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Volumn 9, Issue 2, 2017, Pages E168-E174

Targeting CD47: The achievements and concerns of current studies on cancer immunotherapy

Author keywords

Antibody dependent cell mediated cytotoxicity (ADCC); Calreticulin; CD47; Syngeneic; Xenograft

Indexed keywords

ANTINEOPLASTIC AGENT; CALRETICULIN; CD47 ANTIBODY; CD47 ANTIGEN; FC RECEPTOR; PROTEIN ANTIBODY; REGULATOR PROTEIN; SIGNAL REGULATORY PROTEIN ALPHA; UNCLASSIFIED DRUG;

EID: 85014106358     PISSN: 20721439     EISSN: 20776624     Source Type: Journal    
DOI: 10.21037/jtd.2017.02.30     Document Type: Article
Times cited : (90)

References (35)
  • 1
    • 77956150056 scopus 로고    scopus 로고
    • Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma
    • Chao MP, Alizadeh AA, Tang C, et al. Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma. Cell 2010;142:699-713.
    • (2010) Cell , vol.142 , pp. 699-713
    • Chao, M.P.1    Alizadeh, A.A.2    Tang, C.3
  • 2
    • 84860174226 scopus 로고    scopus 로고
    • The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
    • Willingham SB, Volkmer JP, Gentles AJ, et al. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A 2012;109:6662-7.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 6662-6667
    • Willingham, S.B.1    Volkmer, J.P.2    Gentles, A.J.3
  • 3
    • 84978381315 scopus 로고    scopus 로고
    • CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer
    • Weiskopf K, Jahchan NS, Schnorr PJ, et al. CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. J Clin Invest 2016;126:2610-20.
    • (2016) J Clin Invest , vol.126 , pp. 2610-2620
    • Weiskopf, K.1    Jahchan, N.S.2    Schnorr, P.J.3
  • 4
    • 85009060716 scopus 로고    scopus 로고
    • Is CD47 an innate immune checkpoint for tumor evasion?
    • Liu X, Kwon H, Li Z, et al. Is CD47 an innate immune checkpoint for tumor evasion? J Hematol Oncol 2017;10:12.
    • (2017) J Hematol Oncol , vol.10 , pp. 12
    • Liu, X.1    Kwon, H.2    Li, Z.3
  • 5
    • 85014082427 scopus 로고    scopus 로고
    • A Phase 1 Study of TTI-621, a Novel Immune Checkpoint Inhibitor Targeting CD47, in Patients with Relapsed or Refractory Hematologic Malignancies
    • Ansell S, Chen RW, Flinn IW, et al. A Phase 1 Study of TTI-621, a Novel Immune Checkpoint Inhibitor Targeting CD47, in Patients with Relapsed or Refractory Hematologic Malignancies. Blood 2016;128:1812.
    • (2016) Blood , vol.128 , pp. 1812
    • Ansell, S.1    Chen, R.W.2    Flinn, I.W.3
  • 6
    • 85014110009 scopus 로고    scopus 로고
    • Abstract PR13: The anti-CD47 antibody Hu5F9-G4 is a novel immune checkpoint inhibitor with synergistic efficacy in combination with clinically active cancer targeting antibodies
    • Chao MP, McKenna KM, Cha A, et al. Abstract PR13: The anti-CD47 antibody Hu5F9-G4 is a novel immune checkpoint inhibitor with synergistic efficacy in combination with clinically active cancer targeting antibodies. Cancer Immunol Res 2016;4:Abstract nr PR13.
    • (2016) Cancer Immunol Res , vol.4
    • Chao, M.P.1    McKenna, K.M.2    Cha, A.3
  • 7
    • 85014060474 scopus 로고    scopus 로고
    • A first-in-human, first-in-class phase I trial of the anti-CD47 antibody Hu5F9-G4 in patients with advanced cancers
    • Sikic BI, Narayanan S, Colevas AD, et al. A first-in-human, first-in-class phase I trial of the anti-CD47 antibody Hu5F9-G4 in patients with advanced cancers. J Clin Oncol 2016;34:abstr 3019.
    • (2016) J Clin Oncol , vol.34
    • Sikic, B.I.1    Narayanan, S.2    Colevas, A.D.3
  • 8
    • 85012939247 scopus 로고    scopus 로고
    • TTI-621 (SIRPaFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding
