Proteomic Analysis of HDAC3 Selective Inhibitor in the Regulation of Inflammatory Response of Primary Microglia

Neural Plasticity

Volumn 2017, Issue , 2017, Pages

  Xia, Mingxu ^a   Zhao, Qiuchen ^a   Zhang, He ^a   Chen, Yanting ^a   Yuan, Zengqiang ^b   Xu, Yun ^a   Zhang, Meijuan ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b INSTITUTE OF BIOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CD16 ANTIGEN; CD32 ANTIGEN; CD36 ANTIGEN; DIMETHYL SULFOXIDE; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE INHIBITOR; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE SYK; RGFP 966; STAT3 PROTEIN; STAT5 PROTEIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 6; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; ACRYLAMIDE DERIVATIVE; HISTONE DEACETYLASE; PHENYLENEDIAMINE DERIVATIVE; RGFP966; STAT3 PROTEIN, MOUSE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FLUORESCENCE; INFLAMMATION; MASS SPECTROMETRY; MICROGLIA; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEOMICS; UPREGULATION; VALIDATION STUDY; ANIMAL; BRAIN CORTEX; C57BL MOUSE; CELL CULTURE; CHEMICALLY INDUCED; DRUG EFFECTS; ENCEPHALITIS; METABOLISM;

ACRYLAMIDES; ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; ENCEPHALITIS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICROGLIA; PHENYLENEDIAMINES; PROTEOMICS; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; TOLL-LIKE RECEPTOR 2;

EID: 85014248611     PISSN: 20905904     EISSN: 16875443     Source Type: Journal    
DOI: 10.1155/2017/6237351     Document Type: Article

References (32)

