고    scopus 로고
    • A possible mechanism whereby skin remodeling may suppress cancer metastasis genes
    • Wiley-Blackwell: Malden, MA, USA
    • Pickart, L.; Pickart, F. A possible mechanism whereby skin remodeling may suppress cancer metastasis genes. In Wound Repair and Regeneration; Wiley-Blackwell: Malden, MA, USA, 2011; Volume 19, p. A62
    • (2011) Wound Repair and Regeneration , vol.19 , pp. A62
    • Pickart, L.1    Pickart, F.2
  • 7
    • 0018826944 scopus 로고
    • Growth-modulating tripeptide (glycylhistidyllysine): Association with copper and iron in plasma, and stimulation of adhesiveness and growth of hepatoma cells in culture by tripeptide-metal ion complexes
    • Pickart, L.; Thaler, M.M. Growth-modulating tripeptide (glycylhistidyllysine): Association with copper and iron in plasma, and stimulation of adhesiveness and growth of hepatoma cells in culture by tripeptide-metal ion complexes. J. Cell. Physiol. 1980, 102, 129-139
    • (1980) J. Cell. Physiol , vol.102 , pp. 129-139
    • Pickart, L.1    Thaler, M.M.2
  • 8
    • 0017395706 scopus 로고
    • Growth-modulating serum tripeptide is glycyl-histidyl-lysine
    • Schlesinger, D.; Pickart, L.; Thaler, M. Growth-modulating serum tripeptide is glycyl-histidyl-lysine. Cell. Mol. Life Sci. 1977, 33, 324-325
    • (1977) Cell. Mol. Life Sci , vol.33 , pp. 324-325
    • Schlesinger, D.1    Pickart, L.2    Thaler, M.3
  • 9
    • 0028355889 scopus 로고
    • SPARC is a source of copper-binding peptides that stimulate angiogenesis
    • Lane, T.; Iruela-Arispe, M.; Johnson, R.; Sage, E. SPARC is a source of copper-binding peptides that stimulate angiogenesis. J. Cell. Biol. 1994, 125, 929-943
    • (1994) J. Cell. Biol , vol.125 , pp. 929-943
    • Lane, T.1    Iruela-Arispe, M.2    Johnson, R.3    Sage, E.4
  • 10
    • 0019155815 scopus 로고
    • Growth-modulating plasma tripeptide may function by facilitating copper uptake into cells
    • Pickart, L.; Freedman, J.; Loker, W.; Peisach, J.; Perkins, C.; Stenkamp, R.; Weinstein, B. Growth-modulating plasma tripeptide may function by facilitating copper uptake into cells. Nature 1980, 288, 715-717
    • (1980) Nature , vol.288 , pp. 715-717
    • Pickart, L.1    Freedman, J.2    Loker, W.3    Peisach, J.4    Perkins, C.5    Stenkamp, R.6    Weinstein, B.7
  • 11
    • 0019834173 scopus 로고
    • The interaction of copper(II) and glycyl-L-histidyl-L-lysine, a growth-modulating tripeptide from plasma
    • Lau, S.; Sarkar, B. The interaction of copper(II) and glycyl-L-histidyl-L-lysine, a growth-modulating tripeptide from plasma. Biochem. J. 1981, 199, 649-656
    • (1981) Biochem. J , vol.199 , pp. 649-656
    • Lau, S.1    Sarkar, B.2
  • 12
    • 0019837937 scopus 로고
    • The use of glycylhistidyllysine in culture systems
    • Pickart, L. The use of glycylhistidyllysine in culture systems. In Vitro 1981, 17, 459-466
    • (1981) In Vitro , vol.17 , pp. 459-466
    • Pickart, L.1
  • 13
    • 0019127509 scopus 로고
    • Glycyl-L-histidyl-L-lysine, a growth promoting factor for human cells
    • Williams, M.V.; Cheng, Y. Glycyl-L-histidyl-L-lysine, a growth promoting factor for human cells. Cytobios 1979, 27, 19-25
    • (1979) Cytobios , vol.27 , pp. 19-25
    • Williams, M.V.1    Cheng, Y.2
  • 14
    • 0023492188 scopus 로고
    • Effects of glycyl-histidyl-lysine on Morris hepatoma 7777 cells
    • Barra, R. Effects of glycyl-histidyl-lysine on Morris hepatoma 7777 cells. Cytobios 1986, 52, 99-107