    • Petrova PS, Viller NN, Wong M, et al. TTI-621 (SIRPaFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding. Clin Cancer Res 2017;23:1068-79.
    • (2017) Clin Cancer Res , vol.23 , pp. 1068-1079
    • Petrova, P.S.1    Viller, N.N.2    Wong, M.3
  • 9
    • 0037092957 scopus 로고    scopus 로고
    • Lethal autoimmune hemolytic anemia in CD47-deficient nonobese diabetic (NOD) mice
    • Oldenborg PA, Gresham HD, Chen Y, et al. Lethal autoimmune hemolytic anemia in CD47-deficient nonobese diabetic (NOD) mice. Blood 2002;99:3500-4.
    • (2002) Blood , vol.99 , pp. 3500-3504
    • Oldenborg, P.A.1    Gresham, H.D.2    Chen, Y.3
  • 10
    • 18244396105 scopus 로고    scopus 로고
    • Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia
    • Olsson M, Bruhns P, Frazier WA, et al. Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia. Blood 2005;105:3577-82.
    • (2005) Blood , vol.105 , pp. 3577-3582
    • Olsson, M.1    Bruhns, P.2    Frazier, W.A.3
  • 11
    • 67650646082 scopus 로고    scopus 로고
    • CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis
    • Jaiswal S, Jamieson CH, Pang WW, et al. CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell 2009;138:271-85.
    • (2009) Cell , vol.138 , pp. 271-285
    • Jaiswal, S.1    Jamieson, C.H.2    Pang, W.W.3
  • 12
    • 67650632683 scopus 로고    scopus 로고
    • CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells
    • Majeti R, Chao MP, Alizadeh AA, et al. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell 2009;138:286-99.
    • (2009) Cell , vol.138 , pp. 286-299
    • Majeti, R.1    Chao, M.P.2    Alizadeh, A.A.3
  • 13
    • 69549114870 scopus 로고    scopus 로고
    • Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells
    • Chan KS, Espinosa I, Chao M, et al. Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc Natl Acad Sci U S A 2009;106:14016-21.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 14016-14021
    • Chan, K.S.1    Espinosa, I.2    Chao, M.3
  • 14
    • 84966270767 scopus 로고    scopus 로고
    • Durable antitumor responses to CD47 blockade require adaptive immune stimulation
    • Sockolosky JT, Dougan M, Ingram JR, et al. Durable antitumor responses to CD47 blockade require adaptive immune stimulation. Proc Natl Acad Sci U S A 2016;113:E2646-54.
    • (2016) Proc Natl Acad Sci U S A , vol.113 , pp. E2646-E2654
    • Sockolosky, J.T.1    Dougan, M.2    Ingram, J.R.3
  • 15
    • 84879797224 scopus 로고    scopus 로고
    • Engineered SIRPa variants as immunotherapeutic adjuvants to anticancer antibodies
    • Weiskopf K, Ring AM, Ho CC, et al. Engineered SIRPa variants as immunotherapeutic adjuvants to anticancer antibodies. Science 2013;341:88-91.
    • (2013) Science , vol.341 , pp. 88-91
    • Weiskopf, K.1    Ring, A.M.2    Ho, C.C.3
  • 16
    • 81055145277 scopus 로고    scopus 로고
    • CD47-signal regulatory protein-a (SIRPa) interactions form a barrier for antibody-mediated tumor cell destruction
    • Zhao XW, van Beek EM, Schornagel K, et al. CD47-signal regulatory protein-a (SIRPa) interactions form a barrier for antibody-mediated tumor cell destruction. Proc Natl Acad Sci U S A 2011;108:18342-7.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 18342-18347
    • Zhao, X.W.1    van Beek, E.M.2    Schornagel, K.3
  • 17
    • 80855128780 scopus 로고    scopus 로고
    • Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy
    • Chao MP, Tang C, Pachynski RK, et al. Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy. Blood 2011;118:4890-901.
    • (2011) Blood , vol.118 , pp. 4890-4901
    • Chao, M.P.1    Tang, C.2    Pachynski, R.K.3
  • 19
