DYNC1H1 mutations associated with neurological diseases compromise processivity of dynein-dynactin-cargo adaptor complexes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 9, 2017, Pages E1597-E1606

  Hoang, Ha Thi ^a   Schlager, Max A ^a,b   Carter, Andrew P ^a   Bullock, Simon L ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b ROCHE DIAGNOSTICS GMBH   (Germany)

Author keywords

Cargo adaptor; DYNC1H1; Dynein; Neurological disease; Processivity

Indexed keywords

BICAUDAL D2 PROTEIN; CARRIER PROTEIN; DYNACTIN; DYNEIN ADENOSINE TRIPHOSPHATASE; MUTANT PROTEIN; UNCLASSIFIED DRUG; CYTOPLASMIC DYNEIN; DYNC1H1 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; PROTEIN BINDING;

ARTICLE; COMPLEX FORMATION; DYNC1H1 GENE; GENE; GENE EXPRESSION SYSTEM; GENE MUTATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MALFORMATION OF CORTICAL DEVELOPMENT GROUP I; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SPINAL MUSCULAR ATROPHY; SPINAL MUSCULAR ATROPHY WITH LOWER EXTREMITY PREDOMINANCE; ANIMAL; CELL LINE; GENETIC LINKAGE; GENETICS; METABOLISM; MOUSE; MUTATION; NEUROLOGIC DISEASE; PIG; SF9 CELL LINE;

ANIMALS; CELL LINE; CYTOPLASMIC DYNEINS; DYNACTIN COMPLEX; DYNEINS; GENETIC LINKAGE; HUMANS; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MUSCULAR ATROPHY, SPINAL; MUTATION; NERVOUS SYSTEM DISEASES; PROTEIN BINDING; SF9 CELLS; SWINE;

EID: 85014270109     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1620141114     Document Type: Article

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