    • (1986) Cytobios , vol.52 , pp. 99-107
    • Barra, R.1
  • 15
    • 17144407587 scopus 로고    scopus 로고
    • Effects of copper tripeptide on the growth and expression of growth factors by normal and irradiated fibroblasts
    • Pollard, J.; Quan, S.; Kang, T.; Koch, R. Effects of copper tripeptide on the growth and expression of growth factors by normal and irradiated fibroblasts. Arch. Facial Plast. Surg. 2005, 7, 27-31
    • (2005) Arch. Facial Plast. Surg , vol.7 , pp. 27-31
    • Pollard, J.1    Quan, S.2    Kang, T.3    Koch, R.4
  • 16
    • 33845876254 scopus 로고    scopus 로고
    • The connectivity map: A new tool for biomedical research
    • Lamb, J. The connectivity map: A new tool for biomedical research. Nat. Rev. Cancer 2007, 7, 54-60
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 54-60
    • Lamb, J.1
  • 18
    • 77949907451 scopus 로고    scopus 로고
    • A "metastasis-prone" signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics
    • Hong, Y.; Downey, T.; Eu, K.; Koh, P.; Cheah, P. A "metastasis-prone" signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics. Clin. Exp. Metastasis 2010, 27, 83-90
    • (2010) Clin. Exp. Metastasis , vol.27 , pp. 83-90
    • Hong, Y.1    Downey, T.2    Eu, K.3    Koh, P.4    Cheah, P.5
  • 22
    • 0022406029 scopus 로고
    • Acceleration of wound healing using glycyl-histidyl-lysine copper (II)
    • Downey, D.; Larrabee, W.; Voci, V.; Pickart, L. Acceleration of wound healing using glycyl-histidyl-lysine copper (II). Surg. Forum 1985, 25, 573-575
    • (1985) Surg. Forum , vol.25 , pp. 573-575
    • Downey, D.1    Larrabee, W.2    Voci, V.3    Pickart, L.4
  • 23
    • 0023719508 scopus 로고
    • Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+
    • Maquart, F.; Pickart, L.; Laurent, M.; Gillery, P.; Monboisse, J.; Borel, J. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Lett. 1988, 238, 343-346
    • (1988) FEBS Lett , vol.238 , pp. 343-346
    • Maquart, F.1    Pickart, L.2    Laurent, M.3    Gillery, P.4    Monboisse, J.5    Borel, J.6
  • 24
    • 0027443057 scopus 로고
    • In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds
    • Maquart, F.; Bellon, G.; Chaqour, B.; Wegrowski, J.; Patt, L.M.; Trachy, R.; Monboisse, J.; Chastang, F.; Birembaut, P.; Gillery, P.; et al. In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds. J. Clin. Invest. 1993, 92, 2368-2376
    • (1993) J. Clin. Invest , vol.92 , pp. 2368-2376
    • Maquart, F.1    Bellon, G.2    Chaqour, B.3    Wegrowski, J.4    Patt, L.M.5    Trachy, R.6    Monboisse, J.7    Chastang, F.8    Birembaut, P.9    Gillery, P.10
  • 25
    • 0026757171 scopus 로고
    • Stimulation of sulfated glycosaminoglycan synthesis by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+
    • Wegrowski, Y.; Maquart, F.; Borel, J. Stimulation of sulfated glycosaminoglycan synthesis by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. Life Sci. 1992, 51, 1049-1056
    • (1992) Life Sci , vol.51 , pp. 1049-1056
    • Wegrowski, Y.1    Maquart, F.2    Borel, J.3
  • 26
    • 0034703502 scopus 로고    scopus 로고
    • The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures
    • Simeon, A.; Emonard, H.; Hornebeck, W.; Maquart, F. The tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ stimulates matrix metalloproteinase-2 expression by fibroblast cultures. Life Sci. 2000, 67, 2257-2265
    • (2000) Life Sci , vol.67 , pp. 2257-2265
    • Simeon, A.1    Emonard, H.2    Hornebeck, W.3    Maquart, F.4
  • 27
