Polychlorinated biphenyl and organochlorine pesticide concentrations in maternal mid-pregnancy serum samples: Association with Autism spectrum disorder and intellectual disability

Environmental Health Perspectives

Volumn 125, Issue 3, 2017, Pages 474-480

  Lyall, Kristen ^a,d   Croen, Lisa A ^b   Sjödin, Andreas ^c   Yoshida, Cathleen K ^b   Zerbo, Ousseny ^b   Kharrazi, Martin ^a   Windham, Gayle C ^a  

^a CALIFORNIA DEPARTMENT OF PUBLIC HEALTH   (United States)

^b DIVISION OF RESEARCH   (United States)

^c NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

^d DREXEL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA HEXACHLOROCYCLOHEXANE; CHLORPHENOTANE; HEXACHLOROBENZENE; LINDANE; MIREX; NONACHLOR; ORGANOCHLORINE PESTICIDE; OXYCHLORDANE; POLYCHLORINATED BIPHENYL; CHLORINATED HYDROCARBON; PESTICIDE; POLLUTANT;

ADULT; ARTICLE; AUTISM; CASE CONTROL STUDY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; GAS CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; INTELLECTUAL IMPAIRMENT; MAJOR CLINICAL STUDY; PRENATAL EXPOSURE; PRIORITY JOURNAL; RISK ASSESSMENT; SECOND TRIMESTER PREGNANCY; TRIACYLGLYCEROL BLOOD LEVEL; AUTISM SPECTRUM DISORDER; BLOOD; CALIFORNIA; CHILD; INTELLECTUAL DISABILITY; MALE; MATERNAL EXPOSURE; ODDS RATIO; POLLUTANT; PREGNANCY; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA;

ADULT; AUTISM SPECTRUM DISORDER; CALIFORNIA; CASE-CONTROL STUDIES; CHILD; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; HYDROCARBONS, CHLORINATED; INTELLECTUAL DISABILITY; LOGISTIC MODELS; MALE; MATERNAL EXPOSURE; ODDS RATIO; PESTICIDES; POLYCHLORINATED BIPHENYLS; PREGNANCY;

EID: 85014387826     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/EHP277     Document Type: Article

References (45)

