-
1
-
-
77956150056
-
Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma
-
Chao MP, Alizadeh AA, Tang C, et al. Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma. Cell 2010;142:699-713.
-
(2010)
Cell
, vol.142
, pp. 699-713
-
-
Chao, M.P.1
Alizadeh, A.A.2
Tang, C.3
-
2
-
-
84860174226
-
The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
-
Willingham SB, Volkmer JP, Gentles AJ, et al. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A 2012;109:6662-7.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 6662-6667
-
-
Willingham, S.B.1
Volkmer, J.P.2
Gentles, A.J.3
-
3
-
-
84978381315
-
CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer
-
Weiskopf K, Jahchan NS, Schnorr PJ, et al. CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. J Clin Invest 2016;126:2610-20.
-
(2016)
J Clin Invest
, vol.126
, pp. 2610-2620
-
-
Weiskopf, K.1
Jahchan, N.S.2
Schnorr, P.J.3
-
4
-
-
85009060716
-
Is CD47 an innate immune checkpoint for tumor evasion?
-
Liu X, Kwon H, Li Z, et al. Is CD47 an innate immune checkpoint for tumor evasion? J Hematol Oncol 2017;10:12.
-
(2017)
J Hematol Oncol
, vol.10
, pp. 12
-
-
Liu, X.1
Kwon, H.2
Li, Z.3
-
5
-
-
85014082427
-
A Phase 1 Study of TTI-621, a Novel Immune Checkpoint Inhibitor Targeting CD47, in Patients with Relapsed or Refractory Hematologic Malignancies
-
Ansell S, Chen RW, Flinn IW, et al. A Phase 1 Study of TTI-621, a Novel Immune Checkpoint Inhibitor Targeting CD47, in Patients with Relapsed or Refractory Hematologic Malignancies. Blood 2016;128:1812.
-
(2016)
Blood
, vol.128
, pp. 1812
-
-
Ansell, S.1
Chen, R.W.2
Flinn, I.W.3
-
6
-
-
85014110009
-
Abstract PR13: The anti-CD47 antibody Hu5F9-G4 is a novel immune checkpoint inhibitor with synergistic efficacy in combination with clinically active cancer targeting antibodies
-
Chao MP, McKenna KM, Cha A, et al. Abstract PR13: The anti-CD47 antibody Hu5F9-G4 is a novel immune checkpoint inhibitor with synergistic efficacy in combination with clinically active cancer targeting antibodies. Cancer Immunol Res 2016;4:Abstract nr PR13.
-
(2016)
Cancer Immunol Res
, vol.4
-
-
Chao, M.P.1
McKenna, K.M.2
Cha, A.3
-
7
-
-
85014060474
-
A first-in-human, first-in-class phase I trial of the anti-CD47 antibody Hu5F9-G4 in patients with advanced cancers
-
Sikic BI, Narayanan S, Colevas AD, et al. A first-in-human, first-in-class phase I trial of the anti-CD47 antibody Hu5F9-G4 in patients with advanced cancers. J Clin Oncol 2016;34:abstr 3019.
-
(2016)
J Clin Oncol
, vol.34
-
-
Sikic, B.I.1
Narayanan, S.2
Colevas, A.D.3
-
8
-
-
85012939247
-
TTI-621 (SIRPaFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding
-
Petrova PS, Viller NN, Wong M, et al. TTI-621 (SIRPaFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding. Clin Cancer Res 2017;23:1068-79.
-
(2017)
Clin Cancer Res
, vol.23
, pp. 1068-1079
-
-
Petrova, P.S.1
Viller, N.N.2
Wong, M.3
-
9
-
-
0037092957
-
Lethal autoimmune hemolytic anemia in CD47-deficient nonobese diabetic (NOD) mice
-
Oldenborg PA, Gresham HD, Chen Y, et al. Lethal autoimmune hemolytic anemia in CD47-deficient nonobese diabetic (NOD) mice. Blood 2002;99:3500-4.
-
(2002)
Blood
, vol.99
, pp. 3500-3504
-
-
Oldenborg, P.A.1
Gresham, H.D.2
Chen, Y.3
-
10
-
-
18244396105
-
Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia
-
Olsson M, Bruhns P, Frazier WA, et al. Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia. Blood 2005;105:3577-82.
-
(2005)
Blood
, vol.105
, pp. 3577-3582
-
-
Olsson, M.1
Bruhns, P.2
Frazier, W.A.3
-
11
-
-
67650646082
-
CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis
-
Jaiswal S, Jamieson CH, Pang WW, et al. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell 2009;138:271-85.
-
(2009)
Cell
, vol.138
, pp. 271-285
-
-
Jaiswal, S.1
Jamieson, C.H.2
Pang, W.W.3
-
12
-
-
67650632683
-
CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells
-
Majeti R, Chao MP, Alizadeh AA, et al. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell 2009;138:286-99.