    • 84943630992 scopus 로고    scopus 로고
    • CD47 blockade triggers T cell-mediated destruction of immunogenic tumors
    • Liu X, Pu Y, Cron K, et al. CD47 blockade triggers T cell-mediated destruction of immunogenic tumors. Nat Med 2015;21:1209-15.
    • (2015) Nat Med , vol.21 , pp. 1209-1215
    • Liu, X.1    Pu, Y.2    Cron, K.3
  • 20
    • 84904888812 scopus 로고    scopus 로고
    • Signal-regulatory protein a from the NOD mouse binds human CD47 with an exceptionally high affinity-implications for engraftment of human cells
    • Kwong LS, Brown MH, Barclay AN, et al. Signal-regulatory protein a from the NOD mouse binds human CD47 with an exceptionally high affinity-implications for engraftment of human cells. Immunology 2014;143:61-7.
    • (2014) Immunology , vol.143 , pp. 61-67
    • Kwong, L.S.1    Brown, M.H.2    Barclay, A.N.3
  • 21
    • 84867648736 scopus 로고    scopus 로고
    • Reply to Soto-Pantoja et al. and Zhao et al.: Targeting CD47 on human solid tumors
    • Willingham SB, Volkmer JP, Weiskopf K, et al. Reply to Soto-Pantoja et al. and Zhao et al.: Targeting CD47 on human solid tumors. Proc Natl Acad Sci U S A 2012;109:E2844-5.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. E2844-E2845
    • Willingham, S.B.1    Volkmer, J.P.2    Weiskopf, K.3
  • 22
    • 84897769541 scopus 로고    scopus 로고
    • The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment
    • Iwamoto C, Takenaka K, Urata S, et al. The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment. Exp Hematol 2014;42:163-171.e1.
    • (2014) Exp Hematol , vol.42 , pp. 163.e1-171.e1
    • Iwamoto, C.1    Takenaka, K.2    Urata, S.3
  • 23
    • 80051988436 scopus 로고    scopus 로고
    • Transgenic expression of human signal regulatory protein alpha in Rag2-/-γc-/-mice improves engraftment of human hematopoietic cells in humanized mice
    • Strowig T, Rongvaux A, Rathinam C, et al. Transgenic expression of human signal regulatory protein alpha in Rag2-/-γc-/-mice improves engraftment of human hematopoietic cells in humanized mice. Proc Natl Acad Sci U S A 2011;108:131218-23.
    • (2011) Proc Natl Acad Sci U S A , vol.108
    • Strowig, T.1    Rongvaux, A.2    Rathinam, C.3
  • 24
    • 84900850997 scopus 로고    scopus 로고
    • Development and function of human innate immune cells in a humanized mouse model
    • Rongvaux A, Willinger T, Martinek J, et al. Development and function of human innate immune cells in a humanized mouse model. Nat Biotechnol 2014;32:364-72.
    • (2014) Nat Biotechnol , vol.32 , pp. 364-372
    • Rongvaux, A.1    Willinger, T.2    Martinek, J.3
  • 25
    • 85026844244 scopus 로고    scopus 로고
    • Abstract B126: Correlation of tumor growth inhibition by check point inhibitors with PD-L1 expression in preclinical patient derived xenograft (PDX) models
    • Stecklum M, Wulf-Goldenberg A, Brzezicha B, et al. Abstract B126: Correlation of tumor growth inhibition by check point inhibitors with PD-L1 expression in preclinical patient derived xenograft (PDX) models. Cancer Immunol Res 2016;4:Abstract nr B126.
    • (2016) Cancer Immunol Res , vol.4
    • Stecklum, M.1    Wulf-Goldenberg, A.2    Brzezicha, B.3
  • 26
    • 84936804591 scopus 로고    scopus 로고
    • Loss of Cell Surface CD47 Clustering Formation and Binding Avidity to SIRPa Facilitate Apoptotic Cell Clearance by Macrophages
    • Lv Z, Bian Z, Shi L, et al. Loss of Cell Surface CD47 Clustering Formation and Binding Avidity to SIRPa Facilitate Apoptotic Cell Clearance by Macrophages. J Immunol 2015;195:661-71.
    • (2015) J Immunol , vol.195 , pp. 661-671
    • Lv, Z.1    Bian, Z.2    Shi, L.3
  • 27
    • 33644809537 scopus 로고    scopus 로고
