ddClone: Joint statistical inference of clonal populations from single cell and bulk tumour sequencing data

Genome Biology

Volumn 18, Issue 1, 2017, Pages

  Salehi, Sohrab ^a   Steif, Adi ^a,b   Roth, Andrew ^a,b   Aparicio, Samuel ^a   Bouchard Côté, Alexandre ^a   Shah, Sohrab P ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

Chinese restaurant process; Clonal evolution; Distance dependent; Intra tumour heterogeneity; Joint probabilistic model; Next generation sequencing; Single cell sequencing

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL HETEROGENEITY; CLONAL EVOLUTION; CONTROLLED STUDY; COPY NUMBER VARIATION; DATA ANALYSIS; DDCLONE; DNA FRAGMENTATION; GENE FREQUENCY; GENE MUTATION; GENE SEQUENCE; GENETIC PROCEDURES; HOMOZYGOSITY; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR DYNAMICS; MOUSE; NEXT GENERATION SEQUENCING; NONHUMAN; PHYLOGENETIC TREE; POINT MUTATION; PROBABILITY; SINGLE CELL SEQUENCING; TRIPLE NEGATIVE BREAST CANCER; TUMOR XENOGRAFT; WHOLE GENOME SEQUENCING; ALLELE; ANIMAL; BIOLOGY; CELL CLONE; CLUSTER ANALYSIS; COMPUTER SIMULATION; DISEASE MODEL; DNA SEQUENCE; FEMALE; GENETICS; GENOTYPE; HIGH THROUGHPUT SEQUENCING; METABOLISM; MUTATION; NEOPLASM; PATHOLOGY; PROCEDURES; REPRODUCIBILITY; SINGLE CELL ANALYSIS; STATISTICAL MODEL; WORKFLOW; XENOGRAFT;

ALLELES; ANIMALS; CLONE CELLS; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DISEASE MODELS, ANIMAL; FEMALE; GENOTYPE; HETEROGRAFTS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MICE; MODELS, STATISTICAL; MUTATION; NEOPLASMS; REPRODUCIBILITY OF RESULTS; SEQUENCE ANALYSIS, DNA; SINGLE-CELL ANALYSIS; TRIPLE NEGATIVE BREAST NEOPLASMS; WORKFLOW;

EID: 85014375647     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-017-1169-3     Document Type: Article

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