    • 0034521219 scopus 로고    scopus 로고
    • Expression of glycosaminoglycans and small proteoglycans in wounds: Modulation by the tripeptide-copper complex glycyl-L-histidyl-Llysine-Cu(2+)
    • Simeon, A.; Wegrowski, Y.; Bontemps, Y.; Maquart, F. Expression of glycosaminoglycans and small proteoglycans in wounds: Modulation by the tripeptide-copper complex glycyl-L-histidyl-Llysine-Cu(2+). J. Invest. Dermatol. 2000, 115, 962-968
    • (2000) J. Invest. Dermatol , vol.115 , pp. 962-968
    • Simeon, A.1    Wegrowski, Y.2    Bontemps, Y.3    Maquart, F.4
  • 28
    • 37549049763 scopus 로고    scopus 로고
    • The effects of topical tripeptide copper complex and helium-neon laser on wound healing in rabbits
    • Gul, N.Y.; Topal, A.; Cangul, I.T.; Yanik, K. The effects of topical tripeptide copper complex and helium-neon laser on wound healing in rabbits. Vet. Dermatol. 2008, 19, 7-14
    • (2008) Vet. Dermatol , vol.19 , pp. 7-14
    • Gul, N.Y.1    Topal, A.2    Cangul, I.T.3    Yanik, K.4
  • 29
    • 33750704278 scopus 로고    scopus 로고
    • Evaluation of the effects of topical tripeptide-copper complex and zinc oxide on open-wound healing in rabbits
    • Cangul, I.T.; Gul, N.Y.; Topal, A.; Yilmaz, R. Evaluation of the effects of topical tripeptide-copper complex and zinc oxide on open-wound healing in rabbits. Vet. Dermatol. 2006, 17, 417-423
    • (2006) Vet. Dermatol , vol.17 , pp. 417-423
    • Cangul, I.T.1    Gul, N.Y.2    Topal, A.3    Yilmaz, R.4
  • 31
    • 33845623411 scopus 로고    scopus 로고
    • A therapeutic approach for diabetic wound healing using biotinylated GHK incorporated collagen matrices
    • Arul, V.; Kartha, R.; Jayakumar, R. A therapeutic approach for diabetic wound healing using biotinylated GHK incorporated collagen matrices. Life Sci. 2007, 80, 275-284
    • (2007) Life Sci , vol.80 , pp. 275-284
    • Arul, V.1    Kartha, R.2    Jayakumar, R.3
  • 34
    • 0026731716 scopus 로고
    • The influence of medium components on Cu2+-dependent oxidation of low-density lipoproteins and its sensitivity to superoxide dismutase
    • Thomas, C.E. The influence of medium components on Cu2+-dependent oxidation of low-density lipoproteins and its sensitivity to superoxide dismutase. Biochim. Biophys. Acta 1992, 1128, 50-57
    • (1992) Biochim. Biophys. Acta , vol.1128 , pp. 50-57
    • Thomas, C.E.1
  • 35
    • 44249095307 scopus 로고    scopus 로고
    • Acrolein sequestering ability of the endogenous tripeptide glycyl-histidyl-lysine (GHK): Characterization of conjugation products by ESI-MSn and theoretical calculations
    • Beretta, G.; Arlandini, E.; Artali, R.; Anton, J.M.; Maffei Facino, R. Acrolein sequestering ability of the endogenous tripeptide glycyl-histidyl-lysine (GHK): Characterization of conjugation products by ESI-MSn and theoretical calculations. J. Pharm Biomed. Anal. 2008, 47, 596-602
    • (2008) J. Pharm Biomed. Anal , vol.47 , pp. 596-602
    • Beretta, G.1    Arlandini, E.2    Artali, R.3    Anton, J.M.4    Maffei Facino, R.5
  • 36
    • 35148824739 scopus 로고    scopus 로고
    • Glycyl-histidyl-lysine (GHK) is a quencher of α,β-4-hydroxy-trans-2-nonenal: A comparison with carnosin. Insights into the mechanism of reaction by electrospray ionization mass spectrometry, 1H NMR, and computational techniques
    • Beretta, G.; Artali, R.; Regazzoni, L.; Panigati, M.; Facino, R.M. Glycyl-histidyl-lysine (GHK) is a quencher of α,β-4-hydroxy-trans-2-nonenal: A comparison with carnosine. Insights into the mechanism of reaction by electrospray ionization mass spectrometry, 1H NMR, and computational techniques. Chem. Res. Toxicol. 2007, 20, 1309-1314