1. N. Cartier, C.-A. Lewis, R. Zhang, and F. M. V. Rossi, "The role of microglia in human disease: therapeutic tool or target?" Acta Neuropathologica, vol. 128, no. 3, pp. 363-380, 2014.
2. J. Ślusarczyk, E. Trojan, K. Głombik et al., "Fractalkine attenuates microglial cell activation induced by prenatal stress, " Neural Plasticity, vol. 2016, Article ID 7258201, 11 pages, 2016.
3. Y. Ren and W. Young, "Managing infammation afer spinal cord injury through manipulation of macrophage function, " Neural Plasticity, vol. 2013, Article ID 945034, 9 pages, 2013.
4. H. Jia, J. Pallos, V. Jacques et al., "Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Hunt-ington's disease, " Neurobiology of Disease, vol. 46, no. 2, pp. 351-361, 2012.
5. N. G. J. Leus, M. R. H. Zwinderman, and F. J. Dekker, "Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-?B-mediated infammation, " Current Opinion in Chemical Biology, vol. 33, pp. 160-168, 2016.
6. K. A. Bode and A. H. Dalpke, "HDAC inhibitors block innate immunity, " Blood, vol. 117, no. 4, pp. 1102-1103, 2011.
7. T. Roger, J. Lugrin, D. Le Roy et al., "Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection, " Blood, vol. 117, no. 4, pp. 1205-1217, 2011.
8. A. M. Grabiec, S. Krausz, W. De Jager et al., "Histone deacetylase inhibitors suppress infammatory activation of rheumatoid arthritis patient synovial macrophages and tissue, " Journal of Immunology, vol. 184, no. 5, pp. 2718-2728, 2010.
9. I. Gojo, A. Jiemjit, J. B. Trepel et al., "Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias, " Blood, vol. 109, no. 7, pp. 2781-2790, 2007.
10. R. S. Broide, J. M. Redwine, N. Afahi, W. Young, F. E. Bloom, and C. J. Winrow, "Distribution of histone deacetylases 1-11 in the rat brain, " Journal of Molecular Neuroscience, vol. 31, no. 1, pp. 47-58, 2007.
11. A. Venkatraman, Y.-S. Hu, A. Didonna et al., "The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1, " Human Molecular Genetics, vol. 23, no. 14, pp. 3733-3745, 2014.
12. G. A. Rogge, H. Singh, R. Dang, and M. A. Wood, "HDAC3 is a negative regulator of cocaine-context-associated memory formation, " Journal of Neuroscience, vol. 33, no. 15, pp. 6623-6632, 2013.
13. X. Chen, I. Barozzi, A. Termanini et al., "Requirement for the histone deacetylase Hdac3 for the infammatory gene expression program in macrophages, " Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 42, pp. E2865-E2874, 2012.
14. S. E. Mullican, C. A. Gaddis, T. Alenghat et al., "Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation, " Genes and Development, vol. 25, no. 23, pp. 2480-2488, 2011.
15. M. Malvaez, S. C. McQuown, G. A. Rogge et al., "HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner, " Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 7, pp. 2647-2652, 2013.
16. C. E. Wells, S. Bhaskara, K. R. Stengel et al., "Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma, " PLoS ONE, vol. 8, no. 7, Article ID e68915, 2013.
17. H. Yu, D. Pardoll, and R. Jove, "STATs in cancer infammation and immunity: a leading role for STAT3, " Nature Reviews Cancer, vol. 9, no. 11, pp. 798-809, 2009.
18. K. Krishna, T. Behnisch, and S. Sajikumar, "Inhibition of histone deacetylase 3 restores amyloid-? oligomer-induced plasticity defcit in hippocampal CA1 pyramidal neurons, " Journal of Alzheimer's Disease, vol. 51, no. 3, pp. 783-791, 2016.
19. J. Brown, H. Wang, G. N. Hajishengallis, and M. Martin, "TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk, " Journal of Dental Research, vol. 90, no. 4, pp. 417-427, 2011.
20. J.-Y. Sun, D.-L. Li, Y. Dong et al., "Baicalin inhibits toll-like receptor 2/4 expression and downstream signaling in rat experi-mental periodontitis, " International Immunopharmacology, vol. 36, pp. 86-93, 2016.
21. M. Shu, D.-D. Huang, Z.-A. Hung, X.-R. Hu, and S. Zhang, "Inhibition of MAPK and NF-?B signaling pathways alleviate carbon tetrachloride (CCl4)-induced liver fbrosis in Toll-like receptor 5 (TLR5) defciency mice, " Biochemical and Biophysical Research Communications, vol. 471, no. 1, pp. 233-239, 2016.
22. D. Awasthi, S. Nagarkoti, A. Kumar et al., "Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation, " Free Radical Biology and Medicine, vol. 93, pp. 190-203, 2016.
23. K. Luu, C. J. Greenhill, A. Majoros, T. Decker, B. J. Jenkins, and A. Mansell, "STAT1 plays a role in TLR signal transduction and infammatory responses, " Immunology and Cell Biology, vol. 92, no. 9, pp. 761-769, 2014.
24. E. Kim, Y.-J. Son, Y. Yang et al., "1-(2, 3-dibenzimidazol-2-ylpropyl)-2-methoxybenzene is a syk inhibitor with anti-infammatory properties, " Molecules, vol. 21, no. 4, article 508, 2016.
25. B. Aouar, D. Kovarova, S. Letard et al., "Dual role of the tyrosine kinase Syk in regulation of Toll-like receptor signaling in plasmacytoid dendritic cells, " PLoS ONE, vol. 11, no. 6, Article ID e0156063, 2016.
26. H. Yin, H. Zhou, Y. Kang et al., "Syk negatively regulates TLR4-mediated IFN? and IL-10 production and promotes infam-matory responses in dendritic cells, " Biochimica et Biophysica Acta-General Subjects, vol. 1860, no. 3, pp. 588-598, 2016.
27. C. Zou, M. J. Synan, J. Li et al., "LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1, " Journal of Cell Science, vol. 129, no. 1, pp. 51-64, 2016.
28. M. Di Gioia and I. Zanoni, "Toll-like receptor co-receptors as master regulators of the immune response, " Molecular Immunology, vol. 63, no. 2, pp. 143-152, 2015.
29. C. R. Stewart, L. M. Stuart, K. Wilkinson et al., "CD36 ligands promote sterile infammation through assembly of a Toll-like receptor 4 and 6 heterodimer, " Nature Immunology, vol. 11, no. 2, pp. 155-161, 2010.
30. G. Faraco, M. Pittelli, L. Cavone et al., "Histone deacetylase (HDAC) inhibitors reduce the glial infammatory response in vitro and in vivo, " Neurobiology of Disease, vol. 36, no. 2, pp. 269-279, 2009.
31. E. A. Stronach, A. Alfraidi, N. Rama et al., "HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer, " Cancer Research, vol. 71, no. 13, pp. 4412-4422, 2011.
32. H. Xiong, W. Du, Y.-J. Zhang et al., "Trichostatin A, a his-tone deacetylase inhibitor, suppresses JAK2/STAT3 signaling via inducing the promoter-associated histone acetylation of SOCS1 and SOCS3 in human colorectal cancer cells, " Molecular Carcinogenesis, vol. 51, no. 2, pp. 174-184, 2012.