-
(2009)
Cell
, vol.138
, pp. 286-299
-
-
Majeti, R.1
Chao, M.P.2
Alizadeh, A.A.3
-
13
-
-
69549114870
-
Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells
-
Chan KS, Espinosa I, Chao M, et al. Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc Natl Acad Sci U S A 2009;106:14016-21.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 14016-14021
-
-
Chan, K.S.1
Espinosa, I.2
Chao, M.3
-
14
-
-
84966270767
-
Durable antitumor responses to CD47 blockade require adaptive immune stimulation
-
Sockolosky JT, Dougan M, Ingram JR, et al. Durable antitumor responses to CD47 blockade require adaptive immune stimulation. Proc Natl Acad Sci U S A 2016;113:E2646-54.
-
(2016)
Proc Natl Acad Sci U S A
, vol.113
, pp. E2646-E2654
-
-
Sockolosky, J.T.1
Dougan, M.2
Ingram, J.R.3
-
15
-
-
84879797224
-
Engineered SIRPa variants as immunotherapeutic adjuvants to anticancer antibodies
-
Weiskopf K, Ring AM, Ho CC, et al. Engineered SIRPa variants as immunotherapeutic adjuvants to anticancer antibodies. Science 2013;341:88-91.
-
(2013)
Science
, vol.341
, pp. 88-91
-
-
Weiskopf, K.1
Ring, A.M.2
Ho, C.C.3
-
16
-
-
81055145277
-
CD47-signal regulatory protein-a (SIRPa) interactions form a barrier for antibody-mediated tumor cell destruction
-
Zhao XW, van Beek EM, Schornagel K, et al. CD47-signal regulatory protein-a (SIRPa) interactions form a barrier for antibody-mediated tumor cell destruction. Proc Natl Acad Sci U S A 2011;108:18342-7.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 18342-18347
-
-
Zhao, X.W.1
van Beek, E.M.2
Schornagel, K.3
-
17
-
-
80855128780
-
Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy
-
Chao MP, Tang C, Pachynski RK, et al. Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy. Blood 2011;118:4890-901.
-
(2011)
Blood
, vol.118
, pp. 4890-4901
-
-
Chao, M.P.1
Tang, C.2
Pachynski, R.K.3
-
19
-
-
84943630992
-
CD47 blockade triggers T cell-mediated destruction of immunogenic tumors
-
Liu X, Pu Y, Cron K, et al. CD47 blockade triggers T cell-mediated destruction of immunogenic tumors. Nat Med 2015;21:1209-15.
-
(2015)
Nat Med
, vol.21
, pp. 1209-1215
-
-
Liu, X.1
Pu, Y.2
Cron, K.3
-
20
-
-
84904888812
-
Signal-regulatory protein a from the NOD mouse binds human CD47 with an exceptionally high affinity-implications for engraftment of human cells
-
Kwong LS, Brown MH, Barclay AN, et al. Signal-regulatory protein a from the NOD mouse binds human CD47 with an exceptionally high affinity-implications for engraftment of human cells. Immunology 2014;143:61-7.
-
(2014)
Immunology
, vol.143
, pp. 61-67
-
-
Kwong, L.S.1
Brown, M.H.2
Barclay, A.N.3
-
21
-
-
84867648736
-
Reply to Soto-Pantoja et al. and Zhao et al.: Targeting CD47 on human solid tumors
-
Willingham SB, Volkmer JP, Weiskopf K, et al. Reply to Soto-Pantoja et al. and Zhao et al.: Targeting CD47 on human solid tumors. Proc Natl Acad Sci U S A 2012;109:E2844-5.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. E2844-E2845
-
-
Willingham, S.B.1
Volkmer, J.P.2
Weiskopf, K.3
-
22
-
-
84897769541
-
The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment
-
Iwamoto C, Takenaka K, Urata S, et al. The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment. Exp Hematol 2014;42:163-171.e1.
-
(2014)
Exp Hematol
, vol.42
, pp. 163.e1-171.e1
-
-
Iwamoto, C.1
Takenaka, K.2
Urata, S.3
-
23
-
-
80051988436
-
Transgenic expression of human signal regulatory protein alpha in Rag2-/-γc-/-mice improves engraftment of human hematopoietic cells in humanized mice
-
Strowig T, Rongvaux A, Rathinam C, et al. Transgenic expression of human signal regulatory protein alpha in Rag2-/-γc-/-mice improves engraftment of human hematopoietic cells in humanized mice. Proc Natl Acad Sci U S A 2011;108:131218-23.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
-
-
Strowig, T.1
Rongvaux, A.2
Rathinam, C.3
-
24
-
-
84900850997
-
Development and function of human innate immune cells in a humanized mouse model
-
Rongvaux A, Willinger T, Martinek J, et al. Development and function of human innate immune cells in a humanized mouse model. Nat Biotechnol 2014;32:364-72.