    • (2007) Chem. Res. Toxicol , vol.20 , pp. 1309-1314
    • Beretta, G.1    Artali, R.2    Regazzoni, L.3    Panigati, M.4    Facino, R.M.5
  • 38
    • 0142027518 scopus 로고    scopus 로고
    • [Pharmacological correction of immuno-metabolic disorders with the peptide Gly-His-Lys in hepatic damage induced by tetrachloromethane]
    • Smakhtin, M.; Konoplia, A.; Sever'ianova, L.; Shveinov, I. [Pharmacological correction of immuno-metabolic disorders with the peptide Gly-His-Lys in hepatic damage induced by tetrachloromethane]. Patol. Fiziol. Eksp. Ter. Russ. 2003, 2, 19-21
    • (2003) Patol. Fiziol. Eksp. Ter. Russ , vol.2 , pp. 19-21
    • Smakhtin, M.1    Konoplia, A.2    Sever'ianova, L.3    Shveinov, I.4
  • 39
    • 84901763497 scopus 로고    scopus 로고
    • Synergetic antioxidant and reparative action of thymogen, dalargin and peptide Gly-His-Lys in tubular bone fractures
    • Cherdakov, V.Y.; Smakhtin, M.Y.; Dubrovin, G.M.; Dudka, V.T.; Bobyntsev, I.I. Synergetic antioxidant and reparative action of thymogen, dalargin and peptide Gly-His-Lys in tubular bone fractures. Exp. Biol. Med. 2010, 4, 15-20
    • (2010) Exp. Biol. Med , vol.4 , pp. 15-20
    • Cherdakov, V.Y.1    Smakhtin, M.Y.2    Dubrovin, G.M.3    Dudka, V.T.4    Bobyntsev, I.I.5
  • 40
    • 0025180049 scopus 로고
    • Effects of glycyl-histidyl-lysyl chelated Cu(II) on ferritin dependent lipid peroxidation
    • Miller, D.M.; DeSilva, D.; Pickart, L.; Aust, S.D. Effects of glycyl-histidyl-lysyl chelated Cu(II) on ferritin dependent lipid peroxidation. Adv. Exp. Med. Biol. 1990, 264, 79-84
    • (1990) Adv. Exp. Med. Biol , vol.264 , pp. 79-84
    • Miller, D.M.1    DeSilva, D.2    Pickart, L.3    Aust, S.D.4
  • 42
    • 84901800410 scopus 로고    scopus 로고
    • GHK, the human skin remodeling peptide, induces anti-cancer expression of numerous caspase, growth regulatory, and DNA repair genes
    • Pickart, L.; Vasquez-Soltero, J.M.; Pickart, F.D.; Majnarich, J. GHK, the human skin remodeling peptide, induces anti-cancer expression of numerous caspase, growth regulatory, and DNA repair genes. J. Anal. Oncol. 2014, 3, 79-87
    • (2014) J. Anal. Oncol , vol.3 , pp. 79-87
    • Pickart, L.1    Vasquez-Soltero, J.M.2    Pickart, F.D.3    Majnarich, J.4
  • 43
    • 74249092946 scopus 로고    scopus 로고
    • NF-kappaB-induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes
    • Mariappan, N.; Elks, C.M.; Sriramula, S.; Guggilam, A.; Liu, Z.; Borkhsenious, O.; Francis, J. NF-kappaB-induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes. Cardiovasc. Res. 2010, 85, 473-483
    • (2010) Cardiovasc. Res , vol.85 , pp. 473-483
    • Mariappan, N.1    Elks, C.M.2    Sriramula, S.3    Guggilam, A.4    Liu, Z.5    Borkhsenious, O.6    Francis, J.7
  • 44
    • 84861828597 scopus 로고    scopus 로고
    • Proteomic identification of in vivo interactors reveals novel function of skin cornification proteins
    • Vermeij, W.P.; Florea, B.I.; Isenia, S.; Alia, A.; Brouwer, J.; Backendorf, C. Proteomic identification of in vivo interactors reveals novel function of skin cornification proteins. J. Proteome Res. 2012, 11, 3068-3076
    • (2012) J. Proteome Res , vol.11 , pp. 3068-3076
    • Vermeij, W.P.1    Florea, B.I.2    Isenia, S.3    Alia, A.4    Brouwer, J.5    Backendorf, C.6
  • 45
    • 79958808930 scopus 로고    scopus 로고