    • Species-and cell type-specific interactions between CD47 and human SIRPalpha
    • Subramanian S, Parthasarathy R, Sen S, et al. Species-and cell type-specific interactions between CD47 and human SIRPalpha. Blood 2006;107:2548-56.
    • (2006) Blood , vol.107 , pp. 2548-2556
    • Subramanian, S.1    Parthasarathy, R.2    Sen, S.3
  • 28
    • 79951845617 scopus 로고    scopus 로고
    • Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia
    • Chao MP, Alizadeh AA, Tang C, et al. Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia. Cancer Res 2011;71:1374-84.
    • (2011) Cancer Res , vol.71 , pp. 1374-1384
    • Chao, M.P.1    Alizadeh, A.A.2    Tang, C.3
  • 29
    • 33847305519 scopus 로고    scopus 로고
    • Phylogenetic divergence of CD47 interactions with human signal regulatory protein alpha reveals locus of species specificity. Implications for the binding site
    • Subramanian S, Boder ET, Discher DE. Phylogenetic divergence of CD47 interactions with human signal regulatory protein alpha reveals locus of species specificity. Implications for the binding site. J Biol Chem 2007;282:1805-18.
    • (2007) J Biol Chem , vol.282 , pp. 1805-1818
    • Subramanian, S.1    Boder, E.T.2    Discher, D.E.3
  • 30
    • 85014098971 scopus 로고    scopus 로고
    • Direct SIRPa blockade augments macrophage responses to therapeutic anticancer antibodies
    • Weiskopf K, Ring AM, Guo N, et al. Direct SIRPa blockade augments macrophage responses to therapeutic anticancer antibodies. Blood 2014;124:2729.
    • (2014) Blood , vol.124 , pp. 2729
    • Weiskopf, K.1    Ring, A.M.2    Guo, N.3
  • 31
    • 51649122800 scopus 로고    scopus 로고
    • Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro
    • Stefanidakis M, Newton G, Lee WY, et al. Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro. Blood 2008;112:1280-9.
    • (2008) Blood , vol.112 , pp. 1280-1289
    • Stefanidakis, M.1    Newton, G.2    Lee, W.Y.3
  • 32
    • 84886603040 scopus 로고    scopus 로고
    • A cytokine-controlled mechanism for integrated regulation of T-lymphocyte motility, adhesion and activation
    • Bergström SE, Bergdahl E, Sundqvist KG. A cytokine-controlled mechanism for integrated regulation of T-lymphocyte motility, adhesion and activation. Immunology 2013;140:441-55.
    • (2013) Immunology , vol.140 , pp. 441-455
    • Bergström, S.E.1    Bergdahl, E.2    Sundqvist, K.G.3
  • 33
    • 78650664067 scopus 로고    scopus 로고
    • Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47
    • Chao MP, Jaiswal S, Weissman-Tsukamoto R, et al. Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47. Sci Transl Med 2010;2:63ra94.
    • (2010) Sci Transl Med , vol.2
    • Chao, M.P.1    Jaiswal, S.2    Weissman-Tsukamoto, R.3
  • 34
    • 84923166595 scopus 로고    scopus 로고
    • Macrophages eat cancer cells using their own calreticulin as a guide: roles of TLR and Btk
    • Feng M, Chen JY, Weissman-Tsukamoto R, et al. Macrophages eat cancer cells using their own calreticulin as a guide: roles of TLR and Btk. Proc Natl Acad Sci U S A 2015;112:2145-50.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 2145-2150
    • Feng, M.1    Chen, J.Y.2    Weissman-Tsukamoto, R.3
  • 35
    • 11844291403 scopus 로고    scopus 로고
    • Autocrine regulation of T cell motility by calreticulin-thrombospondin-1 interaction
    • Li SS, Forslöw A, Sundqvist KG. Autocrine regulation of T cell motility by calreticulin-thrombospondin-1 interaction. J Immunol 2005;174:654-61.
    • (2005) J Immunol , vol.174 , pp. 654-661
    • Li, S.S.1    Forslöw, A.2    Sundqvist, K.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.