1. American Psychiatric Association. 1994. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV. Washington, DC:American Psychiatric Association.
2. Antonelli MC, Pallarés ME, Ceccatelli S, Spulber S. 2016. Long-term consequences of prenatal stress and neurotoxicants exposure on neurodevelopment. Prog Neurobiol, http://dx.doi.org/10.1016/j.pneurobio.2016.05.005 [Online 25 May 2016].
3. Axelrad DA, Goodman S, Woodruff TJ. 2009. PCB body burdens in US women of childbearing age 2001–2002: an evaluation of alternate summary metrics of NHANES data. Environ Res 109(4):368–378.
4. Bell MR. 2014. Endocrine-disrupting actions of PCBs on brain development and social and reproductive behaviors. Curr Opin Pharmacol 19:134–144.
5. Bilbo SD, Schwarz JM. 2012. The immune system and developmental programming of brain and behavior. Front Neuroendocrinol 33(3):267–286.
6. Braun JM, Kalkbrenner AE, Just AC, Yolton K, Calafat AM, Sjödin A, et al. 2014. Gestational exposure to endocrine-disrupting chemicals and reciprocal social, repetitive, and stereotypic behaviors in 4- and 5-year-old children: the HOME study. Environ Health Perspect 122:513–520, doi: 10.1289/ehp.1307261.
7. Casas M, Nieuwenhuijsen M, Martínez D, Ballester F, Basagaña X, Basterrechea M, et al. 2015. Prenatal exposure to PCB-153, p,p´-DDE and birth outcomes in 9000 mother–child pairs: exposure–response relationship and effect modifiers. Environ Int 74:23–31.
8. CDC (Centers for Disease Control and Prevention). 2009. Fourth National Report on Human Exposure to Environmental Chemicals. https://www.cdc.gov/exposurereport/pdf/fourthreport.pdf [accessed 16 February 2016].
9. Chakrabarti B, Dudbridge F, Kent L, Wheelwright S, Hill-Cawthorne G, Allison C, et al. 2009. Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. Autism Res 2(3):157–177.
10. Cheslack-Postava K, Rantakokko PV, Hinkka-Yli-Salomäki S, Surcel HM, McKeague IW, Kiviranta HA, et al. 2013. Maternal serum persistent organic pollutants in the Finnish Prenatal Study of Autism: a pilot study. Neurotoxicol Teratol 38:1–5.
11. Chevrier J, Eskenazi B, Holland N, Bradman A, Barr DB. 2008. Effects of exposure to polychlorinated biphenyls and organochlorine pesticides on thyroid function during pregnancy. Am J Epidemiol 168(3):298–310.
12. Croen LA, Braunschweig D, Haapanen L, Yoshida CK, Fireman B, Grether JK, et al. 2008. Maternal midpregnancy autoantibodies to fetal brain protein: the early markers for autism study. Biol Psychiatry 64(7):583–588.
13. Felicetti T. 1981. Parents of autistic children: some notes on a chemical connection. Milieu Ther 1:13–16.
14. Goines P, Haapanen L, Boyce R, Duncanson P, Braunschweig D, Delwiche L, et al. 2011. Autoanti bodies to cerebellum in children with autism associate with behavior. Brain Behav Immun 25(3):514–523.
15. Grandjean P, Landrigan PJ. 2014. Neurobehavioural effects of developmental toxicity. Lancet Neurol 13(3):330–338.
16. Hallmayer J, Cleveland S, Torres A, Phillips J, Cohen B, Torigoe T, et al. 2011. Genetic heritability and shared environmental factors among twin pairs with autism. Arch Gen Psychiatry 68(11):1095–1102.
17. Hertz-Picciotto I, Park HY, Dostal M, Kocan A, Trnovec T, Sram R. 2008. Prenatal exposures to persistent and non-persistent organic compounds and effects on immune system development. Basic Clin Pharmacol Toxicol 102(2):146–154.
18. Jones R, Edenfield E, Anderson S, Zhang Y, Sjödin A. 2012. Semi-automated extraction and cleanup method for measuring persistent organic pollutants in human serum. Organohalogen Compounds 74:97–98.
19. Jurewicz J, Polańska K, Hanke W. 2013. Chemical exposure early in life and the neurodevelopment of children—an overview of current epidemiological evidence. Ann Agric Environ Med 20(3):465–486.
20. Kimura-Kuroda J, Nagata I, Kuroda Y. 2007. Disrupting effects of hydroxy-polychlorinated biphenyl (PCB) congeners on neuronal development of cerebellar Purkinje cells: a possible causal factor for developmental brain disorders? Chemosphere 67(9):S412–S420.
21. Korrick SA, Sagiv SK. 2008. Polychlorinated biphenyls, organochlorine pesticides and neurodevelopment. Curr Opin Pediatr 20(2):198–204.
22. Liu C, Wang C, Yan M, Quan C, Zhou J, Yang K. 2012. PCB153 disrupts thyroid hormone homeostasis by affecting its biosynthesis, biotransformation, feedback regulation, and metabolism. Horm Metab Res 44(9):662–669.