    • ROS quenching potential of the epidermal cornified cell envelope
    • Vermeij, W.P.; Alia, A.; Backendorf, C. ROS quenching potential of the epidermal cornified cell envelope. J. Invest. Dermatol. 2011, 131, 1435-1441
    • (2011) J. Invest. Dermatol , vol.131 , pp. 1435-1441
    • Vermeij, W.P.1    Alia, A.2    Backendorf, C.3
  • 46
    • 77955013815 scopus 로고    scopus 로고
    • Wound repair and anti-oxidative capacity is regulated by ITGB4 in airway epithelial cells
    • Liu, C.; Liu, H.J.; Xiang, Y.; Tan, Y.R.; Zhu, X.L.; Qin, X.Q. Wound repair and anti-oxidative capacity is regulated by ITGB4 in airway epithelial cells. Mol. Cell. Biochem. 2010, 341, 259-269
    • (2010) Mol. Cell. Biochem , vol.341 , pp. 259-269
    • Liu, C.1    Liu, H.J.2    Xiang, Y.3    Tan, Y.R.4    Zhu, X.L.5    Qin, X.Q.6
  • 48
    • 83455197120 scopus 로고    scopus 로고
    • Disruption of paraoxonase 3 impairs proliferation and antioxidant defenses in human A549 cells and causes embryonic lethality in mice
    • Kempster, S.L.; Belteki, G.; Licence, D.; Charnock-Jones, D.S.; Smith, G.C. Disruption of paraoxonase 3 impairs proliferation and antioxidant defenses in human A549 cells and causes embryonic lethality in mice. Am. J. Physiol. Endocrinol. Metab. 2012, 302, E103-E107
    • (2012) Am. J. Physiol. Endocrinol. Metab , vol.302 , pp. E103-E107
    • Kempster, S.L.1    Belteki, G.2    Licence, D.3    Charnock-Jones, D.S.4    Smith, G.C.5
  • 50
    • 77954998621 scopus 로고    scopus 로고
    • Ferroportin1 and hephaestin overexpression attenuate iron-induced oxidative stress in MES23.5 dopaminergic cells
    • Song, N.; Wang, J.; Jiang, H.; Xie, J. Ferroportin1 and hephaestin overexpression attenuate iron-induced oxidative stress in MES23.5 dopaminergic cells. J. Cell. Biochem. 2010, 110, 1063-1072
    • (2010) J. Cell. Biochem , vol.110 , pp. 1063-1072
    • Song, N.1    Wang, J.2    Jiang, H.3    Xie, J.4
  • 52
    • 84897492235 scopus 로고    scopus 로고
    • Hepatoprotective role of liver fatty acid binding protein in acetaminophen induced toxicity
    • Gong, Y.; Wang, G.; Gong, Y.; Yan, J.; Chen, Y.; Burczynski, F.J. Hepatoprotective role of liver fatty acid binding protein in acetaminophen induced toxicity. BMC Gastroenterol. 2014, 14, doi:10.1186/1471-230X-14-44
    • (2014) BMC Gastroenterol , vol.14
    • Gong, Y.1    Wang, G.2    Gong, Y.3    Yan, J.4    Chen, Y.5    Burczynski, F.J.6
  • 54
    • 33744511920 scopus 로고    scopus 로고
    • Paraoxonase 1 (PON1) is a more potent antioxidant and stimulant of macrophage cholesterol efflux, when present in HDL than in lipoprotein-deficient serum: Relevance to diabetes
    • Rosenblat, M.; Karry, R.; Aviram, M. Paraoxonase 1 (PON1) is a more potent antioxidant and stimulant of macrophage cholesterol efflux, when present in HDL than in lipoprotein-deficient serum: Relevance to diabetes. Atherosclerosis 2006, 187, 74-81
    • (2006) Atherosclerosis , vol.187 , pp. 74-81
    • Rosenblat, M.1    Karry, R.2    Aviram, M.3
  • 55
    • 0030222319 scopus 로고    scopus 로고
    • Role of metallothionein and other antioxidants in scavenging superoxide radicals and their possible role in neuroprotection
    • Hussain, S.; Slikker, W., Jr.; Ali, S.F. Role of metallothionein and other antioxidants in scavenging superoxide radicals and their possible role in neuroprotection. Neurochem. Int. 1996, 29, 145-152
    • (1996) Neurochem. Int , vol.29 , pp. 145-152
    • Hussain, S.1    Slikker, W.2    Ali, S.F.3