-
(2014)
Nat Biotechnol
, vol.32
, pp. 364-372
-
-
Rongvaux, A.1
Willinger, T.2
Martinek, J.3
-
25
-
-
85026844244
-
Abstract B126: Correlation of tumor growth inhibition by check point inhibitors with PD-L1 expression in preclinical patient derived xenograft (PDX) models
-
Stecklum M, Wulf-Goldenberg A, Brzezicha B, et al. Abstract B126: Correlation of tumor growth inhibition by check point inhibitors with PD-L1 expression in preclinical patient derived xenograft (PDX) models. Cancer Immunol Res 2016;4:Abstract nr B126.
-
(2016)
Cancer Immunol Res
, vol.4
-
-
Stecklum, M.1
Wulf-Goldenberg, A.2
Brzezicha, B.3
-
26
-
-
84936804591
-
Loss of Cell Surface CD47 Clustering Formation and Binding Avidity to SIRPa Facilitate Apoptotic Cell Clearance by Macrophages
-
Lv Z, Bian Z, Shi L, et al. Loss of Cell Surface CD47 Clustering Formation and Binding Avidity to SIRPa Facilitate Apoptotic Cell Clearance by Macrophages. J Immunol 2015;195:661-71.
-
(2015)
J Immunol
, vol.195
, pp. 661-671
-
-
Lv, Z.1
Bian, Z.2
Shi, L.3
-
27
-
-
33644809537
-
Species-and cell type-specific interactions between CD47 and human SIRPalpha
-
Subramanian S, Parthasarathy R, Sen S, et al. Species-and cell type-specific interactions between CD47 and human SIRPalpha. Blood 2006;107:2548-56.
-
(2006)
Blood
, vol.107
, pp. 2548-2556
-
-
Subramanian, S.1
Parthasarathy, R.2
Sen, S.3
-
28
-
-
79951845617
-
Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia
-
Chao MP, Alizadeh AA, Tang C, et al. Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia. Cancer Res 2011;71:1374-84.
-
(2011)
Cancer Res
, vol.71
, pp. 1374-1384
-
-
Chao, M.P.1
Alizadeh, A.A.2
Tang, C.3
-
29
-
-
33847305519
-
Phylogenetic divergence of CD47 interactions with human signal regulatory protein alpha reveals locus of species specificity. Implications for the binding site
-
Subramanian S, Boder ET, Discher DE. Phylogenetic divergence of CD47 interactions with human signal regulatory protein alpha reveals locus of species specificity. Implications for the binding site. J Biol Chem 2007;282:1805-18.
-
(2007)
J Biol Chem
, vol.282
, pp. 1805-1818
-
-
Subramanian, S.1
Boder, E.T.2
Discher, D.E.3
-
30
-
-
85014098971
-
Direct SIRPa blockade augments macrophage responses to therapeutic anticancer antibodies
-
Weiskopf K, Ring AM, Guo N, et al. Direct SIRPa blockade augments macrophage responses to therapeutic anticancer antibodies. Blood 2014;124:2729.
-
(2014)
Blood
, vol.124
, pp. 2729
-
-
Weiskopf, K.1
Ring, A.M.2
Guo, N.3
-
31
-
-
51649122800
-
Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro
-
Stefanidakis M, Newton G, Lee WY, et al. Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro. Blood 2008;112:1280-9.
-
(2008)
Blood
, vol.112
, pp. 1280-1289
-
-
Stefanidakis, M.1
Newton, G.2
Lee, W.Y.3
-
32
-
-
84886603040
-
A cytokine-controlled mechanism for integrated regulation of T-lymphocyte motility, adhesion and activation
-
Bergström SE, Bergdahl E, Sundqvist KG. A cytokine-controlled mechanism for integrated regulation of T-lymphocyte motility, adhesion and activation. Immunology 2013;140:441-55.
-
(2013)
Immunology
, vol.140
, pp. 441-455
-
-
Bergström, S.E.1
Bergdahl, E.2
Sundqvist, K.G.3
-
33
-
-
78650664067
-
Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47
-
Chao MP, Jaiswal S, Weissman-Tsukamoto R, et al. Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47. Sci Transl Med 2010;2:63ra94.
-
(2010)
Sci Transl Med
, vol.2
-
-
Chao, M.P.1
Jaiswal, S.2
Weissman-Tsukamoto, R.3
-
34
-
-
84923166595
-
Macrophages eat cancer cells using their own calreticulin as a guide: roles of TLR and Btk
-
Feng M, Chen JY, Weissman-Tsukamoto R, et al. Macrophages eat cancer cells using their own calreticulin as a guide: roles of TLR and Btk. Proc Natl Acad Sci U S A 2015;112:2145-50.
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, pp. 2145-2150
-
-
Feng, M.1
Chen, J.Y.2
Weissman-Tsukamoto, R.3
-
35
-
-
11844291403
-
Autocrine regulation of T cell motility by calreticulin-thrombospondin-1 interaction
-
Li SS, Forslöw A, Sundqvist KG. Autocrine regulation of T cell motility by calreticulin-thrombospondin-1 interaction. J Immunol 2005;174:654-61.
-
(2005)
J Immunol
, vol.174
, pp. 654-661
-
-
Li, S.S.1
Forslöw, A.2
Sundqvist, K.G.3
|