Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor−κB, and Up-regulating Expression of MicroRNA-21

Gastroenterology

Volumn 152, Issue 4, 2017, Pages 851-866.e24

  Yang, Yongzhi ^a,b,c   Weng, Wenhao ^c,d   Peng, Junjie ^a,b   Hong, Leiming ^c   Yang, Lei ^c   Toiyama, Yuji ^e   Gao, Renyuan ^c   Liu, Minfeng ^c   Yin, Mingming ^c   Pan, Cheng ^c   Li, Hao ^c   Guo, Bomin ^f   Zhu, Qingchao ^f   Wei, Qing ^c   Moyer, Mary Pat ^g   Wang, Ping ^c   Cai, Sanjun ^a,b   Goel, Ajay ^d   Qin, Huanlong ^c   Ma, Yanlei ^a,b  

^a FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^b FUDAN UNIVERSITY   (China)

^c TENTH PEOPLE S HOSPITAL OF TONGJI UNIVERSITY   (China)

^d BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

^e MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

^g INCELL Corporation ^*  (United States)

Author keywords

Carcinogenesis; Gene Regulation; Microbe; Signal Transduction

Indexed keywords

AZOXYMETHANE; DEXTRAN SULFATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17F; INTERLEUKIN 21; INTERLEUKIN 22; MICRORNA 21; RAS PROTEIN; TOLL LIKE RECEPTOR 4; APC PROTEIN; BACTERIAL DNA; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MICRORNA; MIRN-21 MICRORNA, MOUSE; MIRN21 MICRORNA, HUMAN; MYELOID DIFFERENTIATION FACTOR 88; RASA1 PROTEIN, HUMAN; RASA1 PROTEIN, MOUSE; SMALL INTERFERING RNA;

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; COLITIS; COLON POLYPOSIS; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; DIARRHEA; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FUSOBACTERIUM NUCLEATUM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR INVASION; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; C57BL MOUSE; CELL MOTION; CHEMICALLY INDUCED; CHEMISTRY; COLON TUMOR; DOWN REGULATION; DRUG EFFECTS; FUSOBACTERIUM INFECTION; GENETICS; HCT 116 CELL LINE; HT-29 CELL LINE; METABOLISM; MICROBIOLOGY; PATHOLOGY; PROGNOSIS; UPREGULATION;

ADENOMATOUS POLYPOSIS COLI PROTEIN; AGED; ANIMALS; AZOXYMETHANE; CARCINOGENESIS; CELL MOVEMENT; CELL PROLIFERATION; COLITIS; COLONIC NEOPLASMS; DEXTRAN SULFATE; DNA, BACTERIAL; DOWN-REGULATION; FEMALE; FUSOBACTERIUM INFECTIONS; FUSOBACTERIUM NUCLEATUM; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HT29 CELLS; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICRORNAS; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; P120 GTPASE ACTIVATING PROTEIN; PROGNOSIS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; UP-REGULATION;

EID: 85014373123     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2016.11.018     Document Type: Article

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