  • 56
    • 0001521566 scopus 로고    scopus 로고
    • Antioxidant role of metallothioneins: A comparative overview
    • Viarengo, A.; Burlando, B.; Ceratto, N.; Panfoli, I. Antioxidant role of metallothioneins: A comparative overview. Cell. Mol. Biol. 2000, 46, 407-417
    • (2000) Cell. Mol. Biol , vol.46 , pp. 407-417
    • Viarengo, A.1    Burlando, B.2    Ceratto, N.3    Panfoli, I.4
  • 57
    • 0037051533 scopus 로고    scopus 로고
    • Antioxidant and cyclooxygenase activities of fatty acids found in food
    • Henry, G.E.; Momin, R.A.; Nair, M.G.; Dewitt, D.L. Antioxidant and cyclooxygenase activities of fatty acids found in food. J. Agric. Food Chem. 2002, 50, 2231-2234
    • (2002) J. Agric. Food Chem , vol.50 , pp. 2231-2234
    • Henry, G.E.1    Momin, R.A.2    Nair, M.G.3    Dewitt, D.L.4
  • 58
    • 84900969667 scopus 로고    scopus 로고
    • The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense
    • Itahana, Y.; Han, R.; Barbier, S.; Lei, Z.; Rozen, S.; Itahana, K. The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense. Oncogene 2015, 34, 1799-1810
    • (2015) Oncogene , vol.34 , pp. 1799-1810
    • Itahana, Y.1    Han, R.2    Barbier, S.3    Lei, Z.4    Rozen, S.5    Itahana, K.6
  • 59
    • 1642368362 scopus 로고    scopus 로고
    • Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: A new therapeutic approach for the treatment of inflammatory diseases
    • Chen, X.L.; Kunsch, C. Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: A new therapeutic approach for the treatment of inflammatory diseases. Curr. Pharm. Des. 2004, 10, 879-891
    • (2004) Curr. Pharm. Des , vol.10 , pp. 879-891
    • Chen, X.L.1    Kunsch, C.2
  • 61
    • 36148948616 scopus 로고    scopus 로고
    • TNF-alpha-induced mitochondrial oxidative stress and cardiac dysfunction: Restoration by superoxide dismutase mimetic Tempol
    • Mariappan, N.; Soorappan, R.N.; Haque, M.; Sriramula, S.; Francis, J. TNF-alpha-induced mitochondrial oxidative stress and cardiac dysfunction: Restoration by superoxide dismutase mimetic Tempol. Am. J. Physiol. Heart Circ. Physiol. 2007, 293, H2726-H2737
    • (2007) Am. J. Physiol. Heart Circ. Physiol , vol.293 , pp. H2726-H2737
    • Mariappan, N.1    Soorappan, R.N.2    Haque, M.3    Sriramula, S.4    Francis, J.5
  • 62
    • 78651366293 scopus 로고    scopus 로고
    • Human skin penetration of a copper tripeptide in vitro as a function of skin layer
    • Hostynek, J.; Dreher, F.; Maibach, H. Human skin penetration of a copper tripeptide in vitro as a function of skin layer. Inflamm. Res. 2011, 60, 79-86
    • (2011) Inflamm. Res , vol.60 , pp. 79-86
    • Hostynek, J.1    Dreher, F.2    Maibach, H.3
  • 63
    • 84866875931 scopus 로고    scopus 로고
    • Oral delivery of peptides and proteins using lipid-based drug delivery systems
    • Li, P.; Nielsen, H.M.; Mullertz, A. Oral delivery of peptides and proteins using lipid-based drug delivery systems. Expert Opin. Drug Deliv. 2012, 9, 1289-1304
    • (2012) Expert Opin. Drug Deliv , vol.9 , pp. 1289-1304
    • Li, P.1    Nielsen, H.M.2    Mullertz, A.3
  • 64
    • 84869773544 scopus 로고    scopus 로고
    • Liposomal delivery of proteins and peptides
    • Swaminathan, J.; Ehrhardt, C. Liposomal delivery of proteins and peptides. Expert Opin. Drug Deliv. 2012, 9, 1489-1503
    • (2012) Expert Opin. Drug Deliv , vol.9 , pp. 1489-1503
    • Swaminathan, J.1    Ehrhardt, C.2


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