23. Lubin JH, Colt JS, Camann D, Davis S, Cerhan JR, Severson RK, et al. 2004. Epidemiologic evaluation of measurement data in the presence of detection limits. Environ Health Perspect 112:1691–1696, doi: 10.1289/ehp.7199.
24. Lyall K, Schmidt RJ, Hertz-Picciotto I. 2014. Maternal lifestyle and environmental risk factors for autism spectrum disorders. Int J Epidemiol 43(2):443–464.
25. Mead J, Ashwood P. 2015. Evidence supporting an altered immune response in ASD. Immunol Lett 163(1):49–55.
26. Newschaffer CJ, Croen LA, Daniels J, Giarelli E, Grether JK, Levy SE, et al. 2007. The epidemiology of autism spectrum disorders. Annu Rev Public Health 28:235–258.
27. Phillips DL, Pirkle JL, Burse VW, Bernert JT Jr, Henderson LO, Needham LL. 1989. Chlorinated hydrocarbon levels in human serum: effects of fasting and feeding. Arch Environ Contam Toxicol 18(4):495–500.
28. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. 2006. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38(8):904–909.
29. Ribas-Fitó N, Sala M, Kogevinas M, Sunyer J. 2001. Polychlorinated biphenyls (PCBs) and neurological development in children: a systematic review. J Epidemiol Community Health 55(8):537–546.
30. Rice D, Barone S Jr. 2000. Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ Health Perspect 108(suppl 3):511–533.
31. Roberts EM, English PB, Grether JK, Windham GC, Somberg L, Wolff C. 2007. Maternal residence near agricultural pesticide applications and autism spectrum disorders among children in the California Central Valley. Environ Health Perspect 115:1482–1489, doi: 10.1289/ehp.10168.
32. Rosas LG, Eskenazi B. 2008. Pesticides and child neurodevelopment. Curr Opin Pediatr 20(2):191–197.
33. Rossignol DA, Genuis SJ, Frye RE. 2014. Environmental toxicants and autism spectrum disorders: a systematic review. Transl Psychiatry 4:e360, doi: 10.1038/tp.2014.4.
34. SAS Institute, Inc. 2015. SAS/STAT 14.1 User’s Guide: The MI Procedure. Cary, NC:SAS Institute, Inc., 5858–5990.
35. Shelton JF, Hertz-Picciotto I, Pessah IN. 2012. Tipping the balance of autism risk: potential mechanisms linking pesticides and autism. Environ Health Perspect 120:944–951, doi: 10.1289/ehp.1104553.
36. Sjödin A, Jones RS, Caudill SP, Wong LY, Turner WE, Calafat AM. 2014. Polybrominated diphenyl ethers, polychlorinated biphenyls, and persistent pesticides in serum from the National Health and Nutrition Examination Survey: 2003–2008. Environ Sci Technol 48(1):753–760.
37. Sjödin A, Wong LY, Jones RS, Park A, Zhang Y, Hodge C, et al. 2008. Serum concentrations of polybrominated diphenyl ethers (PBDEs) and polybrominated biphenyl (PBB) in the United States population: 2003–2004. Environ Sci Technol 42(4):1377–1384.
38. Torres-Sánchez L, Schnaas L, Rothenberg SJ, Cebrián ME, Osorio-Valencia E, del Carmen Hernández M, et al. 2013. Prenatal p,p’-DDE exposure and neurodevelopment among children 3.5–5 years of age. Environ Health Perspect 121:263–268, doi: 10.1289/ehp.1205034.
39. Veatch OJ, Pendergast JS, Allen MJ, Leu RM, Johnson CH, Elsea SH, et al. 2015. Genetic variation in melatonin pathway enzymes in children with autism spectrum disorder and comorbid sleep onset delay. J Autism Dev Disord 45(1):100–110.
40. Windham GC, Pinney SM, Voss RW, Sjödin A, Biro FM, Greenspan LC, et al. 2015. Brominated flame retardants and other persistent organohalogenated compounds in relation to timing of puberty in a longitudinal study of girls. Environ Health Perspect 123:1046–1052, doi: 10.1289/ehp.1408778.
41. Windham GC, Sumner A, Li SX, Anderson M, Katz E, Croen LA, et al. 2013. Use of birth certificates to examine maternal occupational exposures and autism spectrum disorders in offspring. Autism Res 6(1):57–63.
42. Wolff MS, Camann D, Gammon M, Stellman SD. 1997. Proposed PCB congener groupings for epidemiological studies. Environ Health Perspect 105:13–14.
43. Wolff MS, Landrigan PJ. 2002. Organochlorine chemicals and children’s health. J Pediatr 140(1):10–13.
44. Woodruf f TJ, Zot a AR, Schwart z JM. 2011. Environmental chemicals in pregnant women in the United States: NHANES 2003–2004. Environ Health Perspect 119:878–885, doi: 10.1289/ehp.1002727.
45. Yeargin-Allsopp M, Rice C, Karapurkar T, Doernberg N, Boyle C, Murphy C. 2003. Prevalence of autism in a US metropolitan area. JAMA 289(1):49–55.